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Research ArticleSpecial Section on Pediatric Drug Disposition and Pharmacokinetics

Predicting Stereoselective Disposition of Carvedilol in Adult and Pediatric Chronic Heart Failure Patients by Incorporating Pathophysiological Changes in Organ Blood Flows–A Physiologically Based Pharmacokinetic Approach

Muhammad Fawad Rasool, Feras Khalil and Stephanie Läer
Drug Metabolism and Disposition July 2016, 44 (7) 1103-1115; DOI: https://doi.org/10.1124/dmd.115.068858

Article Information

vol. 44 no. 7 1103-1115
DOI 
https://doi.org/10.1124/dmd.115.068858
PubMed 
27068272
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received December 8, 2015
  • Accepted April 7, 2016
  • Published online June 14, 2016.

Article Versions

Copyright & Usage 
Copyright © 2016 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Muhammad Fawad Rasool,
  2. Feras Khalil, and
  3. Stephanie Läer
  1. Department of Clinical Pharmacy and Pharmacotherapy, Heinrich-Heine University, Düsseldorf, Germany (M.F.R., F.K., S.L.); and Faculty of Pharmacy, Bahauddin Zakariya University, Multan, Pakistan (M.F.R.)
  1. Address correspondence to:
    Muhammad Fawad Rasool, Department of Clinical Pharmacy and Pharmacotherapy, Heinrich-Heine University, 40225 Düsseldorf, Germany. E-mail: fawadrasool{at}bzu.edu.pk; fawad.rasool{at}uni-duesseldorf.de
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Research ArticleSpecial Section on Pediatric Drug Disposition and Pharmacokinetics

Predicting Stereoselective PK of Carvedilol–A PBPK Approach

Muhammad Fawad Rasool, Feras Khalil and Stephanie Läer
Drug Metabolism and Disposition July 1, 2016, 44 (7) 1103-1115; DOI: https://doi.org/10.1124/dmd.115.068858
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