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Index by author

July 01, 2016; Volume 44,Issue 7

A

  1. Abduljalil, Khaled

    1. Considering Age Variation When Coining Drugs as High versus Low Hepatic Extraction Ratio
      Farzaneh Salem, Khaled Abduljalil, Yoshiteru Kamiyama and Amin Rostami-Hodjegan
      Drug Metabolism and Disposition July 2016, 44 (7) 1099-1102; DOI: https://doi.org/10.1124/dmd.115.067595

  2. Akai, Sho

    1. Zomepirac Acyl Glucuronide Is Responsible for Zomepirac-Induced Acute Kidney Injury in Mice
      Atsushi Iwamura, Katsuhito Watanabe, Sho Akai, Tsubasa Nishinosono, Koichi Tsuneyama, Shingo Oda, Toshiyuki Kume and Tsuyoshi Yokoi
      Drug Metabolism and Disposition July 2016, 44 (7) 888-896; DOI: https://doi.org/10.1124/dmd.116.069575

  3. Aleksunes, Lauren M.

    1. Correlation between Conjugated Bisphenol A Concentrations and Efflux Transporter Expression in Human Fetal Livers
      Jamie E. Moscovitz, Muna S. Nahar, Stuart L. Shalat, Angela L. Slitt, Dana C. Dolinoy and Lauren M. Aleksunes
      Drug Metabolism and Disposition July 2016, 44 (7) 1061-1065; DOI: https://doi.org/10.1124/dmd.115.068668

  4. Anderson, Lindsey N.

    1. Hepatic Cytochrome P450 Activity, Abundance, and Expression Throughout Human Development
      Hepatic Cytochrome P450 Activity, Abundance, and Expression Throughout Human Development
      Natalie C. Sadler, Premchendar Nandhikonda, Bobbie-Jo Webb-Robertson, Charles Ansong, Lindsey N. Anderson, Jordan N. Smith, Richard A. Corley and Aaron T. Wright
      Drug Metabolism and Disposition July 2016, 44 (7) 984-991; DOI: https://doi.org/10.1124/dmd.115.068593

  5. Annaert, Pieter

    1. Effect of Age on The Hepatocellularity Number for Wistar rats
      Sarinj Fattah, Patrick Augustijns and Pieter Annaert
      Drug Metabolism and Disposition July 2016, 44 (7) 944-947; DOI: https://doi.org/10.1124/dmd.115.066381

  6. Ansong, Charles

    1. Hepatic Cytochrome P450 Activity, Abundance, and Expression Throughout Human Development
      Hepatic Cytochrome P450 Activity, Abundance, and Expression Throughout Human Development
      Natalie C. Sadler, Premchendar Nandhikonda, Bobbie-Jo Webb-Robertson, Charles Ansong, Lindsey N. Anderson, Jordan N. Smith, Richard A. Corley and Aaron T. Wright
      Drug Metabolism and Disposition July 2016, 44 (7) 984-991; DOI: https://doi.org/10.1124/dmd.115.068593

  7. Augustijns, Patrick

    1. Effect of Age on The Hepatocellularity Number for Wistar rats
      Sarinj Fattah, Patrick Augustijns and Pieter Annaert
      Drug Metabolism and Disposition July 2016, 44 (7) 944-947; DOI: https://doi.org/10.1124/dmd.115.066381

B

  1. Barber, Jill

    1. Ontogeny of Hepatic Drug Transporters and Relevance to Drugs Used in Pediatrics
      Yasmine Elmorsi, Jill Barber and Amin Rostami-Hodjegan
      Drug Metabolism and Disposition July 2016, 44 (7) 992-998; DOI: https://doi.org/10.1124/dmd.115.067801

  2. Berman, Jacob M.

    1. The Ontogeny and Population Variability of Human Hepatic NADPH Dehydrogenase Quinone Oxido-Reductase 1 (NQO1)
      Luc R.A. Rougée, Zoe Riches, Jacob M. Berman and Abby C. Collier
      Drug Metabolism and Disposition July 2016, 44 (7) 967-974; DOI: https://doi.org/10.1124/dmd.115.068650

  3. Bhattaram, Atul

    1. Role of Quantitative Clinical Pharmacology in Pediatric Approval and Labeling
      Nitin Mehrotra, Atul Bhattaram, Justin C. Earp, Jeffry Florian, Kevin Krudys, Jee Eun Lee, Joo Yeon Lee, Jiang Liu, Yeruk Mulugeta, Jingyu Yu, Ping Zhao and Vikram Sinha
      Drug Metabolism and Disposition July 2016, 44 (7) 924-933; DOI: https://doi.org/10.1124/dmd.116.069559

  4. Bi, Chengpeng

    1. Dynamics of Cytosine Methylation in the Proximal Promoters of CYP3A4 and CYP3A7 in Pediatric and Prenatal Livers
      Carrie A. Vyhlidal, Chengpeng Bi, Shui Qing Ye and J. Steven Leeder
      Drug Metabolism and Disposition July 2016, 44 (7) 1020-1026; DOI: https://doi.org/10.1124/dmd.115.068726

  5. Bilic, Sanela

    1. New Insights in Tissue Distribution, Metabolism, and Excretion of [3H]-Labeled Antibody Maytansinoid Conjugates in Female Tumor-Bearing Nude Rats
      Markus Walles, Bettina Rudolph, Thierry Wolf, Julien Bourgailh, Martina Suetterlin, Thomas Moenius, Gisela Peraus, Olivier Heudi, Walid Elbast, Christian Lanshoeft and Sanela Bilic
      Drug Metabolism and Disposition July 2016, 44 (7) 897-910; DOI: https://doi.org/10.1124/dmd.115.069021

  6. Birg, Anna V.

    1. Population Pharmacokinetics of Oral Topotecan in Infants and Very Young Children with Brain Tumors Demonstrates a Role of ABCG2 rs4148157 on the Absorption Rate Constant
      Jessica K. Roberts, Anna V. Birg, Tong Lin, Vinay M. Daryani, John C. Panetta, Alberto Broniscer, Giles W. Robinson, Amar J. Gajjar and Clinton F. Stewart
      Drug Metabolism and Disposition July 2016, 44 (7) 1116-1122; DOI: https://doi.org/10.1124/dmd.115.068676

  7. Bourgailh, Julien

    1. New Insights in Tissue Distribution, Metabolism, and Excretion of [3H]-Labeled Antibody Maytansinoid Conjugates in Female Tumor-Bearing Nude Rats
      Markus Walles, Bettina Rudolph, Thierry Wolf, Julien Bourgailh, Martina Suetterlin, Thomas Moenius, Gisela Peraus, Olivier Heudi, Walid Elbast, Christian Lanshoeft and Sanela Bilic
      Drug Metabolism and Disposition July 2016, 44 (7) 897-910; DOI: https://doi.org/10.1124/dmd.115.069021

  8. Broniscer, Alberto

    1. Population Pharmacokinetics of Oral Topotecan in Infants and Very Young Children with Brain Tumors Demonstrates a Role of ABCG2 rs4148157 on the Absorption Rate Constant
      Jessica K. Roberts, Anna V. Birg, Tong Lin, Vinay M. Daryani, John C. Panetta, Alberto Broniscer, Giles W. Robinson, Amar J. Gajjar and Clinton F. Stewart
      Drug Metabolism and Disposition July 2016, 44 (7) 1116-1122; DOI: https://doi.org/10.1124/dmd.115.068676

  9. Bush, Kevin T.

    1. Kidney versus Liver Specification of SLC and ABC Drug Transporters, Tight Junction Molecules, and Biomarkers
      Gleb Martovetsky, Kevin T. Bush and Sanjay K. Nigam
      Drug Metabolism and Disposition July 2016, 44 (7) 1050-1060; DOI: https://doi.org/10.1124/dmd.115.068254

C

  1. Chen, Shu

    1. Metabolite Kinetics: The Segregated Flow Model for Intestinal and Whole Body Physiologically Based Pharmacokinetic Modeling to Describe Intestinal and Hepatic Glucuronidation of Morphine in Rats In Vivo
      Qi Joy Yang, Jianghong Fan, Shu Chen, Lutan Liu, Huadong Sun and K. Sandy Pang
      Drug Metabolism and Disposition July 2016, 44 (7) 1123-1138; DOI: https://doi.org/10.1124/dmd.116.069542

  2. Chen, Yao

    1. Quantification of Flavin-containing Monooxygenases 1, 3, and 5 in Human Liver Microsomes by UPLC-MRM-Based Targeted Quantitative Proteomics and Its Application to the Study of Ontogeny
      Yao Chen, Nicole R. Zane, Dhiren R. Thakker and Michael Zhuo Wang
      Drug Metabolism and Disposition July 2016, 44 (7) 975-983; DOI: https://doi.org/10.1124/dmd.115.067538

  3. Collier, Abby C.

    1. The Ontogeny and Population Variability of Human Hepatic NADPH Dehydrogenase Quinone Oxido-Reductase 1 (NQO1)
      Luc R.A. Rougée, Zoe Riches, Jacob M. Berman and Abby C. Collier
      Drug Metabolism and Disposition July 2016, 44 (7) 967-974; DOI: https://doi.org/10.1124/dmd.115.068650

  4. Corley, Richard A.

    1. Hepatic Cytochrome P450 Activity, Abundance, and Expression Throughout Human Development
      Hepatic Cytochrome P450 Activity, Abundance, and Expression Throughout Human Development
      Natalie C. Sadler, Premchendar Nandhikonda, Bobbie-Jo Webb-Robertson, Charles Ansong, Lindsey N. Anderson, Jordan N. Smith, Richard A. Corley and Aaron T. Wright
      Drug Metabolism and Disposition July 2016, 44 (7) 984-991; DOI: https://doi.org/10.1124/dmd.115.068593

  5. Cui, Julia Yue

    1. Age-Specific Regulation of Drug-Processing Genes in Mouse Liver by Ligands of Xenobiotic-Sensing Transcription Factors
      Cindy Yanfei Li, Helen J. Renaud, Curtis D. Klaassen and Julia Yue Cui
      Drug Metabolism and Disposition July 2016, 44 (7) 1038-1049; DOI: https://doi.org/10.1124/dmd.115.066639

D

  1. Dai, Hongying

    1. Developmental Expression of CYP2B6: A Comprehensive Analysis of mRNA Expression, Protein Content and Bupropion Hydroxylase Activity and the Impact of Genetic Variation
      Robin E. Pearce, Roger Gaedigk, Greyson P. Twist, Hongying Dai, Amanda K. Riffel, J. Steven Leeder and Andrea Gaedigk
      Drug Metabolism and Disposition July 2016, 44 (7) 948-958; DOI: https://doi.org/10.1124/dmd.115.067546

  2. Daniel, James

    1. Open Access
      Decreased Pregnane X Receptor Expression in Children with Active Crohn’s Disease
      Valentina Shakhnovich, Carrie Vyhlidal, Craig Friesen, Amber Hildreth, Vivekanand Singh, James Daniel, Gregory L. Kearns and J. Steven Leeder
      Drug Metabolism and Disposition July 2016, 44 (7) 1066-1069; DOI: https://doi.org/10.1124/dmd.115.068742

  3. Daryani, Vinay M.

    1. Population Pharmacokinetics of Oral Topotecan in Infants and Very Young Children with Brain Tumors Demonstrates a Role of ABCG2 rs4148157 on the Absorption Rate Constant
      Jessica K. Roberts, Anna V. Birg, Tong Lin, Vinay M. Daryani, John C. Panetta, Alberto Broniscer, Giles W. Robinson, Amar J. Gajjar and Clinton F. Stewart
      Drug Metabolism and Disposition July 2016, 44 (7) 1116-1122; DOI: https://doi.org/10.1124/dmd.115.068676

  4. de Koning, Barbara A.E.

