Research ArticleSpecial Section on Pediatric Drug Disposition and Pharmacokinetics
Population Pharmacokinetics of Oral Topotecan in Infants and Very Young Children with Brain Tumors Demonstrates a Role of ABCG2 rs4148157 on the Absorption Rate Constant
Jessica K. Roberts, Anna V. Birg, Tong Lin, Vinay M. Daryani, John C. Panetta, Alberto Broniscer, Giles W. Robinson, Amar J. Gajjar and Clinton F. Stewart
Drug Metabolism and Disposition July 2016, 44 (7) 1116-1122; DOI: https://doi.org/10.1124/dmd.115.068676
Jessica K. Roberts
Department of Pharmaceutical Sciences (J.K.R., A.V.B., V.M.D., J.C.P., C.F.S.), Department of Biostatistics (T.L.), and Department of Oncology (A.B., G.W.R., A.J.G.), St. Jude Children’s Research Hospital, Memphis, Tennessee
Anna V. Birg
Department of Pharmaceutical Sciences (J.K.R., A.V.B., V.M.D., J.C.P., C.F.S.), Department of Biostatistics (T.L.), and Department of Oncology (A.B., G.W.R., A.J.G.), St. Jude Children’s Research Hospital, Memphis, Tennessee
Tong Lin
Department of Pharmaceutical Sciences (J.K.R., A.V.B., V.M.D., J.C.P., C.F.S.), Department of Biostatistics (T.L.), and Department of Oncology (A.B., G.W.R., A.J.G.), St. Jude Children’s Research Hospital, Memphis, Tennessee
Vinay M. Daryani
Department of Pharmaceutical Sciences (J.K.R., A.V.B., V.M.D., J.C.P., C.F.S.), Department of Biostatistics (T.L.), and Department of Oncology (A.B., G.W.R., A.J.G.), St. Jude Children’s Research Hospital, Memphis, Tennessee
John C. Panetta
Department of Pharmaceutical Sciences (J.K.R., A.V.B., V.M.D., J.C.P., C.F.S.), Department of Biostatistics (T.L.), and Department of Oncology (A.B., G.W.R., A.J.G.), St. Jude Children’s Research Hospital, Memphis, Tennessee
Alberto Broniscer
Department of Pharmaceutical Sciences (J.K.R., A.V.B., V.M.D., J.C.P., C.F.S.), Department of Biostatistics (T.L.), and Department of Oncology (A.B., G.W.R., A.J.G.), St. Jude Children’s Research Hospital, Memphis, Tennessee
Giles W. Robinson
Department of Pharmaceutical Sciences (J.K.R., A.V.B., V.M.D., J.C.P., C.F.S.), Department of Biostatistics (T.L.), and Department of Oncology (A.B., G.W.R., A.J.G.), St. Jude Children’s Research Hospital, Memphis, Tennessee
Amar J. Gajjar
Department of Pharmaceutical Sciences (J.K.R., A.V.B., V.M.D., J.C.P., C.F.S.), Department of Biostatistics (T.L.), and Department of Oncology (A.B., G.W.R., A.J.G.), St. Jude Children’s Research Hospital, Memphis, Tennessee
Clinton F. Stewart
Department of Pharmaceutical Sciences (J.K.R., A.V.B., V.M.D., J.C.P., C.F.S.), Department of Biostatistics (T.L.), and Department of Oncology (A.B., G.W.R., A.J.G.), St. Jude Children’s Research Hospital, Memphis, Tennessee

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Research ArticleSpecial Section on Pediatric Drug Disposition and Pharmacokinetics
Pharmacokinetics of Oral Topotecan in Very Young Children
Jessica K. Roberts, Anna V. Birg, Tong Lin, Vinay M. Daryani, John C. Panetta, Alberto Broniscer, Giles W. Robinson, Amar J. Gajjar and Clinton F. Stewart
Drug Metabolism and Disposition July 1, 2016, 44 (7) 1116-1122; DOI: https://doi.org/10.1124/dmd.115.068676
Research ArticleSpecial Section on Pediatric Drug Disposition and Pharmacokinetics
Pharmacokinetics of Oral Topotecan in Very Young Children
Jessica K. Roberts, Anna V. Birg, Tong Lin, Vinay M. Daryani, John C. Panetta, Alberto Broniscer, Giles W. Robinson, Amar J. Gajjar and Clinton F. Stewart
Drug Metabolism and Disposition July 1, 2016, 44 (7) 1116-1122; DOI: https://doi.org/10.1124/dmd.115.068676
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