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Drug Metabolism & Disposition

Advanced Search

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  • Articles
    • Current Issue
    • Fast Forward
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Index by author

August 01, 2016; Volume 44,Issue 8
  • A
  • B
  • C
  • D
  • E
  • F
  • G
  • H
  • I
  • J
  • K
  • L
  • M
  • N
  • O
  • P
  • Q
  • R
  • S
  • T
  • U
  • V
  • W
  • X
  • Y
  • Z

A

  1. Adams, Lisa A.

    1. You have access
      Difference in the Pharmacokinetics and Hepatic Metabolism of Antidiabetic Drugs in Zucker Diabetic Fatty and Sprague-Dawley Rats
      Xin Zhou, Luc R. A. Rougée, David W. Bedwell, Jeff W. Cramer, Michael A. Mohutsky, Nathan A. Calvert, Richard D. Moulton, Kenneth C. Cassidy, Nathan P. Yumibe, Lisa A. Adams and Kenneth J. Ruterbories
      Drug Metabolism and Disposition August 2016, 44 (8) 1184-1192; DOI: https://doi.org/10.1124/dmd.116.070623
  2. Argikar, Upendra A.

    1. You have access
      Ocular Metabolism of Levobunolol: Historic and Emerging Metabolic Pathways
      Upendra A. Argikar, Jennifer L. Dumouchel, Christine E. Dunne, Chitra Saran, Amanda L. Cirello and Mithat Gunduz
      Drug Metabolism and Disposition August 2016, 44 (8) 1304-1312; DOI: https://doi.org/10.1124/dmd.116.070458

B

  1. Backman, Janne T.

    1. You have access
      Clopidogrel Markedly Increases Plasma Concentrations of CYP2C8 Substrate Pioglitazone
      Matti K. Itkonen, Aleksi Tornio, Mikko Neuvonen, Pertti J. Neuvonen, Mikko Niemi and Janne T. Backman
      Drug Metabolism and Disposition August 2016, 44 (8) 1364-1371; DOI: https://doi.org/10.1124/dmd.116.070375
  2. Badri, Prajakta

    1. You have access
      Metabolism and Disposition of Pan-Genotypic Inhibitor of Hepatitis C Virus NS5A Ombitasvir in Humans
      Jianwei Shen, Michael Serby, Bruce Surber, Anthony J. Lee, Junli Ma, Prajakta Badri, Rajeev Menon, Olga Kavetskaia, Sonia M. de Morais, Jens Sydor and Volker Fischer
      Drug Metabolism and Disposition August 2016, 44 (8) 1148-1157; DOI: https://doi.org/10.1124/dmd.115.067496
  3. Baker, James A.

    1. You have access
      A Pharmacokinetic Modeling Approach to Predict the Contribution of Active Metabolites to Human Efficacious Dose
      Iain J. Martin, Susan E. Hill, James A. Baker, Sujal V. Deshmukh and Erin F. Mulrooney
      Drug Metabolism and Disposition August 2016, 44 (8) 1435-1440; DOI: https://doi.org/10.1124/dmd.116.070391
  4. Ballard, Peter

    1. You have access
      Metabolic Disposition of Osimertinib in Rats, Dogs, and Humans: Insights into a Drug Designed to Bind Covalently to a Cysteine Residue of Epidermal Growth Factor Receptor
      Paul A. Dickinson, Mireille V. Cantarini, Jo Collier, Paul Frewer, Scott Martin, Kathryn Pickup and Peter Ballard
      Drug Metabolism and Disposition August 2016, 44 (8) 1201-1212; DOI: https://doi.org/10.1124/dmd.115.069203
  5. Barrett, Kathleen G.

    1. You have access
      Transcriptional Regulation of Cytosolic Sulfotransferase 1C2 by Vitamin D Receptor in LS180 Human Colorectal Adenocarcinoma Cells
      Kathleen G. Barrett, Hailin Fang, Thomas A. Kocarek and Melissa Runge-Morris
      Drug Metabolism and Disposition August 2016, 44 (8) 1431-1434; DOI: https://doi.org/10.1124/dmd.116.070300
  6. Beauchemin, Stephanie

    1. You have access
      Effects of Chronic Renal Failure on Brain Cytochrome P450 in Rats
      Judith Naud, Jessica Harding, Caroline Lamarche, Stephanie Beauchemin, Francois A. Leblond and Vincent Pichette
      Drug Metabolism and Disposition August 2016, 44 (8) 1174-1179; DOI: https://doi.org/10.1124/dmd.116.070052
  7. Bedwell, David W.

    1. You have access
      Difference in the Pharmacokinetics and Hepatic Metabolism of Antidiabetic Drugs in Zucker Diabetic Fatty and Sprague-Dawley Rats
      Xin Zhou, Luc R. A. Rougée, David W. Bedwell, Jeff W. Cramer, Michael A. Mohutsky, Nathan A. Calvert, Richard D. Moulton, Kenneth C. Cassidy, Nathan P. Yumibe, Lisa A. Adams and Kenneth J. Ruterbories
      Drug Metabolism and Disposition August 2016, 44 (8) 1184-1192; DOI: https://doi.org/10.1124/dmd.116.070623
  8. Berggren, Kristina

    1. Discovery of a Novel Microsomal Epoxide Hydrolase–Catalyzed Hydration of a Spiro Oxetane
      You have access
      Discovery of a Novel Microsomal Epoxide Hydrolase–Catalyzed Hydration of a Spiro Oxetane
      Xue-Qing Li, Martin A. Hayes, Gunnar Grönberg, Kristina Berggren, Neal Castagnoli and Lars Weidolf
      Drug Metabolism and Disposition August 2016, 44 (8) 1341-1348; DOI: https://doi.org/10.1124/dmd.116.071142
  9. Bischoff, Rainer

    1. You have access
      Microbial Flavoprotein Monooxygenases as Mimics of Mammalian Flavin-Containing Monooxygenases for the Enantioselective Preparation of Drug Metabolites
      Turan Gul, Marzena Krzek, Hjalmar P. Permentier, Marco W. Fraaije and Rainer Bischoff
      Drug Metabolism and Disposition August 2016, 44 (8) 1270-1276; DOI: https://doi.org/10.1124/dmd.115.069104
  10. Blanchard, Andrew P.

    1. You have access
      Selective Time- and NADPH-Dependent Inhibition of Human CYP2E1 by Clomethiazole
      David M. Stresser, Elke S. Perloff, Andrew K. Mason, Andrew P. Blanchard, Shangara S. Dehal, Timothy P. Creegan, Ritu Singh and Eric T. Gangl
      Drug Metabolism and Disposition August 2016, 44 (8) 1424-1430; DOI: https://doi.org/10.1124/dmd.116.070193
  11. Bohnert, Tonika

    1. You have access
      Evaluation of a New Molecular Entity as a Victim of Metabolic Drug-Drug Interactions—an Industry Perspective
      Tonika Bohnert, Aarti Patel, Ian Templeton, Yuan Chen, Chuang Lu, George Lai, Louis Leung, Susanna Tse, Heidi J Einolf, Ying-Hong Wang, Michael Sinz, Ralph Stearns, Robert Walsky, Wanping Geng, Sirimas Sudsakorn, David Moore, Ling He, Jan Wahlstrom, Jim Keirns, Rangaraj Narayanan, Dieter Lang, Xiaoqing Yang and International Consortium for Innovation and Quality in Pharmaceutical Development (IQ) Victim Drug-Drug Interactions Working Group
      Drug Metabolism and Disposition August 2016, 44 (8) 1399-1423; DOI: https://doi.org/10.1124/dmd.115.069096
  12. Buckbinder, Leonard

    1. You have access
      Species Differences in the Oxidative Desulfurization of a Thiouracil-Based Irreversible Myeloperoxidase Inactivator by Flavin-Containing Monooxygenase Enzymes
      Heather Eng, Raman Sharma, Angela Wolford, Li Di, Roger B. Ruggeri, Leonard Buckbinder, Edward L. Conn, Deepak K. Dalvie and Amit S. Kalgutkar
      Drug Metabolism and Disposition August 2016, 44 (8) 1262-1269; DOI: https://doi.org/10.1124/dmd.116.070185
  13. Byers, Frank W.

    1. You have access
      Evaluating the Disposition of a Mixed Aldehyde Oxidase/Cytochrome P450 Substrate in Rats with Attenuated P450 Activity
      Rachel D. Crouch, Ryan D. Morrison, Frank W. Byers, Craig W. Lindsley, Kyle A. Emmitte and J. Scott Daniels
      Drug Metabolism and Disposition August 2016, 44 (8) 1296-1303; DOI: https://doi.org/10.1124/dmd.115.068338

C

  1. Calvert, Nathan A.

    1. You have access
      Difference in the Pharmacokinetics and Hepatic Metabolism of Antidiabetic Drugs in Zucker Diabetic Fatty and Sprague-Dawley Rats
      Xin Zhou, Luc R. A. Rougée, David W. Bedwell, Jeff W. Cramer, Michael A. Mohutsky, Nathan A. Calvert, Richard D. Moulton, Kenneth C. Cassidy, Nathan P. Yumibe, Lisa A. Adams and Kenneth J. Ruterbories
      Drug Metabolism and Disposition August 2016, 44 (8) 1184-1192; DOI: https://doi.org/10.1124/dmd.116.070623
  2. Cantarini, Mireille V.

    1. You have access
      Metabolic Disposition of Osimertinib in Rats, Dogs, and Humans: Insights into a Drug Designed to Bind Covalently to a Cysteine Residue of Epidermal Growth Factor Receptor
      Paul A. Dickinson, Mireille V. Cantarini, Jo Collier, Paul Frewer, Scott Martin, Kathryn Pickup and Peter Ballard
      Drug Metabolism and Disposition August 2016, 44 (8) 1201-1212; DOI: https://doi.org/10.1124/dmd.115.069203
  3. Cantone, Joseph L.

    1. You have access
      Phosphocholine Conjugation: An Unexpected In Vivo Conjugation Pathway Associated with Hepatitis C NS5B Inhibitors Featuring A Bicyclo[1.1.1]Pentane
      Xiaoliang Zhuo, Joseph L. Cantone, Yingzi Wang, John E. Leet, Dieter M. Drexler, Kap-Sun Yeung, Xiaohua Stella Huang, Kyle J. Eastman, Kyle E. Parcella, Kathleen W. Mosure, Matthew G. Soars, John F. Kadow and Benjamin M. Johnson
      Drug Metabolism and Disposition August 2016, 44 (8) 1332-1340; DOI: https://doi.org/10.1124/dmd.115.069062
  4. Cassidy, Kenneth C.

    1. You have access
      Difference in the Pharmacokinetics and Hepatic Metabolism of Antidiabetic Drugs in Zucker Diabetic Fatty and Sprague-Dawley Rats
      Xin Zhou, Luc R. A. Rougée, David W. Bedwell, Jeff W. Cramer, Michael A. Mohutsky, Nathan A. Calvert, Richard D. Moulton, Kenneth C. Cassidy, Nathan P. Yumibe, Lisa A. Adams and Kenneth J. Ruterbories
      Drug Metabolism and Disposition August 2016, 44 (8) 1184-1192; DOI: https://doi.org/10.1124/dmd.116.070623
  5. Castagnoli, Neal

    1. Discovery of a Novel Microsomal Epoxide Hydrolase–Catalyzed Hydration of a Spiro Oxetane
      You have access
      Discovery of a Novel Microsomal Epoxide Hydrolase–Catalyzed Hydration of a Spiro Oxetane
      Xue-Qing Li, Martin A. Hayes, Gunnar Grönberg, Kristina Berggren, Neal Castagnoli and Lars Weidolf
      Drug Metabolism and Disposition August 2016, 44 (8) 1341-1348; DOI: https://doi.org/10.1124/dmd.116.071142
  6. Cerny, Matthew A.

    1. Prevalence of Non–Cytochrome P450–Mediated Metabolism in Food and Drug Administration–Approved Oral and Intravenous Drugs: 2006–2015
      You have access
      Prevalence of Non–Cytochrome P450–Mediated Metabolism in Food and Drug Administration–Approved Oral and Intravenous Drugs: 2006–2015
      Matthew A. Cerny
      Drug Metabolism and Disposition August 2016, 44 (8) 1246-1252; DOI: https://doi.org/10.1124/dmd.116.070763
  7. Chakilam, Ananthsrinivas

    1. You have access
      VX-509 (Decernotinib)-Mediated CYP3A Time-Dependent Inhibition: An Aldehyde Oxidase Metabolite as a Perpetrator of Drug-Drug Interactions
      Craig Zetterberg, Francois Maltais, Leena Laitinen, Shengkai Liao, Hong Tsao, Ananthsrinivas Chakilam and Niresh Hariparsad
      Drug Metabolism and Disposition August 2016, 44 (8) 1286-1295; DOI: https://doi.org/10.1124/dmd.116.071100
  8. Chang, Shu-Ying

    1. You have access
      Application of Static Models to Predict Midazolam Clinical Interactions in the Presence of Single or Multiple Hepatitis C Virus Drugs
      Yaofeng Cheng, Li Ma, Shu-Ying Chang, W. Griffith Humphreys and Wenying Li
      Drug Metabolism and Disposition August 2016, 44 (8) 1372-1380; DOI: https://doi.org/10.1124/dmd.116.070409
  9. Chen, Yuan

    1. You have access
      Evaluation of a New Molecular Entity as a Victim of Metabolic Drug-Drug Interactions—an Industry Perspective
      Tonika Bohnert, Aarti Patel, Ian Templeton, Yuan Chen, Chuang Lu, George Lai, Louis Leung, Susanna Tse, Heidi J Einolf, Ying-Hong Wang, Michael Sinz, Ralph Stearns, Robert Walsky, Wanping Geng, Sirimas Sudsakorn, David Moore, Ling He, Jan Wahlstrom, Jim Keirns, Rangaraj Narayanan, Dieter Lang, Xiaoqing Yang and International Consortium for Innovation and Quality in Pharmaceutical Development (IQ) Victim Drug-Drug Interactions Working Group
      Drug Metabolism and Disposition August 2016, 44 (8) 1399-1423; DOI: https://doi.org/10.1124/dmd.115.069096
  10. Cheng, Yaofeng

    1. You have access
      Application of Static Models to Predict Midazolam Clinical Interactions in the Presence of Single or Multiple Hepatitis C Virus Drugs
      Yaofeng Cheng, Li Ma, Shu-Ying Chang, W. Griffith Humphreys and Wenying Li
      Drug Metabolism and Disposition August 2016, 44 (8) 1372-1380; DOI: https://doi.org/10.1124/dmd.116.070409
  11. Cirello, Amanda L.

    1. You have access
      Ocular Metabolism of Levobunolol: Historic and Emerging Metabolic Pathways
      Upendra A. Argikar, Jennifer L. Dumouchel, Christine E. Dunne, Chitra Saran, Amanda L. Cirello and Mithat Gunduz
      Drug Metabolism and Disposition August 2016, 44 (8) 1304-1312; DOI: https://doi.org/10.1124/dmd.116.070458
  12. Coelho, Catarina

    1. You have access
      Optimization of the Expression of Human Aldehyde Oxidase for Investigations of Single-Nucleotide Polymorphisms
      Alessandro Foti, Tobias Hartmann, Catarina Coelho, Teresa Santos-Silva, Maria João Romão and Silke Leimkühler
      Drug Metabolism and Disposition August 2016, 44 (8) 1277-1285; DOI: https://doi.org/10.1124/dmd.115.068395
  13. Collier, Jo

    1. You have access
      Metabolic Disposition of Osimertinib in Rats, Dogs, and Humans: Insights into a Drug Designed to Bind Covalently to a Cysteine Residue of Epidermal Growth Factor Receptor
      Paul A. Dickinson, Mireille V. Cantarini, Jo Collier, Paul Frewer, Scott Martin, Kathryn Pickup and Peter Ballard
      Drug Metabolism and Disposition August 2016, 44 (8) 1201-1212; DOI: https://doi.org/10.1124/dmd.115.069203
  14. Conn, Edward L.

    1. You have access
      Species Differences in the Oxidative Desulfurization of a Thiouracil-Based Irreversible Myeloperoxidase Inactivator by Flavin-Containing Monooxygenase Enzymes
      Heather Eng, Raman Sharma, Angela Wolford, Li Di, Roger B. Ruggeri, Leonard Buckbinder, Edward L. Conn, Deepak K. Dalvie and Amit S. Kalgutkar
      Drug Metabolism and Disposition August 2016, 44 (8) 1262-1269; DOI: https://doi.org/10.1124/dmd.116.070185
  15. Cramer, Jeff W.

    1. You have access
      Difference in the Pharmacokinetics and Hepatic Metabolism of Antidiabetic Drugs in Zucker Diabetic Fatty and Sprague-Dawley Rats
      Xin Zhou, Luc R. A. Rougée, David W. Bedwell, Jeff W. Cramer, Michael A. Mohutsky, Nathan A. Calvert, Richard D. Moulton, Kenneth C. Cassidy, Nathan P. Yumibe, Lisa A. Adams and Kenneth J. Ruterbories
      Drug Metabolism and Disposition August 2016, 44 (8) 1184-1192; DOI: https://doi.org/10.1124/dmd.116.070623
  16. Creegan, Timothy P.

    1. You have access
      Selective Time- and NADPH-Dependent Inhibition of Human CYP2E1 by Clomethiazole
      David M. Stresser, Elke S. Perloff, Andrew K. Mason, Andrew P. Blanchard, Shangara S. Dehal, Timothy P. Creegan, Ritu Singh and Eric T. Gangl
      Drug Metabolism and Disposition August 2016, 44 (8) 1424-1430; DOI: https://doi.org/10.1124/dmd.116.070193
  17. Crouch, Rachel D.