    1. Proteomic Analysis of the Developmental Trajectory of Human Hepatic Membrane Transporter Proteins in the First Three Months of Life
      Miriam G. Mooij, Evita van de Steeg, Joost van Rosmalen, Jonathan D. Windster, Barbara A.E. de Koning, Wouter H. J. Vaes, Bianca D. van Groen, Dick Tibboel, Heleen M. Wortelboer and Saskia N. de Wildt
      Drug Metabolism and Disposition July 2016, 44 (7) 1005-1013; DOI: https://doi.org/10.1124/dmd.115.068577

  5. de Koning, Barbara E. A.

    1. Human Intestinal PEPT1 Transporter Expression and Localization in Preterm and Term Infants
      Miriam G. Mooij, Barbara E. A. de Koning, Dicky J. Lindenbergh-Kortleve, Ytje Simons-Oosterhuis, Bianca D. van Groen, Dick Tibboel, Janneke N. Samsom and Saskia N. de Wildt
      Drug Metabolism and Disposition July 2016, 44 (7) 1014-1019; DOI: https://doi.org/10.1124/dmd.115.068809

  6. de Wildt, Saskia N.

    1. Human Intestinal PEPT1 Transporter Expression and Localization in Preterm and Term Infants
      Miriam G. Mooij, Barbara E. A. de Koning, Dicky J. Lindenbergh-Kortleve, Ytje Simons-Oosterhuis, Bianca D. van Groen, Dick Tibboel, Janneke N. Samsom and Saskia N. de Wildt
      Drug Metabolism and Disposition July 2016, 44 (7) 1014-1019; DOI: https://doi.org/10.1124/dmd.115.068809
    2. Proteomic Analysis of the Developmental Trajectory of Human Hepatic Membrane Transporter Proteins in the First Three Months of Life
      Miriam G. Mooij, Evita van de Steeg, Joost van Rosmalen, Jonathan D. Windster, Barbara A.E. de Koning, Wouter H. J. Vaes, Bianca D. van Groen, Dick Tibboel, Heleen M. Wortelboer and Saskia N. de Wildt
      Drug Metabolism and Disposition July 2016, 44 (7) 1005-1013; DOI: https://doi.org/10.1124/dmd.115.068577

  7. Dinh, Jean C.

    1. Characterization of Atomoxetine Biotransformation and Implications for Development of PBPK Models for Dose Individualization in Children
      Jean C. Dinh, Robin E. Pearce, Leon Van Haandel, Andrea Gaedigk and J. Steven Leeder
      Drug Metabolism and Disposition July 2016, 44 (7) 1070-1079; DOI: https://doi.org/10.1124/dmd.116.069518

  8. Dolinoy, Dana C.

    1. Correlation between Conjugated Bisphenol A Concentrations and Efflux Transporter Expression in Human Fetal Livers
      Jamie E. Moscovitz, Muna S. Nahar, Stuart L. Shalat, Angela L. Slitt, Dana C. Dolinoy and Lauren M. Aleksunes
      Drug Metabolism and Disposition July 2016, 44 (7) 1061-1065; DOI: https://doi.org/10.1124/dmd.115.068668

  9. Dorko, Kenneth

    1. Role of Chromatin Structural Changes in Regulating Human CYP3A Ontogeny
      Nicholas L. Giebel, Jeffrey D. Shadley, D. Gail McCarver, Kenneth Dorko, Roberto Gramignoli, Stephen C. Strom, Ke Yan, Pippa M. Simpson and Ronald N. Hines
      Drug Metabolism and Disposition July 2016, 44 (7) 1027-1037; DOI: https://doi.org/10.1124/dmd.116.069344

E

  1. Earp, Justin C.

    1. Role of Quantitative Clinical Pharmacology in Pediatric Approval and Labeling
      Nitin Mehrotra, Atul Bhattaram, Justin C. Earp, Jeffry Florian, Kevin Krudys, Jee Eun Lee, Joo Yeon Lee, Jiang Liu, Yeruk Mulugeta, Jingyu Yu, Ping Zhao and Vikram Sinha
      Drug Metabolism and Disposition July 2016, 44 (7) 924-933; DOI: https://doi.org/10.1124/dmd.116.069559

  2. Edginton, Andrea N.

    1. Examining Small Intestinal Transit Time as a Function of Age: Is There Evidence to Support Age-Dependent Differences among Children?
      Anil R. Maharaj and Andrea N. Edginton
      Drug Metabolism and Disposition July 2016, 44 (7) 1080-1089; DOI: https://doi.org/10.1124/dmd.115.068700

  3. Elbast, Walid

    1. New Insights in Tissue Distribution, Metabolism, and Excretion of [3H]-Labeled Antibody Maytansinoid Conjugates in Female Tumor-Bearing Nude Rats
      Markus Walles, Bettina Rudolph, Thierry Wolf, Julien Bourgailh, Martina Suetterlin, Thomas Moenius, Gisela Peraus, Olivier Heudi, Walid Elbast, Christian Lanshoeft and Sanela Bilic
      Drug Metabolism and Disposition July 2016, 44 (7) 897-910; DOI: https://doi.org/10.1124/dmd.115.069021

  4. Elmorsi, Yasmine

    1. Ontogeny of Hepatic Drug Transporters and Relevance to Drugs Used in Pediatrics
      Yasmine Elmorsi, Jill Barber and Amin Rostami-Hodjegan
      Drug Metabolism and Disposition July 2016, 44 (7) 992-998; DOI: https://doi.org/10.1124/dmd.115.067801

F

  1. Fan, Jianghong

    1. Metabolite Kinetics: The Segregated Flow Model for Intestinal and Whole Body Physiologically Based Pharmacokinetic Modeling to Describe Intestinal and Hepatic Glucuronidation of Morphine in Rats In Vivo
      Qi Joy Yang, Jianghong Fan, Shu Chen, Lutan Liu, Huadong Sun and K. Sandy Pang
      Drug Metabolism and Disposition July 2016, 44 (7) 1123-1138; DOI: https://doi.org/10.1124/dmd.116.069542

  2. Fattah, Sarinj

    1. Effect of Age on The Hepatocellularity Number for Wistar rats
      Sarinj Fattah, Patrick Augustijns and Pieter Annaert
      Drug Metabolism and Disposition July 2016, 44 (7) 944-947; DOI: https://doi.org/10.1124/dmd.115.066381

  3. Florian, Jeffry

    1. Role of Quantitative Clinical Pharmacology in Pediatric Approval and Labeling
      Nitin Mehrotra, Atul Bhattaram, Justin C. Earp, Jeffry Florian, Kevin Krudys, Jee Eun Lee, Joo Yeon Lee, Jiang Liu, Yeruk Mulugeta, Jingyu Yu, Ping Zhao and Vikram Sinha
      Drug Metabolism and Disposition July 2016, 44 (7) 924-933; DOI: https://doi.org/10.1124/dmd.116.069559

  4. Friesen, Craig

    1. Open Access
      Decreased Pregnane X Receptor Expression in Children with Active Crohn’s Disease
      Valentina Shakhnovich, Carrie Vyhlidal, Craig Friesen, Amber Hildreth, Vivekanand Singh, James Daniel, Gregory L. Kearns and J. Steven Leeder
      Drug Metabolism and Disposition July 2016, 44 (7) 1066-1069; DOI: https://doi.org/10.1124/dmd.115.068742

G

  1. Gaedigk, Andrea

    1. Developmental Expression of CYP2B6: A Comprehensive Analysis of mRNA Expression, Protein Content and Bupropion Hydroxylase Activity and the Impact of Genetic Variation
      Robin E. Pearce, Roger Gaedigk, Greyson P. Twist, Hongying Dai, Amanda K. Riffel, J. Steven Leeder and Andrea Gaedigk
      Drug Metabolism and Disposition July 2016, 44 (7) 948-958; DOI: https://doi.org/10.1124/dmd.115.067546
    2. Characterization of Atomoxetine Biotransformation and Implications for Development of PBPK Models for Dose Individualization in Children
      Jean C. Dinh, Robin E. Pearce, Leon Van Haandel, Andrea Gaedigk and J. Steven Leeder
      Drug Metabolism and Disposition July 2016, 44 (7) 1070-1079; DOI: https://doi.org/10.1124/dmd.116.069518

  2. Gaedigk, Roger

    1. Developmental Expression of CYP2B6: A Comprehensive Analysis of mRNA Expression, Protein Content and Bupropion Hydroxylase Activity and the Impact of Genetic Variation
      Robin E. Pearce, Roger Gaedigk, Greyson P. Twist, Hongying Dai, Amanda K. Riffel, J. Steven Leeder and Andrea Gaedigk
      Drug Metabolism and Disposition July 2016, 44 (7) 948-958; DOI: https://doi.org/10.1124/dmd.115.067546

  3. Gajjar, Amar J.

    1. Population Pharmacokinetics of Oral Topotecan in Infants and Very Young Children with Brain Tumors Demonstrates a Role of ABCG2 rs4148157 on the Absorption Rate Constant
      Jessica K. Roberts, Anna V. Birg, Tong Lin, Vinay M. Daryani, John C. Panetta, Alberto Broniscer, Giles W. Robinson, Amar J. Gajjar and Clinton F. Stewart
      Drug Metabolism and Disposition July 2016, 44 (7) 1116-1122; DOI: https://doi.org/10.1124/dmd.115.068676

  4. Giebel, Nicholas L.

    1. Role of Chromatin Structural Changes in Regulating Human CYP3A Ontogeny
      Nicholas L. Giebel, Jeffrey D. Shadley, D. Gail McCarver, Kenneth Dorko, Roberto Gramignoli, Stephen C. Strom, Ke Yan, Pippa M. Simpson and Ronald N. Hines
      Drug Metabolism and Disposition July 2016, 44 (7) 1027-1037; DOI: https://doi.org/10.1124/dmd.116.069344

  5. Gramignoli, Roberto

    1. Role of Chromatin Structural Changes in Regulating Human CYP3A Ontogeny
      Nicholas L. Giebel, Jeffrey D. Shadley, D. Gail McCarver, Kenneth Dorko, Roberto Gramignoli, Stephen C. Strom, Ke Yan, Pippa M. Simpson and Ronald N. Hines
      Drug Metabolism and Disposition July 2016, 44 (7) 1027-1037; DOI: https://doi.org/10.1124/dmd.116.069344

H

  1. Hao, Haiping

    1. Cardiotonic Pill Reduces Myocardial Ischemia-Reperfusion Injury via Increasing EET Concentrations in Rats
      Cardiotonic Pill Reduces Myocardial Ischemia-Reperfusion Injury via Increasing EET Concentrations in Rats
      Meijuan Xu, Haiping Hao, Lifeng Jiang, Yidan Wei, Fang Zhou, Jianguo Sun, Jingwei Zhang, Hui Ji, Guangji Wang, Wenzheng Ju and Ping Li
      Drug Metabolism and Disposition July 2016, 44 (7) 878-887; DOI: https://doi.org/10.1124/dmd.116.069914

