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Drug Metabolism & Disposition

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Table of Contents

August 01, 2016; Volume 44,Issue 8

Special Section on Emerging Novel Enzyme Pathways in Drug Metabolism

  • You have access
    Cytochrome P450 and Non–Cytochrome P450 Oxidative Metabolism: Contributions to the Pharmacokinetics, Safety, and Efficacy of Xenobiotics
    Robert S. Foti and Deepak K. Dalvie
    Drug Metabolism and Disposition August 2016, 44 (8) 1229-1245; DOI: https://doi.org/10.1124/dmd.116.071753
  • Prevalence of Non–Cytochrome P450–Mediated Metabolism in Food and Drug Administration–Approved Oral and Intravenous Drugs: 2006–2015
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    Prevalence of Non–Cytochrome P450–Mediated Metabolism in Food and Drug Administration–Approved Oral and Intravenous Drugs: 2006–2015
    Matthew A. Cerny
    Drug Metabolism and Disposition August 2016, 44 (8) 1246-1252; DOI: https://doi.org/10.1124/dmd.116.070763
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    Going Beyond Common Drug Metabolizing Enzymes: Case Studies of Biotransformation Involving Aldehyde Oxidase, γ-Glutamyl Transpeptidase, Cathepsin B, Flavin-Containing Monooxygenase, and ADP-Ribosyltransferase
    Peter W. Fan, Donglu Zhang, Jason S. Halladay, James P. Driscoll and S. Cyrus Khojasteh
    Drug Metabolism and Disposition August 2016, 44 (8) 1253-1261; DOI: https://doi.org/10.1124/dmd.116.070169
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    Species Differences in the Oxidative Desulfurization of a Thiouracil-Based Irreversible Myeloperoxidase Inactivator by Flavin-Containing Monooxygenase Enzymes
    Heather Eng, Raman Sharma, Angela Wolford, Li Di, Roger B. Ruggeri, Leonard Buckbinder, Edward L. Conn, Deepak K. Dalvie and Amit S. Kalgutkar
    Drug Metabolism and Disposition August 2016, 44 (8) 1262-1269; DOI: https://doi.org/10.1124/dmd.116.070185
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    Microbial Flavoprotein Monooxygenases as Mimics of Mammalian Flavin-Containing Monooxygenases for the Enantioselective Preparation of Drug Metabolites
    Turan Gul, Marzena Krzek, Hjalmar P. Permentier, Marco W. Fraaije and Rainer Bischoff
    Drug Metabolism and Disposition August 2016, 44 (8) 1270-1276; DOI: https://doi.org/10.1124/dmd.115.069104
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    Optimization of the Expression of Human Aldehyde Oxidase for Investigations of Single-Nucleotide Polymorphisms
    Alessandro Foti, Tobias Hartmann, Catarina Coelho, Teresa Santos-Silva, Maria João Romão and Silke Leimkühler
    Drug Metabolism and Disposition August 2016, 44 (8) 1277-1285; DOI: https://doi.org/10.1124/dmd.115.068395
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    VX-509 (Decernotinib)-Mediated CYP3A Time-Dependent Inhibition: An Aldehyde Oxidase Metabolite as a Perpetrator of Drug-Drug Interactions
    Craig Zetterberg, Francois Maltais, Leena Laitinen, Shengkai Liao, Hong Tsao, Ananthsrinivas Chakilam and Niresh Hariparsad
    Drug Metabolism and Disposition August 2016, 44 (8) 1286-1295; DOI: https://doi.org/10.1124/dmd.116.071100
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    Evaluating the Disposition of a Mixed Aldehyde Oxidase/Cytochrome P450 Substrate in Rats with Attenuated P450 Activity
    Rachel D. Crouch, Ryan D. Morrison, Frank W. Byers, Craig W. Lindsley, Kyle A. Emmitte and J. Scott Daniels
    Drug Metabolism and Disposition August 2016, 44 (8) 1296-1303; DOI: https://doi.org/10.1124/dmd.115.068338
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    Ocular Metabolism of Levobunolol: Historic and Emerging Metabolic Pathways
    Upendra A. Argikar, Jennifer L. Dumouchel, Christine E. Dunne, Chitra Saran, Amanda L. Cirello and Mithat Gunduz
    Drug Metabolism and Disposition August 2016, 44 (8) 1304-1312; DOI: https://doi.org/10.1124/dmd.116.070458
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    Biotransformation Capacity of Carboxylesterase in Skin and Keratinocytes for the Penta-Ethyl Ester Prodrug of DTPA
    Jing Fu, Matthew Sadgrove, Lesley Marson and Michael Jay
    Drug Metabolism and Disposition August 2016, 44 (8) 1313-1318; DOI: https://doi.org/10.1124/dmd.116.069377
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    Nonclinical Pharmacokinetics, Disposition, and Drug-Drug Interaction Potential of a Novel d-Amino Acid Peptide Agonist of the Calcium-Sensing Receptor AMG 416 (Etelcalcetide)
    Raju Subramanian, Xiaochun Zhu, Savannah J. Kerr, Joel D. Esmay, Steven W. Louie, Katheryne Z. Edson, Sarah Walter, Michael Fitzsimmons, Mylo Wagner, Marcus Soto, Roger Pham, Sarah F. Wilson and Gary L. Skiles
    Drug Metabolism and Disposition August 2016, 44 (8) 1319-1331; DOI: https://doi.org/10.1124/dmd.115.068007
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    Phosphocholine Conjugation: An Unexpected In Vivo Conjugation Pathway Associated with Hepatitis C NS5B Inhibitors Featuring A Bicyclo[1.1.1]Pentane
    Xiaoliang Zhuo, Joseph L. Cantone, Yingzi Wang, John E. Leet, Dieter M. Drexler, Kap-Sun Yeung, Xiaohua Stella Huang, Kyle J. Eastman, Kyle E. Parcella, Kathleen W. Mosure, Matthew G. Soars, John F. Kadow and Benjamin M. Johnson
    Drug Metabolism and Disposition August 2016, 44 (8) 1332-1340; DOI: https://doi.org/10.1124/dmd.115.069062
  • Discovery of a Novel Microsomal Epoxide Hydrolase–Catalyzed Hydration of a Spiro Oxetane
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    Discovery of a Novel Microsomal Epoxide Hydrolase–Catalyzed Hydration of a Spiro Oxetane
    Xue-Qing Li, Martin A. Hayes, Gunnar Grönberg, Kristina Berggren, Neal Castagnoli and Lars Weidolf
    Drug Metabolism and Disposition August 2016, 44 (8) 1341-1348; DOI: https://doi.org/10.1124/dmd.116.071142
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    Biotransformation and Rearrangement of Laromustine
    Alaa-Eldin F. Nassar, Adam V. Wisnewski and Ivan King
    Drug Metabolism and Disposition August 2016, 44 (8) 1349-1363; DOI: https://doi.org/10.1124/dmd.116.069823