    1. You have access
      Evaluating the Disposition of a Mixed Aldehyde Oxidase/Cytochrome P450 Substrate in Rats with Attenuated P450 Activity
      Rachel D. Crouch, Ryan D. Morrison, Frank W. Byers, Craig W. Lindsley, Kyle A. Emmitte and J. Scott Daniels
      Drug Metabolism and Disposition August 2016, 44 (8) 1296-1303; DOI: https://doi.org/10.1124/dmd.115.068338
  18. Cui, Ming-Zhu

    1. Open Access
      Correlation of Cytochrome P450 Oxidoreductase Expression with the Expression of 10 Isoforms of Cytochrome P450 in Human Liver
      Hai-Feng Zhang, Zhi-Hui Li, Jia-Yu Liu, Ting-Ting Liu, Ping Wang, Yan Fang, Jun Zhou, Ming-Zhu Cui, Na Gao, Xin Tian, Jie Gao, Qiang Wen, Lin-Jing Jia and Hai-Ling Qiao
      Drug Metabolism and Disposition August 2016, 44 (8) 1193-1200; DOI: https://doi.org/10.1124/dmd.116.069849

D

  1. Dalvie, Deepak K.

    1. You have access
      Cytochrome P450 and Non–Cytochrome P450 Oxidative Metabolism: Contributions to the Pharmacokinetics, Safety, and Efficacy of Xenobiotics
      Robert S. Foti and Deepak K. Dalvie
      Drug Metabolism and Disposition August 2016, 44 (8) 1229-1245; DOI: https://doi.org/10.1124/dmd.116.071753
    2. You have access
      Species Differences in the Oxidative Desulfurization of a Thiouracil-Based Irreversible Myeloperoxidase Inactivator by Flavin-Containing Monooxygenase Enzymes
      Heather Eng, Raman Sharma, Angela Wolford, Li Di, Roger B. Ruggeri, Leonard Buckbinder, Edward L. Conn, Deepak K. Dalvie and Amit S. Kalgutkar
      Drug Metabolism and Disposition August 2016, 44 (8) 1262-1269; DOI: https://doi.org/10.1124/dmd.116.070185
  2. Daniels, J. Scott

    1. You have access
      Evaluating the Disposition of a Mixed Aldehyde Oxidase/Cytochrome P450 Substrate in Rats with Attenuated P450 Activity
      Rachel D. Crouch, Ryan D. Morrison, Frank W. Byers, Craig W. Lindsley, Kyle A. Emmitte and J. Scott Daniels
      Drug Metabolism and Disposition August 2016, 44 (8) 1296-1303; DOI: https://doi.org/10.1124/dmd.115.068338
  3. Dehal, Shangara S.

    1. You have access
      Selective Time- and NADPH-Dependent Inhibition of Human CYP2E1 by Clomethiazole
      David M. Stresser, Elke S. Perloff, Andrew K. Mason, Andrew P. Blanchard, Shangara S. Dehal, Timothy P. Creegan, Ritu Singh and Eric T. Gangl
      Drug Metabolism and Disposition August 2016, 44 (8) 1424-1430; DOI: https://doi.org/10.1124/dmd.116.070193
  4. de Morais, Sonia M.

    1. You have access
      Metabolism and Disposition of Pan-Genotypic Inhibitor of Hepatitis C Virus NS5A Ombitasvir in Humans
      Jianwei Shen, Michael Serby, Bruce Surber, Anthony J. Lee, Junli Ma, Prajakta Badri, Rajeev Menon, Olga Kavetskaia, Sonia M. de Morais, Jens Sydor and Volker Fischer
      Drug Metabolism and Disposition August 2016, 44 (8) 1148-1157; DOI: https://doi.org/10.1124/dmd.115.067496
  5. Deshmukh, Sujal V.

    1. You have access
      A Pharmacokinetic Modeling Approach to Predict the Contribution of Active Metabolites to Human Efficacious Dose
      Iain J. Martin, Susan E. Hill, James A. Baker, Sujal V. Deshmukh and Erin F. Mulrooney
      Drug Metabolism and Disposition August 2016, 44 (8) 1435-1440; DOI: https://doi.org/10.1124/dmd.116.070391
  6. Di, Li

    1. You have access
      Species Differences in the Oxidative Desulfurization of a Thiouracil-Based Irreversible Myeloperoxidase Inactivator by Flavin-Containing Monooxygenase Enzymes
      Heather Eng, Raman Sharma, Angela Wolford, Li Di, Roger B. Ruggeri, Leonard Buckbinder, Edward L. Conn, Deepak K. Dalvie and Amit S. Kalgutkar
      Drug Metabolism and Disposition August 2016, 44 (8) 1262-1269; DOI: https://doi.org/10.1124/dmd.116.070185
  7. Dickinson, Paul A.

    1. You have access
      Metabolic Disposition of Osimertinib in Rats, Dogs, and Humans: Insights into a Drug Designed to Bind Covalently to a Cysteine Residue of Epidermal Growth Factor Receptor
      Paul A. Dickinson, Mireille V. Cantarini, Jo Collier, Paul Frewer, Scott Martin, Kathryn Pickup and Peter Ballard
      Drug Metabolism and Disposition August 2016, 44 (8) 1201-1212; DOI: https://doi.org/10.1124/dmd.115.069203
  8. Drexler, Dieter M.

    1. You have access
      Phosphocholine Conjugation: An Unexpected In Vivo Conjugation Pathway Associated with Hepatitis C NS5B Inhibitors Featuring A Bicyclo[1.1.1]Pentane
      Xiaoliang Zhuo, Joseph L. Cantone, Yingzi Wang, John E. Leet, Dieter M. Drexler, Kap-Sun Yeung, Xiaohua Stella Huang, Kyle J. Eastman, Kyle E. Parcella, Kathleen W. Mosure, Matthew G. Soars, John F. Kadow and Benjamin M. Johnson
      Drug Metabolism and Disposition August 2016, 44 (8) 1332-1340; DOI: https://doi.org/10.1124/dmd.115.069062
  9. Driscoll, James P.

    1. You have access
      Going Beyond Common Drug Metabolizing Enzymes: Case Studies of Biotransformation Involving Aldehyde Oxidase, γ-Glutamyl Transpeptidase, Cathepsin B, Flavin-Containing Monooxygenase, and ADP-Ribosyltransferase
      Peter W. Fan, Donglu Zhang, Jason S. Halladay, James P. Driscoll and S. Cyrus Khojasteh
      Drug Metabolism and Disposition August 2016, 44 (8) 1253-1261; DOI: https://doi.org/10.1124/dmd.116.070169
  10. Dumouchel, Jennifer L.

    1. You have access
      Ocular Metabolism of Levobunolol: Historic and Emerging Metabolic Pathways
      Upendra A. Argikar, Jennifer L. Dumouchel, Christine E. Dunne, Chitra Saran, Amanda L. Cirello and Mithat Gunduz
      Drug Metabolism and Disposition August 2016, 44 (8) 1304-1312; DOI: https://doi.org/10.1124/dmd.116.070458
  11. Dunne, Christine E.

    1. You have access
      Ocular Metabolism of Levobunolol: Historic and Emerging Metabolic Pathways
      Upendra A. Argikar, Jennifer L. Dumouchel, Christine E. Dunne, Chitra Saran, Amanda L. Cirello and Mithat Gunduz
      Drug Metabolism and Disposition August 2016, 44 (8) 1304-1312; DOI: https://doi.org/10.1124/dmd.116.070458

E

  1. Eastman, Kyle J.

    1. You have access
      Phosphocholine Conjugation: An Unexpected In Vivo Conjugation Pathway Associated with Hepatitis C NS5B Inhibitors Featuring A Bicyclo[1.1.1]Pentane
      Xiaoliang Zhuo, Joseph L. Cantone, Yingzi Wang, John E. Leet, Dieter M. Drexler, Kap-Sun Yeung, Xiaohua Stella Huang, Kyle J. Eastman, Kyle E. Parcella, Kathleen W. Mosure, Matthew G. Soars, John F. Kadow and Benjamin M. Johnson
      Drug Metabolism and Disposition August 2016, 44 (8) 1332-1340; DOI: https://doi.org/10.1124/dmd.115.069062
  2. Edson, Katheryne Z.

    1. You have access
      Nonclinical Pharmacokinetics, Disposition, and Drug-Drug Interaction Potential of a Novel d-Amino Acid Peptide Agonist of the Calcium-Sensing Receptor AMG 416 (Etelcalcetide)
      Raju Subramanian, Xiaochun Zhu, Savannah J. Kerr, Joel D. Esmay, Steven W. Louie, Katheryne Z. Edson, Sarah Walter, Michael Fitzsimmons, Mylo Wagner, Marcus Soto, Roger Pham, Sarah F. Wilson and Gary L. Skiles
      Drug Metabolism and Disposition August 2016, 44 (8) 1319-1331; DOI: https://doi.org/10.1124/dmd.115.068007
  3. Einolf, Heidi J

    1. You have access
      Evaluation of a New Molecular Entity as a Victim of Metabolic Drug-Drug Interactions—an Industry Perspective
      Tonika Bohnert, Aarti Patel, Ian Templeton, Yuan Chen, Chuang Lu, George Lai, Louis Leung, Susanna Tse, Heidi J Einolf, Ying-Hong Wang, Michael Sinz, Ralph Stearns, Robert Walsky, Wanping Geng, Sirimas Sudsakorn, David Moore, Ling He, Jan Wahlstrom, Jim Keirns, Rangaraj Narayanan, Dieter Lang, Xiaoqing Yang and International Consortium for Innovation and Quality in Pharmaceutical Development (IQ) Victim Drug-Drug Interactions Working Group
      Drug Metabolism and Disposition August 2016, 44 (8) 1399-1423; DOI: https://doi.org/10.1124/dmd.115.069096
  4. Emmitte, Kyle A.

    1. You have access
      Evaluating the Disposition of a Mixed Aldehyde Oxidase/Cytochrome P450 Substrate in Rats with Attenuated P450 Activity
      Rachel D. Crouch, Ryan D. Morrison, Frank W. Byers, Craig W. Lindsley, Kyle A. Emmitte and J. Scott Daniels
      Drug Metabolism and Disposition August 2016, 44 (8) 1296-1303; DOI: https://doi.org/10.1124/dmd.115.068338
  5. Eng, Heather

    1. You have access
      Use of Human Plasma Samples to Identify Circulating Drug Metabolites that Inhibit Cytochrome P450 Enzymes
      Heather Eng and R. Scott Obach
      Drug Metabolism and Disposition August 2016, 44 (8) 1217-1228; DOI: https://doi.org/10.1124/dmd.116.071084
    2. You have access
      Species Differences in the Oxidative Desulfurization of a Thiouracil-Based Irreversible Myeloperoxidase Inactivator by Flavin-Containing Monooxygenase Enzymes
      Heather Eng, Raman Sharma, Angela Wolford, Li Di, Roger B. Ruggeri, Leonard Buckbinder, Edward L. Conn, Deepak K. Dalvie and Amit S. Kalgutkar
      Drug Metabolism and Disposition August 2016, 44 (8) 1262-1269; DOI: https://doi.org/10.1124/dmd.116.070185
  6. Esmay, Joel D.

    1. You have access
      Nonclinical Pharmacokinetics, Disposition, and Drug-Drug Interaction Potential of a Novel d-Amino Acid Peptide Agonist of the Calcium-Sensing Receptor AMG 416 (Etelcalcetide)
      Raju Subramanian, Xiaochun Zhu, Savannah J. Kerr, Joel D. Esmay, Steven W. Louie, Katheryne Z. Edson, Sarah Walter, Michael Fitzsimmons, Mylo Wagner, Marcus Soto, Roger Pham, Sarah F. Wilson and Gary L. Skiles
      Drug Metabolism and Disposition August 2016, 44 (8) 1319-1331; DOI: https://doi.org/10.1124/dmd.115.068007

F

  1. Fan, Peter W.

    1. You have access
      Going Beyond Common Drug Metabolizing Enzymes: Case Studies of Biotransformation Involving Aldehyde Oxidase, γ-Glutamyl Transpeptidase, Cathepsin B, Flavin-Containing Monooxygenase, and ADP-Ribosyltransferase
      Peter W. Fan, Donglu Zhang, Jason S. Halladay, James P. Driscoll and S. Cyrus Khojasteh
      Drug Metabolism and Disposition August 2016, 44 (8) 1253-1261; DOI: https://doi.org/10.1124/dmd.116.070169
  2. Fang, Hailin

    1. You have access
      Transcriptional Regulation of Cytosolic Sulfotransferase 1C2 by Vitamin D Receptor in LS180 Human Colorectal Adenocarcinoma Cells
      Kathleen G. Barrett, Hailin Fang, Thomas A. Kocarek and Melissa Runge-Morris
      Drug Metabolism and Disposition August 2016, 44 (8) 1431-1434; DOI: https://doi.org/10.1124/dmd.116.070300
  3. Fang, Yan

    1. Open Access
      Correlation of Cytochrome P450 Oxidoreductase Expression with the Expression of 10 Isoforms of Cytochrome P450 in Human Liver
      Hai-Feng Zhang, Zhi-Hui Li, Jia-Yu Liu, Ting-Ting Liu, Ping Wang, Yan Fang, Jun Zhou, Ming-Zhu Cui, Na Gao, Xin Tian, Jie Gao, Qiang Wen, Lin-Jing Jia and Hai-Ling Qiao
      Drug Metabolism and Disposition August 2016, 44 (8) 1193-1200; DOI: https://doi.org/10.1124/dmd.116.069849
  4. Ferreira, Suzie

    1. You have access
      Application of Osmotic Pumps for Sustained Release of 1-Aminobenzotriazole and Inhibition of Cytochrome P450 Enzymes in Mice: Model Comparison with the Hepatic P450 Reductase Null Mouse
      Rowan A. Stringer, Suzie Ferreira, Jonathan Rose and Sebastien Ronseaux
      Drug Metabolism and Disposition August 2016, 44 (8) 1213-1216; DOI: https://doi.org/10.1124/dmd.116.070151
  5. Fischer, Volker

    1. You have access
      Metabolism and Disposition of Pan-Genotypic Inhibitor of Hepatitis C Virus NS5A Ombitasvir in Humans
      Jianwei Shen, Michael Serby, Bruce Surber, Anthony J. Lee, Junli Ma, Prajakta Badri, Rajeev Menon, Olga Kavetskaia, Sonia M. de Morais, Jens Sydor and Volker Fischer
      Drug Metabolism and Disposition August 2016, 44 (8) 1148-1157; DOI: https://doi.org/10.1124/dmd.115.067496
    2. You have access
      Metabolism and Disposition of the Hepatitis C Protease Inhibitor Paritaprevir in Humans
      Jianwei Shen, Michael Serby, Aimee Reed, Anthony J. Lee, Xiaomei Zhang, Kennan Marsh, Amit Khatri, Rajeev Menon, Olga Kavetskaia and Volker Fischer
      Drug Metabolism and Disposition August 2016, 44 (8) 1164-1173; DOI: https://doi.org/10.1124/dmd.115.067488
    3. You have access
      Metabolism and Disposition of Hepatitis C Polymerase Inhibitor Dasabuvir in Humans
      Jianwei Shen, Michael Serby, Aimee Reed, Anthony J. Lee, Rajeev Menon, Xiaomei Zhang, Kennan Marsh, Xia Wan, Olga Kavetskaia and Volker Fischer
      Drug Metabolism and Disposition August 2016, 44 (8) 1139-1147; DOI: https://doi.org/10.1124/dmd.115.067512
  6. Fitzsimmons, Michael

    1. You have access
      Nonclinical Pharmacokinetics, Disposition, and Drug-Drug Interaction Potential of a Novel d-Amino Acid Peptide Agonist of the Calcium-Sensing Receptor AMG 416 (Etelcalcetide)
      Raju Subramanian, Xiaochun Zhu, Savannah J. Kerr, Joel D. Esmay, Steven W. Louie, Katheryne Z. Edson, Sarah Walter, Michael Fitzsimmons, Mylo Wagner, Marcus Soto, Roger Pham, Sarah F. Wilson and Gary L. Skiles
      Drug Metabolism and Disposition August 2016, 44 (8) 1319-1331; DOI: https://doi.org/10.1124/dmd.115.068007
  7. Foti, Alessandro

    1. You have access
      Optimization of the Expression of Human Aldehyde Oxidase for Investigations of Single-Nucleotide Polymorphisms
      Alessandro Foti, Tobias Hartmann, Catarina Coelho, Teresa Santos-Silva, Maria João Romão and Silke Leimkühler
      Drug Metabolism and Disposition August 2016, 44 (8) 1277-1285; DOI: https://doi.org/10.1124/dmd.115.068395
  8. Foti, Robert S.

    1. You have access
      Cytochrome P450 and Non–Cytochrome P450 Oxidative Metabolism: Contributions to the Pharmacokinetics, Safety, and Efficacy of Xenobiotics
      Robert S. Foti and Deepak K. Dalvie
      Drug Metabolism and Disposition August 2016, 44 (8) 1229-1245; DOI: https://doi.org/10.1124/dmd.116.071753
  9. Fraaije, Marco W.

