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Drug Metabolism & Disposition

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Table of Contents

July 01, 2016; Volume 44,Issue 7

Special Section on Pediatric Drug Disposition and Pharmacokinetics

  • You have access
    Challenges and Opportunities for Increasing the Knowledge Base Related to Drug Biotransformation and Pharmacokinetics during Growth and Development
    J. Steven Leeder and Bernd Meibohm
    Drug Metabolism and Disposition July 2016, 44 (7) 916-923; DOI: https://doi.org/10.1124/dmd.116.071159
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    Role of Quantitative Clinical Pharmacology in Pediatric Approval and Labeling
    Nitin Mehrotra, Atul Bhattaram, Justin C. Earp, Jeffry Florian, Kevin Krudys, Jee Eun Lee, Joo Yeon Lee, Jiang Liu, Yeruk Mulugeta, Jingyu Yu, Ping Zhao and Vikram Sinha
    Drug Metabolism and Disposition July 2016, 44 (7) 924-933; DOI: https://doi.org/10.1124/dmd.116.069559
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    Physiologically Based Pharmacokinetic Modeling in Pediatric Oncology Drug Development
    Nathalie Rioux and Nigel J. Waters
    Drug Metabolism and Disposition July 2016, 44 (7) 934-943; DOI: https://doi.org/10.1124/dmd.115.068031
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    Effect of Age on The Hepatocellularity Number for Wistar rats
    Sarinj Fattah, Patrick Augustijns and Pieter Annaert
    Drug Metabolism and Disposition July 2016, 44 (7) 944-947; DOI: https://doi.org/10.1124/dmd.115.066381
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    Developmental Expression of CYP2B6: A Comprehensive Analysis of mRNA Expression, Protein Content and Bupropion Hydroxylase Activity and the Impact of Genetic Variation
    Robin E. Pearce, Roger Gaedigk, Greyson P. Twist, Hongying Dai, Amanda K. Riffel, J. Steven Leeder and Andrea Gaedigk
    Drug Metabolism and Disposition July 2016, 44 (7) 948-958; DOI: https://doi.org/10.1124/dmd.115.067546
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    Age-Dependent Human Hepatic Carboxylesterase 1 (CES1) and Carboxylesterase 2 (CES2) Postnatal Ontogeny
    Ronald N. Hines, Pippa M. Simpson and D. Gail McCarver
    Drug Metabolism and Disposition July 2016, 44 (7) 959-966; DOI: https://doi.org/10.1124/dmd.115.068957
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    The Ontogeny and Population Variability of Human Hepatic NADPH Dehydrogenase Quinone Oxido-Reductase 1 (NQO1)
    Luc R.A. Rougée, Zoe Riches, Jacob M. Berman and Abby C. Collier
    Drug Metabolism and Disposition July 2016, 44 (7) 967-974; DOI: https://doi.org/10.1124/dmd.115.068650
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    Quantification of Flavin-containing Monooxygenases 1, 3, and 5 in Human Liver Microsomes by UPLC-MRM-Based Targeted Quantitative Proteomics and Its Application to the Study of Ontogeny
    Yao Chen, Nicole R. Zane, Dhiren R. Thakker and Michael Zhuo Wang
    Drug Metabolism and Disposition July 2016, 44 (7) 975-983; DOI: https://doi.org/10.1124/dmd.115.067538
  • Hepatic Cytochrome P450 Activity, Abundance, and Expression Throughout Human Development
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    Hepatic Cytochrome P450 Activity, Abundance, and Expression Throughout Human Development
    Natalie C. Sadler, Premchendar Nandhikonda, Bobbie-Jo Webb-Robertson, Charles Ansong, Lindsey N. Anderson, Jordan N. Smith, Richard A. Corley and Aaron T. Wright
    Drug Metabolism and Disposition July 2016, 44 (7) 984-991; DOI: https://doi.org/10.1124/dmd.115.068593
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    Ontogeny of Hepatic Drug Transporters and Relevance to Drugs Used in Pediatrics
    Yasmine Elmorsi, Jill Barber and Amin Rostami-Hodjegan
    Drug Metabolism and Disposition July 2016, 44 (7) 992-998; DOI: https://doi.org/10.1124/dmd.115.067801
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    Expression Patterns of Organic Anion Transporting Polypeptides 1B1 and 1B3 Protein in Human Pediatric Liver
    Margaret M. S. Thomson, Ronald N. Hines, Erin G. Schuetz and Bernd Meibohm
    Drug Metabolism and Disposition July 2016, 44 (7) 999-1004; DOI: https://doi.org/10.1124/dmd.115.069252
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    Proteomic Analysis of the Developmental Trajectory of Human Hepatic Membrane Transporter Proteins in the First Three Months of Life
    Miriam G. Mooij, Evita van de Steeg, Joost van Rosmalen, Jonathan D. Windster, Barbara A.E. de Koning, Wouter H. J. Vaes, Bianca D. van Groen, Dick Tibboel, Heleen M. Wortelboer and Saskia N. de Wildt
    Drug Metabolism and Disposition July 2016, 44 (7) 1005-1013; DOI: https://doi.org/10.1124/dmd.115.068577
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    Human Intestinal PEPT1 Transporter Expression and Localization in Preterm and Term Infants
