Index by author
August 01, 2016; Volume 44,Issue 8
A
Adams, Lisa A.
- You have accessDifference in the Pharmacokinetics and Hepatic Metabolism of Antidiabetic Drugs in Zucker Diabetic Fatty and Sprague-Dawley RatsXin Zhou, Luc R. A. Rougée, David W. Bedwell, Jeff W. Cramer, Michael A. Mohutsky, Nathan A. Calvert, Richard D. Moulton, Kenneth C. Cassidy, Nathan P. Yumibe, Lisa A. Adams and Kenneth J. RuterboriesDrug Metabolism and Disposition August 2016, 44 (8) 1184-1192; DOI: https://doi.org/10.1124/dmd.116.070623
Argikar, Upendra A.
- You have accessOcular Metabolism of Levobunolol: Historic and Emerging Metabolic PathwaysUpendra A. Argikar, Jennifer L. Dumouchel, Christine E. Dunne, Chitra Saran, Amanda L. Cirello and Mithat GunduzDrug Metabolism and Disposition August 2016, 44 (8) 1304-1312; DOI: https://doi.org/10.1124/dmd.116.070458
B
Backman, Janne T.
- You have accessClopidogrel Markedly Increases Plasma Concentrations of CYP2C8 Substrate PioglitazoneMatti K. Itkonen, Aleksi Tornio, Mikko Neuvonen, Pertti J. Neuvonen, Mikko Niemi and Janne T. BackmanDrug Metabolism and Disposition August 2016, 44 (8) 1364-1371; DOI: https://doi.org/10.1124/dmd.116.070375
Badri, Prajakta
- You have accessMetabolism and Disposition of Pan-Genotypic Inhibitor of Hepatitis C Virus NS5A Ombitasvir in HumansJianwei Shen, Michael Serby, Bruce Surber, Anthony J. Lee, Junli Ma, Prajakta Badri, Rajeev Menon, Olga Kavetskaia, Sonia M. de Morais, Jens Sydor and Volker FischerDrug Metabolism and Disposition August 2016, 44 (8) 1148-1157; DOI: https://doi.org/10.1124/dmd.115.067496
Baker, James A.
- You have accessA Pharmacokinetic Modeling Approach to Predict the Contribution of Active Metabolites to Human Efficacious DoseIain J. Martin, Susan E. Hill, James A. Baker, Sujal V. Deshmukh and Erin F. MulrooneyDrug Metabolism and Disposition August 2016, 44 (8) 1435-1440; DOI: https://doi.org/10.1124/dmd.116.070391
Ballard, Peter
- You have accessMetabolic Disposition of Osimertinib in Rats, Dogs, and Humans: Insights into a Drug Designed to Bind Covalently to a Cysteine Residue of Epidermal Growth Factor ReceptorPaul A. Dickinson, Mireille V. Cantarini, Jo Collier, Paul Frewer, Scott Martin, Kathryn Pickup and Peter BallardDrug Metabolism and Disposition August 2016, 44 (8) 1201-1212; DOI: https://doi.org/10.1124/dmd.115.069203
Barrett, Kathleen G.
- You have accessTranscriptional Regulation of Cytosolic Sulfotransferase 1C2 by Vitamin D Receptor in LS180 Human Colorectal Adenocarcinoma CellsKathleen G. Barrett, Hailin Fang, Thomas A. Kocarek and Melissa Runge-MorrisDrug Metabolism and Disposition August 2016, 44 (8) 1431-1434; DOI: https://doi.org/10.1124/dmd.116.070300
Beauchemin, Stephanie
- You have accessEffects of Chronic Renal Failure on Brain Cytochrome P450 in RatsJudith Naud, Jessica Harding, Caroline Lamarche, Stephanie Beauchemin, Francois A. Leblond and Vincent PichetteDrug Metabolism and Disposition August 2016, 44 (8) 1174-1179; DOI: https://doi.org/10.1124/dmd.116.070052
Bedwell, David W.
- You have accessDifference in the Pharmacokinetics and Hepatic Metabolism of Antidiabetic Drugs in Zucker Diabetic Fatty and Sprague-Dawley RatsXin Zhou, Luc R. A. Rougée, David W. Bedwell, Jeff W. Cramer, Michael A. Mohutsky, Nathan A. Calvert, Richard D. Moulton, Kenneth C. Cassidy, Nathan P. Yumibe, Lisa A. Adams and Kenneth J. RuterboriesDrug Metabolism and Disposition August 2016, 44 (8) 1184-1192; DOI: https://doi.org/10.1124/dmd.116.070623
Berggren, Kristina
- You have accessDiscovery of a Novel Microsomal Epoxide Hydrolase–Catalyzed Hydration of a Spiro OxetaneXue-Qing Li, Martin A. Hayes, Gunnar Grönberg, Kristina Berggren, Neal Castagnoli and Lars WeidolfDrug Metabolism and Disposition August 2016, 44 (8) 1341-1348; DOI: https://doi.org/10.1124/dmd.116.071142
Bischoff, Rainer
- You have accessMicrobial Flavoprotein Monooxygenases as Mimics of Mammalian Flavin-Containing Monooxygenases for the Enantioselective Preparation of Drug MetabolitesTuran Gul, Marzena Krzek, Hjalmar P. Permentier, Marco W. Fraaije and Rainer BischoffDrug Metabolism and Disposition August 2016, 44 (8) 1270-1276; DOI: https://doi.org/10.1124/dmd.115.069104
Blanchard, Andrew P.
