Skip to main content
Advertisement

Main menu

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Special Sections
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Submit
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET

User menu

  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
Drug Metabolism & Disposition
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET
  • My alerts
  • Log in
  • My Cart
Drug Metabolism & Disposition

Advanced Search

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Special Sections
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Submit
  • Visit dmd on Facebook
  • Follow dmd on Twitter
  • Follow ASPET on LinkedIn
Research ArticleSpecial Section on Pediatric Drug Disposition and Pharmacokinetics

Population Pharmacokinetics of Oral Topotecan in Infants and Very Young Children with Brain Tumors Demonstrates a Role of ABCG2 rs4148157 on the Absorption Rate Constant

Jessica K. Roberts, Anna V. Birg, Tong Lin, Vinay M. Daryani, John C. Panetta, Alberto Broniscer, Giles W. Robinson, Amar J. Gajjar and Clinton F. Stewart
Drug Metabolism and Disposition July 2016, 44 (7) 1116-1122; DOI: https://doi.org/10.1124/dmd.115.068676
Jessica K. Roberts
Department of Pharmaceutical Sciences (J.K.R., A.V.B., V.M.D., J.C.P., C.F.S.), Department of Biostatistics (T.L.), and Department of Oncology (A.B., G.W.R., A.J.G.), St. Jude Children’s Research Hospital, Memphis, Tennessee
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Anna V. Birg
Department of Pharmaceutical Sciences (J.K.R., A.V.B., V.M.D., J.C.P., C.F.S.), Department of Biostatistics (T.L.), and Department of Oncology (A.B., G.W.R., A.J.G.), St. Jude Children’s Research Hospital, Memphis, Tennessee
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Tong Lin
Department of Pharmaceutical Sciences (J.K.R., A.V.B., V.M.D., J.C.P., C.F.S.), Department of Biostatistics (T.L.), and Department of Oncology (A.B., G.W.R., A.J.G.), St. Jude Children’s Research Hospital, Memphis, Tennessee
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Vinay M. Daryani
Department of Pharmaceutical Sciences (J.K.R., A.V.B., V.M.D., J.C.P., C.F.S.), Department of Biostatistics (T.L.), and Department of Oncology (A.B., G.W.R., A.J.G.), St. Jude Children’s Research Hospital, Memphis, Tennessee
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
John C. Panetta
Department of Pharmaceutical Sciences (J.K.R., A.V.B., V.M.D., J.C.P., C.F.S.), Department of Biostatistics (T.L.), and Department of Oncology (A.B., G.W.R., A.J.G.), St. Jude Children’s Research Hospital, Memphis, Tennessee
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Alberto Broniscer
Department of Pharmaceutical Sciences (J.K.R., A.V.B., V.M.D., J.C.P., C.F.S.), Department of Biostatistics (T.L.), and Department of Oncology (A.B., G.W.R., A.J.G.), St. Jude Children’s Research Hospital, Memphis, Tennessee
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Giles W. Robinson
Department of Pharmaceutical Sciences (J.K.R., A.V.B., V.M.D., J.C.P., C.F.S.), Department of Biostatistics (T.L.), and Department of Oncology (A.B., G.W.R., A.J.G.), St. Jude Children’s Research Hospital, Memphis, Tennessee
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Amar J. Gajjar
Department of Pharmaceutical Sciences (J.K.R., A.V.B., V.M.D., J.C.P., C.F.S.), Department of Biostatistics (T.L.), and Department of Oncology (A.B., G.W.R., A.J.G.), St. Jude Children’s Research Hospital, Memphis, Tennessee
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Clinton F. Stewart
Department of Pharmaceutical Sciences (J.K.R., A.V.B., V.M.D., J.C.P., C.F.S.), Department of Biostatistics (T.L.), and Department of Oncology (A.B., G.W.R., A.J.G.), St. Jude Children’s Research Hospital, Memphis, Tennessee
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF
Loading

Article Information

vol. 44 no. 7 1116-1122
DOI 
https://doi.org/10.1124/dmd.115.068676
PubMed 
27052877

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received November 30, 2015
  • Accepted April 5, 2016
  • Published online June 14, 2016.