  2. Heudi, Olivier

    1. New Insights in Tissue Distribution, Metabolism, and Excretion of [3H]-Labeled Antibody Maytansinoid Conjugates in Female Tumor-Bearing Nude Rats
      Markus Walles, Bettina Rudolph, Thierry Wolf, Julien Bourgailh, Martina Suetterlin, Thomas Moenius, Gisela Peraus, Olivier Heudi, Walid Elbast, Christian Lanshoeft and Sanela Bilic
      Drug Metabolism and Disposition July 2016, 44 (7) 897-910; DOI: https://doi.org/10.1124/dmd.115.069021

  3. Hildreth, Amber

    1. Open Access
      Decreased Pregnane X Receptor Expression in Children with Active Crohn’s Disease
      Valentina Shakhnovich, Carrie Vyhlidal, Craig Friesen, Amber Hildreth, Vivekanand Singh, James Daniel, Gregory L. Kearns and J. Steven Leeder
      Drug Metabolism and Disposition July 2016, 44 (7) 1066-1069; DOI: https://doi.org/10.1124/dmd.115.068742

  4. Hines, Ronald N.

    1. Age-Dependent Human Hepatic Carboxylesterase 1 (CES1) and Carboxylesterase 2 (CES2) Postnatal Ontogeny
      Ronald N. Hines, Pippa M. Simpson and D. Gail McCarver
      Drug Metabolism and Disposition July 2016, 44 (7) 959-966; DOI: https://doi.org/10.1124/dmd.115.068957
    2. Expression Patterns of Organic Anion Transporting Polypeptides 1B1 and 1B3 Protein in Human Pediatric Liver
      Margaret M. S. Thomson, Ronald N. Hines, Erin G. Schuetz and Bernd Meibohm
      Drug Metabolism and Disposition July 2016, 44 (7) 999-1004; DOI: https://doi.org/10.1124/dmd.115.069252
    3. Role of Chromatin Structural Changes in Regulating Human CYP3A Ontogeny
      Nicholas L. Giebel, Jeffrey D. Shadley, D. Gail McCarver, Kenneth Dorko, Roberto Gramignoli, Stephen C. Strom, Ke Yan, Pippa M. Simpson and Ronald N. Hines
      Drug Metabolism and Disposition July 2016, 44 (7) 1027-1037; DOI: https://doi.org/10.1124/dmd.116.069344

I

  1. Inoue, Takashi

    1. Individual Differences in Metabolic Clearance of <em>S</em>-Warfarin Efficiently Mediated by Polymorphic Marmoset Cytochrome P450 2C19 in Livers
      Individual Differences in Metabolic Clearance of S-Warfarin Efficiently Mediated by Polymorphic Marmoset Cytochrome P450 2C19 in Livers
      Shotaro Uehara, Yasuhiro Uno, Takashi Inoue, Mirai Kawano, Makiko Shimizu, Akiko Toda, Masahiro Utoh, Erika Sasaki and Hiroshi Yamazaki
      Drug Metabolism and Disposition July 2016, 44 (7) 911-915; DOI: https://doi.org/10.1124/dmd.116.070383

  2. Iwamura, Atsushi

    1. Zomepirac Acyl Glucuronide Is Responsible for Zomepirac-Induced Acute Kidney Injury in Mice
      Atsushi Iwamura, Katsuhito Watanabe, Sho Akai, Tsubasa Nishinosono, Koichi Tsuneyama, Shingo Oda, Toshiyuki Kume and Tsuyoshi Yokoi
      Drug Metabolism and Disposition July 2016, 44 (7) 888-896; DOI: https://doi.org/10.1124/dmd.116.069575

J

  1. Jamei, Masoud

    1. How Does In Vivo Biliary Elimination of Drugs Change with Age? Evidence from In Vitro and Clinical Data Using a Systems Pharmacology Approach
      Trevor N. Johnson, Masoud Jamei and Karen Rowland-Yeo
      Drug Metabolism and Disposition July 2016, 44 (7) 1090-1098; DOI: https://doi.org/10.1124/dmd.115.068643

  2. Ji, Hui

    1. Cardiotonic Pill Reduces Myocardial Ischemia-Reperfusion Injury via Increasing EET Concentrations in Rats
      Cardiotonic Pill Reduces Myocardial Ischemia-Reperfusion Injury via Increasing EET Concentrations in Rats
      Meijuan Xu, Haiping Hao, Lifeng Jiang, Yidan Wei, Fang Zhou, Jianguo Sun, Jingwei Zhang, Hui Ji, Guangji Wang, Wenzheng Ju and Ping Li
      Drug Metabolism and Disposition July 2016, 44 (7) 878-887; DOI: https://doi.org/10.1124/dmd.116.069914

  3. Jiang, Lifeng

    1. Cardiotonic Pill Reduces Myocardial Ischemia-Reperfusion Injury via Increasing EET Concentrations in Rats
      Cardiotonic Pill Reduces Myocardial Ischemia-Reperfusion Injury via Increasing EET Concentrations in Rats
      Meijuan Xu, Haiping Hao, Lifeng Jiang, Yidan Wei, Fang Zhou, Jianguo Sun, Jingwei Zhang, Hui Ji, Guangji Wang, Wenzheng Ju and Ping Li
      Drug Metabolism and Disposition July 2016, 44 (7) 878-887; DOI: https://doi.org/10.1124/dmd.116.069914

  4. Johnson, Trevor N.

    1. How Does In Vivo Biliary Elimination of Drugs Change with Age? Evidence from In Vitro and Clinical Data Using a Systems Pharmacology Approach
      Trevor N. Johnson, Masoud Jamei and Karen Rowland-Yeo
      Drug Metabolism and Disposition July 2016, 44 (7) 1090-1098; DOI: https://doi.org/10.1124/dmd.115.068643

  5. Ju, Wenzheng

    1. Cardiotonic Pill Reduces Myocardial Ischemia-Reperfusion Injury via Increasing EET Concentrations in Rats
      Cardiotonic Pill Reduces Myocardial Ischemia-Reperfusion Injury via Increasing EET Concentrations in Rats
      Meijuan Xu, Haiping Hao, Lifeng Jiang, Yidan Wei, Fang Zhou, Jianguo Sun, Jingwei Zhang, Hui Ji, Guangji Wang, Wenzheng Ju and Ping Li
      Drug Metabolism and Disposition July 2016, 44 (7) 878-887; DOI: https://doi.org/10.1124/dmd.116.069914

K

  1. Kamiyama, Yoshiteru

    1. Considering Age Variation When Coining Drugs as High versus Low Hepatic Extraction Ratio
      Farzaneh Salem, Khaled Abduljalil, Yoshiteru Kamiyama and Amin Rostami-Hodjegan
      Drug Metabolism and Disposition July 2016, 44 (7) 1099-1102; DOI: https://doi.org/10.1124/dmd.115.067595

  2. Kawano, Mirai

    1. Individual Differences in Metabolic Clearance of <em>S</em>-Warfarin Efficiently Mediated by Polymorphic Marmoset Cytochrome P450 2C19 in Livers
      Individual Differences in Metabolic Clearance of S-Warfarin Efficiently Mediated by Polymorphic Marmoset Cytochrome P450 2C19 in Livers
      Shotaro Uehara, Yasuhiro Uno, Takashi Inoue, Mirai Kawano, Makiko Shimizu, Akiko Toda, Masahiro Utoh, Erika Sasaki and Hiroshi Yamazaki
      Drug Metabolism and Disposition July 2016, 44 (7) 911-915; DOI: https://doi.org/10.1124/dmd.116.070383

  3. Kearns, Gregory L.

    1. Open Access
      Decreased Pregnane X Receptor Expression in Children with Active Crohn’s Disease
      Valentina Shakhnovich, Carrie Vyhlidal, Craig Friesen, Amber Hildreth, Vivekanand Singh, James Daniel, Gregory L. Kearns and J. Steven Leeder
      Drug Metabolism and Disposition July 2016, 44 (7) 1066-1069; DOI: https://doi.org/10.1124/dmd.115.068742

  4. Khalil, Feras

    1. Predicting Stereoselective Disposition of Carvedilol in Adult and Pediatric Chronic Heart Failure Patients by Incorporating Pathophysiological Changes in Organ Blood Flows–A Physiologically Based Pharmacokinetic Approach
      Muhammad Fawad Rasool, Feras Khalil and Stephanie Läer
      Drug Metabolism and Disposition July 2016, 44 (7) 1103-1115; DOI: https://doi.org/10.1124/dmd.115.068858

  5. Klaassen, Curtis D.

    1. Age-Specific Regulation of Drug-Processing Genes in Mouse Liver by Ligands of Xenobiotic-Sensing Transcription Factors
      Cindy Yanfei Li, Helen J. Renaud, Curtis D. Klaassen and Julia Yue Cui
      Drug Metabolism and Disposition July 2016, 44 (7) 1038-1049; DOI: https://doi.org/10.1124/dmd.115.066639

  6. Krudys, Kevin

    1. Role of Quantitative Clinical Pharmacology in Pediatric Approval and Labeling
      Nitin Mehrotra, Atul Bhattaram, Justin C. Earp, Jeffry Florian, Kevin Krudys, Jee Eun Lee, Joo Yeon Lee, Jiang Liu, Yeruk Mulugeta, Jingyu Yu, Ping Zhao and Vikram Sinha
      Drug Metabolism and Disposition July 2016, 44 (7) 924-933; DOI: https://doi.org/10.1124/dmd.116.069559

  7. Kume, Toshiyuki

    1. Zomepirac Acyl Glucuronide Is Responsible for Zomepirac-Induced Acute Kidney Injury in Mice
      Atsushi Iwamura, Katsuhito Watanabe, Sho Akai, Tsubasa Nishinosono, Koichi Tsuneyama, Shingo Oda, Toshiyuki Kume and Tsuyoshi Yokoi
      Drug Metabolism and Disposition July 2016, 44 (7) 888-896; DOI: https://doi.org/10.1124/dmd.116.069575

L

  1. Läer, Stephanie

    1. Predicting Stereoselective Disposition of Carvedilol in Adult and Pediatric Chronic Heart Failure Patients by Incorporating Pathophysiological Changes in Organ Blood Flows–A Physiologically Based Pharmacokinetic Approach
      Muhammad Fawad Rasool, Feras Khalil and Stephanie Läer
      Drug Metabolism and Disposition July 2016, 44 (7) 1103-1115; DOI: https://doi.org/10.1124/dmd.115.068858

  2. Lanshoeft, Christian

    1. New Insights in Tissue Distribution, Metabolism, and Excretion of [3H]-Labeled Antibody Maytansinoid Conjugates in Female Tumor-Bearing Nude Rats
      Markus Walles, Bettina Rudolph, Thierry Wolf, Julien Bourgailh, Martina Suetterlin, Thomas Moenius, Gisela Peraus, Olivier Heudi, Walid Elbast, Christian Lanshoeft and Sanela Bilic
      Drug Metabolism and Disposition July 2016, 44 (7) 897-910; DOI: https://doi.org/10.1124/dmd.115.069021

