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Research ArticleSpecial Section on Pediatric Drug Disposition and Pharmacokinetics

Population Pharmacokinetics of Oral Topotecan in Infants and Very Young Children with Brain Tumors Demonstrates a Role of ABCG2 rs4148157 on the Absorption Rate Constant

Jessica K. Roberts, Anna V. Birg, Tong Lin, Vinay M. Daryani, John C. Panetta, Alberto Broniscer, Giles W. Robinson, Amar J. Gajjar and Clinton F. Stewart
Drug Metabolism and Disposition July 2016, 44 (7) 1116-1122; DOI: https://doi.org/10.1124/dmd.115.068676

Article Information

vol. 44 no. 7 1116-1122
DOI 
https://doi.org/10.1124/dmd.115.068676
PubMed 
27052877
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received November 30, 2015
  • Accepted April 5, 2016
  • Published online June 14, 2016.

Article Versions

Copyright & Usage 
Copyright © 2016 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Jessica K. Roberts,
  2. Anna V. Birg,
  3. Tong Lin,
  4. Vinay M. Daryani,
  5. John C. Panetta,
  6. Alberto Broniscer,
  7. Giles W. Robinson,
  8. Amar J. Gajjar, and
  9. Clinton F. Stewart
  1. Department of Pharmaceutical Sciences (J.K.R., A.V.B., V.M.D., J.C.P., C.F.S.), Department of Biostatistics (T.L.), and Department of Oncology (A.B., G.W.R., A.J.G.), St. Jude Children’s Research Hospital, Memphis, Tennessee
  1. Address correspondence to:
    Clinton F. Stewart, Department of Pharmaceutical Sciences, St. Jude Children’s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105. E-mail: Clinton.stewart{at}stjude.org
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Research ArticleSpecial Section on Pediatric Drug Disposition and Pharmacokinetics

Pharmacokinetics of Oral Topotecan in Very Young Children

Jessica K. Roberts, Anna V. Birg, Tong Lin, Vinay M. Daryani, John C. Panetta, Alberto Broniscer, Giles W. Robinson, Amar J. Gajjar and Clinton F. Stewart
Drug Metabolism and Disposition July 1, 2016, 44 (7) 1116-1122; DOI: https://doi.org/10.1124/dmd.115.068676
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