Research ArticleSpecial Section on Pediatric Drug Disposition and Pharmacokinetics—Commentary
Challenges and Opportunities for Increasing the Knowledge Base Related to Drug Biotransformation and Pharmacokinetics during Growth and Development
J. Steven Leeder and Bernd Meibohm
Drug Metabolism and Disposition July 2016, 44 (7) 916-923; DOI: https://doi.org/10.1124/dmd.116.071159
J. Steven Leeder
Division of Clinical Pharmacology, Toxicology and Therapeutic Innovation, Department of Pediatrics, Children’s Mercy Hospitals and Clinics, University of Missouri-Kansas City, Kansas City, Missouri (J.S.L.); and Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Sciences Center, Memphis, Tennessee (B.M.)
Bernd Meibohm
Division of Clinical Pharmacology, Toxicology and Therapeutic Innovation, Department of Pediatrics, Children’s Mercy Hospitals and Clinics, University of Missouri-Kansas City, Kansas City, Missouri (J.S.L.); and Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Sciences Center, Memphis, Tennessee (B.M.)
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Research ArticleSpecial Section on Pediatric Drug Disposition and Pharmacokinetics—Commentary
Pediatric Drug Biotransformation and Pharmacokinetics
J. Steven Leeder and Bernd Meibohm
Drug Metabolism and Disposition July 1, 2016, 44 (7) 916-923; DOI: https://doi.org/10.1124/dmd.116.071159
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- Article
- Abstract
- Introduction
- Modeling and Simulation Approaches
- Uncertainty and Variability in the Development of Pediatric PK Models
- Developmental Trajectories of DMEs and Transporters
- Mechanisms of Developmental Regulation of DMEs and Transporters
- Functional Consequences of DME and Transporter Ontogeny In Vitro
- Ontogeny of Physiologic Functions and Pharmacokinetic Processes for PBPK Modeling
- Functional Consequences of Ontogeny and Genetic Variation In Vivo
- Summary
- Authorship Contributions
- Footnotes
- Abbreviations
- References
- Info & Metrics
- eLetters
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