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Research ArticleArticle

Metabolite Kinetics: The Segregated Flow Model for Intestinal and Whole Body Physiologically Based Pharmacokinetic Modeling to Describe Intestinal and Hepatic Glucuronidation of Morphine in Rats In Vivo

Qi Joy Yang, Jianghong Fan, Shu Chen, Lutan Liu, Huadong Sun and K. Sandy Pang
Drug Metabolism and Disposition July 2016, 44 (7) 1123-1138; DOI: https://doi.org/10.1124/dmd.116.069542
Qi Joy Yang
Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada
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Jianghong Fan
Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada
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Shu Chen
Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada
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Lutan Liu
Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada
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Huadong Sun
Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada
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K. Sandy Pang
Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada
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Article Information

vol. 44 no. 7 1123-1138
DOI 
https://doi.org/10.1124/dmd.116.069542
PubMed 
27098743

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received January 16, 2016
  • Accepted April 19, 2016
  • Published online June 23, 2016.

Article Versions

  • Earlier version (April 20, 2016 - 06:36).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2016 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Qi Joy Yang,
  2. Jianghong Fan1,
  3. Shu Chen2,
  4. Lutan Liu,
  5. Huadong Sun3, and
  6. K. Sandy Pang
  1. Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada
  1. Address correspondence to:
    Dr. K. Sandy Pang, Leslie Dan Faculty of Pharmacy, University of Toronto, 144 College Street, Toronto, ON M5S 3M2, Canada. E-mail: ks.pang{at}utoronto.ca
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Drug Metabolism and Disposition: 44 (7)
Drug Metabolism and Disposition
Vol. 44, Issue 7
1 Jul 2016
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Research ArticleArticle

Segregated Flow Model for Intestinal Morphine Glucuronidation

Qi Joy Yang, Jianghong Fan, Shu Chen, Lutan Liu, Huadong Sun and K. Sandy Pang
Drug Metabolism and Disposition July 1, 2016, 44 (7) 1123-1138; DOI: https://doi.org/10.1124/dmd.116.069542

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Research ArticleArticle

Segregated Flow Model for Intestinal Morphine Glucuronidation

Qi Joy Yang, Jianghong Fan, Shu Chen, Lutan Liu, Huadong Sun and K. Sandy Pang
Drug Metabolism and Disposition July 1, 2016, 44 (7) 1123-1138; DOI: https://doi.org/10.1124/dmd.116.069542
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