Drug Metabolism and Disposition: 44 (8)

August 01, 2016; Volume 44,Issue 8

Special Section on Emerging Novel Enzyme Pathways in Drug Metabolism

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Cytochrome P450 and Non–Cytochrome P450 Oxidative Metabolism: Contributions to the Pharmacokinetics, Safety, and Efficacy of Xenobiotics
Robert S. Foti and Deepak K. Dalvie

Drug Metabolism and Disposition August 2016, 44 (8) 1229-1245; DOI: https://doi.org/10.1124/dmd.116.071753
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Prevalence of Non–Cytochrome P450–Mediated Metabolism in Food and Drug Administration–Approved Oral and Intravenous Drugs: 2006–2015
Matthew A. Cerny

Drug Metabolism and Disposition August 2016, 44 (8) 1246-1252; DOI: https://doi.org/10.1124/dmd.116.070763
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Going Beyond Common Drug Metabolizing Enzymes: Case Studies of Biotransformation Involving Aldehyde Oxidase, γ-Glutamyl Transpeptidase, Cathepsin B, Flavin-Containing Monooxygenase, and ADP-Ribosyltransferase
Peter W. Fan, Donglu Zhang, Jason S. Halladay, James P. Driscoll and S. Cyrus Khojasteh

Drug Metabolism and Disposition August 2016, 44 (8) 1253-1261; DOI: https://doi.org/10.1124/dmd.116.070169
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Species Differences in the Oxidative Desulfurization of a Thiouracil-Based Irreversible Myeloperoxidase Inactivator by Flavin-Containing Monooxygenase Enzymes
Heather Eng, Raman Sharma, Angela Wolford, Li Di, Roger B. Ruggeri, Leonard Buckbinder, Edward L. Conn, Deepak K. Dalvie and Amit S. Kalgutkar

Drug Metabolism and Disposition August 2016, 44 (8) 1262-1269; DOI: https://doi.org/10.1124/dmd.116.070185
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Microbial Flavoprotein Monooxygenases as Mimics of Mammalian Flavin-Containing Monooxygenases for the Enantioselective Preparation of Drug Metabolites
Turan Gul, Marzena Krzek, Hjalmar P. Permentier, Marco W. Fraaije and Rainer Bischoff

Drug Metabolism and Disposition August 2016, 44 (8) 1270-1276; DOI: https://doi.org/10.1124/dmd.115.069104
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Optimization of the Expression of Human Aldehyde Oxidase for Investigations of Single-Nucleotide Polymorphisms
Alessandro Foti, Tobias Hartmann, Catarina Coelho, Teresa Santos-Silva, Maria João Romão and Silke Leimkühler

Drug Metabolism and Disposition August 2016, 44 (8) 1277-1285; DOI: https://doi.org/10.1124/dmd.115.068395
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VX-509 (Decernotinib)-Mediated CYP3A Time-Dependent Inhibition: An Aldehyde Oxidase Metabolite as a Perpetrator of Drug-Drug Interactions
Craig Zetterberg, Francois Maltais, Leena Laitinen, Shengkai Liao, Hong Tsao, Ananthsrinivas Chakilam and Niresh Hariparsad

Drug Metabolism and Disposition August 2016, 44 (8) 1286-1295; DOI: https://doi.org/10.1124/dmd.116.071100
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Evaluating the Disposition of a Mixed Aldehyde Oxidase/Cytochrome P450 Substrate in Rats with Attenuated P450 Activity
Rachel D. Crouch, Ryan D. Morrison, Frank W. Byers, Craig W. Lindsley, Kyle A. Emmitte and J. Scott Daniels

Drug Metabolism and Disposition August 2016, 44 (8) 1296-1303; DOI: https://doi.org/10.1124/dmd.115.068338
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Ocular Metabolism of Levobunolol: Historic and Emerging Metabolic Pathways
Upendra A. Argikar, Jennifer L. Dumouchel, Christine E. Dunne, Chitra Saran, Amanda L. Cirello and Mithat Gunduz