Perspective

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    Evaluation of a New Molecular Entity as a Victim of Metabolic Drug-Drug Interactions—an Industry Perspective
    Tonika Bohnert, Aarti Patel, Ian Templeton, Yuan Chen, Chuang Lu, George Lai, Louis Leung, Susanna Tse, Heidi J Einolf, Ying-Hong Wang, Michael Sinz, Ralph Stearns, Robert Walsky, Wanping Geng, Sirimas Sudsakorn, David Moore, Ling He, Jan Wahlstrom, Jim Keirns, Rangaraj Narayanan, Dieter Lang, Xiaoqing Yang and International Consortium for Innovation and Quality in Pharmaceutical Development (IQ) Victim Drug-Drug Interactions Working Group
    Drug Metabolism and Disposition August 2016, 44 (8) 1399-1423; DOI: https://doi.org/10.1124/dmd.115.069096

Articles

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    Metabolism and Disposition of Hepatitis C Polymerase Inhibitor Dasabuvir in Humans
    Jianwei Shen, Michael Serby, Aimee Reed, Anthony J. Lee, Rajeev Menon, Xiaomei Zhang, Kennan Marsh, Xia Wan, Olga Kavetskaia and Volker Fischer
    Drug Metabolism and Disposition August 2016, 44 (8) 1139-1147; DOI: https://doi.org/10.1124/dmd.115.067512
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    Metabolism and Disposition of Pan-Genotypic Inhibitor of Hepatitis C Virus NS5A Ombitasvir in Humans
    Jianwei Shen, Michael Serby, Bruce Surber, Anthony J. Lee, Junli Ma, Prajakta Badri, Rajeev Menon, Olga Kavetskaia, Sonia M. de Morais, Jens Sydor and Volker Fischer
    Drug Metabolism and Disposition August 2016, 44 (8) 1148-1157; DOI: https://doi.org/10.1124/dmd.115.067496
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    Differences in Gene Regulation by Dual Ligands of Nuclear Receptors Constitutive Androstane Receptor (CAR) and Pregnane X Receptor (PXR) in HepG2 Cells Stably Expressing CAR/PXR
    Yuichiro Kanno, Nobuaki Tanuma, Saki Yazawa, Shuai Zhao, Miki Inaba, Satoshi Nakamura, Kiyomitsu Nemoto and Yoshio Inouye
    Drug Metabolism and Disposition August 2016, 44 (8) 1158-1163; DOI: https://doi.org/10.1124/dmd.116.070888
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    Metabolism and Disposition of the Hepatitis C Protease Inhibitor Paritaprevir in Humans
    Jianwei Shen, Michael Serby, Aimee Reed, Anthony J. Lee, Xiaomei Zhang, Kennan Marsh, Amit Khatri, Rajeev Menon, Olga Kavetskaia and Volker Fischer
    Drug Metabolism and Disposition August 2016, 44 (8) 1164-1173; DOI: https://doi.org/10.1124/dmd.115.067488
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    Effects of Chronic Renal Failure on Brain Cytochrome P450 in Rats
    Judith Naud, Jessica Harding, Caroline Lamarche, Stephanie Beauchemin, Francois A. Leblond and Vincent Pichette
    Drug Metabolism and Disposition August 2016, 44 (8) 1174-1179; DOI: https://doi.org/10.1124/dmd.116.070052
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    Difference in the Pharmacokinetics and Hepatic Metabolism of Antidiabetic Drugs in Zucker Diabetic Fatty and Sprague-Dawley Rats
    Xin Zhou, Luc R. A. Rougée, David W. Bedwell, Jeff W. Cramer, Michael A. Mohutsky, Nathan A. Calvert, Richard D. Moulton, Kenneth C. Cassidy, Nathan P. Yumibe, Lisa A. Adams and Kenneth J. Ruterbories
    Drug Metabolism and Disposition August 2016, 44 (8) 1184-1192; DOI: https://doi.org/10.1124/dmd.116.070623
  • Open Access
    Correlation of Cytochrome P450 Oxidoreductase Expression with the Expression of 10 Isoforms of Cytochrome P450 in Human Liver