- You have accessSelective Time- and NADPH-Dependent Inhibition of Human CYP2E1 by ClomethiazoleDavid M. Stresser, Elke S. Perloff, Andrew K. Mason, Andrew P. Blanchard, Shangara S. Dehal, Timothy P. Creegan, Ritu Singh and Eric T. GanglDrug Metabolism and Disposition August 2016, 44 (8) 1424-1430; DOI: https://doi.org/10.1124/dmd.116.070193
Bohnert, Tonika
- You have accessEvaluation of a New Molecular Entity as a Victim of Metabolic Drug-Drug Interactions—an Industry PerspectiveTonika Bohnert, Aarti Patel, Ian Templeton, Yuan Chen, Chuang Lu, George Lai, Louis Leung, Susanna Tse, Heidi J Einolf, Ying-Hong Wang, Michael Sinz, Ralph Stearns, Robert Walsky, Wanping Geng, Sirimas Sudsakorn, David Moore, Ling He, Jan Wahlstrom, Jim Keirns, Rangaraj Narayanan, Dieter Lang, Xiaoqing Yang and International Consortium for Innovation and Quality in Pharmaceutical Development (IQ) Victim Drug-Drug Interactions Working GroupDrug Metabolism and Disposition August 2016, 44 (8) 1399-1423; DOI: https://doi.org/10.1124/dmd.115.069096
Buckbinder, Leonard
- You have accessSpecies Differences in the Oxidative Desulfurization of a Thiouracil-Based Irreversible Myeloperoxidase Inactivator by Flavin-Containing Monooxygenase EnzymesHeather Eng, Raman Sharma, Angela Wolford, Li Di, Roger B. Ruggeri, Leonard Buckbinder, Edward L. Conn, Deepak K. Dalvie and Amit S. KalgutkarDrug Metabolism and Disposition August 2016, 44 (8) 1262-1269; DOI: https://doi.org/10.1124/dmd.116.070185
Byers, Frank W.
- You have accessEvaluating the Disposition of a Mixed Aldehyde Oxidase/Cytochrome P450 Substrate in Rats with Attenuated P450 ActivityRachel D. Crouch, Ryan D. Morrison, Frank W. Byers, Craig W. Lindsley, Kyle A. Emmitte and J. Scott DanielsDrug Metabolism and Disposition August 2016, 44 (8) 1296-1303; DOI: https://doi.org/10.1124/dmd.115.068338
C
Calvert, Nathan A.
- You have accessDifference in the Pharmacokinetics and Hepatic Metabolism of Antidiabetic Drugs in Zucker Diabetic Fatty and Sprague-Dawley RatsXin Zhou, Luc R. A. Rougée, David W. Bedwell, Jeff W. Cramer, Michael A. Mohutsky, Nathan A. Calvert, Richard D. Moulton, Kenneth C. Cassidy, Nathan P. Yumibe, Lisa A. Adams and Kenneth J. RuterboriesDrug Metabolism and Disposition August 2016, 44 (8) 1184-1192; DOI: https://doi.org/10.1124/dmd.116.070623
Cantarini, Mireille V.
- You have accessMetabolic Disposition of Osimertinib in Rats, Dogs, and Humans: Insights into a Drug Designed to Bind Covalently to a Cysteine Residue of Epidermal Growth Factor ReceptorPaul A. Dickinson, Mireille V. Cantarini, Jo Collier, Paul Frewer, Scott Martin, Kathryn Pickup and Peter BallardDrug Metabolism and Disposition August 2016, 44 (8) 1201-1212; DOI: https://doi.org/10.1124/dmd.115.069203
Cantone, Joseph L.
- You have accessPhosphocholine Conjugation: An Unexpected In Vivo Conjugation Pathway Associated with Hepatitis C NS5B Inhibitors Featuring A Bicyclo[1.1.1]PentaneXiaoliang Zhuo, Joseph L. Cantone, Yingzi Wang, John E. Leet, Dieter M. Drexler, Kap-Sun Yeung, Xiaohua Stella Huang, Kyle J. Eastman, Kyle E. Parcella, Kathleen W. Mosure, Matthew G. Soars, John F. Kadow and Benjamin M. JohnsonDrug Metabolism and Disposition August 2016, 44 (8) 1332-1340; DOI: https://doi.org/10.1124/dmd.115.069062
Cassidy, Kenneth C.
- You have accessDifference in the Pharmacokinetics and Hepatic Metabolism of Antidiabetic Drugs in Zucker Diabetic Fatty and Sprague-Dawley RatsXin Zhou, Luc R. A. Rougée, David W. Bedwell, Jeff W. Cramer, Michael A. Mohutsky, Nathan A. Calvert, Richard D. Moulton, Kenneth C. Cassidy, Nathan P. Yumibe, Lisa A. Adams and Kenneth J. RuterboriesDrug Metabolism and Disposition August 2016, 44 (8) 1184-1192; DOI: https://doi.org/10.1124/dmd.116.070623
Castagnoli, Neal
- You have accessDiscovery of a Novel Microsomal Epoxide Hydrolase–Catalyzed Hydration of a Spiro OxetaneXue-Qing Li, Martin A. Hayes, Gunnar Grönberg, Kristina Berggren, Neal Castagnoli and Lars WeidolfDrug Metabolism and Disposition August 2016, 44 (8) 1341-1348; DOI: https://doi.org/10.1124/dmd.116.071142
Cerny, Matthew A.