    1. You have access
      Microbial Flavoprotein Monooxygenases as Mimics of Mammalian Flavin-Containing Monooxygenases for the Enantioselective Preparation of Drug Metabolites
      Turan Gul, Marzena Krzek, Hjalmar P. Permentier, Marco W. Fraaije and Rainer Bischoff
      Drug Metabolism and Disposition August 2016, 44 (8) 1270-1276; DOI: https://doi.org/10.1124/dmd.115.069104
  10. Frewer, Paul

    1. You have access
      Metabolic Disposition of Osimertinib in Rats, Dogs, and Humans: Insights into a Drug Designed to Bind Covalently to a Cysteine Residue of Epidermal Growth Factor Receptor
      Paul A. Dickinson, Mireille V. Cantarini, Jo Collier, Paul Frewer, Scott Martin, Kathryn Pickup and Peter Ballard
      Drug Metabolism and Disposition August 2016, 44 (8) 1201-1212; DOI: https://doi.org/10.1124/dmd.115.069203
  11. Fu, Jing

    1. You have access
      Biotransformation Capacity of Carboxylesterase in Skin and Keratinocytes for the Penta-Ethyl Ester Prodrug of DTPA
      Jing Fu, Matthew Sadgrove, Lesley Marson and Michael Jay
      Drug Metabolism and Disposition August 2016, 44 (8) 1313-1318; DOI: https://doi.org/10.1124/dmd.116.069377
  12. Fukuhara, Ayano

    1. You have access
      Impact of Experimental Conditions on the Evaluation of Interactions between Multidrug and Toxin Extrusion Proteins and Candidate Drugs
      Christian Lechner, Naoki Ishiguro, Ayano Fukuhara, Hidetada Shimizu, Naoko Ohtsu, Masahito Takatani, Kotaro Nishiyama, Ikumi Washio, Norio Yamamura and Hiroyuki Kusuhara
      Drug Metabolism and Disposition August 2016, 44 (8) 1381-1389; DOI: https://doi.org/10.1124/dmd.115.068163

G

  1. Gangl, Eric T.

    1. You have access
      Selective Time- and NADPH-Dependent Inhibition of Human CYP2E1 by Clomethiazole
      David M. Stresser, Elke S. Perloff, Andrew K. Mason, Andrew P. Blanchard, Shangara S. Dehal, Timothy P. Creegan, Ritu Singh and Eric T. Gangl
      Drug Metabolism and Disposition August 2016, 44 (8) 1424-1430; DOI: https://doi.org/10.1124/dmd.116.070193
  2. Gao, Jie

    1. Open Access
      Correlation of Cytochrome P450 Oxidoreductase Expression with the Expression of 10 Isoforms of Cytochrome P450 in Human Liver
      Hai-Feng Zhang, Zhi-Hui Li, Jia-Yu Liu, Ting-Ting Liu, Ping Wang, Yan Fang, Jun Zhou, Ming-Zhu Cui, Na Gao, Xin Tian, Jie Gao, Qiang Wen, Lin-Jing Jia and Hai-Ling Qiao
      Drug Metabolism and Disposition August 2016, 44 (8) 1193-1200; DOI: https://doi.org/10.1124/dmd.116.069849
  3. Gao, Na

    1. Open Access
      Correlation of Cytochrome P450 Oxidoreductase Expression with the Expression of 10 Isoforms of Cytochrome P450 in Human Liver
      Hai-Feng Zhang, Zhi-Hui Li, Jia-Yu Liu, Ting-Ting Liu, Ping Wang, Yan Fang, Jun Zhou, Ming-Zhu Cui, Na Gao, Xin Tian, Jie Gao, Qiang Wen, Lin-Jing Jia and Hai-Ling Qiao
      Drug Metabolism and Disposition August 2016, 44 (8) 1193-1200; DOI: https://doi.org/10.1124/dmd.116.069849
  4. Geng, Wanping

    1. You have access
      Evaluation of a New Molecular Entity as a Victim of Metabolic Drug-Drug Interactions—an Industry Perspective
      Tonika Bohnert, Aarti Patel, Ian Templeton, Yuan Chen, Chuang Lu, George Lai, Louis Leung, Susanna Tse, Heidi J Einolf, Ying-Hong Wang, Michael Sinz, Ralph Stearns, Robert Walsky, Wanping Geng, Sirimas Sudsakorn, David Moore, Ling He, Jan Wahlstrom, Jim Keirns, Rangaraj Narayanan, Dieter Lang, Xiaoqing Yang and International Consortium for Innovation and Quality in Pharmaceutical Development (IQ) Victim Drug-Drug Interactions Working Group
      Drug Metabolism and Disposition August 2016, 44 (8) 1399-1423; DOI: https://doi.org/10.1124/dmd.115.069096
  5. Grönberg, Gunnar

    1. Discovery of a Novel Microsomal Epoxide Hydrolase–Catalyzed Hydration of a Spiro Oxetane
      You have access
      Discovery of a Novel Microsomal Epoxide Hydrolase–Catalyzed Hydration of a Spiro Oxetane
      Xue-Qing Li, Martin A. Hayes, Gunnar Grönberg, Kristina Berggren, Neal Castagnoli and Lars Weidolf
      Drug Metabolism and Disposition August 2016, 44 (8) 1341-1348; DOI: https://doi.org/10.1124/dmd.116.071142
  6. Gul, Turan

    1. You have access
      Microbial Flavoprotein Monooxygenases as Mimics of Mammalian Flavin-Containing Monooxygenases for the Enantioselective Preparation of Drug Metabolites
      Turan Gul, Marzena Krzek, Hjalmar P. Permentier, Marco W. Fraaije and Rainer Bischoff
      Drug Metabolism and Disposition August 2016, 44 (8) 1270-1276; DOI: https://doi.org/10.1124/dmd.115.069104
  7. Gunduz, Mithat

    1. You have access
      Ocular Metabolism of Levobunolol: Historic and Emerging Metabolic Pathways
      Upendra A. Argikar, Jennifer L. Dumouchel, Christine E. Dunne, Chitra Saran, Amanda L. Cirello and Mithat Gunduz
      Drug Metabolism and Disposition August 2016, 44 (8) 1304-1312; DOI: https://doi.org/10.1124/dmd.116.070458

H

  1. Halladay, Jason S.

    1. You have access
      Going Beyond Common Drug Metabolizing Enzymes: Case Studies of Biotransformation Involving Aldehyde Oxidase, γ-Glutamyl Transpeptidase, Cathepsin B, Flavin-Containing Monooxygenase, and ADP-Ribosyltransferase
      Peter W. Fan, Donglu Zhang, Jason S. Halladay, James P. Driscoll and S. Cyrus Khojasteh
      Drug Metabolism and Disposition August 2016, 44 (8) 1253-1261; DOI: https://doi.org/10.1124/dmd.116.070169
  2. Harding, Jessica

    1. You have access
      Effects of Chronic Renal Failure on Brain Cytochrome P450 in Rats
      Judith Naud, Jessica Harding, Caroline Lamarche, Stephanie Beauchemin, Francois A. Leblond and Vincent Pichette
      Drug Metabolism and Disposition August 2016, 44 (8) 1174-1179; DOI: https://doi.org/10.1124/dmd.116.070052
  3. Hariparsad, Niresh

    1. You have access
      VX-509 (Decernotinib)-Mediated CYP3A Time-Dependent Inhibition: An Aldehyde Oxidase Metabolite as a Perpetrator of Drug-Drug Interactions
      Craig Zetterberg, Francois Maltais, Leena Laitinen, Shengkai Liao, Hong Tsao, Ananthsrinivas Chakilam and Niresh Hariparsad
      Drug Metabolism and Disposition August 2016, 44 (8) 1286-1295; DOI: https://doi.org/10.1124/dmd.116.071100
  4. Hartmann, Tobias

    1. You have access
      Optimization of the Expression of Human Aldehyde Oxidase for Investigations of Single-Nucleotide Polymorphisms
      Alessandro Foti, Tobias Hartmann, Catarina Coelho, Teresa Santos-Silva, Maria João Romão and Silke Leimkühler
      Drug Metabolism and Disposition August 2016, 44 (8) 1277-1285; DOI: https://doi.org/10.1124/dmd.115.068395
  5. Hasegawa, Yoshitaka

    1. You have access
      Recommendation to Exclude Bile-Duct-Cannulated Rats with Hyperbilirubinemia for Proper Conduct of Biliary Drug Excretion Studies
      Koji Kato, Yoshitaka Hasegawa, Katsuya Iwata, Takuya Ichikawa, Tohru Yahara, Satoshi Tsuji, Masayuki Sugiura and Jun-ichi Yamaguchi
      Drug Metabolism and Disposition August 2016, 44 (8) 1180-1183; DOI: https://doi.org/10.1124/dmd.116.070532
  6. Hayes, Martin A.

    1. Discovery of a Novel Microsomal Epoxide Hydrolase–Catalyzed Hydration of a Spiro Oxetane
      You have access
      Discovery of a Novel Microsomal Epoxide Hydrolase–Catalyzed Hydration of a Spiro Oxetane
      Xue-Qing Li, Martin A. Hayes, Gunnar Grönberg, Kristina Berggren, Neal Castagnoli and Lars Weidolf
      Drug Metabolism and Disposition August 2016, 44 (8) 1341-1348; DOI: https://doi.org/10.1124/dmd.116.071142
  7. He, Ling

    1. You have access
      Evaluation of a New Molecular Entity as a Victim of Metabolic Drug-Drug Interactions—an Industry Perspective
      Tonika Bohnert, Aarti Patel, Ian Templeton, Yuan Chen, Chuang Lu, George Lai, Louis Leung, Susanna Tse, Heidi J Einolf, Ying-Hong Wang, Michael Sinz, Ralph Stearns, Robert Walsky, Wanping Geng, Sirimas Sudsakorn, David Moore, Ling He, Jan Wahlstrom, Jim Keirns, Rangaraj Narayanan, Dieter Lang, Xiaoqing Yang and International Consortium for Innovation and Quality in Pharmaceutical Development (IQ) Victim Drug-Drug Interactions Working Group
      Drug Metabolism and Disposition August 2016, 44 (8) 1399-1423; DOI: https://doi.org/10.1124/dmd.115.069096
  8. Hill, Susan E.

    1. You have access
      A Pharmacokinetic Modeling Approach to Predict the Contribution of Active Metabolites to Human Efficacious Dose
      Iain J. Martin, Susan E. Hill, James A. Baker, Sujal V. Deshmukh and Erin F. Mulrooney
      Drug Metabolism and Disposition August 2016, 44 (8) 1435-1440; DOI: https://doi.org/10.1124/dmd.116.070391
  9. Huang, Xiaohua Stella

    1. You have access
      Phosphocholine Conjugation: An Unexpected In Vivo Conjugation Pathway Associated with Hepatitis C NS5B Inhibitors Featuring A Bicyclo[1.1.1]Pentane
      Xiaoliang Zhuo, Joseph L. Cantone, Yingzi Wang, John E. Leet, Dieter M. Drexler, Kap-Sun Yeung, Xiaohua Stella Huang, Kyle J. Eastman, Kyle E. Parcella, Kathleen W. Mosure, Matthew G. Soars, John F. Kadow and Benjamin M. Johnson
      Drug Metabolism and Disposition August 2016, 44 (8) 1332-1340; DOI: https://doi.org/10.1124/dmd.115.069062
  10. Humphreys, W. Griffith

    1. You have access
      Application of Static Models to Predict Midazolam Clinical Interactions in the Presence of Single or Multiple Hepatitis C Virus Drugs
      Yaofeng Cheng, Li Ma, Shu-Ying Chang, W. Griffith Humphreys and Wenying Li
      Drug Metabolism and Disposition August 2016, 44 (8) 1372-1380; DOI: https://doi.org/10.1124/dmd.116.070409

I

  1. Ichikawa, Takuya

    1. You have access
      Recommendation to Exclude Bile-Duct-Cannulated Rats with Hyperbilirubinemia for Proper Conduct of Biliary Drug Excretion Studies
      Koji Kato, Yoshitaka Hasegawa, Katsuya Iwata, Takuya Ichikawa, Tohru Yahara, Satoshi Tsuji, Masayuki Sugiura and Jun-ichi Yamaguchi
      Drug Metabolism and Disposition August 2016, 44 (8) 1180-1183; DOI: https://doi.org/10.1124/dmd.116.070532
  2. Inaba, Miki

    1. You have access
      Differences in Gene Regulation by Dual Ligands of Nuclear Receptors Constitutive Androstane Receptor (CAR) and Pregnane X Receptor (PXR) in HepG2 Cells Stably Expressing CAR/PXR
      Yuichiro Kanno, Nobuaki Tanuma, Saki Yazawa, Shuai Zhao, Miki Inaba, Satoshi Nakamura, Kiyomitsu Nemoto and Yoshio Inouye
      Drug Metabolism and Disposition August 2016, 44 (8) 1158-1163; DOI: https://doi.org/10.1124/dmd.116.070888
  3. Inouye, Yoshio

    1. You have access
      Differences in Gene Regulation by Dual Ligands of Nuclear Receptors Constitutive Androstane Receptor (CAR) and Pregnane X Receptor (PXR) in HepG2 Cells Stably Expressing CAR/PXR
      Yuichiro Kanno, Nobuaki Tanuma, Saki Yazawa, Shuai Zhao, Miki Inaba, Satoshi Nakamura, Kiyomitsu Nemoto and Yoshio Inouye
      Drug Metabolism and Disposition August 2016, 44 (8) 1158-1163; DOI: https://doi.org/10.1124/dmd.116.070888
  4. Ishiguro, Naoki

    1. You have access
      Impact of Experimental Conditions on the Evaluation of Interactions between Multidrug and Toxin Extrusion Proteins and Candidate Drugs
      Christian Lechner, Naoki Ishiguro, Ayano Fukuhara, Hidetada Shimizu, Naoko Ohtsu, Masahito Takatani, Kotaro Nishiyama, Ikumi Washio, Norio Yamamura and Hiroyuki Kusuhara
      Drug Metabolism and Disposition August 2016, 44 (8) 1381-1389; DOI: https://doi.org/10.1124/dmd.115.068163
  5. Itkonen, Matti K.

    1. You have access
      Clopidogrel Markedly Increases Plasma Concentrations of CYP2C8 Substrate Pioglitazone
      Matti K. Itkonen, Aleksi Tornio, Mikko Neuvonen, Pertti J. Neuvonen, Mikko Niemi and Janne T. Backman
      Drug Metabolism and Disposition August 2016, 44 (8) 1364-1371; DOI: https://doi.org/10.1124/dmd.116.070375
  6. Iwata, Katsuya

    1. You have access
      Recommendation to Exclude Bile-Duct-Cannulated Rats with Hyperbilirubinemia for Proper Conduct of Biliary Drug Excretion Studies
      Koji Kato, Yoshitaka Hasegawa, Katsuya Iwata, Takuya Ichikawa, Tohru Yahara, Satoshi Tsuji, Masayuki Sugiura and Jun-ichi Yamaguchi
      Drug Metabolism and Disposition August 2016, 44 (8) 1180-1183; DOI: https://doi.org/10.1124/dmd.116.070532

J

  1. Jay, Michael

    1. You have access
      Biotransformation Capacity of Carboxylesterase in Skin and Keratinocytes for the Penta-Ethyl Ester Prodrug of DTPA
      Jing Fu, Matthew Sadgrove, Lesley Marson and Michael Jay
      Drug Metabolism and Disposition August 2016, 44 (8) 1313-1318; DOI: https://doi.org/10.1124/dmd.116.069377
  2. Jia, Lin-Jing

    1. Open Access
      Correlation of Cytochrome P450 Oxidoreductase Expression with the Expression of 10 Isoforms of Cytochrome P450 in Human Liver
      Hai-Feng Zhang, Zhi-Hui Li, Jia-Yu Liu, Ting-Ting Liu, Ping Wang, Yan Fang, Jun Zhou, Ming-Zhu Cui, Na Gao, Xin Tian, Jie Gao, Qiang Wen, Lin-Jing Jia and Hai-Ling Qiao
      Drug Metabolism and Disposition August 2016, 44 (8) 1193-1200; DOI: https://doi.org/10.1124/dmd.116.069849
  3. Johnson, Benjamin M.

    1. You have access
      Phosphocholine Conjugation: An Unexpected In Vivo Conjugation Pathway Associated with Hepatitis C NS5B Inhibitors Featuring A Bicyclo[1.1.1]Pentane
      Xiaoliang Zhuo, Joseph L. Cantone, Yingzi Wang, John E. Leet, Dieter M. Drexler, Kap-Sun Yeung, Xiaohua Stella Huang, Kyle J. Eastman, Kyle E. Parcella, Kathleen W. Mosure, Matthew G. Soars, John F. Kadow and Benjamin M. Johnson
      Drug Metabolism and Disposition August 2016, 44 (8) 1332-1340; DOI: https://doi.org/10.1124/dmd.115.069062

K

  1. Kadow, John F.

    1. You have access
      Phosphocholine Conjugation: An Unexpected In Vivo Conjugation Pathway Associated with Hepatitis C NS5B Inhibitors Featuring A Bicyclo[1.1.1]Pentane
      Xiaoliang Zhuo, Joseph L. Cantone, Yingzi Wang, John E. Leet, Dieter M. Drexler, Kap-Sun Yeung, Xiaohua Stella Huang, Kyle J. Eastman, Kyle E. Parcella, Kathleen W. Mosure, Matthew G. Soars, John F. Kadow and Benjamin M. Johnson
      Drug Metabolism and Disposition August 2016, 44 (8) 1332-1340; DOI: https://doi.org/10.1124/dmd.115.069062
  2. Kalgutkar, Amit S.