Drug Metabolism and Disposition August 2016, 44 (8) 1304-1312; DOI: https://doi.org/10.1124/dmd.116.070458
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Biotransformation Capacity of Carboxylesterase in Skin and Keratinocytes for the Penta-Ethyl Ester Prodrug of DTPA
Jing Fu, Matthew Sadgrove, Lesley Marson and Michael Jay

Drug Metabolism and Disposition August 2016, 44 (8) 1313-1318; DOI: https://doi.org/10.1124/dmd.116.069377
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Nonclinical Pharmacokinetics, Disposition, and Drug-Drug Interaction Potential of a Novel d-Amino Acid Peptide Agonist of the Calcium-Sensing Receptor AMG 416 (Etelcalcetide)
Raju Subramanian, Xiaochun Zhu, Savannah J. Kerr, Joel D. Esmay, Steven W. Louie, Katheryne Z. Edson, Sarah Walter, Michael Fitzsimmons, Mylo Wagner, Marcus Soto, Roger Pham, Sarah F. Wilson and Gary L. Skiles

Drug Metabolism and Disposition August 2016, 44 (8) 1319-1331; DOI: https://doi.org/10.1124/dmd.115.068007
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Phosphocholine Conjugation: An Unexpected In Vivo Conjugation Pathway Associated with Hepatitis C NS5B Inhibitors Featuring A Bicyclo[1.1.1]Pentane
Xiaoliang Zhuo, Joseph L. Cantone, Yingzi Wang, John E. Leet, Dieter M. Drexler, Kap-Sun Yeung, Xiaohua Stella Huang, Kyle J. Eastman, Kyle E. Parcella, Kathleen W. Mosure, Matthew G. Soars, John F. Kadow and Benjamin M. Johnson

Drug Metabolism and Disposition August 2016, 44 (8) 1332-1340; DOI: https://doi.org/10.1124/dmd.115.069062
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Discovery of a Novel Microsomal Epoxide Hydrolase–Catalyzed Hydration of a Spiro Oxetane
Xue-Qing Li, Martin A. Hayes, Gunnar Grönberg, Kristina Berggren, Neal Castagnoli and Lars Weidolf

Drug Metabolism and Disposition August 2016, 44 (8) 1341-1348; DOI: https://doi.org/10.1124/dmd.116.071142
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Biotransformation and Rearrangement of Laromustine
Alaa-Eldin F. Nassar, Adam V. Wisnewski and Ivan King

Drug Metabolism and Disposition August 2016, 44 (8) 1349-1363; DOI: https://doi.org/10.1124/dmd.116.069823

Perspective

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Evaluation of a New Molecular Entity as a Victim of Metabolic Drug-Drug Interactions—an Industry Perspective
Tonika Bohnert, Aarti Patel, Ian Templeton, Yuan Chen, Chuang Lu, George Lai, Louis Leung, Susanna Tse, Heidi J Einolf, Ying-Hong Wang, Michael Sinz, Ralph Stearns, Robert Walsky, Wanping Geng, Sirimas Sudsakorn, David Moore, Ling He, Jan Wahlstrom, Jim Keirns, Rangaraj Narayanan, Dieter Lang, Xiaoqing Yang and International Consortium for Innovation and Quality in Pharmaceutical Development (IQ) Victim Drug-Drug Interactions Working Group

Drug Metabolism and Disposition August 2016, 44 (8) 1399-1423; DOI: https://doi.org/10.1124/dmd.115.069096

Articles

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Metabolism and Disposition of Hepatitis C Polymerase Inhibitor Dasabuvir in Humans
Jianwei Shen, Michael Serby, Aimee Reed, Anthony J. Lee, Rajeev Menon, Xiaomei Zhang, Kennan Marsh, Xia Wan, Olga Kavetskaia and Volker Fischer

