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Metabolite Kinetics: The Segregated Flow Model for Intestinal and Whole Body Physiologically Based Pharmacokinetic Modeling to Describe Intestinal and Hepatic Glucuronidation of Morphine in Rats In Vivo

Qi Joy Yang, Jianghong Fan, Shu Chen, Lutan Liu, Huadong Sun and K. Sandy Pang
Drug Metabolism and Disposition July 2016, 44 (7) 1123-1138; DOI: https://doi.org/10.1124/dmd.116.069542

Article Information

vol. 44 no. 7 1123-1138
DOI 
https://doi.org/10.1124/dmd.116.069542
PubMed 
27098743
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received January 16, 2016
  • Accepted April 19, 2016
  • Published online June 23, 2016.

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Copyright & Usage 
Copyright © 2016 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Qi Joy Yang,
  2. Jianghong Fan1,
  3. Shu Chen2,
  4. Lutan Liu,
  5. Huadong Sun3, and
  6. K. Sandy Pang
  1. Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada
  1. Address correspondence to:
    Dr. K. Sandy Pang, Leslie Dan Faculty of Pharmacy, University of Toronto, 144 College Street, Toronto, ON M5S 3M2, Canada. E-mail: ks.pang{at}utoronto.ca
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Research ArticleArticle

Segregated Flow Model for Intestinal Morphine Glucuronidation

Qi Joy Yang, Jianghong Fan, Shu Chen, Lutan Liu, Huadong Sun and K. Sandy Pang
Drug Metabolism and Disposition July 1, 2016, 44 (7) 1123-1138; DOI: https://doi.org/10.1124/dmd.116.069542
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