- You have accessPrevalence of Non–Cytochrome P450–Mediated Metabolism in Food and Drug Administration–Approved Oral and Intravenous Drugs: 2006–2015Matthew A. CernyDrug Metabolism and Disposition August 2016, 44 (8) 1246-1252; DOI: https://doi.org/10.1124/dmd.116.070763
Chakilam, Ananthsrinivas
- You have accessVX-509 (Decernotinib)-Mediated CYP3A Time-Dependent Inhibition: An Aldehyde Oxidase Metabolite as a Perpetrator of Drug-Drug InteractionsCraig Zetterberg, Francois Maltais, Leena Laitinen, Shengkai Liao, Hong Tsao, Ananthsrinivas Chakilam and Niresh HariparsadDrug Metabolism and Disposition August 2016, 44 (8) 1286-1295; DOI: https://doi.org/10.1124/dmd.116.071100
Chang, Shu-Ying
- You have accessApplication of Static Models to Predict Midazolam Clinical Interactions in the Presence of Single or Multiple Hepatitis C Virus DrugsYaofeng Cheng, Li Ma, Shu-Ying Chang, W. Griffith Humphreys and Wenying LiDrug Metabolism and Disposition August 2016, 44 (8) 1372-1380; DOI: https://doi.org/10.1124/dmd.116.070409
Chen, Yuan
- You have accessEvaluation of a New Molecular Entity as a Victim of Metabolic Drug-Drug Interactions—an Industry PerspectiveTonika Bohnert, Aarti Patel, Ian Templeton, Yuan Chen, Chuang Lu, George Lai, Louis Leung, Susanna Tse, Heidi J Einolf, Ying-Hong Wang, Michael Sinz, Ralph Stearns, Robert Walsky, Wanping Geng, Sirimas Sudsakorn, David Moore, Ling He, Jan Wahlstrom, Jim Keirns, Rangaraj Narayanan, Dieter Lang, Xiaoqing Yang and International Consortium for Innovation and Quality in Pharmaceutical Development (IQ) Victim Drug-Drug Interactions Working GroupDrug Metabolism and Disposition August 2016, 44 (8) 1399-1423; DOI: https://doi.org/10.1124/dmd.115.069096
Cheng, Yaofeng
- You have accessApplication of Static Models to Predict Midazolam Clinical Interactions in the Presence of Single or Multiple Hepatitis C Virus DrugsYaofeng Cheng, Li Ma, Shu-Ying Chang, W. Griffith Humphreys and Wenying LiDrug Metabolism and Disposition August 2016, 44 (8) 1372-1380; DOI: https://doi.org/10.1124/dmd.116.070409
Cirello, Amanda L.
- You have accessOcular Metabolism of Levobunolol: Historic and Emerging Metabolic PathwaysUpendra A. Argikar, Jennifer L. Dumouchel, Christine E. Dunne, Chitra Saran, Amanda L. Cirello and Mithat GunduzDrug Metabolism and Disposition August 2016, 44 (8) 1304-1312; DOI: https://doi.org/10.1124/dmd.116.070458
Coelho, Catarina
- You have accessOptimization of the Expression of Human Aldehyde Oxidase for Investigations of Single-Nucleotide PolymorphismsAlessandro Foti, Tobias Hartmann, Catarina Coelho, Teresa Santos-Silva, Maria João Romão and Silke LeimkühlerDrug Metabolism and Disposition August 2016, 44 (8) 1277-1285; DOI: https://doi.org/10.1124/dmd.115.068395
Collier, Jo
- You have accessMetabolic Disposition of Osimertinib in Rats, Dogs, and Humans: Insights into a Drug Designed to Bind Covalently to a Cysteine Residue of Epidermal Growth Factor ReceptorPaul A. Dickinson, Mireille V. Cantarini, Jo Collier, Paul Frewer, Scott Martin, Kathryn Pickup and Peter BallardDrug Metabolism and Disposition August 2016, 44 (8) 1201-1212; DOI: https://doi.org/10.1124/dmd.115.069203
Conn, Edward L.
- You have accessSpecies Differences in the Oxidative Desulfurization of a Thiouracil-Based Irreversible Myeloperoxidase Inactivator by Flavin-Containing Monooxygenase EnzymesHeather Eng, Raman Sharma, Angela Wolford, Li Di, Roger B. Ruggeri, Leonard Buckbinder, Edward L. Conn, Deepak K. Dalvie and Amit S. KalgutkarDrug Metabolism and Disposition August 2016, 44 (8) 1262-1269; DOI: https://doi.org/10.1124/dmd.116.070185
Cramer, Jeff W.
- You have accessDifference in the Pharmacokinetics and Hepatic Metabolism of Antidiabetic Drugs in Zucker Diabetic Fatty and Sprague-Dawley RatsXin Zhou, Luc R. A. Rougée, David W. Bedwell, Jeff W. Cramer, Michael A. Mohutsky, Nathan A. Calvert, Richard D. Moulton, Kenneth C. Cassidy, Nathan P. Yumibe, Lisa A. Adams and Kenneth J. RuterboriesDrug Metabolism and Disposition August 2016, 44 (8) 1184-1192; DOI: https://doi.org/10.1124/dmd.116.070623
Creegan, Timothy P.
- You have accessSelective Time- and NADPH-Dependent Inhibition of Human CYP2E1 by ClomethiazoleDavid M. Stresser, Elke S. Perloff, Andrew K. Mason, Andrew P. Blanchard, Shangara S. Dehal, Timothy P. Creegan, Ritu Singh and Eric T. GanglDrug Metabolism and Disposition August 2016, 44 (8) 1424-1430; DOI: https://doi.org/10.1124/dmd.116.070193
Crouch, Rachel D.