  3. Lee, Jee Eun

    1. Role of Quantitative Clinical Pharmacology in Pediatric Approval and Labeling
      Nitin Mehrotra, Atul Bhattaram, Justin C. Earp, Jeffry Florian, Kevin Krudys, Jee Eun Lee, Joo Yeon Lee, Jiang Liu, Yeruk Mulugeta, Jingyu Yu, Ping Zhao and Vikram Sinha
      Drug Metabolism and Disposition July 2016, 44 (7) 924-933; DOI: https://doi.org/10.1124/dmd.116.069559

  4. Lee, Joo Yeon

    1. Role of Quantitative Clinical Pharmacology in Pediatric Approval and Labeling
      Nitin Mehrotra, Atul Bhattaram, Justin C. Earp, Jeffry Florian, Kevin Krudys, Jee Eun Lee, Joo Yeon Lee, Jiang Liu, Yeruk Mulugeta, Jingyu Yu, Ping Zhao and Vikram Sinha
      Drug Metabolism and Disposition July 2016, 44 (7) 924-933; DOI: https://doi.org/10.1124/dmd.116.069559

  5. Leeder, J. Steven

    1. Developmental Expression of CYP2B6: A Comprehensive Analysis of mRNA Expression, Protein Content and Bupropion Hydroxylase Activity and the Impact of Genetic Variation
      Robin E. Pearce, Roger Gaedigk, Greyson P. Twist, Hongying Dai, Amanda K. Riffel, J. Steven Leeder and Andrea Gaedigk
      Drug Metabolism and Disposition July 2016, 44 (7) 948-958; DOI: https://doi.org/10.1124/dmd.115.067546
    2. Characterization of Atomoxetine Biotransformation and Implications for Development of PBPK Models for Dose Individualization in Children
      Jean C. Dinh, Robin E. Pearce, Leon Van Haandel, Andrea Gaedigk and J. Steven Leeder
      Drug Metabolism and Disposition July 2016, 44 (7) 1070-1079; DOI: https://doi.org/10.1124/dmd.116.069518
    3. Dynamics of Cytosine Methylation in the Proximal Promoters of CYP3A4 and CYP3A7 in Pediatric and Prenatal Livers
      Carrie A. Vyhlidal, Chengpeng Bi, Shui Qing Ye and J. Steven Leeder
      Drug Metabolism and Disposition July 2016, 44 (7) 1020-1026; DOI: https://doi.org/10.1124/dmd.115.068726
    4. Challenges and Opportunities for Increasing the Knowledge Base Related to Drug Biotransformation and Pharmacokinetics during Growth and Development
      J. Steven Leeder and Bernd Meibohm
      Drug Metabolism and Disposition July 2016, 44 (7) 916-923; DOI: https://doi.org/10.1124/dmd.116.071159
    5. Open Access
      Decreased Pregnane X Receptor Expression in Children with Active Crohn’s Disease
      Valentina Shakhnovich, Carrie Vyhlidal, Craig Friesen, Amber Hildreth, Vivekanand Singh, James Daniel, Gregory L. Kearns and J. Steven Leeder
      Drug Metabolism and Disposition July 2016, 44 (7) 1066-1069; DOI: https://doi.org/10.1124/dmd.115.068742

  6. Li, Cindy Yanfei

    1. Age-Specific Regulation of Drug-Processing Genes in Mouse Liver by Ligands of Xenobiotic-Sensing Transcription Factors
      Cindy Yanfei Li, Helen J. Renaud, Curtis D. Klaassen and Julia Yue Cui
      Drug Metabolism and Disposition July 2016, 44 (7) 1038-1049; DOI: https://doi.org/10.1124/dmd.115.066639

  7. Li, Ping

    1. Cardiotonic Pill Reduces Myocardial Ischemia-Reperfusion Injury via Increasing EET Concentrations in Rats
      Cardiotonic Pill Reduces Myocardial Ischemia-Reperfusion Injury via Increasing EET Concentrations in Rats
      Meijuan Xu, Haiping Hao, Lifeng Jiang, Yidan Wei, Fang Zhou, Jianguo Sun, Jingwei Zhang, Hui Ji, Guangji Wang, Wenzheng Ju and Ping Li
      Drug Metabolism and Disposition July 2016, 44 (7) 878-887; DOI: https://doi.org/10.1124/dmd.116.069914

  8. Lin, Tong

    1. Population Pharmacokinetics of Oral Topotecan in Infants and Very Young Children with Brain Tumors Demonstrates a Role of ABCG2 rs4148157 on the Absorption Rate Constant
      Jessica K. Roberts, Anna V. Birg, Tong Lin, Vinay M. Daryani, John C. Panetta, Alberto Broniscer, Giles W. Robinson, Amar J. Gajjar and Clinton F. Stewart
      Drug Metabolism and Disposition July 2016, 44 (7) 1116-1122; DOI: https://doi.org/10.1124/dmd.115.068676

  9. Lindenbergh-Kortleve, Dicky J.

    1. Human Intestinal PEPT1 Transporter Expression and Localization in Preterm and Term Infants
      Miriam G. Mooij, Barbara E. A. de Koning, Dicky J. Lindenbergh-Kortleve, Ytje Simons-Oosterhuis, Bianca D. van Groen, Dick Tibboel, Janneke N. Samsom and Saskia N. de Wildt
      Drug Metabolism and Disposition July 2016, 44 (7) 1014-1019; DOI: https://doi.org/10.1124/dmd.115.068809

  10. Liu, Jiang

    1. Role of Quantitative Clinical Pharmacology in Pediatric Approval and Labeling
      Nitin Mehrotra, Atul Bhattaram, Justin C. Earp, Jeffry Florian, Kevin Krudys, Jee Eun Lee, Joo Yeon Lee, Jiang Liu, Yeruk Mulugeta, Jingyu Yu, Ping Zhao and Vikram Sinha
      Drug Metabolism and Disposition July 2016, 44 (7) 924-933; DOI: https://doi.org/10.1124/dmd.116.069559

  11. Liu, Lutan

    1. Metabolite Kinetics: The Segregated Flow Model for Intestinal and Whole Body Physiologically Based Pharmacokinetic Modeling to Describe Intestinal and Hepatic Glucuronidation of Morphine in Rats In Vivo
      Qi Joy Yang, Jianghong Fan, Shu Chen, Lutan Liu, Huadong Sun and K. Sandy Pang
      Drug Metabolism and Disposition July 2016, 44 (7) 1123-1138; DOI: https://doi.org/10.1124/dmd.116.069542

M

  1. Maharaj, Anil R.

    1. Examining Small Intestinal Transit Time as a Function of Age: Is There Evidence to Support Age-Dependent Differences among Children?
      Anil R. Maharaj and Andrea N. Edginton
      Drug Metabolism and Disposition July 2016, 44 (7) 1080-1089; DOI: https://doi.org/10.1124/dmd.115.068700

  2. Martovetsky, Gleb

    1. Kidney versus Liver Specification of SLC and ABC Drug Transporters, Tight Junction Molecules, and Biomarkers
      Gleb Martovetsky, Kevin T. Bush and Sanjay K. Nigam
      Drug Metabolism and Disposition July 2016, 44 (7) 1050-1060; DOI: https://doi.org/10.1124/dmd.115.068254

  3. McCarver, D. Gail

    1. Age-Dependent Human Hepatic Carboxylesterase 1 (CES1) and Carboxylesterase 2 (CES2) Postnatal Ontogeny
      Ronald N. Hines, Pippa M. Simpson and D. Gail McCarver
      Drug Metabolism and Disposition July 2016, 44 (7) 959-966; DOI: https://doi.org/10.1124/dmd.115.068957
    2. Role of Chromatin Structural Changes in Regulating Human CYP3A Ontogeny
      Nicholas L. Giebel, Jeffrey D. Shadley, D. Gail McCarver, Kenneth Dorko, Roberto Gramignoli, Stephen C. Strom, Ke Yan, Pippa M. Simpson and Ronald N. Hines
      Drug Metabolism and Disposition July 2016, 44 (7) 1027-1037; DOI: https://doi.org/10.1124/dmd.116.069344

  4. Mehrotra, Nitin

    1. Role of Quantitative Clinical Pharmacology in Pediatric Approval and Labeling
      Nitin Mehrotra, Atul Bhattaram, Justin C. Earp, Jeffry Florian, Kevin Krudys, Jee Eun Lee, Joo Yeon Lee, Jiang Liu, Yeruk Mulugeta, Jingyu Yu, Ping Zhao and Vikram Sinha
      Drug Metabolism and Disposition July 2016, 44 (7) 924-933; DOI: https://doi.org/10.1124/dmd.116.069559

  5. Meibohm, Bernd

    1. Expression Patterns of Organic Anion Transporting Polypeptides 1B1 and 1B3 Protein in Human Pediatric Liver
      Margaret M. S. Thomson, Ronald N. Hines, Erin G. Schuetz and Bernd Meibohm
      Drug Metabolism and Disposition July 2016, 44 (7) 999-1004; DOI: https://doi.org/10.1124/dmd.115.069252
    2. Challenges and Opportunities for Increasing the Knowledge Base Related to Drug Biotransformation and Pharmacokinetics during Growth and Development
      J. Steven Leeder and Bernd Meibohm
      Drug Metabolism and Disposition July 2016, 44 (7) 916-923; DOI: https://doi.org/10.1124/dmd.116.071159

  6. Moenius, Thomas

    1. New Insights in Tissue Distribution, Metabolism, and Excretion of [3H]-Labeled Antibody Maytansinoid Conjugates in Female Tumor-Bearing Nude Rats
      Markus Walles, Bettina Rudolph, Thierry Wolf, Julien Bourgailh, Martina Suetterlin, Thomas Moenius, Gisela Peraus, Olivier Heudi, Walid Elbast, Christian Lanshoeft and Sanela Bilic
      Drug Metabolism and Disposition July 2016, 44 (7) 897-910; DOI: https://doi.org/10.1124/dmd.115.069021

  7. Mooij, Miriam G.

    1. Human Intestinal PEPT1 Transporter Expression and Localization in Preterm and Term Infants
      Miriam G. Mooij, Barbara E. A. de Koning, Dicky J. Lindenbergh-Kortleve, Ytje Simons-Oosterhuis, Bianca D. van Groen, Dick Tibboel, Janneke N. Samsom and Saskia N. de Wildt
      Drug Metabolism and Disposition July 2016, 44 (7) 1014-1019; DOI: https://doi.org/10.1124/dmd.115.068809
    2. Proteomic Analysis of the Developmental Trajectory of Human Hepatic Membrane Transporter Proteins in the First Three Months of Life
      Miriam G. Mooij, Evita van de Steeg, Joost van Rosmalen, Jonathan D. Windster, Barbara A.E. de Koning, Wouter H. J. Vaes, Bianca D. van Groen, Dick Tibboel, Heleen M. Wortelboer and Saskia N. de Wildt
      Drug Metabolism and Disposition July 2016, 44 (7) 1005-1013; DOI: https://doi.org/10.1124/dmd.115.068577

  8. Moscovitz, Jamie E.

    1. Correlation between Conjugated Bisphenol A Concentrations and Efflux Transporter Expression in Human Fetal Livers
      Jamie E. Moscovitz, Muna S. Nahar, Stuart L. Shalat, Angela L. Slitt, Dana C. Dolinoy and Lauren M. Aleksunes
      Drug Metabolism and Disposition July 2016, 44 (7) 1061-1065; DOI: https://doi.org/10.1124/dmd.115.068668

