Article Figures & Data
Figures
- Fig. 1.
Univariate modeling of gene expression and conjugated BPA levels in fetal livers. Linear regressions for NRF2 mRNA, NQO1 mRNA, MRP1 mRNA, and conjugated BPA levels are shown. Data are presented as mean relative expression (n = 49, normalized to β-2-microglobulin). Dashed lines represent 95% confidence limits. B2M, β-2-microglobulin.
Tables
- TABLE 1
Correlation matrix for sample characteristics
Summary of the correlations between different BPA species concentrations and gestational age. A value of 1.0 represents a perfect correlation.
Characteristic Total BPA Conjugated BPA Free BPA Gestational Age Total BPA 1.00 Conjugated BPA 0.748* 1.00 Free BPA 0.963* 0.539* 1.00 Gestational age 0.199 0.067 0.224 1.00 * P < 0.001.
- TABLE 2
Normalized gene expression correlation matrix
Summary of the correlations between gene expression of different transcription factors and transporters in human fetal liver. A value of 1.0 represents a perfect correlation.
Gene MRP1 MRP2 MRP3 MRP4 MDR1 BCRP NRF2 NQO1 MRP1 1.00 MRP2 0.739* 1.00 MRP3 0.462* 0.301*** 1.00 MRP4 0.380** 0.169 0.741* 1.00 MDR1 0.320*** 0.147 0.689* 0.734* 1.00 BCRP 0.370** 0.212 0.796* 0.941* 0.816* 1.00 NRF2 0.418** 0.235 0.315*** 0.266 0.266 0.264 1.00 NQO1 0.859* 0.597* 0.300*** 0.302*** 0.167 0.233 0.475* 1.00 * P < 0.001; **P < 0.01; ***P < 0.05.
- TABLE 3
Regression coefficients for gene expression and BPA levels in human fetal livers
Regression coefficients (β) were calculated from simple linear regression analysis for each gene and BPA species (n = 49).
Gene BPA Species Total Conjugated Free β P Value β P Value β P Value MRP1 1.45 × 10−3 0.666 1.13 × 10−2 <0.001* 4.36 × 10−4 0.728 MRP2 3.79 × 10−4 0.815 5.54 × 10−3 0.038** −3.14 × 10−4 0.779 MRP3 8.82 × 10−4 0.350 7.12 × 10−3 0.013** 2.26 × 10−4 0.851 MRP4 1.19 × 10−3 0.185 4.79 × 10−3 0.085 1.11 × 10−3 0.332 MDR1 5.16 × 10−4 0.677 3.37 × 10−3 0.380 2.62 × 10−4 0.868 BCRP 1.03 × 10−3 0.288 4.45 × 10−3 0.138 9.08 × 10−4 0.462 NRF2 1.82 × 10−3 0.057 1.04 × 10−2 <0.001* 1.19 × 10−3 0.334 NQO1 1.66 × 10−3 0.124 1.27 × 10−2 <0.001* 1.19 × 10−3 0.334 * P < 0.001; **P < 0.05.
Data Supplement
Files in this Data Supplement:
- Supplemental Table -
qPCR primer sequences
- Supplemental Table -
In this issue
BPA and Efflux Transporters in Fetal Livers