    1. You have access
      Species Differences in the Oxidative Desulfurization of a Thiouracil-Based Irreversible Myeloperoxidase Inactivator by Flavin-Containing Monooxygenase Enzymes
      Heather Eng, Raman Sharma, Angela Wolford, Li Di, Roger B. Ruggeri, Leonard Buckbinder, Edward L. Conn, Deepak K. Dalvie and Amit S. Kalgutkar
      Drug Metabolism and Disposition August 2016, 44 (8) 1262-1269; DOI: https://doi.org/10.1124/dmd.116.070185
  3. Kanno, Yuichiro

    1. You have access
      Differences in Gene Regulation by Dual Ligands of Nuclear Receptors Constitutive Androstane Receptor (CAR) and Pregnane X Receptor (PXR) in HepG2 Cells Stably Expressing CAR/PXR
      Yuichiro Kanno, Nobuaki Tanuma, Saki Yazawa, Shuai Zhao, Miki Inaba, Satoshi Nakamura, Kiyomitsu Nemoto and Yoshio Inouye
      Drug Metabolism and Disposition August 2016, 44 (8) 1158-1163; DOI: https://doi.org/10.1124/dmd.116.070888
  4. Kato, Koji

    1. You have access
      Recommendation to Exclude Bile-Duct-Cannulated Rats with Hyperbilirubinemia for Proper Conduct of Biliary Drug Excretion Studies
      Koji Kato, Yoshitaka Hasegawa, Katsuya Iwata, Takuya Ichikawa, Tohru Yahara, Satoshi Tsuji, Masayuki Sugiura and Jun-ichi Yamaguchi
      Drug Metabolism and Disposition August 2016, 44 (8) 1180-1183; DOI: https://doi.org/10.1124/dmd.116.070532
  5. Kavetskaia, Olga

    1. You have access
      Metabolism and Disposition of Pan-Genotypic Inhibitor of Hepatitis C Virus NS5A Ombitasvir in Humans
      Jianwei Shen, Michael Serby, Bruce Surber, Anthony J. Lee, Junli Ma, Prajakta Badri, Rajeev Menon, Olga Kavetskaia, Sonia M. de Morais, Jens Sydor and Volker Fischer
      Drug Metabolism and Disposition August 2016, 44 (8) 1148-1157; DOI: https://doi.org/10.1124/dmd.115.067496
    2. You have access
      Metabolism and Disposition of the Hepatitis C Protease Inhibitor Paritaprevir in Humans
      Jianwei Shen, Michael Serby, Aimee Reed, Anthony J. Lee, Xiaomei Zhang, Kennan Marsh, Amit Khatri, Rajeev Menon, Olga Kavetskaia and Volker Fischer
      Drug Metabolism and Disposition August 2016, 44 (8) 1164-1173; DOI: https://doi.org/10.1124/dmd.115.067488
    3. You have access
      Metabolism and Disposition of Hepatitis C Polymerase Inhibitor Dasabuvir in Humans
      Jianwei Shen, Michael Serby, Aimee Reed, Anthony J. Lee, Rajeev Menon, Xiaomei Zhang, Kennan Marsh, Xia Wan, Olga Kavetskaia and Volker Fischer
      Drug Metabolism and Disposition August 2016, 44 (8) 1139-1147; DOI: https://doi.org/10.1124/dmd.115.067512
  6. Keirns, Jim

    1. You have access
      Evaluation of a New Molecular Entity as a Victim of Metabolic Drug-Drug Interactions—an Industry Perspective
      Tonika Bohnert, Aarti Patel, Ian Templeton, Yuan Chen, Chuang Lu, George Lai, Louis Leung, Susanna Tse, Heidi J Einolf, Ying-Hong Wang, Michael Sinz, Ralph Stearns, Robert Walsky, Wanping Geng, Sirimas Sudsakorn, David Moore, Ling He, Jan Wahlstrom, Jim Keirns, Rangaraj Narayanan, Dieter Lang, Xiaoqing Yang and International Consortium for Innovation and Quality in Pharmaceutical Development (IQ) Victim Drug-Drug Interactions Working Group
      Drug Metabolism and Disposition August 2016, 44 (8) 1399-1423; DOI: https://doi.org/10.1124/dmd.115.069096
  7. Kerr, Savannah J.

    1. You have access
      Nonclinical Pharmacokinetics, Disposition, and Drug-Drug Interaction Potential of a Novel d-Amino Acid Peptide Agonist of the Calcium-Sensing Receptor AMG 416 (Etelcalcetide)
      Raju Subramanian, Xiaochun Zhu, Savannah J. Kerr, Joel D. Esmay, Steven W. Louie, Katheryne Z. Edson, Sarah Walter, Michael Fitzsimmons, Mylo Wagner, Marcus Soto, Roger Pham, Sarah F. Wilson and Gary L. Skiles
      Drug Metabolism and Disposition August 2016, 44 (8) 1319-1331; DOI: https://doi.org/10.1124/dmd.115.068007
  8. Khatri, Amit

    1. You have access
      Metabolism and Disposition of the Hepatitis C Protease Inhibitor Paritaprevir in Humans
      Jianwei Shen, Michael Serby, Aimee Reed, Anthony J. Lee, Xiaomei Zhang, Kennan Marsh, Amit Khatri, Rajeev Menon, Olga Kavetskaia and Volker Fischer
      Drug Metabolism and Disposition August 2016, 44 (8) 1164-1173; DOI: https://doi.org/10.1124/dmd.115.067488
  9. Khojasteh, S. Cyrus

    1. You have access
      Going Beyond Common Drug Metabolizing Enzymes: Case Studies of Biotransformation Involving Aldehyde Oxidase, γ-Glutamyl Transpeptidase, Cathepsin B, Flavin-Containing Monooxygenase, and ADP-Ribosyltransferase
      Peter W. Fan, Donglu Zhang, Jason S. Halladay, James P. Driscoll and S. Cyrus Khojasteh
      Drug Metabolism and Disposition August 2016, 44 (8) 1253-1261; DOI: https://doi.org/10.1124/dmd.116.070169
  10. King, Ivan

    1. You have access
      Biotransformation and Rearrangement of Laromustine
      Alaa-Eldin F. Nassar, Adam V. Wisnewski and Ivan King
      Drug Metabolism and Disposition August 2016, 44 (8) 1349-1363; DOI: https://doi.org/10.1124/dmd.116.069823
  11. Kocarek, Thomas A.

    1. You have access
      Transcriptional Regulation of Cytosolic Sulfotransferase 1C2 by Vitamin D Receptor in LS180 Human Colorectal Adenocarcinoma Cells
      Kathleen G. Barrett, Hailin Fang, Thomas A. Kocarek and Melissa Runge-Morris
      Drug Metabolism and Disposition August 2016, 44 (8) 1431-1434; DOI: https://doi.org/10.1124/dmd.116.070300
  12. Konno, Yoshihiro

    1. You have access
      Establishment of In Silico Prediction Models for CYP3A4 and CYP2B6 Induction in Human Hepatocytes by Multiple Regression Analysis Using Azole Compounds
      Mika Nagai, Yoshihiro Konno, Masahiro Satsukawa, Shinji Yamashita and Kouichi Yoshinari
      Drug Metabolism and Disposition August 2016, 44 (8) 1390-1398; DOI: https://doi.org/10.1124/dmd.115.068619
  13. Krzek, Marzena

    1. You have access
      Microbial Flavoprotein Monooxygenases as Mimics of Mammalian Flavin-Containing Monooxygenases for the Enantioselective Preparation of Drug Metabolites
      Turan Gul, Marzena Krzek, Hjalmar P. Permentier, Marco W. Fraaije and Rainer Bischoff
      Drug Metabolism and Disposition August 2016, 44 (8) 1270-1276; DOI: https://doi.org/10.1124/dmd.115.069104
  14. Kusuhara, Hiroyuki

    1. You have access
      Impact of Experimental Conditions on the Evaluation of Interactions between Multidrug and Toxin Extrusion Proteins and Candidate Drugs
      Christian Lechner, Naoki Ishiguro, Ayano Fukuhara, Hidetada Shimizu, Naoko Ohtsu, Masahito Takatani, Kotaro Nishiyama, Ikumi Washio, Norio Yamamura and Hiroyuki Kusuhara
      Drug Metabolism and Disposition August 2016, 44 (8) 1381-1389; DOI: https://doi.org/10.1124/dmd.115.068163

L

  1. Lai, George

    1. You have access
      Evaluation of a New Molecular Entity as a Victim of Metabolic Drug-Drug Interactions—an Industry Perspective
      Tonika Bohnert, Aarti Patel, Ian Templeton, Yuan Chen, Chuang Lu, George Lai, Louis Leung, Susanna Tse, Heidi J Einolf, Ying-Hong Wang, Michael Sinz, Ralph Stearns, Robert Walsky, Wanping Geng, Sirimas Sudsakorn, David Moore, Ling He, Jan Wahlstrom, Jim Keirns, Rangaraj Narayanan, Dieter Lang, Xiaoqing Yang and International Consortium for Innovation and Quality in Pharmaceutical Development (IQ) Victim Drug-Drug Interactions Working Group
      Drug Metabolism and Disposition August 2016, 44 (8) 1399-1423; DOI: https://doi.org/10.1124/dmd.115.069096
  2. Laitinen, Leena

    1. You have access
      VX-509 (Decernotinib)-Mediated CYP3A Time-Dependent Inhibition: An Aldehyde Oxidase Metabolite as a Perpetrator of Drug-Drug Interactions
      Craig Zetterberg, Francois Maltais, Leena Laitinen, Shengkai Liao, Hong Tsao, Ananthsrinivas Chakilam and Niresh Hariparsad
      Drug Metabolism and Disposition August 2016, 44 (8) 1286-1295; DOI: https://doi.org/10.1124/dmd.116.071100
  3. Lamarche, Caroline

    1. You have access
      Effects of Chronic Renal Failure on Brain Cytochrome P450 in Rats
      Judith Naud, Jessica Harding, Caroline Lamarche, Stephanie Beauchemin, Francois A. Leblond and Vincent Pichette
      Drug Metabolism and Disposition August 2016, 44 (8) 1174-1179; DOI: https://doi.org/10.1124/dmd.116.070052
  4. Lang, Dieter

    1. You have access
      Evaluation of a New Molecular Entity as a Victim of Metabolic Drug-Drug Interactions—an Industry Perspective
      Tonika Bohnert, Aarti Patel, Ian Templeton, Yuan Chen, Chuang Lu, George Lai, Louis Leung, Susanna Tse, Heidi J Einolf, Ying-Hong Wang, Michael Sinz, Ralph Stearns, Robert Walsky, Wanping Geng, Sirimas Sudsakorn, David Moore, Ling He, Jan Wahlstrom, Jim Keirns, Rangaraj Narayanan, Dieter Lang, Xiaoqing Yang and International Consortium for Innovation and Quality in Pharmaceutical Development (IQ) Victim Drug-Drug Interactions Working Group
      Drug Metabolism and Disposition August 2016, 44 (8) 1399-1423; DOI: https://doi.org/10.1124/dmd.115.069096
  5. Leblond, Francois A.

    1. You have access
      Effects of Chronic Renal Failure on Brain Cytochrome P450 in Rats
      Judith Naud, Jessica Harding, Caroline Lamarche, Stephanie Beauchemin, Francois A. Leblond and Vincent Pichette
      Drug Metabolism and Disposition August 2016, 44 (8) 1174-1179; DOI: https://doi.org/10.1124/dmd.116.070052
  6. Lechner, Christian

    1. You have access
      Impact of Experimental Conditions on the Evaluation of Interactions between Multidrug and Toxin Extrusion Proteins and Candidate Drugs
      Christian Lechner, Naoki Ishiguro, Ayano Fukuhara, Hidetada Shimizu, Naoko Ohtsu, Masahito Takatani, Kotaro Nishiyama, Ikumi Washio, Norio Yamamura and Hiroyuki Kusuhara
      Drug Metabolism and Disposition August 2016, 44 (8) 1381-1389; DOI: https://doi.org/10.1124/dmd.115.068163
  7. Lee, Anthony J.

    1. You have access
      Metabolism and Disposition of Pan-Genotypic Inhibitor of Hepatitis C Virus NS5A Ombitasvir in Humans
      Jianwei Shen, Michael Serby, Bruce Surber, Anthony J. Lee, Junli Ma, Prajakta Badri, Rajeev Menon, Olga Kavetskaia, Sonia M. de Morais, Jens Sydor and Volker Fischer
      Drug Metabolism and Disposition August 2016, 44 (8) 1148-1157; DOI: https://doi.org/10.1124/dmd.115.067496
    2. You have access
      Metabolism and Disposition of the Hepatitis C Protease Inhibitor Paritaprevir in Humans
      Jianwei Shen, Michael Serby, Aimee Reed, Anthony J. Lee, Xiaomei Zhang, Kennan Marsh, Amit Khatri, Rajeev Menon, Olga Kavetskaia and Volker Fischer
      Drug Metabolism and Disposition August 2016, 44 (8) 1164-1173; DOI: https://doi.org/10.1124/dmd.115.067488
    3. You have access
      Metabolism and Disposition of Hepatitis C Polymerase Inhibitor Dasabuvir in Humans
      Jianwei Shen, Michael Serby, Aimee Reed, Anthony J. Lee, Rajeev Menon, Xiaomei Zhang, Kennan Marsh, Xia Wan, Olga Kavetskaia and Volker Fischer
      Drug Metabolism and Disposition August 2016, 44 (8) 1139-1147; DOI: https://doi.org/10.1124/dmd.115.067512
  8. Leet, John E.

    1. You have access
      Phosphocholine Conjugation: An Unexpected In Vivo Conjugation Pathway Associated with Hepatitis C NS5B Inhibitors Featuring A Bicyclo[1.1.1]Pentane
      Xiaoliang Zhuo, Joseph L. Cantone, Yingzi Wang, John E. Leet, Dieter M. Drexler, Kap-Sun Yeung, Xiaohua Stella Huang, Kyle J. Eastman, Kyle E. Parcella, Kathleen W. Mosure, Matthew G. Soars, John F. Kadow and Benjamin M. Johnson
      Drug Metabolism and Disposition August 2016, 44 (8) 1332-1340; DOI: https://doi.org/10.1124/dmd.115.069062
  9. Leimkühler, Silke

    1. You have access
      Optimization of the Expression of Human Aldehyde Oxidase for Investigations of Single-Nucleotide Polymorphisms
      Alessandro Foti, Tobias Hartmann, Catarina Coelho, Teresa Santos-Silva, Maria João Romão and Silke Leimkühler
      Drug Metabolism and Disposition August 2016, 44 (8) 1277-1285; DOI: https://doi.org/10.1124/dmd.115.068395
  10. Leung, Louis

    1. You have access
      Evaluation of a New Molecular Entity as a Victim of Metabolic Drug-Drug Interactions—an Industry Perspective
      Tonika Bohnert, Aarti Patel, Ian Templeton, Yuan Chen, Chuang Lu, George Lai, Louis Leung, Susanna Tse, Heidi J Einolf, Ying-Hong Wang, Michael Sinz, Ralph Stearns, Robert Walsky, Wanping Geng, Sirimas Sudsakorn, David Moore, Ling He, Jan Wahlstrom, Jim Keirns, Rangaraj Narayanan, Dieter Lang, Xiaoqing Yang and International Consortium for Innovation and Quality in Pharmaceutical Development (IQ) Victim Drug-Drug Interactions Working Group
      Drug Metabolism and Disposition August 2016, 44 (8) 1399-1423; DOI: https://doi.org/10.1124/dmd.115.069096
  11. Li, Wenying

    1. You have access
      Application of Static Models to Predict Midazolam Clinical Interactions in the Presence of Single or Multiple Hepatitis C Virus Drugs
      Yaofeng Cheng, Li Ma, Shu-Ying Chang, W. Griffith Humphreys and Wenying Li
      Drug Metabolism and Disposition August 2016, 44 (8) 1372-1380; DOI: https://doi.org/10.1124/dmd.116.070409
  12. Li, Xue-Qing

    1. Discovery of a Novel Microsomal Epoxide Hydrolase–Catalyzed Hydration of a Spiro Oxetane
      You have access
      Discovery of a Novel Microsomal Epoxide Hydrolase–Catalyzed Hydration of a Spiro Oxetane
      Xue-Qing Li, Martin A. Hayes, Gunnar Grönberg, Kristina Berggren, Neal Castagnoli and Lars Weidolf
      Drug Metabolism and Disposition August 2016, 44 (8) 1341-1348; DOI: https://doi.org/10.1124/dmd.116.071142
  13. Li, Zhi-Hui

    1. Open Access
      Correlation of Cytochrome P450 Oxidoreductase Expression with the Expression of 10 Isoforms of Cytochrome P450 in Human Liver
      Hai-Feng Zhang, Zhi-Hui Li, Jia-Yu Liu, Ting-Ting Liu, Ping Wang, Yan Fang, Jun Zhou, Ming-Zhu Cui, Na Gao, Xin Tian, Jie Gao, Qiang Wen, Lin-Jing Jia and Hai-Ling Qiao
      Drug Metabolism and Disposition August 2016, 44 (8) 1193-1200; DOI: https://doi.org/10.1124/dmd.116.069849
  14. Liao, Shengkai

    1. You have access
      VX-509 (Decernotinib)-Mediated CYP3A Time-Dependent Inhibition: An Aldehyde Oxidase Metabolite as a Perpetrator of Drug-Drug Interactions
      Craig Zetterberg, Francois Maltais, Leena Laitinen, Shengkai Liao, Hong Tsao, Ananthsrinivas Chakilam and Niresh Hariparsad
      Drug Metabolism and Disposition August 2016, 44 (8) 1286-1295; DOI: https://doi.org/10.1124/dmd.116.071100
  15. Lindsley, Craig W.