  9. Mulugeta, Yeruk

    1. Role of Quantitative Clinical Pharmacology in Pediatric Approval and Labeling
      Nitin Mehrotra, Atul Bhattaram, Justin C. Earp, Jeffry Florian, Kevin Krudys, Jee Eun Lee, Joo Yeon Lee, Jiang Liu, Yeruk Mulugeta, Jingyu Yu, Ping Zhao and Vikram Sinha
      Drug Metabolism and Disposition July 2016, 44 (7) 924-933; DOI: https://doi.org/10.1124/dmd.116.069559

N

  1. Nahar, Muna S.

    1. Correlation between Conjugated Bisphenol A Concentrations and Efflux Transporter Expression in Human Fetal Livers
      Jamie E. Moscovitz, Muna S. Nahar, Stuart L. Shalat, Angela L. Slitt, Dana C. Dolinoy and Lauren M. Aleksunes
      Drug Metabolism and Disposition July 2016, 44 (7) 1061-1065; DOI: https://doi.org/10.1124/dmd.115.068668

  2. Nandhikonda, Premchendar

    1. Hepatic Cytochrome P450 Activity, Abundance, and Expression Throughout Human Development
      Hepatic Cytochrome P450 Activity, Abundance, and Expression Throughout Human Development
      Natalie C. Sadler, Premchendar Nandhikonda, Bobbie-Jo Webb-Robertson, Charles Ansong, Lindsey N. Anderson, Jordan N. Smith, Richard A. Corley and Aaron T. Wright
      Drug Metabolism and Disposition July 2016, 44 (7) 984-991; DOI: https://doi.org/10.1124/dmd.115.068593

  3. Nigam, Sanjay K.

    1. Kidney versus Liver Specification of SLC and ABC Drug Transporters, Tight Junction Molecules, and Biomarkers
      Gleb Martovetsky, Kevin T. Bush and Sanjay K. Nigam
      Drug Metabolism and Disposition July 2016, 44 (7) 1050-1060; DOI: https://doi.org/10.1124/dmd.115.068254

  4. Nishinosono, Tsubasa

    1. Zomepirac Acyl Glucuronide Is Responsible for Zomepirac-Induced Acute Kidney Injury in Mice
      Atsushi Iwamura, Katsuhito Watanabe, Sho Akai, Tsubasa Nishinosono, Koichi Tsuneyama, Shingo Oda, Toshiyuki Kume and Tsuyoshi Yokoi
      Drug Metabolism and Disposition July 2016, 44 (7) 888-896; DOI: https://doi.org/10.1124/dmd.116.069575

O

  1. Oda, Shingo

    1. Zomepirac Acyl Glucuronide Is Responsible for Zomepirac-Induced Acute Kidney Injury in Mice
      Atsushi Iwamura, Katsuhito Watanabe, Sho Akai, Tsubasa Nishinosono, Koichi Tsuneyama, Shingo Oda, Toshiyuki Kume and Tsuyoshi Yokoi
      Drug Metabolism and Disposition July 2016, 44 (7) 888-896; DOI: https://doi.org/10.1124/dmd.116.069575

P

  1. Panetta, John C.

    1. Population Pharmacokinetics of Oral Topotecan in Infants and Very Young Children with Brain Tumors Demonstrates a Role of ABCG2 rs4148157 on the Absorption Rate Constant
      Jessica K. Roberts, Anna V. Birg, Tong Lin, Vinay M. Daryani, John C. Panetta, Alberto Broniscer, Giles W. Robinson, Amar J. Gajjar and Clinton F. Stewart
      Drug Metabolism and Disposition July 2016, 44 (7) 1116-1122; DOI: https://doi.org/10.1124/dmd.115.068676

  2. Pang, K. Sandy

    1. Metabolite Kinetics: The Segregated Flow Model for Intestinal and Whole Body Physiologically Based Pharmacokinetic Modeling to Describe Intestinal and Hepatic Glucuronidation of Morphine in Rats In Vivo
      Qi Joy Yang, Jianghong Fan, Shu Chen, Lutan Liu, Huadong Sun and K. Sandy Pang
      Drug Metabolism and Disposition July 2016, 44 (7) 1123-1138; DOI: https://doi.org/10.1124/dmd.116.069542

  3. Pearce, Robin E.

    1. Developmental Expression of CYP2B6: A Comprehensive Analysis of mRNA Expression, Protein Content and Bupropion Hydroxylase Activity and the Impact of Genetic Variation
      Robin E. Pearce, Roger Gaedigk, Greyson P. Twist, Hongying Dai, Amanda K. Riffel, J. Steven Leeder and Andrea Gaedigk
      Drug Metabolism and Disposition July 2016, 44 (7) 948-958; DOI: https://doi.org/10.1124/dmd.115.067546
    2. Characterization of Atomoxetine Biotransformation and Implications for Development of PBPK Models for Dose Individualization in Children
      Jean C. Dinh, Robin E. Pearce, Leon Van Haandel, Andrea Gaedigk and J. Steven Leeder
      Drug Metabolism and Disposition July 2016, 44 (7) 1070-1079; DOI: https://doi.org/10.1124/dmd.116.069518

  4. Peraus, Gisela

    1. New Insights in Tissue Distribution, Metabolism, and Excretion of [3H]-Labeled Antibody Maytansinoid Conjugates in Female Tumor-Bearing Nude Rats
      Markus Walles, Bettina Rudolph, Thierry Wolf, Julien Bourgailh, Martina Suetterlin, Thomas Moenius, Gisela Peraus, Olivier Heudi, Walid Elbast, Christian Lanshoeft and Sanela Bilic
      Drug Metabolism and Disposition July 2016, 44 (7) 897-910; DOI: https://doi.org/10.1124/dmd.115.069021

R

  1. Rasool, Muhammad Fawad

    1. Predicting Stereoselective Disposition of Carvedilol in Adult and Pediatric Chronic Heart Failure Patients by Incorporating Pathophysiological Changes in Organ Blood Flows–A Physiologically Based Pharmacokinetic Approach
      Muhammad Fawad Rasool, Feras Khalil and Stephanie Läer
      Drug Metabolism and Disposition July 2016, 44 (7) 1103-1115; DOI: https://doi.org/10.1124/dmd.115.068858

  2. Renaud, Helen J.

    1. Age-Specific Regulation of Drug-Processing Genes in Mouse Liver by Ligands of Xenobiotic-Sensing Transcription Factors
      Cindy Yanfei Li, Helen J. Renaud, Curtis D. Klaassen and Julia Yue Cui
      Drug Metabolism and Disposition July 2016, 44 (7) 1038-1049; DOI: https://doi.org/10.1124/dmd.115.066639

  3. Riches, Zoe

    1. The Ontogeny and Population Variability of Human Hepatic NADPH Dehydrogenase Quinone Oxido-Reductase 1 (NQO1)
      Luc R.A. Rougée, Zoe Riches, Jacob M. Berman and Abby C. Collier
      Drug Metabolism and Disposition July 2016, 44 (7) 967-974; DOI: https://doi.org/10.1124/dmd.115.068650

  4. Riffel, Amanda K.

    1. Developmental Expression of CYP2B6: A Comprehensive Analysis of mRNA Expression, Protein Content and Bupropion Hydroxylase Activity and the Impact of Genetic Variation
      Robin E. Pearce, Roger Gaedigk, Greyson P. Twist, Hongying Dai, Amanda K. Riffel, J. Steven Leeder and Andrea Gaedigk
      Drug Metabolism and Disposition July 2016, 44 (7) 948-958; DOI: https://doi.org/10.1124/dmd.115.067546

  5. Rioux, Nathalie

    1. Physiologically Based Pharmacokinetic Modeling in Pediatric Oncology Drug Development
      Nathalie Rioux and Nigel J. Waters
      Drug Metabolism and Disposition July 2016, 44 (7) 934-943; DOI: https://doi.org/10.1124/dmd.115.068031

  6. Roberts, Jessica K.

    1. Population Pharmacokinetics of Oral Topotecan in Infants and Very Young Children with Brain Tumors Demonstrates a Role of ABCG2 rs4148157 on the Absorption Rate Constant
      Jessica K. Roberts, Anna V. Birg, Tong Lin, Vinay M. Daryani, John C. Panetta, Alberto Broniscer, Giles W. Robinson, Amar J. Gajjar and Clinton F. Stewart
      Drug Metabolism and Disposition July 2016, 44 (7) 1116-1122; DOI: https://doi.org/10.1124/dmd.115.068676

  7. Robinson, Giles W.

    1. Population Pharmacokinetics of Oral Topotecan in Infants and Very Young Children with Brain Tumors Demonstrates a Role of ABCG2 rs4148157 on the Absorption Rate Constant
      Jessica K. Roberts, Anna V. Birg, Tong Lin, Vinay M. Daryani, John C. Panetta, Alberto Broniscer, Giles W. Robinson, Amar J. Gajjar and Clinton F. Stewart
      Drug Metabolism and Disposition July 2016, 44 (7) 1116-1122; DOI: https://doi.org/10.1124/dmd.115.068676

  8. Rostami-Hodjegan, Amin

    1. Ontogeny of Hepatic Drug Transporters and Relevance to Drugs Used in Pediatrics
      Yasmine Elmorsi, Jill Barber and Amin Rostami-Hodjegan
      Drug Metabolism and Disposition July 2016, 44 (7) 992-998; DOI: https://doi.org/10.1124/dmd.115.067801
    2. Considering Age Variation When Coining Drugs as High versus Low Hepatic Extraction Ratio
      Farzaneh Salem, Khaled Abduljalil, Yoshiteru Kamiyama and Amin Rostami-Hodjegan
      Drug Metabolism and Disposition July 2016, 44 (7) 1099-1102; DOI: https://doi.org/10.1124/dmd.115.067595

  9. Rougée, Luc R.A.

    1. The Ontogeny and Population Variability of Human Hepatic NADPH Dehydrogenase Quinone Oxido-Reductase 1 (NQO1)
      Luc R.A. Rougée, Zoe Riches, Jacob M. Berman and Abby C. Collier
      Drug Metabolism and Disposition July 2016, 44 (7) 967-974; DOI: https://doi.org/10.1124/dmd.115.068650

  10. Rowland-Yeo, Karen

    1. How Does In Vivo Biliary Elimination of Drugs Change with Age? Evidence from In Vitro and Clinical Data Using a Systems Pharmacology Approach
      Trevor N. Johnson, Masoud Jamei and Karen Rowland-Yeo
      Drug Metabolism and Disposition July 2016, 44 (7) 1090-1098; DOI: https://doi.org/10.1124/dmd.115.068643

  11. Rudolph, Bettina

    1. New Insights in Tissue Distribution, Metabolism, and Excretion of [3H]-Labeled Antibody Maytansinoid Conjugates in Female Tumor-Bearing Nude Rats
      Markus Walles, Bettina Rudolph, Thierry Wolf, Julien Bourgailh, Martina Suetterlin, Thomas Moenius, Gisela Peraus, Olivier Heudi, Walid Elbast, Christian Lanshoeft and Sanela Bilic
      Drug Metabolism and Disposition July 2016, 44 (7) 897-910; DOI: https://doi.org/10.1124/dmd.115.069021

