Table of Contents

Special Section on Pediatric Drug Disposition and Pharmacokinetics

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  Challenges and Opportunities for Increasing the Knowledge Base Related to Drug Biotransformation and Pharmacokinetics during Growth and Development

  J. Steven Leeder and Bernd Meibohm

  Drug Metabolism and Disposition July 2016, 44 (7) 916-923; DOI: https://doi.org/10.1124/dmd.116.071159
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  Role of Quantitative Clinical Pharmacology in Pediatric Approval and Labeling

  Nitin Mehrotra, Atul Bhattaram, Justin C. Earp, Jeffry Florian, Kevin Krudys, Jee Eun Lee, Joo Yeon Lee, Jiang Liu, Yeruk Mulugeta, Jingyu Yu, Ping Zhao and Vikram Sinha

  Drug Metabolism and Disposition July 2016, 44 (7) 924-933; DOI: https://doi.org/10.1124/dmd.116.069559
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  Physiologically Based Pharmacokinetic Modeling in Pediatric Oncology Drug Development

  Nathalie Rioux and Nigel J. Waters

  Drug Metabolism and Disposition July 2016, 44 (7) 934-943; DOI: https://doi.org/10.1124/dmd.115.068031
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  Effect of Age on The Hepatocellularity Number for Wistar rats

  Sarinj Fattah, Patrick Augustijns and Pieter Annaert

  Drug Metabolism and Disposition July 2016, 44 (7) 944-947; DOI: https://doi.org/10.1124/dmd.115.066381
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  Developmental Expression of CYP2B6: A Comprehensive Analysis of mRNA Expression, Protein Content and Bupropion Hydroxylase Activity and the Impact of Genetic Variation

  Robin E. Pearce, Roger Gaedigk, Greyson P. Twist, Hongying Dai, Amanda K. Riffel, J. Steven Leeder and Andrea Gaedigk

  Drug Metabolism and Disposition July 2016, 44 (7) 948-958; DOI: https://doi.org/10.1124/dmd.115.067546
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  Age-Dependent Human Hepatic Carboxylesterase 1 (CES1) and Carboxylesterase 2 (CES2) Postnatal Ontogeny

  Ronald N. Hines, Pippa M. Simpson and D. Gail McCarver

  Drug Metabolism and Disposition July 2016, 44 (7) 959-966; DOI: https://doi.org/10.1124/dmd.115.068957
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  The Ontogeny and Population Variability of Human Hepatic NADPH Dehydrogenase Quinone Oxido-Reductase 1 (NQO1)

  Luc R.A. Rougée, Zoe Riches, Jacob M. Berman and Abby C. Collier

  Drug Metabolism and Disposition July 2016, 44 (7) 967-974; DOI: https://doi.org/10.1124/dmd.115.068650
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  Quantification of Flavin-containing Monooxygenases 1, 3, and 5 in Human Liver Microsomes by UPLC-MRM-Based Targeted Quantitative Proteomics and Its Application to the Study of Ontogeny

  Yao Chen, Nicole R. Zane, Dhiren R. Thakker and Michael Zhuo Wang

  Drug Metabolism and Disposition July 2016, 44 (7) 975-983; DOI: https://doi.org/10.1124/dmd.115.067538
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  Hepatic Cytochrome P450 Activity, Abundance, and Expression Throughout Human Development

  Natalie C. Sadler, Premchendar Nandhikonda, Bobbie-Jo Webb-Robertson, Charles Ansong, Lindsey N. Anderson, Jordan N. Smith, Richard A. Corley and Aaron T. Wright

  Drug Metabolism and Disposition July 2016, 44 (7) 984-991; DOI: https://doi.org/10.1124/dmd.115.068593
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  Ontogeny of Hepatic Drug Transporters and Relevance to Drugs Used in Pediatrics

  Yasmine Elmorsi, Jill Barber and Amin Rostami-Hodjegan

  Drug Metabolism and Disposition July 2016, 44 (7) 992-998; DOI: https://doi.org/10.1124/dmd.115.067801
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  Expression Patterns of Organic Anion Transporting Polypeptides 1B1 and 1B3 Protein in Human Pediatric Liver

  Margaret M. S. Thomson, Ronald N. Hines, Erin G. Schuetz and Bernd Meibohm

  Drug Metabolism and Disposition July 2016, 44 (7) 999-1004; DOI: https://doi.org/10.1124/dmd.115.069252
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  Proteomic Analysis of the Developmental Trajectory of Human Hepatic Membrane Transporter Proteins in the First Three Months of Life

  Miriam G. Mooij, Evita van de Steeg, Joost van Rosmalen, Jonathan D. Windster, Barbara A.E. de Koning, Wouter H. J. Vaes, Bianca D. van Groen, Dick Tibboel, Heleen M. Wortelboer and Saskia N. de Wildt

  Drug Metabolism and Disposition July 2016, 44 (7) 1005-1013; DOI: https://doi.org/10.1124/dmd.115.068577
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  Human Intestinal PEPT1 Transporter Expression and Localization in Preterm and Term Infants

  Miriam G. Mooij, Barbara E. A. de Koning, Dicky J. Lindenbergh-Kortleve, Ytje Simons-Oosterhuis, Bianca D. van Groen, Dick Tibboel, Janneke N. Samsom and Saskia N. de Wildt