- You have accessEvaluating the Disposition of a Mixed Aldehyde Oxidase/Cytochrome P450 Substrate in Rats with Attenuated P450 ActivityRachel D. Crouch, Ryan D. Morrison, Frank W. Byers, Craig W. Lindsley, Kyle A. Emmitte and J. Scott DanielsDrug Metabolism and Disposition August 2016, 44 (8) 1296-1303; DOI: https://doi.org/10.1124/dmd.115.068338
Cui, Ming-Zhu
- Open AccessCorrelation of Cytochrome P450 Oxidoreductase Expression with the Expression of 10 Isoforms of Cytochrome P450 in Human LiverHai-Feng Zhang, Zhi-Hui Li, Jia-Yu Liu, Ting-Ting Liu, Ping Wang, Yan Fang, Jun Zhou, Ming-Zhu Cui, Na Gao, Xin Tian, Jie Gao, Qiang Wen, Lin-Jing Jia and Hai-Ling QiaoDrug Metabolism and Disposition August 2016, 44 (8) 1193-1200; DOI: https://doi.org/10.1124/dmd.116.069849
D
Dalvie, Deepak K.
- You have accessCytochrome P450 and Non–Cytochrome P450 Oxidative Metabolism: Contributions to the Pharmacokinetics, Safety, and Efficacy of XenobioticsRobert S. Foti and Deepak K. DalvieDrug Metabolism and Disposition August 2016, 44 (8) 1229-1245; DOI: https://doi.org/10.1124/dmd.116.071753
- You have accessSpecies Differences in the Oxidative Desulfurization of a Thiouracil-Based Irreversible Myeloperoxidase Inactivator by Flavin-Containing Monooxygenase EnzymesHeather Eng, Raman Sharma, Angela Wolford, Li Di, Roger B. Ruggeri, Leonard Buckbinder, Edward L. Conn, Deepak K. Dalvie and Amit S. KalgutkarDrug Metabolism and Disposition August 2016, 44 (8) 1262-1269; DOI: https://doi.org/10.1124/dmd.116.070185
Daniels, J. Scott
- You have accessEvaluating the Disposition of a Mixed Aldehyde Oxidase/Cytochrome P450 Substrate in Rats with Attenuated P450 ActivityRachel D. Crouch, Ryan D. Morrison, Frank W. Byers, Craig W. Lindsley, Kyle A. Emmitte and J. Scott DanielsDrug Metabolism and Disposition August 2016, 44 (8) 1296-1303; DOI: https://doi.org/10.1124/dmd.115.068338
Dehal, Shangara S.
- You have accessSelective Time- and NADPH-Dependent Inhibition of Human CYP2E1 by ClomethiazoleDavid M. Stresser, Elke S. Perloff, Andrew K. Mason, Andrew P. Blanchard, Shangara S. Dehal, Timothy P. Creegan, Ritu Singh and Eric T. GanglDrug Metabolism and Disposition August 2016, 44 (8) 1424-1430; DOI: https://doi.org/10.1124/dmd.116.070193
de Morais, Sonia M.
- You have accessMetabolism and Disposition of Pan-Genotypic Inhibitor of Hepatitis C Virus NS5A Ombitasvir in HumansJianwei Shen, Michael Serby, Bruce Surber, Anthony J. Lee, Junli Ma, Prajakta Badri, Rajeev Menon, Olga Kavetskaia, Sonia M. de Morais, Jens Sydor and Volker FischerDrug Metabolism and Disposition August 2016, 44 (8) 1148-1157; DOI: https://doi.org/10.1124/dmd.115.067496
Deshmukh, Sujal V.
- You have accessA Pharmacokinetic Modeling Approach to Predict the Contribution of Active Metabolites to Human Efficacious DoseIain J. Martin, Susan E. Hill, James A. Baker, Sujal V. Deshmukh and Erin F. MulrooneyDrug Metabolism and Disposition August 2016, 44 (8) 1435-1440; DOI: https://doi.org/10.1124/dmd.116.070391
Di, Li
- You have accessSpecies Differences in the Oxidative Desulfurization of a Thiouracil-Based Irreversible Myeloperoxidase Inactivator by Flavin-Containing Monooxygenase EnzymesHeather Eng, Raman Sharma, Angela Wolford, Li Di, Roger B. Ruggeri, Leonard Buckbinder, Edward L. Conn, Deepak K. Dalvie and Amit S. KalgutkarDrug Metabolism and Disposition August 2016, 44 (8) 1262-1269; DOI: https://doi.org/10.1124/dmd.116.070185
Dickinson, Paul A.
- You have accessMetabolic Disposition of Osimertinib in Rats, Dogs, and Humans: Insights into a Drug Designed to Bind Covalently to a Cysteine Residue of Epidermal Growth Factor ReceptorPaul A. Dickinson, Mireille V. Cantarini, Jo Collier, Paul Frewer, Scott Martin, Kathryn Pickup and Peter BallardDrug Metabolism and Disposition August 2016, 44 (8) 1201-1212; DOI: https://doi.org/10.1124/dmd.115.069203
Drexler, Dieter M.
- You have accessPhosphocholine Conjugation: An Unexpected In Vivo Conjugation Pathway Associated with Hepatitis C NS5B Inhibitors Featuring A Bicyclo[1.1.1]PentaneXiaoliang Zhuo, Joseph L. Cantone, Yingzi Wang, John E. Leet, Dieter M. Drexler, Kap-Sun Yeung, Xiaohua Stella Huang, Kyle J. Eastman, Kyle E. Parcella, Kathleen W. Mosure, Matthew G. Soars, John F. Kadow and Benjamin M. JohnsonDrug Metabolism and Disposition August 2016, 44 (8) 1332-1340; DOI: https://doi.org/10.1124/dmd.115.069062
Driscoll, James P.