S

  1. Sadler, Natalie C.

    1. Hepatic Cytochrome P450 Activity, Abundance, and Expression Throughout Human Development
      Hepatic Cytochrome P450 Activity, Abundance, and Expression Throughout Human Development
      Natalie C. Sadler, Premchendar Nandhikonda, Bobbie-Jo Webb-Robertson, Charles Ansong, Lindsey N. Anderson, Jordan N. Smith, Richard A. Corley and Aaron T. Wright
      Drug Metabolism and Disposition July 2016, 44 (7) 984-991; DOI: https://doi.org/10.1124/dmd.115.068593

  2. Salem, Farzaneh

    1. Considering Age Variation When Coining Drugs as High versus Low Hepatic Extraction Ratio
      Farzaneh Salem, Khaled Abduljalil, Yoshiteru Kamiyama and Amin Rostami-Hodjegan
      Drug Metabolism and Disposition July 2016, 44 (7) 1099-1102; DOI: https://doi.org/10.1124/dmd.115.067595

  3. Samsom, Janneke N.

    1. Human Intestinal PEPT1 Transporter Expression and Localization in Preterm and Term Infants
      Miriam G. Mooij, Barbara E. A. de Koning, Dicky J. Lindenbergh-Kortleve, Ytje Simons-Oosterhuis, Bianca D. van Groen, Dick Tibboel, Janneke N. Samsom and Saskia N. de Wildt
      Drug Metabolism and Disposition July 2016, 44 (7) 1014-1019; DOI: https://doi.org/10.1124/dmd.115.068809

  4. Sasaki, Erika

    1. Individual Differences in Metabolic Clearance of <em>S</em>-Warfarin Efficiently Mediated by Polymorphic Marmoset Cytochrome P450 2C19 in Livers
      Individual Differences in Metabolic Clearance of S-Warfarin Efficiently Mediated by Polymorphic Marmoset Cytochrome P450 2C19 in Livers
      Shotaro Uehara, Yasuhiro Uno, Takashi Inoue, Mirai Kawano, Makiko Shimizu, Akiko Toda, Masahiro Utoh, Erika Sasaki and Hiroshi Yamazaki
      Drug Metabolism and Disposition July 2016, 44 (7) 911-915; DOI: https://doi.org/10.1124/dmd.116.070383

  5. Schuetz, Erin G.

    1. Expression Patterns of Organic Anion Transporting Polypeptides 1B1 and 1B3 Protein in Human Pediatric Liver
      Margaret M. S. Thomson, Ronald N. Hines, Erin G. Schuetz and Bernd Meibohm
      Drug Metabolism and Disposition July 2016, 44 (7) 999-1004; DOI: https://doi.org/10.1124/dmd.115.069252

  6. Shadley, Jeffrey D.

    1. Role of Chromatin Structural Changes in Regulating Human CYP3A Ontogeny
      Nicholas L. Giebel, Jeffrey D. Shadley, D. Gail McCarver, Kenneth Dorko, Roberto Gramignoli, Stephen C. Strom, Ke Yan, Pippa M. Simpson and Ronald N. Hines
      Drug Metabolism and Disposition July 2016, 44 (7) 1027-1037; DOI: https://doi.org/10.1124/dmd.116.069344

  7. Shakhnovich, Valentina

    1. Open Access
      Decreased Pregnane X Receptor Expression in Children with Active Crohn’s Disease
      Valentina Shakhnovich, Carrie Vyhlidal, Craig Friesen, Amber Hildreth, Vivekanand Singh, James Daniel, Gregory L. Kearns and J. Steven Leeder
      Drug Metabolism and Disposition July 2016, 44 (7) 1066-1069; DOI: https://doi.org/10.1124/dmd.115.068742

  8. Shalat, Stuart L.

    1. Correlation between Conjugated Bisphenol A Concentrations and Efflux Transporter Expression in Human Fetal Livers
      Jamie E. Moscovitz, Muna S. Nahar, Stuart L. Shalat, Angela L. Slitt, Dana C. Dolinoy and Lauren M. Aleksunes
      Drug Metabolism and Disposition July 2016, 44 (7) 1061-1065; DOI: https://doi.org/10.1124/dmd.115.068668

  9. Shimizu, Makiko

    1. Individual Differences in Metabolic Clearance of <em>S</em>-Warfarin Efficiently Mediated by Polymorphic Marmoset Cytochrome P450 2C19 in Livers
      Individual Differences in Metabolic Clearance of S-Warfarin Efficiently Mediated by Polymorphic Marmoset Cytochrome P450 2C19 in Livers
      Shotaro Uehara, Yasuhiro Uno, Takashi Inoue, Mirai Kawano, Makiko Shimizu, Akiko Toda, Masahiro Utoh, Erika Sasaki and Hiroshi Yamazaki
      Drug Metabolism and Disposition July 2016, 44 (7) 911-915; DOI: https://doi.org/10.1124/dmd.116.070383

  10. Simons-Oosterhuis, Ytje

    1. Human Intestinal PEPT1 Transporter Expression and Localization in Preterm and Term Infants
      Miriam G. Mooij, Barbara E. A. de Koning, Dicky J. Lindenbergh-Kortleve, Ytje Simons-Oosterhuis, Bianca D. van Groen, Dick Tibboel, Janneke N. Samsom and Saskia N. de Wildt
      Drug Metabolism and Disposition July 2016, 44 (7) 1014-1019; DOI: https://doi.org/10.1124/dmd.115.068809

  11. Simpson, Pippa M.

    1. Age-Dependent Human Hepatic Carboxylesterase 1 (CES1) and Carboxylesterase 2 (CES2) Postnatal Ontogeny
      Ronald N. Hines, Pippa M. Simpson and D. Gail McCarver
      Drug Metabolism and Disposition July 2016, 44 (7) 959-966; DOI: https://doi.org/10.1124/dmd.115.068957
    2. Role of Chromatin Structural Changes in Regulating Human CYP3A Ontogeny
      Nicholas L. Giebel, Jeffrey D. Shadley, D. Gail McCarver, Kenneth Dorko, Roberto Gramignoli, Stephen C. Strom, Ke Yan, Pippa M. Simpson and Ronald N. Hines
      Drug Metabolism and Disposition July 2016, 44 (7) 1027-1037; DOI: https://doi.org/10.1124/dmd.116.069344

  12. Singh, Vivekanand

    1. Open Access
      Decreased Pregnane X Receptor Expression in Children with Active Crohn’s Disease
      Valentina Shakhnovich, Carrie Vyhlidal, Craig Friesen, Amber Hildreth, Vivekanand Singh, James Daniel, Gregory L. Kearns and J. Steven Leeder
      Drug Metabolism and Disposition July 2016, 44 (7) 1066-1069; DOI: https://doi.org/10.1124/dmd.115.068742

  13. Sinha, Vikram

    1. Role of Quantitative Clinical Pharmacology in Pediatric Approval and Labeling
      Nitin Mehrotra, Atul Bhattaram, Justin C. Earp, Jeffry Florian, Kevin Krudys, Jee Eun Lee, Joo Yeon Lee, Jiang Liu, Yeruk Mulugeta, Jingyu Yu, Ping Zhao and Vikram Sinha
      Drug Metabolism and Disposition July 2016, 44 (7) 924-933; DOI: https://doi.org/10.1124/dmd.116.069559

  14. Slitt, Angela L.

    1. Correlation between Conjugated Bisphenol A Concentrations and Efflux Transporter Expression in Human Fetal Livers
      Jamie E. Moscovitz, Muna S. Nahar, Stuart L. Shalat, Angela L. Slitt, Dana C. Dolinoy and Lauren M. Aleksunes
      Drug Metabolism and Disposition July 2016, 44 (7) 1061-1065; DOI: https://doi.org/10.1124/dmd.115.068668

  15. Smith, Jordan N.

    1. Hepatic Cytochrome P450 Activity, Abundance, and Expression Throughout Human Development
      Hepatic Cytochrome P450 Activity, Abundance, and Expression Throughout Human Development
      Natalie C. Sadler, Premchendar Nandhikonda, Bobbie-Jo Webb-Robertson, Charles Ansong, Lindsey N. Anderson, Jordan N. Smith, Richard A. Corley and Aaron T. Wright
      Drug Metabolism and Disposition July 2016, 44 (7) 984-991; DOI: https://doi.org/10.1124/dmd.115.068593

  16. Stewart, Clinton F.

    1. Population Pharmacokinetics of Oral Topotecan in Infants and Very Young Children with Brain Tumors Demonstrates a Role of ABCG2 rs4148157 on the Absorption Rate Constant
      Jessica K. Roberts, Anna V. Birg, Tong Lin, Vinay M. Daryani, John C. Panetta, Alberto Broniscer, Giles W. Robinson, Amar J. Gajjar and Clinton F. Stewart
      Drug Metabolism and Disposition July 2016, 44 (7) 1116-1122; DOI: https://doi.org/10.1124/dmd.115.068676

  17. Strom, Stephen C.

    1. Role of Chromatin Structural Changes in Regulating Human CYP3A Ontogeny
      Nicholas L. Giebel, Jeffrey D. Shadley, D. Gail McCarver, Kenneth Dorko, Roberto Gramignoli, Stephen C. Strom, Ke Yan, Pippa M. Simpson and Ronald N. Hines
      Drug Metabolism and Disposition July 2016, 44 (7) 1027-1037; DOI: https://doi.org/10.1124/dmd.116.069344

  18. Suetterlin, Martina

    1. New Insights in Tissue Distribution, Metabolism, and Excretion of [3H]-Labeled Antibody Maytansinoid Conjugates in Female Tumor-Bearing Nude Rats
      Markus Walles, Bettina Rudolph, Thierry Wolf, Julien Bourgailh, Martina Suetterlin, Thomas Moenius, Gisela Peraus, Olivier Heudi, Walid Elbast, Christian Lanshoeft and Sanela Bilic
      Drug Metabolism and Disposition July 2016, 44 (7) 897-910; DOI: https://doi.org/10.1124/dmd.115.069021

  19. Sun, Huadong

    1. Metabolite Kinetics: The Segregated Flow Model for Intestinal and Whole Body Physiologically Based Pharmacokinetic Modeling to Describe Intestinal and Hepatic Glucuronidation of Morphine in Rats In Vivo
      Qi Joy Yang, Jianghong Fan, Shu Chen, Lutan Liu, Huadong Sun and K. Sandy Pang
      Drug Metabolism and Disposition July 2016, 44 (7) 1123-1138; DOI: https://doi.org/10.1124/dmd.116.069542

  20. Sun, Jianguo

    1. Cardiotonic Pill Reduces Myocardial Ischemia-Reperfusion Injury via Increasing EET Concentrations in Rats
      Cardiotonic Pill Reduces Myocardial Ischemia-Reperfusion Injury via Increasing EET Concentrations in Rats
      Meijuan Xu, Haiping Hao, Lifeng Jiang, Yidan Wei, Fang Zhou, Jianguo Sun, Jingwei Zhang, Hui Ji, Guangji Wang, Wenzheng Ju and Ping Li
      Drug Metabolism and Disposition July 2016, 44 (7) 878-887; DOI: https://doi.org/10.1124/dmd.116.069914