    1. You have access
      Evaluating the Disposition of a Mixed Aldehyde Oxidase/Cytochrome P450 Substrate in Rats with Attenuated P450 Activity
      Rachel D. Crouch, Ryan D. Morrison, Frank W. Byers, Craig W. Lindsley, Kyle A. Emmitte and J. Scott Daniels
      Drug Metabolism and Disposition August 2016, 44 (8) 1296-1303; DOI: https://doi.org/10.1124/dmd.115.068338
  16. Liu, Jia-Yu

    1. Open Access
      Correlation of Cytochrome P450 Oxidoreductase Expression with the Expression of 10 Isoforms of Cytochrome P450 in Human Liver
      Hai-Feng Zhang, Zhi-Hui Li, Jia-Yu Liu, Ting-Ting Liu, Ping Wang, Yan Fang, Jun Zhou, Ming-Zhu Cui, Na Gao, Xin Tian, Jie Gao, Qiang Wen, Lin-Jing Jia and Hai-Ling Qiao
      Drug Metabolism and Disposition August 2016, 44 (8) 1193-1200; DOI: https://doi.org/10.1124/dmd.116.069849
  17. Liu, Ting-Ting

    1. Open Access
      Correlation of Cytochrome P450 Oxidoreductase Expression with the Expression of 10 Isoforms of Cytochrome P450 in Human Liver
      Hai-Feng Zhang, Zhi-Hui Li, Jia-Yu Liu, Ting-Ting Liu, Ping Wang, Yan Fang, Jun Zhou, Ming-Zhu Cui, Na Gao, Xin Tian, Jie Gao, Qiang Wen, Lin-Jing Jia and Hai-Ling Qiao
      Drug Metabolism and Disposition August 2016, 44 (8) 1193-1200; DOI: https://doi.org/10.1124/dmd.116.069849
  18. Louie, Steven W.

    1. You have access
      Nonclinical Pharmacokinetics, Disposition, and Drug-Drug Interaction Potential of a Novel d-Amino Acid Peptide Agonist of the Calcium-Sensing Receptor AMG 416 (Etelcalcetide)
      Raju Subramanian, Xiaochun Zhu, Savannah J. Kerr, Joel D. Esmay, Steven W. Louie, Katheryne Z. Edson, Sarah Walter, Michael Fitzsimmons, Mylo Wagner, Marcus Soto, Roger Pham, Sarah F. Wilson and Gary L. Skiles
      Drug Metabolism and Disposition August 2016, 44 (8) 1319-1331; DOI: https://doi.org/10.1124/dmd.115.068007
  19. Lu, Chuang

    1. You have access
      Evaluation of a New Molecular Entity as a Victim of Metabolic Drug-Drug Interactions—an Industry Perspective
      Tonika Bohnert, Aarti Patel, Ian Templeton, Yuan Chen, Chuang Lu, George Lai, Louis Leung, Susanna Tse, Heidi J Einolf, Ying-Hong Wang, Michael Sinz, Ralph Stearns, Robert Walsky, Wanping Geng, Sirimas Sudsakorn, David Moore, Ling He, Jan Wahlstrom, Jim Keirns, Rangaraj Narayanan, Dieter Lang, Xiaoqing Yang and International Consortium for Innovation and Quality in Pharmaceutical Development (IQ) Victim Drug-Drug Interactions Working Group
      Drug Metabolism and Disposition August 2016, 44 (8) 1399-1423; DOI: https://doi.org/10.1124/dmd.115.069096

M

  1. Ma, Junli

    1. You have access
      Metabolism and Disposition of Pan-Genotypic Inhibitor of Hepatitis C Virus NS5A Ombitasvir in Humans
      Jianwei Shen, Michael Serby, Bruce Surber, Anthony J. Lee, Junli Ma, Prajakta Badri, Rajeev Menon, Olga Kavetskaia, Sonia M. de Morais, Jens Sydor and Volker Fischer
      Drug Metabolism and Disposition August 2016, 44 (8) 1148-1157; DOI: https://doi.org/10.1124/dmd.115.067496
  2. Ma, Li

    1. You have access
      Application of Static Models to Predict Midazolam Clinical Interactions in the Presence of Single or Multiple Hepatitis C Virus Drugs
      Yaofeng Cheng, Li Ma, Shu-Ying Chang, W. Griffith Humphreys and Wenying Li
      Drug Metabolism and Disposition August 2016, 44 (8) 1372-1380; DOI: https://doi.org/10.1124/dmd.116.070409
  3. Maltais, Francois

    1. You have access
      VX-509 (Decernotinib)-Mediated CYP3A Time-Dependent Inhibition: An Aldehyde Oxidase Metabolite as a Perpetrator of Drug-Drug Interactions
      Craig Zetterberg, Francois Maltais, Leena Laitinen, Shengkai Liao, Hong Tsao, Ananthsrinivas Chakilam and Niresh Hariparsad
      Drug Metabolism and Disposition August 2016, 44 (8) 1286-1295; DOI: https://doi.org/10.1124/dmd.116.071100
  4. Marsh, Kennan

    1. You have access
      Metabolism and Disposition of the Hepatitis C Protease Inhibitor Paritaprevir in Humans
      Jianwei Shen, Michael Serby, Aimee Reed, Anthony J. Lee, Xiaomei Zhang, Kennan Marsh, Amit Khatri, Rajeev Menon, Olga Kavetskaia and Volker Fischer
      Drug Metabolism and Disposition August 2016, 44 (8) 1164-1173; DOI: https://doi.org/10.1124/dmd.115.067488
    2. You have access
      Metabolism and Disposition of Hepatitis C Polymerase Inhibitor Dasabuvir in Humans
      Jianwei Shen, Michael Serby, Aimee Reed, Anthony J. Lee, Rajeev Menon, Xiaomei Zhang, Kennan Marsh, Xia Wan, Olga Kavetskaia and Volker Fischer
      Drug Metabolism and Disposition August 2016, 44 (8) 1139-1147; DOI: https://doi.org/10.1124/dmd.115.067512
  5. Marson, Lesley

    1. You have access
      Biotransformation Capacity of Carboxylesterase in Skin and Keratinocytes for the Penta-Ethyl Ester Prodrug of DTPA
      Jing Fu, Matthew Sadgrove, Lesley Marson and Michael Jay
      Drug Metabolism and Disposition August 2016, 44 (8) 1313-1318; DOI: https://doi.org/10.1124/dmd.116.069377
  6. Martin, Iain J.

    1. You have access
      A Pharmacokinetic Modeling Approach to Predict the Contribution of Active Metabolites to Human Efficacious Dose
      Iain J. Martin, Susan E. Hill, James A. Baker, Sujal V. Deshmukh and Erin F. Mulrooney
      Drug Metabolism and Disposition August 2016, 44 (8) 1435-1440; DOI: https://doi.org/10.1124/dmd.116.070391
  7. Martin, Scott

    1. You have access
      Metabolic Disposition of Osimertinib in Rats, Dogs, and Humans: Insights into a Drug Designed to Bind Covalently to a Cysteine Residue of Epidermal Growth Factor Receptor
      Paul A. Dickinson, Mireille V. Cantarini, Jo Collier, Paul Frewer, Scott Martin, Kathryn Pickup and Peter Ballard
      Drug Metabolism and Disposition August 2016, 44 (8) 1201-1212; DOI: https://doi.org/10.1124/dmd.115.069203
  8. Mason, Andrew K.

    1. You have access
      Selective Time- and NADPH-Dependent Inhibition of Human CYP2E1 by Clomethiazole
      David M. Stresser, Elke S. Perloff, Andrew K. Mason, Andrew P. Blanchard, Shangara S. Dehal, Timothy P. Creegan, Ritu Singh and Eric T. Gangl
      Drug Metabolism and Disposition August 2016, 44 (8) 1424-1430; DOI: https://doi.org/10.1124/dmd.116.070193
  9. Menon, Rajeev

    1. You have access
      Metabolism and Disposition of Pan-Genotypic Inhibitor of Hepatitis C Virus NS5A Ombitasvir in Humans
      Jianwei Shen, Michael Serby, Bruce Surber, Anthony J. Lee, Junli Ma, Prajakta Badri, Rajeev Menon, Olga Kavetskaia, Sonia M. de Morais, Jens Sydor and Volker Fischer
      Drug Metabolism and Disposition August 2016, 44 (8) 1148-1157; DOI: https://doi.org/10.1124/dmd.115.067496
    2. You have access
      Metabolism and Disposition of the Hepatitis C Protease Inhibitor Paritaprevir in Humans
      Jianwei Shen, Michael Serby, Aimee Reed, Anthony J. Lee, Xiaomei Zhang, Kennan Marsh, Amit Khatri, Rajeev Menon, Olga Kavetskaia and Volker Fischer
      Drug Metabolism and Disposition August 2016, 44 (8) 1164-1173; DOI: https://doi.org/10.1124/dmd.115.067488
    3. You have access
      Metabolism and Disposition of Hepatitis C Polymerase Inhibitor Dasabuvir in Humans
      Jianwei Shen, Michael Serby, Aimee Reed, Anthony J. Lee, Rajeev Menon, Xiaomei Zhang, Kennan Marsh, Xia Wan, Olga Kavetskaia and Volker Fischer
      Drug Metabolism and Disposition August 2016, 44 (8) 1139-1147; DOI: https://doi.org/10.1124/dmd.115.067512
  10. Mohutsky, Michael A.

    1. You have access
      Difference in the Pharmacokinetics and Hepatic Metabolism of Antidiabetic Drugs in Zucker Diabetic Fatty and Sprague-Dawley Rats
      Xin Zhou, Luc R. A. Rougée, David W. Bedwell, Jeff W. Cramer, Michael A. Mohutsky, Nathan A. Calvert, Richard D. Moulton, Kenneth C. Cassidy, Nathan P. Yumibe, Lisa A. Adams and Kenneth J. Ruterbories
      Drug Metabolism and Disposition August 2016, 44 (8) 1184-1192; DOI: https://doi.org/10.1124/dmd.116.070623
  11. Moore, David

    1. You have access
      Evaluation of a New Molecular Entity as a Victim of Metabolic Drug-Drug Interactions—an Industry Perspective
      Tonika Bohnert, Aarti Patel, Ian Templeton, Yuan Chen, Chuang Lu, George Lai, Louis Leung, Susanna Tse, Heidi J Einolf, Ying-Hong Wang, Michael Sinz, Ralph Stearns, Robert Walsky, Wanping Geng, Sirimas Sudsakorn, David Moore, Ling He, Jan Wahlstrom, Jim Keirns, Rangaraj Narayanan, Dieter Lang, Xiaoqing Yang and International Consortium for Innovation and Quality in Pharmaceutical Development (IQ) Victim Drug-Drug Interactions Working Group
      Drug Metabolism and Disposition August 2016, 44 (8) 1399-1423; DOI: https://doi.org/10.1124/dmd.115.069096
  12. Morrison, Ryan D.

    1. You have access
      Evaluating the Disposition of a Mixed Aldehyde Oxidase/Cytochrome P450 Substrate in Rats with Attenuated P450 Activity
      Rachel D. Crouch, Ryan D. Morrison, Frank W. Byers, Craig W. Lindsley, Kyle A. Emmitte and J. Scott Daniels
      Drug Metabolism and Disposition August 2016, 44 (8) 1296-1303; DOI: https://doi.org/10.1124/dmd.115.068338
  13. Mosure, Kathleen W.

    1. You have access
      Phosphocholine Conjugation: An Unexpected In Vivo Conjugation Pathway Associated with Hepatitis C NS5B Inhibitors Featuring A Bicyclo[1.1.1]Pentane
      Xiaoliang Zhuo, Joseph L. Cantone, Yingzi Wang, John E. Leet, Dieter M. Drexler, Kap-Sun Yeung, Xiaohua Stella Huang, Kyle J. Eastman, Kyle E. Parcella, Kathleen W. Mosure, Matthew G. Soars, John F. Kadow and Benjamin M. Johnson
      Drug Metabolism and Disposition August 2016, 44 (8) 1332-1340; DOI: https://doi.org/10.1124/dmd.115.069062
  14. Moulton, Richard D.

    1. You have access
      Difference in the Pharmacokinetics and Hepatic Metabolism of Antidiabetic Drugs in Zucker Diabetic Fatty and Sprague-Dawley Rats
      Xin Zhou, Luc R. A. Rougée, David W. Bedwell, Jeff W. Cramer, Michael A. Mohutsky, Nathan A. Calvert, Richard D. Moulton, Kenneth C. Cassidy, Nathan P. Yumibe, Lisa A. Adams and Kenneth J. Ruterbories
      Drug Metabolism and Disposition August 2016, 44 (8) 1184-1192; DOI: https://doi.org/10.1124/dmd.116.070623
  15. Mulrooney, Erin F.

    1. You have access
      A Pharmacokinetic Modeling Approach to Predict the Contribution of Active Metabolites to Human Efficacious Dose
      Iain J. Martin, Susan E. Hill, James A. Baker, Sujal V. Deshmukh and Erin F. Mulrooney
      Drug Metabolism and Disposition August 2016, 44 (8) 1435-1440; DOI: https://doi.org/10.1124/dmd.116.070391

N

  1. Nagai, Mika

    1. You have access
      Establishment of In Silico Prediction Models for CYP3A4 and CYP2B6 Induction in Human Hepatocytes by Multiple Regression Analysis Using Azole Compounds
      Mika Nagai, Yoshihiro Konno, Masahiro Satsukawa, Shinji Yamashita and Kouichi Yoshinari
      Drug Metabolism and Disposition August 2016, 44 (8) 1390-1398; DOI: https://doi.org/10.1124/dmd.115.068619
  2. Nakamura, Satoshi

    1. You have access
      Differences in Gene Regulation by Dual Ligands of Nuclear Receptors Constitutive Androstane Receptor (CAR) and Pregnane X Receptor (PXR) in HepG2 Cells Stably Expressing CAR/PXR
      Yuichiro Kanno, Nobuaki Tanuma, Saki Yazawa, Shuai Zhao, Miki Inaba, Satoshi Nakamura, Kiyomitsu Nemoto and Yoshio Inouye
      Drug Metabolism and Disposition August 2016, 44 (8) 1158-1163; DOI: https://doi.org/10.1124/dmd.116.070888
  3. Narayanan, Rangaraj

    1. You have access
      Evaluation of a New Molecular Entity as a Victim of Metabolic Drug-Drug Interactions—an Industry Perspective
      Tonika Bohnert, Aarti Patel, Ian Templeton, Yuan Chen, Chuang Lu, George Lai, Louis Leung, Susanna Tse, Heidi J Einolf, Ying-Hong Wang, Michael Sinz, Ralph Stearns, Robert Walsky, Wanping Geng, Sirimas Sudsakorn, David Moore, Ling He, Jan Wahlstrom, Jim Keirns, Rangaraj Narayanan, Dieter Lang, Xiaoqing Yang and International Consortium for Innovation and Quality in Pharmaceutical Development (IQ) Victim Drug-Drug Interactions Working Group
      Drug Metabolism and Disposition August 2016, 44 (8) 1399-1423; DOI: https://doi.org/10.1124/dmd.115.069096
  4. Nassar, Alaa-Eldin F.

    1. You have access
      Biotransformation and Rearrangement of Laromustine
      Alaa-Eldin F. Nassar, Adam V. Wisnewski and Ivan King
      Drug Metabolism and Disposition August 2016, 44 (8) 1349-1363; DOI: https://doi.org/10.1124/dmd.116.069823
  5. Naud, Judith

    1. You have access
      Effects of Chronic Renal Failure on Brain Cytochrome P450 in Rats
      Judith Naud, Jessica Harding, Caroline Lamarche, Stephanie Beauchemin, Francois A. Leblond and Vincent Pichette
      Drug Metabolism and Disposition August 2016, 44 (8) 1174-1179; DOI: https://doi.org/10.1124/dmd.116.070052
  6. Nemoto, Kiyomitsu

    1. You have access
      Differences in Gene Regulation by Dual Ligands of Nuclear Receptors Constitutive Androstane Receptor (CAR) and Pregnane X Receptor (PXR) in HepG2 Cells Stably Expressing CAR/PXR
      Yuichiro Kanno, Nobuaki Tanuma, Saki Yazawa, Shuai Zhao, Miki Inaba, Satoshi Nakamura, Kiyomitsu Nemoto and Yoshio Inouye
      Drug Metabolism and Disposition August 2016, 44 (8) 1158-1163; DOI: https://doi.org/10.1124/dmd.116.070888
  7. Neuvonen, Mikko

    1. You have access
      Clopidogrel Markedly Increases Plasma Concentrations of CYP2C8 Substrate Pioglitazone
      Matti K. Itkonen, Aleksi Tornio, Mikko Neuvonen, Pertti J. Neuvonen, Mikko Niemi and Janne T. Backman
      Drug Metabolism and Disposition August 2016, 44 (8) 1364-1371; DOI: https://doi.org/10.1124/dmd.116.070375
  8. Neuvonen, Pertti J.