    Miriam G. Mooij, Barbara E. A. de Koning, Dicky J. Lindenbergh-Kortleve, Ytje Simons-Oosterhuis, Bianca D. van Groen, Dick Tibboel, Janneke N. Samsom and Saskia N. de Wildt
    Drug Metabolism and Disposition July 2016, 44 (7) 1014-1019; DOI: https://doi.org/10.1124/dmd.115.068809
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    Dynamics of Cytosine Methylation in the Proximal Promoters of CYP3A4 and CYP3A7 in Pediatric and Prenatal Livers
    Carrie A. Vyhlidal, Chengpeng Bi, Shui Qing Ye and J. Steven Leeder
    Drug Metabolism and Disposition July 2016, 44 (7) 1020-1026; DOI: https://doi.org/10.1124/dmd.115.068726
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    Role of Chromatin Structural Changes in Regulating Human CYP3A Ontogeny
    Nicholas L. Giebel, Jeffrey D. Shadley, D. Gail McCarver, Kenneth Dorko, Roberto Gramignoli, Stephen C. Strom, Ke Yan, Pippa M. Simpson and Ronald N. Hines
    Drug Metabolism and Disposition July 2016, 44 (7) 1027-1037; DOI: https://doi.org/10.1124/dmd.116.069344
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    Age-Specific Regulation of Drug-Processing Genes in Mouse Liver by Ligands of Xenobiotic-Sensing Transcription Factors
    Cindy Yanfei Li, Helen J. Renaud, Curtis D. Klaassen and Julia Yue Cui
    Drug Metabolism and Disposition July 2016, 44 (7) 1038-1049; DOI: https://doi.org/10.1124/dmd.115.066639
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    Kidney versus Liver Specification of SLC and ABC Drug Transporters, Tight Junction Molecules, and Biomarkers
    Gleb Martovetsky, Kevin T. Bush and Sanjay K. Nigam
    Drug Metabolism and Disposition July 2016, 44 (7) 1050-1060; DOI: https://doi.org/10.1124/dmd.115.068254
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    Correlation between Conjugated Bisphenol A Concentrations and Efflux Transporter Expression in Human Fetal Livers
    Jamie E. Moscovitz, Muna S. Nahar, Stuart L. Shalat, Angela L. Slitt, Dana C. Dolinoy and Lauren M. Aleksunes
    Drug Metabolism and Disposition July 2016, 44 (7) 1061-1065; DOI: https://doi.org/10.1124/dmd.115.068668
  • Open Access
    Decreased Pregnane X Receptor Expression in Children with Active Crohn’s Disease
    Valentina Shakhnovich, Carrie Vyhlidal, Craig Friesen, Amber Hildreth, Vivekanand Singh, James Daniel, Gregory L. Kearns and J. Steven Leeder
    Drug Metabolism and Disposition July 2016, 44 (7) 1066-1069; DOI: https://doi.org/10.1124/dmd.115.068742
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    Characterization of Atomoxetine Biotransformation and Implications for Development of PBPK Models for Dose Individualization in Children
    Jean C. Dinh, Robin E. Pearce, Leon Van Haandel, Andrea Gaedigk and J. Steven Leeder
    Drug Metabolism and Disposition July 2016, 44 (7) 1070-1079; DOI: https://doi.org/10.1124/dmd.116.069518
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    Examining Small Intestinal Transit Time as a Function of Age: Is There Evidence to Support Age-Dependent Differences among Children?
    Anil R. Maharaj and Andrea N. Edginton
    Drug Metabolism and Disposition July 2016, 44 (7) 1080-1089; DOI: https://doi.org/10.1124/dmd.115.068700
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    How Does In Vivo Biliary Elimination of Drugs Change with Age? Evidence from In Vitro and Clinical Data Using a Systems Pharmacology Approach
    Trevor N. Johnson, Masoud Jamei and Karen Rowland-Yeo
    Drug Metabolism and Disposition July 2016, 44 (7) 1090-1098; DOI: https://doi.org/10.1124/dmd.115.068643
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    Considering Age Variation When Coining Drugs as High versus Low Hepatic Extraction Ratio
    Farzaneh Salem, Khaled Abduljalil, Yoshiteru Kamiyama and Amin Rostami-Hodjegan
    Drug Metabolism and Disposition July 2016, 44 (7) 1099-1102; DOI: https://doi.org/10.1124/dmd.115.067595
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    Predicting Stereoselective Disposition of Carvedilol in Adult and Pediatric Chronic Heart Failure Patients by Incorporating Pathophysiological Changes in Organ Blood Flows–A Physiologically Based Pharmacokinetic Approach
    Muhammad Fawad Rasool, Feras Khalil and Stephanie Läer
    Drug Metabolism and Disposition July 2016, 44 (7) 1103-1115; DOI: https://doi.org/10.1124/dmd.115.068858
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    Population Pharmacokinetics of Oral Topotecan in Infants and Very Young Children with Brain Tumors Demonstrates a Role of ABCG2 rs4148157 on the Absorption Rate Constant
    Jessica K. Roberts, Anna V. Birg, Tong Lin, Vinay M. Daryani, John C. Panetta, Alberto Broniscer, Giles W. Robinson, Amar J. Gajjar and Clinton F. Stewart
    Drug Metabolism and Disposition July 2016, 44 (7) 1116-1122; DOI: https://doi.org/10.1124/dmd.115.068676