T

  1. Thakker, Dhiren R.

    1. Quantification of Flavin-containing Monooxygenases 1, 3, and 5 in Human Liver Microsomes by UPLC-MRM-Based Targeted Quantitative Proteomics and Its Application to the Study of Ontogeny
      Yao Chen, Nicole R. Zane, Dhiren R. Thakker and Michael Zhuo Wang
      Drug Metabolism and Disposition July 2016, 44 (7) 975-983; DOI: https://doi.org/10.1124/dmd.115.067538

  2. Thomson, Margaret M. S.

    1. Expression Patterns of Organic Anion Transporting Polypeptides 1B1 and 1B3 Protein in Human Pediatric Liver
      Margaret M. S. Thomson, Ronald N. Hines, Erin G. Schuetz and Bernd Meibohm
      Drug Metabolism and Disposition July 2016, 44 (7) 999-1004; DOI: https://doi.org/10.1124/dmd.115.069252

  3. Tibboel, Dick

    1. Human Intestinal PEPT1 Transporter Expression and Localization in Preterm and Term Infants
      Miriam G. Mooij, Barbara E. A. de Koning, Dicky J. Lindenbergh-Kortleve, Ytje Simons-Oosterhuis, Bianca D. van Groen, Dick Tibboel, Janneke N. Samsom and Saskia N. de Wildt
      Drug Metabolism and Disposition July 2016, 44 (7) 1014-1019; DOI: https://doi.org/10.1124/dmd.115.068809
    2. Proteomic Analysis of the Developmental Trajectory of Human Hepatic Membrane Transporter Proteins in the First Three Months of Life
      Miriam G. Mooij, Evita van de Steeg, Joost van Rosmalen, Jonathan D. Windster, Barbara A.E. de Koning, Wouter H. J. Vaes, Bianca D. van Groen, Dick Tibboel, Heleen M. Wortelboer and Saskia N. de Wildt
      Drug Metabolism and Disposition July 2016, 44 (7) 1005-1013; DOI: https://doi.org/10.1124/dmd.115.068577

  4. Toda, Akiko

    1. Individual Differences in Metabolic Clearance of <em>S</em>-Warfarin Efficiently Mediated by Polymorphic Marmoset Cytochrome P450 2C19 in Livers
      Individual Differences in Metabolic Clearance of S-Warfarin Efficiently Mediated by Polymorphic Marmoset Cytochrome P450 2C19 in Livers
      Shotaro Uehara, Yasuhiro Uno, Takashi Inoue, Mirai Kawano, Makiko Shimizu, Akiko Toda, Masahiro Utoh, Erika Sasaki and Hiroshi Yamazaki
      Drug Metabolism and Disposition July 2016, 44 (7) 911-915; DOI: https://doi.org/10.1124/dmd.116.070383

  5. Tsuneyama, Koichi

    1. Zomepirac Acyl Glucuronide Is Responsible for Zomepirac-Induced Acute Kidney Injury in Mice
      Atsushi Iwamura, Katsuhito Watanabe, Sho Akai, Tsubasa Nishinosono, Koichi Tsuneyama, Shingo Oda, Toshiyuki Kume and Tsuyoshi Yokoi
      Drug Metabolism and Disposition July 2016, 44 (7) 888-896; DOI: https://doi.org/10.1124/dmd.116.069575

  6. Twist, Greyson P.

    1. Developmental Expression of CYP2B6: A Comprehensive Analysis of mRNA Expression, Protein Content and Bupropion Hydroxylase Activity and the Impact of Genetic Variation
      Robin E. Pearce, Roger Gaedigk, Greyson P. Twist, Hongying Dai, Amanda K. Riffel, J. Steven Leeder and Andrea Gaedigk
      Drug Metabolism and Disposition July 2016, 44 (7) 948-958; DOI: https://doi.org/10.1124/dmd.115.067546

U

  1. Uehara, Shotaro

    1. Individual Differences in Metabolic Clearance of <em>S</em>-Warfarin Efficiently Mediated by Polymorphic Marmoset Cytochrome P450 2C19 in Livers
      Individual Differences in Metabolic Clearance of S-Warfarin Efficiently Mediated by Polymorphic Marmoset Cytochrome P450 2C19 in Livers
      Shotaro Uehara, Yasuhiro Uno, Takashi Inoue, Mirai Kawano, Makiko Shimizu, Akiko Toda, Masahiro Utoh, Erika Sasaki and Hiroshi Yamazaki
      Drug Metabolism and Disposition July 2016, 44 (7) 911-915; DOI: https://doi.org/10.1124/dmd.116.070383

  2. Uno, Yasuhiro

    1. Individual Differences in Metabolic Clearance of <em>S</em>-Warfarin Efficiently Mediated by Polymorphic Marmoset Cytochrome P450 2C19 in Livers
      Individual Differences in Metabolic Clearance of S-Warfarin Efficiently Mediated by Polymorphic Marmoset Cytochrome P450 2C19 in Livers
      Shotaro Uehara, Yasuhiro Uno, Takashi Inoue, Mirai Kawano, Makiko Shimizu, Akiko Toda, Masahiro Utoh, Erika Sasaki and Hiroshi Yamazaki
      Drug Metabolism and Disposition July 2016, 44 (7) 911-915; DOI: https://doi.org/10.1124/dmd.116.070383

  3. Utoh, Masahiro

    1. Individual Differences in Metabolic Clearance of <em>S</em>-Warfarin Efficiently Mediated by Polymorphic Marmoset Cytochrome P450 2C19 in Livers
      Individual Differences in Metabolic Clearance of S-Warfarin Efficiently Mediated by Polymorphic Marmoset Cytochrome P450 2C19 in Livers
      Shotaro Uehara, Yasuhiro Uno, Takashi Inoue, Mirai Kawano, Makiko Shimizu, Akiko Toda, Masahiro Utoh, Erika Sasaki and Hiroshi Yamazaki
      Drug Metabolism and Disposition July 2016, 44 (7) 911-915; DOI: https://doi.org/10.1124/dmd.116.070383

V

  1. Vaes, Wouter H. J.

    1. Proteomic Analysis of the Developmental Trajectory of Human Hepatic Membrane Transporter Proteins in the First Three Months of Life
      Miriam G. Mooij, Evita van de Steeg, Joost van Rosmalen, Jonathan D. Windster, Barbara A.E. de Koning, Wouter H. J. Vaes, Bianca D. van Groen, Dick Tibboel, Heleen M. Wortelboer and Saskia N. de Wildt
      Drug Metabolism and Disposition July 2016, 44 (7) 1005-1013; DOI: https://doi.org/10.1124/dmd.115.068577

  2. van de Steeg, Evita

    1. Proteomic Analysis of the Developmental Trajectory of Human Hepatic Membrane Transporter Proteins in the First Three Months of Life
      Miriam G. Mooij, Evita van de Steeg, Joost van Rosmalen, Jonathan D. Windster, Barbara A.E. de Koning, Wouter H. J. Vaes, Bianca D. van Groen, Dick Tibboel, Heleen M. Wortelboer and Saskia N. de Wildt
      Drug Metabolism and Disposition July 2016, 44 (7) 1005-1013; DOI: https://doi.org/10.1124/dmd.115.068577

  3. van Groen, Bianca D.

    1. Human Intestinal PEPT1 Transporter Expression and Localization in Preterm and Term Infants
      Miriam G. Mooij, Barbara E. A. de Koning, Dicky J. Lindenbergh-Kortleve, Ytje Simons-Oosterhuis, Bianca D. van Groen, Dick Tibboel, Janneke N. Samsom and Saskia N. de Wildt
      Drug Metabolism and Disposition July 2016, 44 (7) 1014-1019; DOI: https://doi.org/10.1124/dmd.115.068809
    2. Proteomic Analysis of the Developmental Trajectory of Human Hepatic Membrane Transporter Proteins in the First Three Months of Life
      Miriam G. Mooij, Evita van de Steeg, Joost van Rosmalen, Jonathan D. Windster, Barbara A.E. de Koning, Wouter H. J. Vaes, Bianca D. van Groen, Dick Tibboel, Heleen M. Wortelboer and Saskia N. de Wildt
      Drug Metabolism and Disposition July 2016, 44 (7) 1005-1013; DOI: https://doi.org/10.1124/dmd.115.068577

  4. Van Haandel, Leon

    1. Characterization of Atomoxetine Biotransformation and Implications for Development of PBPK Models for Dose Individualization in Children
      Jean C. Dinh, Robin E. Pearce, Leon Van Haandel, Andrea Gaedigk and J. Steven Leeder
      Drug Metabolism and Disposition July 2016, 44 (7) 1070-1079; DOI: https://doi.org/10.1124/dmd.116.069518

  5. van Rosmalen, Joost

    1. Proteomic Analysis of the Developmental Trajectory of Human Hepatic Membrane Transporter Proteins in the First Three Months of Life
      Miriam G. Mooij, Evita van de Steeg, Joost van Rosmalen, Jonathan D. Windster, Barbara A.E. de Koning, Wouter H. J. Vaes, Bianca D. van Groen, Dick Tibboel, Heleen M. Wortelboer and Saskia N. de Wildt
      Drug Metabolism and Disposition July 2016, 44 (7) 1005-1013; DOI: https://doi.org/10.1124/dmd.115.068577

  6. Vyhlidal, Carrie

    1. Open Access
      Decreased Pregnane X Receptor Expression in Children with Active Crohn’s Disease
      Valentina Shakhnovich, Carrie Vyhlidal, Craig Friesen, Amber Hildreth, Vivekanand Singh, James Daniel, Gregory L. Kearns and J. Steven Leeder
      Drug Metabolism and Disposition July 2016, 44 (7) 1066-1069; DOI: https://doi.org/10.1124/dmd.115.068742

  7. Vyhlidal, Carrie A.

    1. Dynamics of Cytosine Methylation in the Proximal Promoters of CYP3A4 and CYP3A7 in Pediatric and Prenatal Livers
      Carrie A. Vyhlidal, Chengpeng Bi, Shui Qing Ye and J. Steven Leeder
      Drug Metabolism and Disposition July 2016, 44 (7) 1020-1026; DOI: https://doi.org/10.1124/dmd.115.068726

W

  1. Walles, Markus

    1. New Insights in Tissue Distribution, Metabolism, and Excretion of [3H]-Labeled Antibody Maytansinoid Conjugates in Female Tumor-Bearing Nude Rats
      Markus Walles, Bettina Rudolph, Thierry Wolf, Julien Bourgailh, Martina Suetterlin, Thomas Moenius, Gisela Peraus, Olivier Heudi, Walid Elbast, Christian Lanshoeft and Sanela Bilic
      Drug Metabolism and Disposition July 2016, 44 (7) 897-910; DOI: https://doi.org/10.1124/dmd.115.069021

  2. Wang, Guangji

    1. Cardiotonic Pill Reduces Myocardial Ischemia-Reperfusion Injury via Increasing EET Concentrations in Rats
      Cardiotonic Pill Reduces Myocardial Ischemia-Reperfusion Injury via Increasing EET Concentrations in Rats
      Meijuan Xu, Haiping Hao, Lifeng Jiang, Yidan Wei, Fang Zhou, Jianguo Sun, Jingwei Zhang, Hui Ji, Guangji Wang, Wenzheng Ju and Ping Li
      Drug Metabolism and Disposition July 2016, 44 (7) 878-887; DOI: https://doi.org/10.1124/dmd.116.069914