- You have accessGoing Beyond Common Drug Metabolizing Enzymes: Case Studies of Biotransformation Involving Aldehyde Oxidase, γ-Glutamyl Transpeptidase, Cathepsin B, Flavin-Containing Monooxygenase, and ADP-RibosyltransferasePeter W. Fan, Donglu Zhang, Jason S. Halladay, James P. Driscoll and S. Cyrus KhojastehDrug Metabolism and Disposition August 2016, 44 (8) 1253-1261; DOI: https://doi.org/10.1124/dmd.116.070169
Dumouchel, Jennifer L.
- You have accessOcular Metabolism of Levobunolol: Historic and Emerging Metabolic PathwaysUpendra A. Argikar, Jennifer L. Dumouchel, Christine E. Dunne, Chitra Saran, Amanda L. Cirello and Mithat GunduzDrug Metabolism and Disposition August 2016, 44 (8) 1304-1312; DOI: https://doi.org/10.1124/dmd.116.070458
Dunne, Christine E.
- You have accessOcular Metabolism of Levobunolol: Historic and Emerging Metabolic PathwaysUpendra A. Argikar, Jennifer L. Dumouchel, Christine E. Dunne, Chitra Saran, Amanda L. Cirello and Mithat GunduzDrug Metabolism and Disposition August 2016, 44 (8) 1304-1312; DOI: https://doi.org/10.1124/dmd.116.070458
E
Eastman, Kyle J.
- You have accessPhosphocholine Conjugation: An Unexpected In Vivo Conjugation Pathway Associated with Hepatitis C NS5B Inhibitors Featuring A Bicyclo[1.1.1]PentaneXiaoliang Zhuo, Joseph L. Cantone, Yingzi Wang, John E. Leet, Dieter M. Drexler, Kap-Sun Yeung, Xiaohua Stella Huang, Kyle J. Eastman, Kyle E. Parcella, Kathleen W. Mosure, Matthew G. Soars, John F. Kadow and Benjamin M. JohnsonDrug Metabolism and Disposition August 2016, 44 (8) 1332-1340; DOI: https://doi.org/10.1124/dmd.115.069062
Edson, Katheryne Z.
- You have accessNonclinical Pharmacokinetics, Disposition, and Drug-Drug Interaction Potential of a Novel d-Amino Acid Peptide Agonist of the Calcium-Sensing Receptor AMG 416 (Etelcalcetide)Raju Subramanian, Xiaochun Zhu, Savannah J. Kerr, Joel D. Esmay, Steven W. Louie, Katheryne Z. Edson, Sarah Walter, Michael Fitzsimmons, Mylo Wagner, Marcus Soto, Roger Pham, Sarah F. Wilson and Gary L. SkilesDrug Metabolism and Disposition August 2016, 44 (8) 1319-1331; DOI: https://doi.org/10.1124/dmd.115.068007
Einolf, Heidi J
- You have accessEvaluation of a New Molecular Entity as a Victim of Metabolic Drug-Drug Interactions—an Industry PerspectiveTonika Bohnert, Aarti Patel, Ian Templeton, Yuan Chen, Chuang Lu, George Lai, Louis Leung, Susanna Tse, Heidi J Einolf, Ying-Hong Wang, Michael Sinz, Ralph Stearns, Robert Walsky, Wanping Geng, Sirimas Sudsakorn, David Moore, Ling He, Jan Wahlstrom, Jim Keirns, Rangaraj Narayanan, Dieter Lang, Xiaoqing Yang and International Consortium for Innovation and Quality in Pharmaceutical Development (IQ) Victim Drug-Drug Interactions Working GroupDrug Metabolism and Disposition August 2016, 44 (8) 1399-1423; DOI: https://doi.org/10.1124/dmd.115.069096
Emmitte, Kyle A.
- You have accessEvaluating the Disposition of a Mixed Aldehyde Oxidase/Cytochrome P450 Substrate in Rats with Attenuated P450 ActivityRachel D. Crouch, Ryan D. Morrison, Frank W. Byers, Craig W. Lindsley, Kyle A. Emmitte and J. Scott DanielsDrug Metabolism and Disposition August 2016, 44 (8) 1296-1303; DOI: https://doi.org/10.1124/dmd.115.068338
Eng, Heather
- You have accessUse of Human Plasma Samples to Identify Circulating Drug Metabolites that Inhibit Cytochrome P450 EnzymesHeather Eng and R. Scott ObachDrug Metabolism and Disposition August 2016, 44 (8) 1217-1228; DOI: https://doi.org/10.1124/dmd.116.071084
- You have accessSpecies Differences in the Oxidative Desulfurization of a Thiouracil-Based Irreversible Myeloperoxidase Inactivator by Flavin-Containing Monooxygenase EnzymesHeather Eng, Raman Sharma, Angela Wolford, Li Di, Roger B. Ruggeri, Leonard Buckbinder, Edward L. Conn, Deepak K. Dalvie and Amit S. KalgutkarDrug Metabolism and Disposition August 2016, 44 (8) 1262-1269; DOI: https://doi.org/10.1124/dmd.116.070185
Esmay, Joel D.
