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Rapid CommunicationSpecial Section on Pediatric Drug Disposition and Pharmacokinetics—Short Communication
Open Access

Decreased Pregnane X Receptor Expression in Children with Active Crohn’s Disease

Valentina Shakhnovich, Carrie Vyhlidal, Craig Friesen, Amber Hildreth, Vivekanand Singh, James Daniel, Gregory L. Kearns and J. Steven Leeder
Drug Metabolism and Disposition July 2016, 44 (7) 1066-1069; DOI: https://doi.org/10.1124/dmd.115.068742
Valentina Shakhnovich
The Children’s Mercy Hospital, Kansas City, Missouri (V.S., C.V., C.F., V.S., J.D., J.S.L.) University of California San Diego, San Diego, California (A.H.); Arkansas Children’s Hospital Research Institute, Little Rock, Arkansas (G.L.K.). Laboratory of origin: The Children’s Mercy Hospital
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Carrie Vyhlidal
The Children’s Mercy Hospital, Kansas City, Missouri (V.S., C.V., C.F., V.S., J.D., J.S.L.) University of California San Diego, San Diego, California (A.H.); Arkansas Children’s Hospital Research Institute, Little Rock, Arkansas (G.L.K.). Laboratory of origin: The Children’s Mercy Hospital
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Craig Friesen
The Children’s Mercy Hospital, Kansas City, Missouri (V.S., C.V., C.F., V.S., J.D., J.S.L.) University of California San Diego, San Diego, California (A.H.); Arkansas Children’s Hospital Research Institute, Little Rock, Arkansas (G.L.K.). Laboratory of origin: The Children’s Mercy Hospital
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Amber Hildreth
The Children’s Mercy Hospital, Kansas City, Missouri (V.S., C.V., C.F., V.S., J.D., J.S.L.) University of California San Diego, San Diego, California (A.H.); Arkansas Children’s Hospital Research Institute, Little Rock, Arkansas (G.L.K.). Laboratory of origin: The Children’s Mercy Hospital
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Vivekanand Singh
The Children’s Mercy Hospital, Kansas City, Missouri (V.S., C.V., C.F., V.S., J.D., J.S.L.) University of California San Diego, San Diego, California (A.H.); Arkansas Children’s Hospital Research Institute, Little Rock, Arkansas (G.L.K.). Laboratory of origin: The Children’s Mercy Hospital
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James Daniel
The Children’s Mercy Hospital, Kansas City, Missouri (V.S., C.V., C.F., V.S., J.D., J.S.L.) University of California San Diego, San Diego, California (A.H.); Arkansas Children’s Hospital Research Institute, Little Rock, Arkansas (G.L.K.). Laboratory of origin: The Children’s Mercy Hospital
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Gregory L. Kearns
The Children’s Mercy Hospital, Kansas City, Missouri (V.S., C.V., C.F., V.S., J.D., J.S.L.) University of California San Diego, San Diego, California (A.H.); Arkansas Children’s Hospital Research Institute, Little Rock, Arkansas (G.L.K.). Laboratory of origin: The Children’s Mercy Hospital
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J. Steven Leeder
The Children’s Mercy Hospital, Kansas City, Missouri (V.S., C.V., C.F., V.S., J.D., J.S.L.) University of California San Diego, San Diego, California (A.H.); Arkansas Children’s Hospital Research Institute, Little Rock, Arkansas (G.L.K.). Laboratory of origin: The Children’s Mercy Hospital
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Article Information

vol. 44 no. 7 1066-1069
DOI 
https://doi.org/10.1124/dmd.115.068742
PubMed 
27013401

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received December 2, 2015
  • Accepted March 22, 2016
  • Published online June 14, 2016.

Article Versions

  • Earlier version (March 24, 2016 - 06:28).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2016 The Author(s) This is an open access article distributed under the CC BY-NC Attribution 4.0 International license.

Author Information

  1. Valentina Shakhnovich,
  2. Carrie Vyhlidal,
  3. Craig Friesen,
  4. Amber Hildreth,
  5. Vivekanand Singh,
  6. James Daniel,
  7. Gregory L. Kearns, and
  8. J. Steven Leeder
  1. The Children’s Mercy Hospital, Kansas City, Missouri (V.S., C.V., C.F., V.S., J.D., J.S.L.) University of California San Diego, San Diego, California (A.H.); Arkansas Children’s Hospital Research Institute, Little Rock, Arkansas (G.L.K.). Laboratory of origin: The Children’s Mercy Hospital
  1. Address correspondence to:
    Dr. Valentina Shakhnovich, 2401 Gillham Rd., Kansas City, MO 64108. E-mail: vshakhnovich{at}cmh.edu
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Drug Metabolism and Disposition: 44 (7)
Drug Metabolism and Disposition
Vol. 44, Issue 7
1 Jul 2016
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Rapid CommunicationSpecial Section on Pediatric Drug Disposition and Pharmacokinetics—Short Communication

PXR Expression in Pediatric Crohn’s

Valentina Shakhnovich, Carrie Vyhlidal, Craig Friesen, Amber Hildreth, Vivekanand Singh, James Daniel, Gregory L. Kearns and J. Steven Leeder
Drug Metabolism and Disposition July 1, 2016, 44 (7) 1066-1069; DOI: https://doi.org/10.1124/dmd.115.068742

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Rapid CommunicationSpecial Section on Pediatric Drug Disposition and Pharmacokinetics—Short Communication

PXR Expression in Pediatric Crohn’s

Valentina Shakhnovich, Carrie Vyhlidal, Craig Friesen, Amber Hildreth, Vivekanand Singh, James Daniel, Gregory L. Kearns and J. Steven Leeder
Drug Metabolism and Disposition July 1, 2016, 44 (7) 1066-1069; DOI: https://doi.org/10.1124/dmd.115.068742
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