  3. Wang, Michael Zhuo

    1. Quantification of Flavin-containing Monooxygenases 1, 3, and 5 in Human Liver Microsomes by UPLC-MRM-Based Targeted Quantitative Proteomics and Its Application to the Study of Ontogeny
      Yao Chen, Nicole R. Zane, Dhiren R. Thakker and Michael Zhuo Wang
      Drug Metabolism and Disposition July 2016, 44 (7) 975-983; DOI: https://doi.org/10.1124/dmd.115.067538

  4. Watanabe, Katsuhito

    1. Zomepirac Acyl Glucuronide Is Responsible for Zomepirac-Induced Acute Kidney Injury in Mice
      Atsushi Iwamura, Katsuhito Watanabe, Sho Akai, Tsubasa Nishinosono, Koichi Tsuneyama, Shingo Oda, Toshiyuki Kume and Tsuyoshi Yokoi
      Drug Metabolism and Disposition July 2016, 44 (7) 888-896; DOI: https://doi.org/10.1124/dmd.116.069575

  5. Waters, Nigel J.

    1. Physiologically Based Pharmacokinetic Modeling in Pediatric Oncology Drug Development
      Nathalie Rioux and Nigel J. Waters
      Drug Metabolism and Disposition July 2016, 44 (7) 934-943; DOI: https://doi.org/10.1124/dmd.115.068031

  6. Webb-Robertson, Bobbie-Jo

    1. Hepatic Cytochrome P450 Activity, Abundance, and Expression Throughout Human Development
      Hepatic Cytochrome P450 Activity, Abundance, and Expression Throughout Human Development
      Natalie C. Sadler, Premchendar Nandhikonda, Bobbie-Jo Webb-Robertson, Charles Ansong, Lindsey N. Anderson, Jordan N. Smith, Richard A. Corley and Aaron T. Wright
      Drug Metabolism and Disposition July 2016, 44 (7) 984-991; DOI: https://doi.org/10.1124/dmd.115.068593

  7. Wei, Yidan

    1. Cardiotonic Pill Reduces Myocardial Ischemia-Reperfusion Injury via Increasing EET Concentrations in Rats
      Cardiotonic Pill Reduces Myocardial Ischemia-Reperfusion Injury via Increasing EET Concentrations in Rats
      Meijuan Xu, Haiping Hao, Lifeng Jiang, Yidan Wei, Fang Zhou, Jianguo Sun, Jingwei Zhang, Hui Ji, Guangji Wang, Wenzheng Ju and Ping Li
      Drug Metabolism and Disposition July 2016, 44 (7) 878-887; DOI: https://doi.org/10.1124/dmd.116.069914

  8. Windster, Jonathan D.

    1. Proteomic Analysis of the Developmental Trajectory of Human Hepatic Membrane Transporter Proteins in the First Three Months of Life
      Miriam G. Mooij, Evita van de Steeg, Joost van Rosmalen, Jonathan D. Windster, Barbara A.E. de Koning, Wouter H. J. Vaes, Bianca D. van Groen, Dick Tibboel, Heleen M. Wortelboer and Saskia N. de Wildt
      Drug Metabolism and Disposition July 2016, 44 (7) 1005-1013; DOI: https://doi.org/10.1124/dmd.115.068577

  9. Wolf, Thierry

    1. New Insights in Tissue Distribution, Metabolism, and Excretion of [3H]-Labeled Antibody Maytansinoid Conjugates in Female Tumor-Bearing Nude Rats
      Markus Walles, Bettina Rudolph, Thierry Wolf, Julien Bourgailh, Martina Suetterlin, Thomas Moenius, Gisela Peraus, Olivier Heudi, Walid Elbast, Christian Lanshoeft and Sanela Bilic
      Drug Metabolism and Disposition July 2016, 44 (7) 897-910; DOI: https://doi.org/10.1124/dmd.115.069021

  10. Wortelboer, Heleen M.

    1. Proteomic Analysis of the Developmental Trajectory of Human Hepatic Membrane Transporter Proteins in the First Three Months of Life
      Miriam G. Mooij, Evita van de Steeg, Joost van Rosmalen, Jonathan D. Windster, Barbara A.E. de Koning, Wouter H. J. Vaes, Bianca D. van Groen, Dick Tibboel, Heleen M. Wortelboer and Saskia N. de Wildt
      Drug Metabolism and Disposition July 2016, 44 (7) 1005-1013; DOI: https://doi.org/10.1124/dmd.115.068577

  11. Wright, Aaron T.

    1. Hepatic Cytochrome P450 Activity, Abundance, and Expression Throughout Human Development
      Hepatic Cytochrome P450 Activity, Abundance, and Expression Throughout Human Development
      Natalie C. Sadler, Premchendar Nandhikonda, Bobbie-Jo Webb-Robertson, Charles Ansong, Lindsey N. Anderson, Jordan N. Smith, Richard A. Corley and Aaron T. Wright
      Drug Metabolism and Disposition July 2016, 44 (7) 984-991; DOI: https://doi.org/10.1124/dmd.115.068593

X

  1. Xu, Meijuan

    1. Cardiotonic Pill Reduces Myocardial Ischemia-Reperfusion Injury via Increasing EET Concentrations in Rats
      Cardiotonic Pill Reduces Myocardial Ischemia-Reperfusion Injury via Increasing EET Concentrations in Rats
      Meijuan Xu, Haiping Hao, Lifeng Jiang, Yidan Wei, Fang Zhou, Jianguo Sun, Jingwei Zhang, Hui Ji, Guangji Wang, Wenzheng Ju and Ping Li
      Drug Metabolism and Disposition July 2016, 44 (7) 878-887; DOI: https://doi.org/10.1124/dmd.116.069914

Y

  1. Yamazaki, Hiroshi

    1. Individual Differences in Metabolic Clearance of <em>S</em>-Warfarin Efficiently Mediated by Polymorphic Marmoset Cytochrome P450 2C19 in Livers
      Individual Differences in Metabolic Clearance of S-Warfarin Efficiently Mediated by Polymorphic Marmoset Cytochrome P450 2C19 in Livers
      Shotaro Uehara, Yasuhiro Uno, Takashi Inoue, Mirai Kawano, Makiko Shimizu, Akiko Toda, Masahiro Utoh, Erika Sasaki and Hiroshi Yamazaki
      Drug Metabolism and Disposition July 2016, 44 (7) 911-915; DOI: https://doi.org/10.1124/dmd.116.070383

  2. Yan, Ke

    1. Role of Chromatin Structural Changes in Regulating Human CYP3A Ontogeny
      Nicholas L. Giebel, Jeffrey D. Shadley, D. Gail McCarver, Kenneth Dorko, Roberto Gramignoli, Stephen C. Strom, Ke Yan, Pippa M. Simpson and Ronald N. Hines
      Drug Metabolism and Disposition July 2016, 44 (7) 1027-1037; DOI: https://doi.org/10.1124/dmd.116.069344

  3. Yang, Qi Joy

    1. Metabolite Kinetics: The Segregated Flow Model for Intestinal and Whole Body Physiologically Based Pharmacokinetic Modeling to Describe Intestinal and Hepatic Glucuronidation of Morphine in Rats In Vivo
      Qi Joy Yang, Jianghong Fan, Shu Chen, Lutan Liu, Huadong Sun and K. Sandy Pang
      Drug Metabolism and Disposition July 2016, 44 (7) 1123-1138; DOI: https://doi.org/10.1124/dmd.116.069542

  4. Ye, Shui Qing

    1. Dynamics of Cytosine Methylation in the Proximal Promoters of CYP3A4 and CYP3A7 in Pediatric and Prenatal Livers
      Carrie A. Vyhlidal, Chengpeng Bi, Shui Qing Ye and J. Steven Leeder
      Drug Metabolism and Disposition July 2016, 44 (7) 1020-1026; DOI: https://doi.org/10.1124/dmd.115.068726

  5. Yokoi, Tsuyoshi

    1. Zomepirac Acyl Glucuronide Is Responsible for Zomepirac-Induced Acute Kidney Injury in Mice
      Atsushi Iwamura, Katsuhito Watanabe, Sho Akai, Tsubasa Nishinosono, Koichi Tsuneyama, Shingo Oda, Toshiyuki Kume and Tsuyoshi Yokoi
      Drug Metabolism and Disposition July 2016, 44 (7) 888-896; DOI: https://doi.org/10.1124/dmd.116.069575

  6. Yu, Jingyu

    1. Role of Quantitative Clinical Pharmacology in Pediatric Approval and Labeling
      Nitin Mehrotra, Atul Bhattaram, Justin C. Earp, Jeffry Florian, Kevin Krudys, Jee Eun Lee, Joo Yeon Lee, Jiang Liu, Yeruk Mulugeta, Jingyu Yu, Ping Zhao and Vikram Sinha
      Drug Metabolism and Disposition July 2016, 44 (7) 924-933; DOI: https://doi.org/10.1124/dmd.116.069559

Z

  1. Zane, Nicole R.

    1. Quantification of Flavin-containing Monooxygenases 1, 3, and 5 in Human Liver Microsomes by UPLC-MRM-Based Targeted Quantitative Proteomics and Its Application to the Study of Ontogeny
      Yao Chen, Nicole R. Zane, Dhiren R. Thakker and Michael Zhuo Wang
      Drug Metabolism and Disposition July 2016, 44 (7) 975-983; DOI: https://doi.org/10.1124/dmd.115.067538

  2. Zhang, Jingwei

    1. Cardiotonic Pill Reduces Myocardial Ischemia-Reperfusion Injury via Increasing EET Concentrations in Rats
      Cardiotonic Pill Reduces Myocardial Ischemia-Reperfusion Injury via Increasing EET Concentrations in Rats
      Meijuan Xu, Haiping Hao, Lifeng Jiang, Yidan Wei, Fang Zhou, Jianguo Sun, Jingwei Zhang, Hui Ji, Guangji Wang, Wenzheng Ju and Ping Li
      Drug Metabolism and Disposition July 2016, 44 (7) 878-887; DOI: https://doi.org/10.1124/dmd.116.069914

  3. Zhao, Ping

    1. Role of Quantitative Clinical Pharmacology in Pediatric Approval and Labeling
      Nitin Mehrotra, Atul Bhattaram, Justin C. Earp, Jeffry Florian, Kevin Krudys, Jee Eun Lee, Joo Yeon Lee, Jiang Liu, Yeruk Mulugeta, Jingyu Yu, Ping Zhao and Vikram Sinha
      Drug Metabolism and Disposition July 2016, 44 (7) 924-933; DOI: https://doi.org/10.1124/dmd.116.069559

  4. Zhou, Fang

    1. Cardiotonic Pill Reduces Myocardial Ischemia-Reperfusion Injury via Increasing EET Concentrations in Rats
      Cardiotonic Pill Reduces Myocardial Ischemia-Reperfusion Injury via Increasing EET Concentrations in Rats
      Meijuan Xu, Haiping Hao, Lifeng Jiang, Yidan Wei, Fang Zhou, Jianguo Sun, Jingwei Zhang, Hui Ji, Guangji Wang, Wenzheng Ju and Ping Li
      Drug Metabolism and Disposition July 2016, 44 (7) 878-887; DOI: https://doi.org/10.1124/dmd.116.069914
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