    Hai-Feng Zhang, Zhi-Hui Li, Jia-Yu Liu, Ting-Ting Liu, Ping Wang, Yan Fang, Jun Zhou, Ming-Zhu Cui, Na Gao, Xin Tian, Jie Gao, Qiang Wen, Lin-Jing Jia and Hai-Ling Qiao
    Drug Metabolism and Disposition August 2016, 44 (8) 1193-1200; DOI: https://doi.org/10.1124/dmd.116.069849
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    Metabolic Disposition of Osimertinib in Rats, Dogs, and Humans: Insights into a Drug Designed to Bind Covalently to a Cysteine Residue of Epidermal Growth Factor Receptor
    Paul A. Dickinson, Mireille V. Cantarini, Jo Collier, Paul Frewer, Scott Martin, Kathryn Pickup and Peter Ballard
    Drug Metabolism and Disposition August 2016, 44 (8) 1201-1212; DOI: https://doi.org/10.1124/dmd.115.069203
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    Use of Human Plasma Samples to Identify Circulating Drug Metabolites that Inhibit Cytochrome P450 Enzymes
    Heather Eng and R. Scott Obach
    Drug Metabolism and Disposition August 2016, 44 (8) 1217-1228; DOI: https://doi.org/10.1124/dmd.116.071084
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    Clopidogrel Markedly Increases Plasma Concentrations of CYP2C8 Substrate Pioglitazone
    Matti K. Itkonen, Aleksi Tornio, Mikko Neuvonen, Pertti J. Neuvonen, Mikko Niemi and Janne T. Backman
    Drug Metabolism and Disposition August 2016, 44 (8) 1364-1371; DOI: https://doi.org/10.1124/dmd.116.070375
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    Application of Static Models to Predict Midazolam Clinical Interactions in the Presence of Single or Multiple Hepatitis C Virus Drugs
    Yaofeng Cheng, Li Ma, Shu-Ying Chang, W. Griffith Humphreys and Wenying Li
    Drug Metabolism and Disposition August 2016, 44 (8) 1372-1380; DOI: https://doi.org/10.1124/dmd.116.070409
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    Impact of Experimental Conditions on the Evaluation of Interactions between Multidrug and Toxin Extrusion Proteins and Candidate Drugs
    Christian Lechner, Naoki Ishiguro, Ayano Fukuhara, Hidetada Shimizu, Naoko Ohtsu, Masahito Takatani, Kotaro Nishiyama, Ikumi Washio, Norio Yamamura and Hiroyuki Kusuhara
    Drug Metabolism and Disposition August 2016, 44 (8) 1381-1389; DOI: https://doi.org/10.1124/dmd.115.068163
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    Establishment of In Silico Prediction Models for CYP3A4 and CYP2B6 Induction in Human Hepatocytes by Multiple Regression Analysis Using Azole Compounds
    Mika Nagai, Yoshihiro Konno, Masahiro Satsukawa, Shinji Yamashita and Kouichi Yoshinari
    Drug Metabolism and Disposition August 2016, 44 (8) 1390-1398; DOI: https://doi.org/10.1124/dmd.115.068619
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    Selective Time- and NADPH-Dependent Inhibition of Human CYP2E1 by Clomethiazole
    David M. Stresser, Elke S. Perloff, Andrew K. Mason, Andrew P. Blanchard, Shangara S. Dehal, Timothy P. Creegan, Ritu Singh and Eric T. Gangl
    Drug Metabolism and Disposition August 2016, 44 (8) 1424-1430; DOI: https://doi.org/10.1124/dmd.116.070193
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    A Pharmacokinetic Modeling Approach to Predict the Contribution of Active Metabolites to Human Efficacious Dose
    Iain J. Martin, Susan E. Hill, James A. Baker, Sujal V. Deshmukh and Erin F. Mulrooney
    Drug Metabolism and Disposition August 2016, 44 (8) 1435-1440; DOI: https://doi.org/10.1124/dmd.116.070391