- You have accessNonclinical Pharmacokinetics, Disposition, and Drug-Drug Interaction Potential of a Novel d-Amino Acid Peptide Agonist of the Calcium-Sensing Receptor AMG 416 (Etelcalcetide)Raju Subramanian, Xiaochun Zhu, Savannah J. Kerr, Joel D. Esmay, Steven W. Louie, Katheryne Z. Edson, Sarah Walter, Michael Fitzsimmons, Mylo Wagner, Marcus Soto, Roger Pham, Sarah F. Wilson and Gary L. SkilesDrug Metabolism and Disposition August 2016, 44 (8) 1319-1331; DOI: https://doi.org/10.1124/dmd.115.068007
F
Fan, Peter W.
- You have accessGoing Beyond Common Drug Metabolizing Enzymes: Case Studies of Biotransformation Involving Aldehyde Oxidase, γ-Glutamyl Transpeptidase, Cathepsin B, Flavin-Containing Monooxygenase, and ADP-RibosyltransferasePeter W. Fan, Donglu Zhang, Jason S. Halladay, James P. Driscoll and S. Cyrus KhojastehDrug Metabolism and Disposition August 2016, 44 (8) 1253-1261; DOI: https://doi.org/10.1124/dmd.116.070169
Fang, Hailin
- You have accessTranscriptional Regulation of Cytosolic Sulfotransferase 1C2 by Vitamin D Receptor in LS180 Human Colorectal Adenocarcinoma CellsKathleen G. Barrett, Hailin Fang, Thomas A. Kocarek and Melissa Runge-MorrisDrug Metabolism and Disposition August 2016, 44 (8) 1431-1434; DOI: https://doi.org/10.1124/dmd.116.070300
Fang, Yan
- Open AccessCorrelation of Cytochrome P450 Oxidoreductase Expression with the Expression of 10 Isoforms of Cytochrome P450 in Human LiverHai-Feng Zhang, Zhi-Hui Li, Jia-Yu Liu, Ting-Ting Liu, Ping Wang, Yan Fang, Jun Zhou, Ming-Zhu Cui, Na Gao, Xin Tian, Jie Gao, Qiang Wen, Lin-Jing Jia and Hai-Ling QiaoDrug Metabolism and Disposition August 2016, 44 (8) 1193-1200; DOI: https://doi.org/10.1124/dmd.116.069849
Ferreira, Suzie
- You have accessApplication of Osmotic Pumps for Sustained Release of 1-Aminobenzotriazole and Inhibition of Cytochrome P450 Enzymes in Mice: Model Comparison with the Hepatic P450 Reductase Null MouseRowan A. Stringer, Suzie Ferreira, Jonathan Rose and Sebastien RonseauxDrug Metabolism and Disposition August 2016, 44 (8) 1213-1216; DOI: https://doi.org/10.1124/dmd.116.070151
Fischer, Volker
- You have accessMetabolism and Disposition of Pan-Genotypic Inhibitor of Hepatitis C Virus NS5A Ombitasvir in HumansJianwei Shen, Michael Serby, Bruce Surber, Anthony J. Lee, Junli Ma, Prajakta Badri, Rajeev Menon, Olga Kavetskaia, Sonia M. de Morais, Jens Sydor and Volker FischerDrug Metabolism and Disposition August 2016, 44 (8) 1148-1157; DOI: https://doi.org/10.1124/dmd.115.067496
- You have accessMetabolism and Disposition of the Hepatitis C Protease Inhibitor Paritaprevir in HumansJianwei Shen, Michael Serby, Aimee Reed, Anthony J. Lee, Xiaomei Zhang, Kennan Marsh, Amit Khatri, Rajeev Menon, Olga Kavetskaia and Volker FischerDrug Metabolism and Disposition August 2016, 44 (8) 1164-1173; DOI: https://doi.org/10.1124/dmd.115.067488
- You have accessMetabolism and Disposition of Hepatitis C Polymerase Inhibitor Dasabuvir in HumansJianwei Shen, Michael Serby, Aimee Reed, Anthony J. Lee, Rajeev Menon, Xiaomei Zhang, Kennan Marsh, Xia Wan, Olga Kavetskaia and Volker FischerDrug Metabolism and Disposition August 2016, 44 (8) 1139-1147; DOI: https://doi.org/10.1124/dmd.115.067512
Fitzsimmons, Michael
- You have accessNonclinical Pharmacokinetics, Disposition, and Drug-Drug Interaction Potential of a Novel d-Amino Acid Peptide Agonist of the Calcium-Sensing Receptor AMG 416 (Etelcalcetide)Raju Subramanian, Xiaochun Zhu, Savannah J. Kerr, Joel D. Esmay, Steven W. Louie, Katheryne Z. Edson, Sarah Walter, Michael Fitzsimmons, Mylo Wagner, Marcus Soto, Roger Pham, Sarah F. Wilson and Gary L. SkilesDrug Metabolism and Disposition August 2016, 44 (8) 1319-1331; DOI: https://doi.org/10.1124/dmd.115.068007
Foti, Alessandro
- You have accessOptimization of the Expression of Human Aldehyde Oxidase for Investigations of Single-Nucleotide PolymorphismsAlessandro Foti, Tobias Hartmann, Catarina Coelho, Teresa Santos-Silva, Maria João Romão and Silke LeimkühlerDrug Metabolism and Disposition August 2016, 44 (8) 1277-1285; DOI: https://doi.org/10.1124/dmd.115.068395
Foti, Robert S.