  Drug Metabolism and Disposition July 2016, 44 (7) 1014-1019; DOI: https://doi.org/10.1124/dmd.115.068809
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  Dynamics of Cytosine Methylation in the Proximal Promoters of CYP3A4 and CYP3A7 in Pediatric and Prenatal Livers

  Carrie A. Vyhlidal, Chengpeng Bi, Shui Qing Ye and J. Steven Leeder

  Drug Metabolism and Disposition July 2016, 44 (7) 1020-1026; DOI: https://doi.org/10.1124/dmd.115.068726
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  Role of Chromatin Structural Changes in Regulating Human CYP3A Ontogeny

  Nicholas L. Giebel, Jeffrey D. Shadley, D. Gail McCarver, Kenneth Dorko, Roberto Gramignoli, Stephen C. Strom, Ke Yan, Pippa M. Simpson and Ronald N. Hines

  Drug Metabolism and Disposition July 2016, 44 (7) 1027-1037; DOI: https://doi.org/10.1124/dmd.116.069344
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  Age-Specific Regulation of Drug-Processing Genes in Mouse Liver by Ligands of Xenobiotic-Sensing Transcription Factors

  Cindy Yanfei Li, Helen J. Renaud, Curtis D. Klaassen and Julia Yue Cui

  Drug Metabolism and Disposition July 2016, 44 (7) 1038-1049; DOI: https://doi.org/10.1124/dmd.115.066639
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  Kidney versus Liver Specification of SLC and ABC Drug Transporters, Tight Junction Molecules, and Biomarkers

  Gleb Martovetsky, Kevin T. Bush and Sanjay K. Nigam

  Drug Metabolism and Disposition July 2016, 44 (7) 1050-1060; DOI: https://doi.org/10.1124/dmd.115.068254
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  Correlation between Conjugated Bisphenol A Concentrations and Efflux Transporter Expression in Human Fetal Livers

  Jamie E. Moscovitz, Muna S. Nahar, Stuart L. Shalat, Angela L. Slitt, Dana C. Dolinoy and Lauren M. Aleksunes

  Drug Metabolism and Disposition July 2016, 44 (7) 1061-1065; DOI: https://doi.org/10.1124/dmd.115.068668
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  Decreased Pregnane X Receptor Expression in Children with Active Crohn’s Disease

  Valentina Shakhnovich, Carrie Vyhlidal, Craig Friesen, Amber Hildreth, Vivekanand Singh, James Daniel, Gregory L. Kearns and J. Steven Leeder

  Drug Metabolism and Disposition July 2016, 44 (7) 1066-1069; DOI: https://doi.org/10.1124/dmd.115.068742
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  Characterization of Atomoxetine Biotransformation and Implications for Development of PBPK Models for Dose Individualization in Children

  Jean C. Dinh, Robin E. Pearce, Leon Van Haandel, Andrea Gaedigk and J. Steven Leeder

  Drug Metabolism and Disposition July 2016, 44 (7) 1070-1079; DOI: https://doi.org/10.1124/dmd.116.069518
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  Examining Small Intestinal Transit Time as a Function of Age: Is There Evidence to Support Age-Dependent Differences among Children?

  Anil R. Maharaj and Andrea N. Edginton

  Drug Metabolism and Disposition July 2016, 44 (7) 1080-1089; DOI: https://doi.org/10.1124/dmd.115.068700
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  How Does In Vivo Biliary Elimination of Drugs Change with Age? Evidence from In Vitro and Clinical Data Using a Systems Pharmacology Approach

  Trevor N. Johnson, Masoud Jamei and Karen Rowland-Yeo

  Drug Metabolism and Disposition July 2016, 44 (7) 1090-1098; DOI: https://doi.org/10.1124/dmd.115.068643
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  Considering Age Variation When Coining Drugs as High versus Low Hepatic Extraction Ratio

  Farzaneh Salem, Khaled Abduljalil, Yoshiteru Kamiyama and Amin Rostami-Hodjegan

  Drug Metabolism and Disposition July 2016, 44 (7) 1099-1102; DOI: https://doi.org/10.1124/dmd.115.067595
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  Predicting Stereoselective Disposition of Carvedilol in Adult and Pediatric Chronic Heart Failure Patients by Incorporating Pathophysiological Changes in Organ Blood Flows–A Physiologically Based Pharmacokinetic Approach

  Muhammad Fawad Rasool, Feras Khalil and Stephanie Läer

  Drug Metabolism and Disposition July 2016, 44 (7) 1103-1115; DOI: https://doi.org/10.1124/dmd.115.068858
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  Population Pharmacokinetics of Oral Topotecan in Infants and Very Young Children with Brain Tumors Demonstrates a Role of ABCG2 rs4148157 on the Absorption Rate Constant

  Jessica K. Roberts, Anna V. Birg, Tong Lin, Vinay M. Daryani, John C. Panetta, Alberto Broniscer, Giles W. Robinson, Amar J. Gajjar and Clinton F. Stewart

  Drug Metabolism and Disposition July 2016, 44 (7) 1116-1122; DOI: https://doi.org/10.1124/dmd.115.068676