Short Communications

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    Recommendation to Exclude Bile-Duct-Cannulated Rats with Hyperbilirubinemia for Proper Conduct of Biliary Drug Excretion Studies
    Koji Kato, Yoshitaka Hasegawa, Katsuya Iwata, Takuya Ichikawa, Tohru Yahara, Satoshi Tsuji, Masayuki Sugiura and Jun-ichi Yamaguchi
    Drug Metabolism and Disposition August 2016, 44 (8) 1180-1183; DOI: https://doi.org/10.1124/dmd.116.070532
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    Application of Osmotic Pumps for Sustained Release of 1-Aminobenzotriazole and Inhibition of Cytochrome P450 Enzymes in Mice: Model Comparison with the Hepatic P450 Reductase Null Mouse
    Rowan A. Stringer, Suzie Ferreira, Jonathan Rose and Sebastien Ronseaux
    Drug Metabolism and Disposition August 2016, 44 (8) 1213-1216; DOI: https://doi.org/10.1124/dmd.116.070151
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    Transcriptional Regulation of Cytosolic Sulfotransferase 1C2 by Vitamin D Receptor in LS180 Human Colorectal Adenocarcinoma Cells
    Kathleen G. Barrett, Hailin Fang, Thomas A. Kocarek and Melissa Runge-Morris
    Drug Metabolism and Disposition August 2016, 44 (8) 1431-1434; DOI: https://doi.org/10.1124/dmd.116.070300
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Drug Metabolism and Disposition: 44 (8)
Drug Metabolism and Disposition
Vol. 44, Issue 8
1 Aug 2016
  • Table of Contents
  • Table of Contents (PDF)
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
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