Drug Metabolism and Disposition August 2016, 44 (8) 1139-1147; DOI: https://doi.org/10.1124/dmd.115.067512
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Metabolism and Disposition of Pan-Genotypic Inhibitor of Hepatitis C Virus NS5A Ombitasvir in Humans
Jianwei Shen, Michael Serby, Bruce Surber, Anthony J. Lee, Junli Ma, Prajakta Badri, Rajeev Menon, Olga Kavetskaia, Sonia M. de Morais, Jens Sydor and Volker Fischer

Drug Metabolism and Disposition August 2016, 44 (8) 1148-1157; DOI: https://doi.org/10.1124/dmd.115.067496
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Differences in Gene Regulation by Dual Ligands of Nuclear Receptors Constitutive Androstane Receptor (CAR) and Pregnane X Receptor (PXR) in HepG2 Cells Stably Expressing CAR/PXR
Yuichiro Kanno, Nobuaki Tanuma, Saki Yazawa, Shuai Zhao, Miki Inaba, Satoshi Nakamura, Kiyomitsu Nemoto and Yoshio Inouye

Drug Metabolism and Disposition August 2016, 44 (8) 1158-1163; DOI: https://doi.org/10.1124/dmd.116.070888
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Metabolism and Disposition of the Hepatitis C Protease Inhibitor Paritaprevir in Humans
Jianwei Shen, Michael Serby, Aimee Reed, Anthony J. Lee, Xiaomei Zhang, Kennan Marsh, Amit Khatri, Rajeev Menon, Olga Kavetskaia and Volker Fischer

Drug Metabolism and Disposition August 2016, 44 (8) 1164-1173; DOI: https://doi.org/10.1124/dmd.115.067488
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Effects of Chronic Renal Failure on Brain Cytochrome P450 in Rats
Judith Naud, Jessica Harding, Caroline Lamarche, Stephanie Beauchemin, Francois A. Leblond and Vincent Pichette

Drug Metabolism and Disposition August 2016, 44 (8) 1174-1179; DOI: https://doi.org/10.1124/dmd.116.070052
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Difference in the Pharmacokinetics and Hepatic Metabolism of Antidiabetic Drugs in Zucker Diabetic Fatty and Sprague-Dawley Rats
Xin Zhou, Luc R. A. Rougée, David W. Bedwell, Jeff W. Cramer, Michael A. Mohutsky, Nathan A. Calvert, Richard D. Moulton, Kenneth C. Cassidy, Nathan P. Yumibe, Lisa A. Adams and Kenneth J. Ruterbories

Drug Metabolism and Disposition August 2016, 44 (8) 1184-1192; DOI: https://doi.org/10.1124/dmd.116.070623
Open Access
Correlation of Cytochrome P450 Oxidoreductase Expression with the Expression of 10 Isoforms of Cytochrome P450 in Human Liver
Hai-Feng Zhang, Zhi-Hui Li, Jia-Yu Liu, Ting-Ting Liu, Ping Wang, Yan Fang, Jun Zhou, Ming-Zhu Cui, Na Gao, Xin Tian, Jie Gao, Qiang Wen, Lin-Jing Jia and Hai-Ling Qiao

Drug Metabolism and Disposition August 2016, 44 (8) 1193-1200; DOI: https://doi.org/10.1124/dmd.116.069849
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Metabolic Disposition of Osimertinib in Rats, Dogs, and Humans: Insights into a Drug Designed to Bind Covalently to a Cysteine Residue of Epidermal Growth Factor Receptor
Paul A. Dickinson, Mireille V. Cantarini, Jo Collier, Paul Frewer, Scott Martin, Kathryn Pickup and Peter Ballard

Drug Metabolism and Disposition August 2016, 44 (8) 1201-1212; DOI: https://doi.org/10.1124/dmd.115.069203
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Use of Human Plasma Samples to Identify Circulating Drug Metabolites that Inhibit Cytochrome P450 Enzymes
Heather Eng and R. Scott Obach