    1. You have access
      Clopidogrel Markedly Increases Plasma Concentrations of CYP2C8 Substrate Pioglitazone
      Matti K. Itkonen, Aleksi Tornio, Mikko Neuvonen, Pertti J. Neuvonen, Mikko Niemi and Janne T. Backman
      Drug Metabolism and Disposition August 2016, 44 (8) 1364-1371; DOI: https://doi.org/10.1124/dmd.116.070375
  9. Niemi, Mikko

    1. You have access
      Clopidogrel Markedly Increases Plasma Concentrations of CYP2C8 Substrate Pioglitazone
      Matti K. Itkonen, Aleksi Tornio, Mikko Neuvonen, Pertti J. Neuvonen, Mikko Niemi and Janne T. Backman
      Drug Metabolism and Disposition August 2016, 44 (8) 1364-1371; DOI: https://doi.org/10.1124/dmd.116.070375
  10. Nishiyama, Kotaro

    1. You have access
      Impact of Experimental Conditions on the Evaluation of Interactions between Multidrug and Toxin Extrusion Proteins and Candidate Drugs
      Christian Lechner, Naoki Ishiguro, Ayano Fukuhara, Hidetada Shimizu, Naoko Ohtsu, Masahito Takatani, Kotaro Nishiyama, Ikumi Washio, Norio Yamamura and Hiroyuki Kusuhara
      Drug Metabolism and Disposition August 2016, 44 (8) 1381-1389; DOI: https://doi.org/10.1124/dmd.115.068163

O

  1. Obach, R. Scott

    1. You have access
      Use of Human Plasma Samples to Identify Circulating Drug Metabolites that Inhibit Cytochrome P450 Enzymes
      Heather Eng and R. Scott Obach
      Drug Metabolism and Disposition August 2016, 44 (8) 1217-1228; DOI: https://doi.org/10.1124/dmd.116.071084
  2. Ohtsu, Naoko

    1. You have access
      Impact of Experimental Conditions on the Evaluation of Interactions between Multidrug and Toxin Extrusion Proteins and Candidate Drugs
      Christian Lechner, Naoki Ishiguro, Ayano Fukuhara, Hidetada Shimizu, Naoko Ohtsu, Masahito Takatani, Kotaro Nishiyama, Ikumi Washio, Norio Yamamura and Hiroyuki Kusuhara
      Drug Metabolism and Disposition August 2016, 44 (8) 1381-1389; DOI: https://doi.org/10.1124/dmd.115.068163

P

  1. Parcella, Kyle E.

    1. You have access
      Phosphocholine Conjugation: An Unexpected In Vivo Conjugation Pathway Associated with Hepatitis C NS5B Inhibitors Featuring A Bicyclo[1.1.1]Pentane
      Xiaoliang Zhuo, Joseph L. Cantone, Yingzi Wang, John E. Leet, Dieter M. Drexler, Kap-Sun Yeung, Xiaohua Stella Huang, Kyle J. Eastman, Kyle E. Parcella, Kathleen W. Mosure, Matthew G. Soars, John F. Kadow and Benjamin M. Johnson
      Drug Metabolism and Disposition August 2016, 44 (8) 1332-1340; DOI: https://doi.org/10.1124/dmd.115.069062
  2. Patel, Aarti

    1. You have access
      Evaluation of a New Molecular Entity as a Victim of Metabolic Drug-Drug Interactions—an Industry Perspective
      Tonika Bohnert, Aarti Patel, Ian Templeton, Yuan Chen, Chuang Lu, George Lai, Louis Leung, Susanna Tse, Heidi J Einolf, Ying-Hong Wang, Michael Sinz, Ralph Stearns, Robert Walsky, Wanping Geng, Sirimas Sudsakorn, David Moore, Ling He, Jan Wahlstrom, Jim Keirns, Rangaraj Narayanan, Dieter Lang, Xiaoqing Yang and International Consortium for Innovation and Quality in Pharmaceutical Development (IQ) Victim Drug-Drug Interactions Working Group
      Drug Metabolism and Disposition August 2016, 44 (8) 1399-1423; DOI: https://doi.org/10.1124/dmd.115.069096
  3. Perloff, Elke S.

    1. You have access
      Selective Time- and NADPH-Dependent Inhibition of Human CYP2E1 by Clomethiazole
      David M. Stresser, Elke S. Perloff, Andrew K. Mason, Andrew P. Blanchard, Shangara S. Dehal, Timothy P. Creegan, Ritu Singh and Eric T. Gangl
      Drug Metabolism and Disposition August 2016, 44 (8) 1424-1430; DOI: https://doi.org/10.1124/dmd.116.070193
  4. Permentier, Hjalmar P.

    1. You have access
      Microbial Flavoprotein Monooxygenases as Mimics of Mammalian Flavin-Containing Monooxygenases for the Enantioselective Preparation of Drug Metabolites
      Turan Gul, Marzena Krzek, Hjalmar P. Permentier, Marco W. Fraaije and Rainer Bischoff
      Drug Metabolism and Disposition August 2016, 44 (8) 1270-1276; DOI: https://doi.org/10.1124/dmd.115.069104
  5. Pham, Roger

    1. You have access
      Nonclinical Pharmacokinetics, Disposition, and Drug-Drug Interaction Potential of a Novel d-Amino Acid Peptide Agonist of the Calcium-Sensing Receptor AMG 416 (Etelcalcetide)
      Raju Subramanian, Xiaochun Zhu, Savannah J. Kerr, Joel D. Esmay, Steven W. Louie, Katheryne Z. Edson, Sarah Walter, Michael Fitzsimmons, Mylo Wagner, Marcus Soto, Roger Pham, Sarah F. Wilson and Gary L. Skiles
      Drug Metabolism and Disposition August 2016, 44 (8) 1319-1331; DOI: https://doi.org/10.1124/dmd.115.068007
  6. Pichette, Vincent

    1. You have access
      Effects of Chronic Renal Failure on Brain Cytochrome P450 in Rats
      Judith Naud, Jessica Harding, Caroline Lamarche, Stephanie Beauchemin, Francois A. Leblond and Vincent Pichette
      Drug Metabolism and Disposition August 2016, 44 (8) 1174-1179; DOI: https://doi.org/10.1124/dmd.116.070052
  7. Pickup, Kathryn

    1. You have access
      Metabolic Disposition of Osimertinib in Rats, Dogs, and Humans: Insights into a Drug Designed to Bind Covalently to a Cysteine Residue of Epidermal Growth Factor Receptor
      Paul A. Dickinson, Mireille V. Cantarini, Jo Collier, Paul Frewer, Scott Martin, Kathryn Pickup and Peter Ballard
      Drug Metabolism and Disposition August 2016, 44 (8) 1201-1212; DOI: https://doi.org/10.1124/dmd.115.069203

Q

  1. Qiao, Hai-Ling

    1. Open Access
      Correlation of Cytochrome P450 Oxidoreductase Expression with the Expression of 10 Isoforms of Cytochrome P450 in Human Liver
      Hai-Feng Zhang, Zhi-Hui Li, Jia-Yu Liu, Ting-Ting Liu, Ping Wang, Yan Fang, Jun Zhou, Ming-Zhu Cui, Na Gao, Xin Tian, Jie Gao, Qiang Wen, Lin-Jing Jia and Hai-Ling Qiao
      Drug Metabolism and Disposition August 2016, 44 (8) 1193-1200; DOI: https://doi.org/10.1124/dmd.116.069849

R

  1. Reed, Aimee

    1. You have access
      Metabolism and Disposition of the Hepatitis C Protease Inhibitor Paritaprevir in Humans
      Jianwei Shen, Michael Serby, Aimee Reed, Anthony J. Lee, Xiaomei Zhang, Kennan Marsh, Amit Khatri, Rajeev Menon, Olga Kavetskaia and Volker Fischer
      Drug Metabolism and Disposition August 2016, 44 (8) 1164-1173; DOI: https://doi.org/10.1124/dmd.115.067488
    2. You have access
      Metabolism and Disposition of Hepatitis C Polymerase Inhibitor Dasabuvir in Humans
      Jianwei Shen, Michael Serby, Aimee Reed, Anthony J. Lee, Rajeev Menon, Xiaomei Zhang, Kennan Marsh, Xia Wan, Olga Kavetskaia and Volker Fischer
      Drug Metabolism and Disposition August 2016, 44 (8) 1139-1147; DOI: https://doi.org/10.1124/dmd.115.067512
  2. Romão, Maria João

    1. You have access
      Optimization of the Expression of Human Aldehyde Oxidase for Investigations of Single-Nucleotide Polymorphisms
      Alessandro Foti, Tobias Hartmann, Catarina Coelho, Teresa Santos-Silva, Maria João Romão and Silke Leimkühler
      Drug Metabolism and Disposition August 2016, 44 (8) 1277-1285; DOI: https://doi.org/10.1124/dmd.115.068395
  3. Ronseaux, Sebastien

    1. You have access
      Application of Osmotic Pumps for Sustained Release of 1-Aminobenzotriazole and Inhibition of Cytochrome P450 Enzymes in Mice: Model Comparison with the Hepatic P450 Reductase Null Mouse
      Rowan A. Stringer, Suzie Ferreira, Jonathan Rose and Sebastien Ronseaux
      Drug Metabolism and Disposition August 2016, 44 (8) 1213-1216; DOI: https://doi.org/10.1124/dmd.116.070151
  4. Rose, Jonathan

    1. You have access
      Application of Osmotic Pumps for Sustained Release of 1-Aminobenzotriazole and Inhibition of Cytochrome P450 Enzymes in Mice: Model Comparison with the Hepatic P450 Reductase Null Mouse
      Rowan A. Stringer, Suzie Ferreira, Jonathan Rose and Sebastien Ronseaux
      Drug Metabolism and Disposition August 2016, 44 (8) 1213-1216; DOI: https://doi.org/10.1124/dmd.116.070151
  5. Rougée, Luc R. A.

    1. You have access
      Difference in the Pharmacokinetics and Hepatic Metabolism of Antidiabetic Drugs in Zucker Diabetic Fatty and Sprague-Dawley Rats
      Xin Zhou, Luc R. A. Rougée, David W. Bedwell, Jeff W. Cramer, Michael A. Mohutsky, Nathan A. Calvert, Richard D. Moulton, Kenneth C. Cassidy, Nathan P. Yumibe, Lisa A. Adams and Kenneth J. Ruterbories
      Drug Metabolism and Disposition August 2016, 44 (8) 1184-1192; DOI: https://doi.org/10.1124/dmd.116.070623
  6. Ruggeri, Roger B.

    1. You have access
      Species Differences in the Oxidative Desulfurization of a Thiouracil-Based Irreversible Myeloperoxidase Inactivator by Flavin-Containing Monooxygenase Enzymes
      Heather Eng, Raman Sharma, Angela Wolford, Li Di, Roger B. Ruggeri, Leonard Buckbinder, Edward L. Conn, Deepak K. Dalvie and Amit S. Kalgutkar
      Drug Metabolism and Disposition August 2016, 44 (8) 1262-1269; DOI: https://doi.org/10.1124/dmd.116.070185
  7. Runge-Morris, Melissa

    1. You have access
      Transcriptional Regulation of Cytosolic Sulfotransferase 1C2 by Vitamin D Receptor in LS180 Human Colorectal Adenocarcinoma Cells
      Kathleen G. Barrett, Hailin Fang, Thomas A. Kocarek and Melissa Runge-Morris
      Drug Metabolism and Disposition August 2016, 44 (8) 1431-1434; DOI: https://doi.org/10.1124/dmd.116.070300
  8. Ruterbories, Kenneth J.

    1. You have access
      Difference in the Pharmacokinetics and Hepatic Metabolism of Antidiabetic Drugs in Zucker Diabetic Fatty and Sprague-Dawley Rats
      Xin Zhou, Luc R. A. Rougée, David W. Bedwell, Jeff W. Cramer, Michael A. Mohutsky, Nathan A. Calvert, Richard D. Moulton, Kenneth C. Cassidy, Nathan P. Yumibe, Lisa A. Adams and Kenneth J. Ruterbories
      Drug Metabolism and Disposition August 2016, 44 (8) 1184-1192; DOI: https://doi.org/10.1124/dmd.116.070623

S

  1. Sadgrove, Matthew

    1. You have access
      Biotransformation Capacity of Carboxylesterase in Skin and Keratinocytes for the Penta-Ethyl Ester Prodrug of DTPA
      Jing Fu, Matthew Sadgrove, Lesley Marson and Michael Jay
      Drug Metabolism and Disposition August 2016, 44 (8) 1313-1318; DOI: https://doi.org/10.1124/dmd.116.069377
  2. Santos-Silva, Teresa

    1. You have access
      Optimization of the Expression of Human Aldehyde Oxidase for Investigations of Single-Nucleotide Polymorphisms
      Alessandro Foti, Tobias Hartmann, Catarina Coelho, Teresa Santos-Silva, Maria João Romão and Silke Leimkühler
      Drug Metabolism and Disposition August 2016, 44 (8) 1277-1285; DOI: https://doi.org/10.1124/dmd.115.068395
  3. Saran, Chitra

    1. You have access
      Ocular Metabolism of Levobunolol: Historic and Emerging Metabolic Pathways
      Upendra A. Argikar, Jennifer L. Dumouchel, Christine E. Dunne, Chitra Saran, Amanda L. Cirello and Mithat Gunduz
      Drug Metabolism and Disposition August 2016, 44 (8) 1304-1312; DOI: https://doi.org/10.1124/dmd.116.070458
  4. Satsukawa, Masahiro

    1. You have access
      Establishment of In Silico Prediction Models for CYP3A4 and CYP2B6 Induction in Human Hepatocytes by Multiple Regression Analysis Using Azole Compounds
      Mika Nagai, Yoshihiro Konno, Masahiro Satsukawa, Shinji Yamashita and Kouichi Yoshinari
      Drug Metabolism and Disposition August 2016, 44 (8) 1390-1398; DOI: https://doi.org/10.1124/dmd.115.068619
  5. Serby, Michael

    1. You have access
      Metabolism and Disposition of Pan-Genotypic Inhibitor of Hepatitis C Virus NS5A Ombitasvir in Humans
      Jianwei Shen, Michael Serby, Bruce Surber, Anthony J. Lee, Junli Ma, Prajakta Badri, Rajeev Menon, Olga Kavetskaia, Sonia M. de Morais, Jens Sydor and Volker Fischer
      Drug Metabolism and Disposition August 2016, 44 (8) 1148-1157; DOI: https://doi.org/10.1124/dmd.115.067496
    2. You have access
      Metabolism and Disposition of the Hepatitis C Protease Inhibitor Paritaprevir in Humans
      Jianwei Shen, Michael Serby, Aimee Reed, Anthony J. Lee, Xiaomei Zhang, Kennan Marsh, Amit Khatri, Rajeev Menon, Olga Kavetskaia and Volker Fischer
      Drug Metabolism and Disposition August 2016, 44 (8) 1164-1173; DOI: https://doi.org/10.1124/dmd.115.067488
    3. You have access
      Metabolism and Disposition of Hepatitis C Polymerase Inhibitor Dasabuvir in Humans
      Jianwei Shen, Michael Serby, Aimee Reed, Anthony J. Lee, Rajeev Menon, Xiaomei Zhang, Kennan Marsh, Xia Wan, Olga Kavetskaia and Volker Fischer
      Drug Metabolism and Disposition August 2016, 44 (8) 1139-1147; DOI: https://doi.org/10.1124/dmd.115.067512
  6. Sharma, Raman

    1. You have access
      Species Differences in the Oxidative Desulfurization of a Thiouracil-Based Irreversible Myeloperoxidase Inactivator by Flavin-Containing Monooxygenase Enzymes
      Heather Eng, Raman Sharma, Angela Wolford, Li Di, Roger B. Ruggeri, Leonard Buckbinder, Edward L. Conn, Deepak K. Dalvie and Amit S. Kalgutkar
      Drug Metabolism and Disposition August 2016, 44 (8) 1262-1269; DOI: https://doi.org/10.1124/dmd.116.070185
  7. Shen, Jianwei

    1. You have access
      Metabolism and Disposition of Pan-Genotypic Inhibitor of Hepatitis C Virus NS5A Ombitasvir in Humans
      Jianwei Shen, Michael Serby, Bruce Surber, Anthony J. Lee, Junli Ma, Prajakta Badri, Rajeev Menon, Olga Kavetskaia, Sonia M. de Morais, Jens Sydor and Volker Fischer
      Drug Metabolism and Disposition August 2016, 44 (8) 1148-1157; DOI: https://doi.org/10.1124/dmd.115.067496
    2. You have access
      Metabolism and Disposition of the Hepatitis C Protease Inhibitor Paritaprevir in Humans
      Jianwei Shen, Michael Serby, Aimee Reed, Anthony J. Lee, Xiaomei Zhang, Kennan Marsh, Amit Khatri, Rajeev Menon, Olga Kavetskaia and Volker Fischer
      Drug Metabolism and Disposition August 2016, 44 (8) 1164-1173; DOI: https://doi.org/10.1124/dmd.115.067488
    3. You have access
      Metabolism and Disposition of Hepatitis C Polymerase Inhibitor Dasabuvir in Humans
      Jianwei Shen, Michael Serby, Aimee Reed, Anthony J. Lee, Rajeev Menon, Xiaomei Zhang, Kennan Marsh, Xia Wan, Olga Kavetskaia and Volker Fischer
      Drug Metabolism and Disposition August 2016, 44 (8) 1139-1147; DOI: https://doi.org/10.1124/dmd.115.067512
  8. Shimizu, Hidetada

    1. You have access
      Impact of Experimental Conditions on the Evaluation of Interactions between Multidrug and Toxin Extrusion Proteins and Candidate Drugs
      Christian Lechner, Naoki Ishiguro, Ayano Fukuhara, Hidetada Shimizu, Naoko Ohtsu, Masahito Takatani, Kotaro Nishiyama, Ikumi Washio, Norio Yamamura and Hiroyuki Kusuhara
      Drug Metabolism and Disposition August 2016, 44 (8) 1381-1389; DOI: https://doi.org/10.1124/dmd.115.068163
  9. Singh, Ritu

    1. You have access
      Selective Time- and NADPH-Dependent Inhibition of Human CYP2E1 by Clomethiazole
      David M. Stresser, Elke S. Perloff, Andrew K. Mason, Andrew P. Blanchard, Shangara S. Dehal, Timothy P. Creegan, Ritu Singh and Eric T. Gangl
      Drug Metabolism and Disposition August 2016, 44 (8) 1424-1430; DOI: https://doi.org/10.1124/dmd.116.070193
  10. Sinz, Michael

    1. You have access
      Evaluation of a New Molecular Entity as a Victim of Metabolic Drug-Drug Interactions—an Industry Perspective
      Tonika Bohnert, Aarti Patel, Ian Templeton, Yuan Chen, Chuang Lu, George Lai, Louis Leung, Susanna Tse, Heidi J Einolf, Ying-Hong Wang, Michael Sinz, Ralph Stearns, Robert Walsky, Wanping Geng, Sirimas Sudsakorn, David Moore, Ling He, Jan Wahlstrom, Jim Keirns, Rangaraj Narayanan, Dieter Lang, Xiaoqing Yang and International Consortium for Innovation and Quality in Pharmaceutical Development (IQ) Victim Drug-Drug Interactions Working Group
      Drug Metabolism and Disposition August 2016, 44 (8) 1399-1423; DOI: https://doi.org/10.1124/dmd.115.069096
  11. Skiles, Gary L.