- You have accessCytochrome P450 and Non–Cytochrome P450 Oxidative Metabolism: Contributions to the Pharmacokinetics, Safety, and Efficacy of XenobioticsRobert S. Foti and Deepak K. DalvieDrug Metabolism and Disposition August 2016, 44 (8) 1229-1245; DOI: https://doi.org/10.1124/dmd.116.071753
Fraaije, Marco W.
- You have accessMicrobial Flavoprotein Monooxygenases as Mimics of Mammalian Flavin-Containing Monooxygenases for the Enantioselective Preparation of Drug MetabolitesTuran Gul, Marzena Krzek, Hjalmar P. Permentier, Marco W. Fraaije and Rainer BischoffDrug Metabolism and Disposition August 2016, 44 (8) 1270-1276; DOI: https://doi.org/10.1124/dmd.115.069104
Frewer, Paul
- You have accessMetabolic Disposition of Osimertinib in Rats, Dogs, and Humans: Insights into a Drug Designed to Bind Covalently to a Cysteine Residue of Epidermal Growth Factor ReceptorPaul A. Dickinson, Mireille V. Cantarini, Jo Collier, Paul Frewer, Scott Martin, Kathryn Pickup and Peter BallardDrug Metabolism and Disposition August 2016, 44 (8) 1201-1212; DOI: https://doi.org/10.1124/dmd.115.069203
Fu, Jing
- You have accessBiotransformation Capacity of Carboxylesterase in Skin and Keratinocytes for the Penta-Ethyl Ester Prodrug of DTPAJing Fu, Matthew Sadgrove, Lesley Marson and Michael JayDrug Metabolism and Disposition August 2016, 44 (8) 1313-1318; DOI: https://doi.org/10.1124/dmd.116.069377
Fukuhara, Ayano
- You have accessImpact of Experimental Conditions on the Evaluation of Interactions between Multidrug and Toxin Extrusion Proteins and Candidate DrugsChristian Lechner, Naoki Ishiguro, Ayano Fukuhara, Hidetada Shimizu, Naoko Ohtsu, Masahito Takatani, Kotaro Nishiyama, Ikumi Washio, Norio Yamamura and Hiroyuki KusuharaDrug Metabolism and Disposition August 2016, 44 (8) 1381-1389; DOI: https://doi.org/10.1124/dmd.115.068163
G
Gangl, Eric T.
- You have accessSelective Time- and NADPH-Dependent Inhibition of Human CYP2E1 by ClomethiazoleDavid M. Stresser, Elke S. Perloff, Andrew K. Mason, Andrew P. Blanchard, Shangara S. Dehal, Timothy P. Creegan, Ritu Singh and Eric T. GanglDrug Metabolism and Disposition August 2016, 44 (8) 1424-1430; DOI: https://doi.org/10.1124/dmd.116.070193
Gao, Jie
- Open AccessCorrelation of Cytochrome P450 Oxidoreductase Expression with the Expression of 10 Isoforms of Cytochrome P450 in Human LiverHai-Feng Zhang, Zhi-Hui Li, Jia-Yu Liu, Ting-Ting Liu, Ping Wang, Yan Fang, Jun Zhou, Ming-Zhu Cui, Na Gao, Xin Tian, Jie Gao, Qiang Wen, Lin-Jing Jia and Hai-Ling QiaoDrug Metabolism and Disposition August 2016, 44 (8) 1193-1200; DOI: https://doi.org/10.1124/dmd.116.069849
Gao, Na
- Open AccessCorrelation of Cytochrome P450 Oxidoreductase Expression with the Expression of 10 Isoforms of Cytochrome P450 in Human LiverHai-Feng Zhang, Zhi-Hui Li, Jia-Yu Liu, Ting-Ting Liu, Ping Wang, Yan Fang, Jun Zhou, Ming-Zhu Cui, Na Gao, Xin Tian, Jie Gao, Qiang Wen, Lin-Jing Jia and Hai-Ling QiaoDrug Metabolism and Disposition August 2016, 44 (8) 1193-1200; DOI: https://doi.org/10.1124/dmd.116.069849
Geng, Wanping
- You have accessEvaluation of a New Molecular Entity as a Victim of Metabolic Drug-Drug Interactions—an Industry PerspectiveTonika Bohnert, Aarti Patel, Ian Templeton, Yuan Chen, Chuang Lu, George Lai, Louis Leung, Susanna Tse, Heidi J Einolf, Ying-Hong Wang, Michael Sinz, Ralph Stearns, Robert Walsky, Wanping Geng, Sirimas Sudsakorn, David Moore, Ling He, Jan Wahlstrom, Jim Keirns, Rangaraj Narayanan, Dieter Lang, Xiaoqing Yang and International Consortium for Innovation and Quality in Pharmaceutical Development (IQ) Victim Drug-Drug Interactions Working GroupDrug Metabolism and Disposition August 2016, 44 (8) 1399-1423; DOI: https://doi.org/10.1124/dmd.115.069096
Grönberg, Gunnar
- You have accessDiscovery of a Novel Microsomal Epoxide Hydrolase–Catalyzed Hydration of a Spiro OxetaneXue-Qing Li, Martin A. Hayes, Gunnar Grönberg, Kristina Berggren, Neal Castagnoli and Lars WeidolfDrug Metabolism and Disposition August 2016, 44 (8) 1341-1348; DOI: https://doi.org/10.1124/dmd.116.071142
Gul, Turan
- You have accessMicrobial Flavoprotein Monooxygenases as Mimics of Mammalian Flavin-Containing Monooxygenases for the Enantioselective Preparation of Drug MetabolitesTuran Gul, Marzena Krzek, Hjalmar P. Permentier, Marco W. Fraaije and Rainer BischoffDrug Metabolism and Disposition August 2016, 44 (8) 1270-1276; DOI: https://doi.org/10.1124/dmd.115.069104
Gunduz, Mithat
- You have accessOcular Metabolism of Levobunolol: Historic and Emerging Metabolic PathwaysUpendra A. Argikar, Jennifer L. Dumouchel, Christine E. Dunne, Chitra Saran, Amanda L. Cirello and Mithat GunduzDrug Metabolism and Disposition August 2016, 44 (8) 1304-1312; DOI: https://doi.org/10.1124/dmd.116.070458
H
Halladay, Jason S.