Articles

  • Cardiotonic Pill Reduces Myocardial Ischemia-Reperfusion Injury via Increasing EET Concentrations in Rats
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    Cardiotonic Pill Reduces Myocardial Ischemia-Reperfusion Injury via Increasing EET Concentrations in Rats
    Meijuan Xu, Haiping Hao, Lifeng Jiang, Yidan Wei, Fang Zhou, Jianguo Sun, Jingwei Zhang, Hui Ji, Guangji Wang, Wenzheng Ju and Ping Li
    Drug Metabolism and Disposition July 2016, 44 (7) 878-887; DOI: https://doi.org/10.1124/dmd.116.069914
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    Zomepirac Acyl Glucuronide Is Responsible for Zomepirac-Induced Acute Kidney Injury in Mice
    Atsushi Iwamura, Katsuhito Watanabe, Sho Akai, Tsubasa Nishinosono, Koichi Tsuneyama, Shingo Oda, Toshiyuki Kume and Tsuyoshi Yokoi
    Drug Metabolism and Disposition July 2016, 44 (7) 888-896; DOI: https://doi.org/10.1124/dmd.116.069575
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    New Insights in Tissue Distribution, Metabolism, and Excretion of [3H]-Labeled Antibody Maytansinoid Conjugates in Female Tumor-Bearing Nude Rats
    Markus Walles, Bettina Rudolph, Thierry Wolf, Julien Bourgailh, Martina Suetterlin, Thomas Moenius, Gisela Peraus, Olivier Heudi, Walid Elbast, Christian Lanshoeft and Sanela Bilic
    Drug Metabolism and Disposition July 2016, 44 (7) 897-910; DOI: https://doi.org/10.1124/dmd.115.069021
  • Individual Differences in Metabolic Clearance of <em>S</em>-Warfarin Efficiently Mediated by Polymorphic Marmoset Cytochrome P450 2C19 in Livers
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    Individual Differences in Metabolic Clearance of S-Warfarin Efficiently Mediated by Polymorphic Marmoset Cytochrome P450 2C19 in Livers
    Shotaro Uehara, Yasuhiro Uno, Takashi Inoue, Mirai Kawano, Makiko Shimizu, Akiko Toda, Masahiro Utoh, Erika Sasaki and Hiroshi Yamazaki
    Drug Metabolism and Disposition July 2016, 44 (7) 911-915; DOI: https://doi.org/10.1124/dmd.116.070383
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    Metabolite Kinetics: The Segregated Flow Model for Intestinal and Whole Body Physiologically Based Pharmacokinetic Modeling to Describe Intestinal and Hepatic Glucuronidation of Morphine in Rats In Vivo
    Qi Joy Yang, Jianghong Fan, Shu Chen, Lutan Liu, Huadong Sun and K. Sandy Pang
    Drug Metabolism and Disposition July 2016, 44 (7) 1123-1138; DOI: https://doi.org/10.1124/dmd.116.069542
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Drug Metabolism and Disposition: 44 (7)
Drug Metabolism and Disposition
Vol. 44, Issue 7
1 Jul 2016
  • Table of Contents
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  • Special Section on Pediatric Drug Disposition and Pharmacokinetics
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
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