Drug Metabolism and Disposition August 2016, 44 (8) 1217-1228; DOI: https://doi.org/10.1124/dmd.116.071084
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Clopidogrel Markedly Increases Plasma Concentrations of CYP2C8 Substrate Pioglitazone
Matti K. Itkonen, Aleksi Tornio, Mikko Neuvonen, Pertti J. Neuvonen, Mikko Niemi and Janne T. Backman

Drug Metabolism and Disposition August 2016, 44 (8) 1364-1371; DOI: https://doi.org/10.1124/dmd.116.070375
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Application of Static Models to Predict Midazolam Clinical Interactions in the Presence of Single or Multiple Hepatitis C Virus Drugs
Yaofeng Cheng, Li Ma, Shu-Ying Chang, W. Griffith Humphreys and Wenying Li

Drug Metabolism and Disposition August 2016, 44 (8) 1372-1380; DOI: https://doi.org/10.1124/dmd.116.070409
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Impact of Experimental Conditions on the Evaluation of Interactions between Multidrug and Toxin Extrusion Proteins and Candidate Drugs
Christian Lechner, Naoki Ishiguro, Ayano Fukuhara, Hidetada Shimizu, Naoko Ohtsu, Masahito Takatani, Kotaro Nishiyama, Ikumi Washio, Norio Yamamura and Hiroyuki Kusuhara

Drug Metabolism and Disposition August 2016, 44 (8) 1381-1389; DOI: https://doi.org/10.1124/dmd.115.068163
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Establishment of In Silico Prediction Models for CYP3A4 and CYP2B6 Induction in Human Hepatocytes by Multiple Regression Analysis Using Azole Compounds
Mika Nagai, Yoshihiro Konno, Masahiro Satsukawa, Shinji Yamashita and Kouichi Yoshinari

Drug Metabolism and Disposition August 2016, 44 (8) 1390-1398; DOI: https://doi.org/10.1124/dmd.115.068619
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Selective Time- and NADPH-Dependent Inhibition of Human CYP2E1 by Clomethiazole
David M. Stresser, Elke S. Perloff, Andrew K. Mason, Andrew P. Blanchard, Shangara S. Dehal, Timothy P. Creegan, Ritu Singh and Eric T. Gangl

Drug Metabolism and Disposition August 2016, 44 (8) 1424-1430; DOI: https://doi.org/10.1124/dmd.116.070193
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A Pharmacokinetic Modeling Approach to Predict the Contribution of Active Metabolites to Human Efficacious Dose
Iain J. Martin, Susan E. Hill, James A. Baker, Sujal V. Deshmukh and Erin F. Mulrooney

Drug Metabolism and Disposition August 2016, 44 (8) 1435-1440; DOI: https://doi.org/10.1124/dmd.116.070391

Short Communications

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Recommendation to Exclude Bile-Duct-Cannulated Rats with Hyperbilirubinemia for Proper Conduct of Biliary Drug Excretion Studies
Koji Kato, Yoshitaka Hasegawa, Katsuya Iwata, Takuya Ichikawa, Tohru Yahara, Satoshi Tsuji, Masayuki Sugiura and Jun-ichi Yamaguchi

Drug Metabolism and Disposition August 2016, 44 (8) 1180-1183; DOI: https://doi.org/10.1124/dmd.116.070532
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Application of Osmotic Pumps for Sustained Release of 1-Aminobenzotriazole and Inhibition of Cytochrome P450 Enzymes in Mice: Model Comparison with the Hepatic P450 Reductase Null Mouse
Rowan A. Stringer, Suzie Ferreira, Jonathan Rose and Sebastien Ronseaux

Drug Metabolism and Disposition August 2016, 44 (8) 1213-1216; DOI: https://doi.org/10.1124/dmd.116.070151
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Transcriptional Regulation of Cytosolic Sulfotransferase 1C2 by Vitamin D Receptor in LS180 Human Colorectal Adenocarcinoma Cells
Kathleen G. Barrett, Hailin Fang, Thomas A. Kocarek and Melissa Runge-Morris

Drug Metabolism and Disposition August 2016, 44 (8) 1431-1434; DOI: https://doi.org/10.1124/dmd.116.070300

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