Article Versions

  • Earlier version (April 6, 2016 - 08:47).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2016 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Jessica K. Roberts,
  2. Anna V. Birg,
  3. Tong Lin,
  4. Vinay M. Daryani,
  5. John C. Panetta,
  6. Alberto Broniscer,
  7. Giles W. Robinson,
  8. Amar J. Gajjar, and
  9. Clinton F. Stewart
  1. Department of Pharmaceutical Sciences (J.K.R., A.V.B., V.M.D., J.C.P., C.F.S.), Department of Biostatistics (T.L.), and Department of Oncology (A.B., G.W.R., A.J.G.), St. Jude Children’s Research Hospital, Memphis, Tennessee
  1. Address correspondence to:
    Clinton F. Stewart, Department of Pharmaceutical Sciences, St. Jude Children’s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105. E-mail: Clinton.stewart{at}stjude.org
View Full Text

Statistics from Altmetric.com

Article usage

Article usage: August 2017 to May 2023

AbstractFullPdf
Aug 201711010
Sep 20171188
Oct 20171212
Nov 20173219
Dec 20174153
Jan 201811183
Feb 20180115
Mar 20180154
Apr 20180133
May 20182163
Jun 20181153
Jul 20181133
Aug 201821211
Sep 20181165
Oct 201802210
Nov 20180164
Dec 201811510
Jan 2019054
Feb 20192107
Mar 2019189
Apr 201922413
May 201902717
Jun 201905911
Jul 201916912
Aug 201929710
Oct 201912413
Nov 201901711
Dec 201972312
Jan 202001920
Feb 202001610
Mar 202013112
May 202021111
Jun 202033818
Jul 20201139
Aug 20200229
Sep 20205297
Oct 202022410
Nov 202031417
Dec 20203147
Jan 202132011
Feb 202131611
Mar 20212234
Apr 20213157
May 202152510
Jun 20215141
Jul 2021113520
Aug 202181512
Sep 202132313
Oct 202102220
Nov 202111022
Dec 202121826
Jan 20220145
Feb 202221012
Mar 202211521
Apr 202222423
May 20220179
Jun 20222944
Jul 20222317
Aug 20222340
Sep 20221932
Oct 20221831
Nov 20221711
Dec 20221425
Jan 20234521
Feb 20231645
Mar 20231021
Apr 20231016
May 20231720

PreviousNext
Back to top

In this issue

Drug Metabolism and Disposition: 44 (7)
Drug Metabolism and Disposition
Vol. 44, Issue 7
1 Jul 2016
  • Table of Contents
  • Table of Contents (PDF)
  • About the Cover
  • Index by author
  • Editorial Board (PDF)
  • Front Matter (PDF)
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for sharing this Drug Metabolism & Disposition article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
Population Pharmacokinetics of Oral Topotecan in Infants and Very Young Children with Brain Tumors Demonstrates a Role of ABCG2 rs4148157 on the Absorption Rate Constant
(Your Name) has forwarded a page to you from Drug Metabolism & Disposition
(Your Name) thought you would be interested in this article in Drug Metabolism & Disposition.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Research ArticleSpecial Section on Pediatric Drug Disposition and Pharmacokinetics

Pharmacokinetics of Oral Topotecan in Very Young Children

Jessica K. Roberts, Anna V. Birg, Tong Lin, Vinay M. Daryani, John C. Panetta, Alberto Broniscer, Giles W. Robinson, Amar J. Gajjar and Clinton F. Stewart
Drug Metabolism and Disposition July 1, 2016, 44 (7) 1116-1122; DOI: https://doi.org/10.1124/dmd.115.068676

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero

Share
Research ArticleSpecial Section on Pediatric Drug Disposition and Pharmacokinetics

Pharmacokinetics of Oral Topotecan in Very Young Children

Jessica K. Roberts, Anna V. Birg, Tong Lin, Vinay M. Daryani, John C. Panetta, Alberto Broniscer, Giles W. Robinson, Amar J. Gajjar and Clinton F. Stewart
Drug Metabolism and Disposition July 1, 2016, 44 (7) 1116-1122; DOI: https://doi.org/10.1124/dmd.115.068676
Reddit logo Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Abstract
    • Introduction
    • Patients and Methods
    • Results
    • Discussion
    • Acknowledgments
    • Authorship Contributions
    • Footnotes
    • Abbreviations
    • References
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF

Related Articles

Cited By...

More in this TOC Section

  • Predicting Stereoselective PK of Carvedilol–A PBPK Approach
  • Consequences of Age Variation in Hepatic Extraction Ratios
Show more Special Section on Pediatric Drug Disposition and Pharmacokinetics

Similar Articles

Advertisement
  • Home
  • Alerts
Facebook   Twitter   LinkedIn   RSS

Navigate

  • Current Issue
  • Fast Forward by date
  • Fast Forward by section
  • Latest Articles
  • Archive
  • Search for Articles
  • Feedback
  • ASPET

More Information

  • About DMD
  • Editorial Board
  • Instructions to Authors
  • Submit a Manuscript
  • Customized Alerts
  • RSS Feeds
  • Subscriptions
  • Permissions
  • Terms & Conditions of Use

ASPET's Other Journals

  • Journal of Pharmacology and Experimental Therapeutics
  • Molecular Pharmacology
  • Pharmacological Reviews
  • Pharmacology Research & Perspectives
ISSN 1521-009X (Online)

Copyright © 2023 by the American Society for Pharmacology and Experimental Therapeutics