    1. You have access
      Nonclinical Pharmacokinetics, Disposition, and Drug-Drug Interaction Potential of a Novel d-Amino Acid Peptide Agonist of the Calcium-Sensing Receptor AMG 416 (Etelcalcetide)
      Raju Subramanian, Xiaochun Zhu, Savannah J. Kerr, Joel D. Esmay, Steven W. Louie, Katheryne Z. Edson, Sarah Walter, Michael Fitzsimmons, Mylo Wagner, Marcus Soto, Roger Pham, Sarah F. Wilson and Gary L. Skiles
      Drug Metabolism and Disposition August 2016, 44 (8) 1319-1331; DOI: https://doi.org/10.1124/dmd.115.068007
  12. Soars, Matthew G.

    1. You have access
      Phosphocholine Conjugation: An Unexpected In Vivo Conjugation Pathway Associated with Hepatitis C NS5B Inhibitors Featuring A Bicyclo[1.1.1]Pentane
      Xiaoliang Zhuo, Joseph L. Cantone, Yingzi Wang, John E. Leet, Dieter M. Drexler, Kap-Sun Yeung, Xiaohua Stella Huang, Kyle J. Eastman, Kyle E. Parcella, Kathleen W. Mosure, Matthew G. Soars, John F. Kadow and Benjamin M. Johnson
      Drug Metabolism and Disposition August 2016, 44 (8) 1332-1340; DOI: https://doi.org/10.1124/dmd.115.069062
  13. Soto, Marcus

    1. You have access
      Nonclinical Pharmacokinetics, Disposition, and Drug-Drug Interaction Potential of a Novel d-Amino Acid Peptide Agonist of the Calcium-Sensing Receptor AMG 416 (Etelcalcetide)
      Raju Subramanian, Xiaochun Zhu, Savannah J. Kerr, Joel D. Esmay, Steven W. Louie, Katheryne Z. Edson, Sarah Walter, Michael Fitzsimmons, Mylo Wagner, Marcus Soto, Roger Pham, Sarah F. Wilson and Gary L. Skiles
      Drug Metabolism and Disposition August 2016, 44 (8) 1319-1331; DOI: https://doi.org/10.1124/dmd.115.068007
  14. Stearns, Ralph

    1. You have access
      Evaluation of a New Molecular Entity as a Victim of Metabolic Drug-Drug Interactions—an Industry Perspective
      Tonika Bohnert, Aarti Patel, Ian Templeton, Yuan Chen, Chuang Lu, George Lai, Louis Leung, Susanna Tse, Heidi J Einolf, Ying-Hong Wang, Michael Sinz, Ralph Stearns, Robert Walsky, Wanping Geng, Sirimas Sudsakorn, David Moore, Ling He, Jan Wahlstrom, Jim Keirns, Rangaraj Narayanan, Dieter Lang, Xiaoqing Yang and International Consortium for Innovation and Quality in Pharmaceutical Development (IQ) Victim Drug-Drug Interactions Working Group
      Drug Metabolism and Disposition August 2016, 44 (8) 1399-1423; DOI: https://doi.org/10.1124/dmd.115.069096
  15. Stresser, David M.

    1. You have access
      Selective Time- and NADPH-Dependent Inhibition of Human CYP2E1 by Clomethiazole
      David M. Stresser, Elke S. Perloff, Andrew K. Mason, Andrew P. Blanchard, Shangara S. Dehal, Timothy P. Creegan, Ritu Singh and Eric T. Gangl
      Drug Metabolism and Disposition August 2016, 44 (8) 1424-1430; DOI: https://doi.org/10.1124/dmd.116.070193
  16. Stringer, Rowan A.

    1. You have access
      Application of Osmotic Pumps for Sustained Release of 1-Aminobenzotriazole and Inhibition of Cytochrome P450 Enzymes in Mice: Model Comparison with the Hepatic P450 Reductase Null Mouse
      Rowan A. Stringer, Suzie Ferreira, Jonathan Rose and Sebastien Ronseaux
      Drug Metabolism and Disposition August 2016, 44 (8) 1213-1216; DOI: https://doi.org/10.1124/dmd.116.070151
  17. Subramanian, Raju

    1. You have access
      Nonclinical Pharmacokinetics, Disposition, and Drug-Drug Interaction Potential of a Novel d-Amino Acid Peptide Agonist of the Calcium-Sensing Receptor AMG 416 (Etelcalcetide)
      Raju Subramanian, Xiaochun Zhu, Savannah J. Kerr, Joel D. Esmay, Steven W. Louie, Katheryne Z. Edson, Sarah Walter, Michael Fitzsimmons, Mylo Wagner, Marcus Soto, Roger Pham, Sarah F. Wilson and Gary L. Skiles
      Drug Metabolism and Disposition August 2016, 44 (8) 1319-1331; DOI: https://doi.org/10.1124/dmd.115.068007
  18. Sudsakorn, Sirimas

    1. You have access
      Evaluation of a New Molecular Entity as a Victim of Metabolic Drug-Drug Interactions—an Industry Perspective
      Tonika Bohnert, Aarti Patel, Ian Templeton, Yuan Chen, Chuang Lu, George Lai, Louis Leung, Susanna Tse, Heidi J Einolf, Ying-Hong Wang, Michael Sinz, Ralph Stearns, Robert Walsky, Wanping Geng, Sirimas Sudsakorn, David Moore, Ling He, Jan Wahlstrom, Jim Keirns, Rangaraj Narayanan, Dieter Lang, Xiaoqing Yang and International Consortium for Innovation and Quality in Pharmaceutical Development (IQ) Victim Drug-Drug Interactions Working Group
      Drug Metabolism and Disposition August 2016, 44 (8) 1399-1423; DOI: https://doi.org/10.1124/dmd.115.069096
  19. Sugiura, Masayuki

    1. You have access
      Recommendation to Exclude Bile-Duct-Cannulated Rats with Hyperbilirubinemia for Proper Conduct of Biliary Drug Excretion Studies
      Koji Kato, Yoshitaka Hasegawa, Katsuya Iwata, Takuya Ichikawa, Tohru Yahara, Satoshi Tsuji, Masayuki Sugiura and Jun-ichi Yamaguchi
      Drug Metabolism and Disposition August 2016, 44 (8) 1180-1183; DOI: https://doi.org/10.1124/dmd.116.070532
  20. Surber, Bruce

    1. You have access
      Metabolism and Disposition of Pan-Genotypic Inhibitor of Hepatitis C Virus NS5A Ombitasvir in Humans
      Jianwei Shen, Michael Serby, Bruce Surber, Anthony J. Lee, Junli Ma, Prajakta Badri, Rajeev Menon, Olga Kavetskaia, Sonia M. de Morais, Jens Sydor and Volker Fischer
      Drug Metabolism and Disposition August 2016, 44 (8) 1148-1157; DOI: https://doi.org/10.1124/dmd.115.067496
  21. Sydor, Jens

    1. You have access
      Metabolism and Disposition of Pan-Genotypic Inhibitor of Hepatitis C Virus NS5A Ombitasvir in Humans
      Jianwei Shen, Michael Serby, Bruce Surber, Anthony J. Lee, Junli Ma, Prajakta Badri, Rajeev Menon, Olga Kavetskaia, Sonia M. de Morais, Jens Sydor and Volker Fischer
      Drug Metabolism and Disposition August 2016, 44 (8) 1148-1157; DOI: https://doi.org/10.1124/dmd.115.067496

T

  1. Takatani, Masahito

    1. You have access
      Impact of Experimental Conditions on the Evaluation of Interactions between Multidrug and Toxin Extrusion Proteins and Candidate Drugs
      Christian Lechner, Naoki Ishiguro, Ayano Fukuhara, Hidetada Shimizu, Naoko Ohtsu, Masahito Takatani, Kotaro Nishiyama, Ikumi Washio, Norio Yamamura and Hiroyuki Kusuhara
      Drug Metabolism and Disposition August 2016, 44 (8) 1381-1389; DOI: https://doi.org/10.1124/dmd.115.068163
  2. Tanuma, Nobuaki

    1. You have access
      Differences in Gene Regulation by Dual Ligands of Nuclear Receptors Constitutive Androstane Receptor (CAR) and Pregnane X Receptor (PXR) in HepG2 Cells Stably Expressing CAR/PXR
      Yuichiro Kanno, Nobuaki Tanuma, Saki Yazawa, Shuai Zhao, Miki Inaba, Satoshi Nakamura, Kiyomitsu Nemoto and Yoshio Inouye
      Drug Metabolism and Disposition August 2016, 44 (8) 1158-1163; DOI: https://doi.org/10.1124/dmd.116.070888
  3. Templeton, Ian

    1. You have access
      Evaluation of a New Molecular Entity as a Victim of Metabolic Drug-Drug Interactions—an Industry Perspective
      Tonika Bohnert, Aarti Patel, Ian Templeton, Yuan Chen, Chuang Lu, George Lai, Louis Leung, Susanna Tse, Heidi J Einolf, Ying-Hong Wang, Michael Sinz, Ralph Stearns, Robert Walsky, Wanping Geng, Sirimas Sudsakorn, David Moore, Ling He, Jan Wahlstrom, Jim Keirns, Rangaraj Narayanan, Dieter Lang, Xiaoqing Yang and International Consortium for Innovation and Quality in Pharmaceutical Development (IQ) Victim Drug-Drug Interactions Working Group
      Drug Metabolism and Disposition August 2016, 44 (8) 1399-1423; DOI: https://doi.org/10.1124/dmd.115.069096
  4. Tian, Xin

    1. Open Access
      Correlation of Cytochrome P450 Oxidoreductase Expression with the Expression of 10 Isoforms of Cytochrome P450 in Human Liver
      Hai-Feng Zhang, Zhi-Hui Li, Jia-Yu Liu, Ting-Ting Liu, Ping Wang, Yan Fang, Jun Zhou, Ming-Zhu Cui, Na Gao, Xin Tian, Jie Gao, Qiang Wen, Lin-Jing Jia and Hai-Ling Qiao
      Drug Metabolism and Disposition August 2016, 44 (8) 1193-1200; DOI: https://doi.org/10.1124/dmd.116.069849
  5. Tornio, Aleksi

    1. You have access
      Clopidogrel Markedly Increases Plasma Concentrations of CYP2C8 Substrate Pioglitazone
      Matti K. Itkonen, Aleksi Tornio, Mikko Neuvonen, Pertti J. Neuvonen, Mikko Niemi and Janne T. Backman
      Drug Metabolism and Disposition August 2016, 44 (8) 1364-1371; DOI: https://doi.org/10.1124/dmd.116.070375
  6. Tsao, Hong

    1. You have access
      VX-509 (Decernotinib)-Mediated CYP3A Time-Dependent Inhibition: An Aldehyde Oxidase Metabolite as a Perpetrator of Drug-Drug Interactions
      Craig Zetterberg, Francois Maltais, Leena Laitinen, Shengkai Liao, Hong Tsao, Ananthsrinivas Chakilam and Niresh Hariparsad
      Drug Metabolism and Disposition August 2016, 44 (8) 1286-1295; DOI: https://doi.org/10.1124/dmd.116.071100
  7. Tse, Susanna

    1. You have access
      Evaluation of a New Molecular Entity as a Victim of Metabolic Drug-Drug Interactions—an Industry Perspective
      Tonika Bohnert, Aarti Patel, Ian Templeton, Yuan Chen, Chuang Lu, George Lai, Louis Leung, Susanna Tse, Heidi J Einolf, Ying-Hong Wang, Michael Sinz, Ralph Stearns, Robert Walsky, Wanping Geng, Sirimas Sudsakorn, David Moore, Ling He, Jan Wahlstrom, Jim Keirns, Rangaraj Narayanan, Dieter Lang, Xiaoqing Yang and International Consortium for Innovation and Quality in Pharmaceutical Development (IQ) Victim Drug-Drug Interactions Working Group
      Drug Metabolism and Disposition August 2016, 44 (8) 1399-1423; DOI: https://doi.org/10.1124/dmd.115.069096
  8. Tsuji, Satoshi

    1. You have access
      Recommendation to Exclude Bile-Duct-Cannulated Rats with Hyperbilirubinemia for Proper Conduct of Biliary Drug Excretion Studies
      Koji Kato, Yoshitaka Hasegawa, Katsuya Iwata, Takuya Ichikawa, Tohru Yahara, Satoshi Tsuji, Masayuki Sugiura and Jun-ichi Yamaguchi
      Drug Metabolism and Disposition August 2016, 44 (8) 1180-1183; DOI: https://doi.org/10.1124/dmd.116.070532

W

  1. Wagner, Mylo

    1. You have access
      Nonclinical Pharmacokinetics, Disposition, and Drug-Drug Interaction Potential of a Novel d-Amino Acid Peptide Agonist of the Calcium-Sensing Receptor AMG 416 (Etelcalcetide)
      Raju Subramanian, Xiaochun Zhu, Savannah J. Kerr, Joel D. Esmay, Steven W. Louie, Katheryne Z. Edson, Sarah Walter, Michael Fitzsimmons, Mylo Wagner, Marcus Soto, Roger Pham, Sarah F. Wilson and Gary L. Skiles
      Drug Metabolism and Disposition August 2016, 44 (8) 1319-1331; DOI: https://doi.org/10.1124/dmd.115.068007
  2. Wahlstrom, Jan

    1. You have access
      Evaluation of a New Molecular Entity as a Victim of Metabolic Drug-Drug Interactions—an Industry Perspective
      Tonika Bohnert, Aarti Patel, Ian Templeton, Yuan Chen, Chuang Lu, George Lai, Louis Leung, Susanna Tse, Heidi J Einolf, Ying-Hong Wang, Michael Sinz, Ralph Stearns, Robert Walsky, Wanping Geng, Sirimas Sudsakorn, David Moore, Ling He, Jan Wahlstrom, Jim Keirns, Rangaraj Narayanan, Dieter Lang, Xiaoqing Yang and International Consortium for Innovation and Quality in Pharmaceutical Development (IQ) Victim Drug-Drug Interactions Working Group
      Drug Metabolism and Disposition August 2016, 44 (8) 1399-1423; DOI: https://doi.org/10.1124/dmd.115.069096
  3. Walsky, Robert

    1. You have access
      Evaluation of a New Molecular Entity as a Victim of Metabolic Drug-Drug Interactions—an Industry Perspective
      Tonika Bohnert, Aarti Patel, Ian Templeton, Yuan Chen, Chuang Lu, George Lai, Louis Leung, Susanna Tse, Heidi J Einolf, Ying-Hong Wang, Michael Sinz, Ralph Stearns, Robert Walsky, Wanping Geng, Sirimas Sudsakorn, David Moore, Ling He, Jan Wahlstrom, Jim Keirns, Rangaraj Narayanan, Dieter Lang, Xiaoqing Yang and International Consortium for Innovation and Quality in Pharmaceutical Development (IQ) Victim Drug-Drug Interactions Working Group
      Drug Metabolism and Disposition August 2016, 44 (8) 1399-1423; DOI: https://doi.org/10.1124/dmd.115.069096
  4. Walter, Sarah

    1. You have access
      Nonclinical Pharmacokinetics, Disposition, and Drug-Drug Interaction Potential of a Novel d-Amino Acid Peptide Agonist of the Calcium-Sensing Receptor AMG 416 (Etelcalcetide)
      Raju Subramanian, Xiaochun Zhu, Savannah J. Kerr, Joel D. Esmay, Steven W. Louie, Katheryne Z. Edson, Sarah Walter, Michael Fitzsimmons, Mylo Wagner, Marcus Soto, Roger Pham, Sarah F. Wilson and Gary L. Skiles
      Drug Metabolism and Disposition August 2016, 44 (8) 1319-1331; DOI: https://doi.org/10.1124/dmd.115.068007
  5. Wan, Xia

    1. You have access
      Metabolism and Disposition of Hepatitis C Polymerase Inhibitor Dasabuvir in Humans
      Jianwei Shen, Michael Serby, Aimee Reed, Anthony J. Lee, Rajeev Menon, Xiaomei Zhang, Kennan Marsh, Xia Wan, Olga Kavetskaia and Volker Fischer
      Drug Metabolism and Disposition August 2016, 44 (8) 1139-1147; DOI: https://doi.org/10.1124/dmd.115.067512
  6. Wang, Ping

    1. Open Access
      Correlation of Cytochrome P450 Oxidoreductase Expression with the Expression of 10 Isoforms of Cytochrome P450 in Human Liver
      Hai-Feng Zhang, Zhi-Hui Li, Jia-Yu Liu, Ting-Ting Liu, Ping Wang, Yan Fang, Jun Zhou, Ming-Zhu Cui, Na Gao, Xin Tian, Jie Gao, Qiang Wen, Lin-Jing Jia and Hai-Ling Qiao
      Drug Metabolism and Disposition August 2016, 44 (8) 1193-1200; DOI: https://doi.org/10.1124/dmd.116.069849
  7. Wang, Ying-Hong

    1. You have access
      Evaluation of a New Molecular Entity as a Victim of Metabolic Drug-Drug Interactions—an Industry Perspective
      Tonika Bohnert, Aarti Patel, Ian Templeton, Yuan Chen, Chuang Lu, George Lai, Louis Leung, Susanna Tse, Heidi J Einolf, Ying-Hong Wang, Michael Sinz, Ralph Stearns, Robert Walsky, Wanping Geng, Sirimas Sudsakorn, David Moore, Ling He, Jan Wahlstrom, Jim Keirns, Rangaraj Narayanan, Dieter Lang, Xiaoqing Yang and International Consortium for Innovation and Quality in Pharmaceutical Development (IQ) Victim Drug-Drug Interactions Working Group
      Drug Metabolism and Disposition August 2016, 44 (8) 1399-1423; DOI: https://doi.org/10.1124/dmd.115.069096
  8. Wang, Yingzi

    1. You have access
      Phosphocholine Conjugation: An Unexpected In Vivo Conjugation Pathway Associated with Hepatitis C NS5B Inhibitors Featuring A Bicyclo[1.1.1]Pentane
      Xiaoliang Zhuo, Joseph L. Cantone, Yingzi Wang, John E. Leet, Dieter M. Drexler, Kap-Sun Yeung, Xiaohua Stella Huang, Kyle J. Eastman, Kyle E. Parcella, Kathleen W. Mosure, Matthew G. Soars, John F. Kadow and Benjamin M. Johnson
      Drug Metabolism and Disposition August 2016, 44 (8) 1332-1340; DOI: https://doi.org/10.1124/dmd.115.069062
  9. Washio, Ikumi

    1. You have access
      Impact of Experimental Conditions on the Evaluation of Interactions between Multidrug and Toxin Extrusion Proteins and Candidate Drugs
      Christian Lechner, Naoki Ishiguro, Ayano Fukuhara, Hidetada Shimizu, Naoko Ohtsu, Masahito Takatani, Kotaro Nishiyama, Ikumi Washio, Norio Yamamura and Hiroyuki Kusuhara
      Drug Metabolism and Disposition August 2016, 44 (8) 1381-1389; DOI: https://doi.org/10.1124/dmd.115.068163
  10. Weidolf, Lars

    1. Discovery of a Novel Microsomal Epoxide Hydrolase–Catalyzed Hydration of a Spiro Oxetane
      You have access
      Discovery of a Novel Microsomal Epoxide Hydrolase–Catalyzed Hydration of a Spiro Oxetane
      Xue-Qing Li, Martin A. Hayes, Gunnar Grönberg, Kristina Berggren, Neal Castagnoli and Lars Weidolf
      Drug Metabolism and Disposition August 2016, 44 (8) 1341-1348; DOI: https://doi.org/10.1124/dmd.116.071142
  11. Wen, Qiang

    1. Open Access
      Correlation of Cytochrome P450 Oxidoreductase Expression with the Expression of 10 Isoforms of Cytochrome P450 in Human Liver
      Hai-Feng Zhang, Zhi-Hui Li, Jia-Yu Liu, Ting-Ting Liu, Ping Wang, Yan Fang, Jun Zhou, Ming-Zhu Cui, Na Gao, Xin Tian, Jie Gao, Qiang Wen, Lin-Jing Jia and Hai-Ling Qiao
      Drug Metabolism and Disposition August 2016, 44 (8) 1193-1200; DOI: https://doi.org/10.1124/dmd.116.069849
  12. Wilson, Sarah F.

    1. You have access
      Nonclinical Pharmacokinetics, Disposition, and Drug-Drug Interaction Potential of a Novel d-Amino Acid Peptide Agonist of the Calcium-Sensing Receptor AMG 416 (Etelcalcetide)
      Raju Subramanian, Xiaochun Zhu, Savannah J. Kerr, Joel D. Esmay, Steven W. Louie, Katheryne Z. Edson, Sarah Walter, Michael Fitzsimmons, Mylo Wagner, Marcus Soto, Roger Pham, Sarah F. Wilson and Gary L. Skiles
      Drug Metabolism and Disposition August 2016, 44 (8) 1319-1331; DOI: https://doi.org/10.1124/dmd.115.068007
  13. Wisnewski, Adam V.

    1. You have access
      Biotransformation and Rearrangement of Laromustine
      Alaa-Eldin F. Nassar, Adam V. Wisnewski and Ivan King
      Drug Metabolism and Disposition August 2016, 44 (8) 1349-1363; DOI: https://doi.org/10.1124/dmd.116.069823
  14. Wolford, Angela

    1. You have access
      Species Differences in the Oxidative Desulfurization of a Thiouracil-Based Irreversible Myeloperoxidase Inactivator by Flavin-Containing Monooxygenase Enzymes
      Heather Eng, Raman Sharma, Angela Wolford, Li Di, Roger B. Ruggeri, Leonard Buckbinder, Edward L. Conn, Deepak K. Dalvie and Amit S. Kalgutkar
      Drug Metabolism and Disposition August 2016, 44 (8) 1262-1269; DOI: https://doi.org/10.1124/dmd.116.070185

Y

  1. Yahara, Tohru

    1. You have access
      Recommendation to Exclude Bile-Duct-Cannulated Rats with Hyperbilirubinemia for Proper Conduct of Biliary Drug Excretion Studies
      Koji Kato, Yoshitaka Hasegawa, Katsuya Iwata, Takuya Ichikawa, Tohru Yahara, Satoshi Tsuji, Masayuki Sugiura and Jun-ichi Yamaguchi
      Drug Metabolism and Disposition August 2016, 44 (8) 1180-1183; DOI: https://doi.org/10.1124/dmd.116.070532
  2. Yamaguchi, Jun-ichi

    1. You have access
      Recommendation to Exclude Bile-Duct-Cannulated Rats with Hyperbilirubinemia for Proper Conduct of Biliary Drug Excretion Studies
      Koji Kato, Yoshitaka Hasegawa, Katsuya Iwata, Takuya Ichikawa, Tohru Yahara, Satoshi Tsuji, Masayuki Sugiura and Jun-ichi Yamaguchi
      Drug Metabolism and Disposition August 2016, 44 (8) 1180-1183; DOI: https://doi.org/10.1124/dmd.116.070532
  3. Yamamura, Norio

    1. You have access
      Impact of Experimental Conditions on the Evaluation of Interactions between Multidrug and Toxin Extrusion Proteins and Candidate Drugs
      Christian Lechner, Naoki Ishiguro, Ayano Fukuhara, Hidetada Shimizu, Naoko Ohtsu, Masahito Takatani, Kotaro Nishiyama, Ikumi Washio, Norio Yamamura and Hiroyuki Kusuhara
      Drug Metabolism and Disposition August 2016, 44 (8) 1381-1389; DOI: https://doi.org/10.1124/dmd.115.068163
  4. Yamashita, Shinji

    1. You have access
      Establishment of In Silico Prediction Models for CYP3A4 and CYP2B6 Induction in Human Hepatocytes by Multiple Regression Analysis Using Azole Compounds
      Mika Nagai, Yoshihiro Konno, Masahiro Satsukawa, Shinji Yamashita and Kouichi Yoshinari
      Drug Metabolism and Disposition August 2016, 44 (8) 1390-1398; DOI: https://doi.org/10.1124/dmd.115.068619
  5. Yang, Xiaoqing

    1. You have access
      Evaluation of a New Molecular Entity as a Victim of Metabolic Drug-Drug Interactions—an Industry Perspective
      Tonika Bohnert, Aarti Patel, Ian Templeton, Yuan Chen, Chuang Lu, George Lai, Louis Leung, Susanna Tse, Heidi J Einolf, Ying-Hong Wang, Michael Sinz, Ralph Stearns, Robert Walsky, Wanping Geng, Sirimas Sudsakorn, David Moore, Ling He, Jan Wahlstrom, Jim Keirns, Rangaraj Narayanan, Dieter Lang, Xiaoqing Yang and International Consortium for Innovation and Quality in Pharmaceutical Development (IQ) Victim Drug-Drug Interactions Working Group
      Drug Metabolism and Disposition August 2016, 44 (8) 1399-1423; DOI: https://doi.org/10.1124/dmd.115.069096
  6. Yazawa, Saki

    1. You have access
      Differences in Gene Regulation by Dual Ligands of Nuclear Receptors Constitutive Androstane Receptor (CAR) and Pregnane X Receptor (PXR) in HepG2 Cells Stably Expressing CAR/PXR
      Yuichiro Kanno, Nobuaki Tanuma, Saki Yazawa, Shuai Zhao, Miki Inaba, Satoshi Nakamura, Kiyomitsu Nemoto and Yoshio Inouye
      Drug Metabolism and Disposition August 2016, 44 (8) 1158-1163; DOI: https://doi.org/10.1124/dmd.116.070888
  7. Yeung, Kap-Sun

    1. You have access
      Phosphocholine Conjugation: An Unexpected In Vivo Conjugation Pathway Associated with Hepatitis C NS5B Inhibitors Featuring A Bicyclo[1.1.1]Pentane
      Xiaoliang Zhuo, Joseph L. Cantone, Yingzi Wang, John E. Leet, Dieter M. Drexler, Kap-Sun Yeung, Xiaohua Stella Huang, Kyle J. Eastman, Kyle E. Parcella, Kathleen W. Mosure, Matthew G. Soars, John F. Kadow and Benjamin M. Johnson
      Drug Metabolism and Disposition August 2016, 44 (8) 1332-1340; DOI: https://doi.org/10.1124/dmd.115.069062
  8. Yoshinari, Kouichi

    1. You have access
      Establishment of In Silico Prediction Models for CYP3A4 and CYP2B6 Induction in Human Hepatocytes by Multiple Regression Analysis Using Azole Compounds
      Mika Nagai, Yoshihiro Konno, Masahiro Satsukawa, Shinji Yamashita and Kouichi Yoshinari
      Drug Metabolism and Disposition August 2016, 44 (8) 1390-1398; DOI: https://doi.org/10.1124/dmd.115.068619
  9. Yumibe, Nathan P.

    1. You have access
      Difference in the Pharmacokinetics and Hepatic Metabolism of Antidiabetic Drugs in Zucker Diabetic Fatty and Sprague-Dawley Rats
      Xin Zhou, Luc R. A. Rougée, David W. Bedwell, Jeff W. Cramer, Michael A. Mohutsky, Nathan A. Calvert, Richard D. Moulton, Kenneth C. Cassidy, Nathan P. Yumibe, Lisa A. Adams and Kenneth J. Ruterbories
      Drug Metabolism and Disposition August 2016, 44 (8) 1184-1192; DOI: https://doi.org/10.1124/dmd.116.070623

Z

  1. Zetterberg, Craig

    1. You have access
      VX-509 (Decernotinib)-Mediated CYP3A Time-Dependent Inhibition: An Aldehyde Oxidase Metabolite as a Perpetrator of Drug-Drug Interactions
      Craig Zetterberg, Francois Maltais, Leena Laitinen, Shengkai Liao, Hong Tsao, Ananthsrinivas Chakilam and Niresh Hariparsad
      Drug Metabolism and Disposition August 2016, 44 (8) 1286-1295; DOI: https://doi.org/10.1124/dmd.116.071100
  2. Zhang, Donglu

    1. You have access
      Going Beyond Common Drug Metabolizing Enzymes: Case Studies of Biotransformation Involving Aldehyde Oxidase, γ-Glutamyl Transpeptidase, Cathepsin B, Flavin-Containing Monooxygenase, and ADP-Ribosyltransferase
      Peter W. Fan, Donglu Zhang, Jason S. Halladay, James P. Driscoll and S. Cyrus Khojasteh
      Drug Metabolism and Disposition August 2016, 44 (8) 1253-1261; DOI: https://doi.org/10.1124/dmd.116.070169
  3. Zhang, Hai-Feng

    1. Open Access
      Correlation of Cytochrome P450 Oxidoreductase Expression with the Expression of 10 Isoforms of Cytochrome P450 in Human Liver
      Hai-Feng Zhang, Zhi-Hui Li, Jia-Yu Liu, Ting-Ting Liu, Ping Wang, Yan Fang, Jun Zhou, Ming-Zhu Cui, Na Gao, Xin Tian, Jie Gao, Qiang Wen, Lin-Jing Jia and Hai-Ling Qiao
      Drug Metabolism and Disposition August 2016, 44 (8) 1193-1200; DOI: https://doi.org/10.1124/dmd.116.069849
  4. Zhang, Xiaomei

    1. You have access
      Metabolism and Disposition of the Hepatitis C Protease Inhibitor Paritaprevir in Humans
      Jianwei Shen, Michael Serby, Aimee Reed, Anthony J. Lee, Xiaomei Zhang, Kennan Marsh, Amit Khatri, Rajeev Menon, Olga Kavetskaia and Volker Fischer
      Drug Metabolism and Disposition August 2016, 44 (8) 1164-1173; DOI: https://doi.org/10.1124/dmd.115.067488
    2. You have access
      Metabolism and Disposition of Hepatitis C Polymerase Inhibitor Dasabuvir in Humans
      Jianwei Shen, Michael Serby, Aimee Reed, Anthony J. Lee, Rajeev Menon, Xiaomei Zhang, Kennan Marsh, Xia Wan, Olga Kavetskaia and Volker Fischer
      Drug Metabolism and Disposition August 2016, 44 (8) 1139-1147; DOI: https://doi.org/10.1124/dmd.115.067512
  5. Zhao, Shuai

    1. You have access
      Differences in Gene Regulation by Dual Ligands of Nuclear Receptors Constitutive Androstane Receptor (CAR) and Pregnane X Receptor (PXR) in HepG2 Cells Stably Expressing CAR/PXR
      Yuichiro Kanno, Nobuaki Tanuma, Saki Yazawa, Shuai Zhao, Miki Inaba, Satoshi Nakamura, Kiyomitsu Nemoto and Yoshio Inouye
      Drug Metabolism and Disposition August 2016, 44 (8) 1158-1163; DOI: https://doi.org/10.1124/dmd.116.070888
  6. Zhou, Jun

    1. Open Access
      Correlation of Cytochrome P450 Oxidoreductase Expression with the Expression of 10 Isoforms of Cytochrome P450 in Human Liver
      Hai-Feng Zhang, Zhi-Hui Li, Jia-Yu Liu, Ting-Ting Liu, Ping Wang, Yan Fang, Jun Zhou, Ming-Zhu Cui, Na Gao, Xin Tian, Jie Gao, Qiang Wen, Lin-Jing Jia and Hai-Ling Qiao
      Drug Metabolism and Disposition August 2016, 44 (8) 1193-1200; DOI: https://doi.org/10.1124/dmd.116.069849
  7. Zhou, Xin

    1. You have access
      Difference in the Pharmacokinetics and Hepatic Metabolism of Antidiabetic Drugs in Zucker Diabetic Fatty and Sprague-Dawley Rats
      Xin Zhou, Luc R. A. Rougée, David W. Bedwell, Jeff W. Cramer, Michael A. Mohutsky, Nathan A. Calvert, Richard D. Moulton, Kenneth C. Cassidy, Nathan P. Yumibe, Lisa A. Adams and Kenneth J. Ruterbories
      Drug Metabolism and Disposition August 2016, 44 (8) 1184-1192; DOI: https://doi.org/10.1124/dmd.116.070623
  8. Zhu, Xiaochun

    1. You have access
      Nonclinical Pharmacokinetics, Disposition, and Drug-Drug Interaction Potential of a Novel d-Amino Acid Peptide Agonist of the Calcium-Sensing Receptor AMG 416 (Etelcalcetide)
      Raju Subramanian, Xiaochun Zhu, Savannah J. Kerr, Joel D. Esmay, Steven W. Louie, Katheryne Z. Edson, Sarah Walter, Michael Fitzsimmons, Mylo Wagner, Marcus Soto, Roger Pham, Sarah F. Wilson and Gary L. Skiles
      Drug Metabolism and Disposition August 2016, 44 (8) 1319-1331; DOI: https://doi.org/10.1124/dmd.115.068007
  9. Zhuo, Xiaoliang

    1. You have access
      Phosphocholine Conjugation: An Unexpected In Vivo Conjugation Pathway Associated with Hepatitis C NS5B Inhibitors Featuring A Bicyclo[1.1.1]Pentane
      Xiaoliang Zhuo, Joseph L. Cantone, Yingzi Wang, John E. Leet, Dieter M. Drexler, Kap-Sun Yeung, Xiaohua Stella Huang, Kyle J. Eastman, Kyle E. Parcella, Kathleen W. Mosure, Matthew G. Soars, John F. Kadow and Benjamin M. Johnson
      Drug Metabolism and Disposition August 2016, 44 (8) 1332-1340; DOI: https://doi.org/10.1124/dmd.115.069062
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Drug Metabolism and Disposition: 44 (8)
Drug Metabolism and Disposition
Vol. 44, Issue 8
1 Aug 2016
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