- You have accessGoing Beyond Common Drug Metabolizing Enzymes: Case Studies of Biotransformation Involving Aldehyde Oxidase, γ-Glutamyl Transpeptidase, Cathepsin B, Flavin-Containing Monooxygenase, and ADP-RibosyltransferasePeter W. Fan, Donglu Zhang, Jason S. Halladay, James P. Driscoll and S. Cyrus KhojastehDrug Metabolism and Disposition August 2016, 44 (8) 1253-1261; DOI: https://doi.org/10.1124/dmd.116.070169
Harding, Jessica
- You have accessEffects of Chronic Renal Failure on Brain Cytochrome P450 in RatsJudith Naud, Jessica Harding, Caroline Lamarche, Stephanie Beauchemin, Francois A. Leblond and Vincent PichetteDrug Metabolism and Disposition August 2016, 44 (8) 1174-1179; DOI: https://doi.org/10.1124/dmd.116.070052
Hariparsad, Niresh
- You have accessVX-509 (Decernotinib)-Mediated CYP3A Time-Dependent Inhibition: An Aldehyde Oxidase Metabolite as a Perpetrator of Drug-Drug InteractionsCraig Zetterberg, Francois Maltais, Leena Laitinen, Shengkai Liao, Hong Tsao, Ananthsrinivas Chakilam and Niresh HariparsadDrug Metabolism and Disposition August 2016, 44 (8) 1286-1295; DOI: https://doi.org/10.1124/dmd.116.071100
Hartmann, Tobias
- You have accessOptimization of the Expression of Human Aldehyde Oxidase for Investigations of Single-Nucleotide PolymorphismsAlessandro Foti, Tobias Hartmann, Catarina Coelho, Teresa Santos-Silva, Maria João Romão and Silke LeimkühlerDrug Metabolism and Disposition August 2016, 44 (8) 1277-1285; DOI: https://doi.org/10.1124/dmd.115.068395
Hasegawa, Yoshitaka
- You have accessRecommendation to Exclude Bile-Duct-Cannulated Rats with Hyperbilirubinemia for Proper Conduct of Biliary Drug Excretion StudiesKoji Kato, Yoshitaka Hasegawa, Katsuya Iwata, Takuya Ichikawa, Tohru Yahara, Satoshi Tsuji, Masayuki Sugiura and Jun-ichi YamaguchiDrug Metabolism and Disposition August 2016, 44 (8) 1180-1183; DOI: https://doi.org/10.1124/dmd.116.070532
Hayes, Martin A.
- You have accessDiscovery of a Novel Microsomal Epoxide Hydrolase–Catalyzed Hydration of a Spiro OxetaneXue-Qing Li, Martin A. Hayes, Gunnar Grönberg, Kristina Berggren, Neal Castagnoli and Lars WeidolfDrug Metabolism and Disposition August 2016, 44 (8) 1341-1348; DOI: https://doi.org/10.1124/dmd.116.071142
He, Ling
- You have accessEvaluation of a New Molecular Entity as a Victim of Metabolic Drug-Drug Interactions—an Industry PerspectiveTonika Bohnert, Aarti Patel, Ian Templeton, Yuan Chen, Chuang Lu, George Lai, Louis Leung, Susanna Tse, Heidi J Einolf, Ying-Hong Wang, Michael Sinz, Ralph Stearns, Robert Walsky, Wanping Geng, Sirimas Sudsakorn, David Moore, Ling He, Jan Wahlstrom, Jim Keirns, Rangaraj Narayanan, Dieter Lang, Xiaoqing Yang and International Consortium for Innovation and Quality in Pharmaceutical Development (IQ) Victim Drug-Drug Interactions Working GroupDrug Metabolism and Disposition August 2016, 44 (8) 1399-1423; DOI: https://doi.org/10.1124/dmd.115.069096
Hill, Susan E.
- You have accessA Pharmacokinetic Modeling Approach to Predict the Contribution of Active Metabolites to Human Efficacious DoseIain J. Martin, Susan E. Hill, James A. Baker, Sujal V. Deshmukh and Erin F. MulrooneyDrug Metabolism and Disposition August 2016, 44 (8) 1435-1440; DOI: https://doi.org/10.1124/dmd.116.070391
Huang, Xiaohua Stella
- You have accessPhosphocholine Conjugation: An Unexpected In Vivo Conjugation Pathway Associated with Hepatitis C NS5B Inhibitors Featuring A Bicyclo[1.1.1]PentaneXiaoliang Zhuo, Joseph L. Cantone, Yingzi Wang, John E. Leet, Dieter M. Drexler, Kap-Sun Yeung, Xiaohua Stella Huang, Kyle J. Eastman, Kyle E. Parcella, Kathleen W. Mosure, Matthew G. Soars, John F. Kadow and Benjamin M. JohnsonDrug Metabolism and Disposition August 2016, 44 (8) 1332-1340; DOI: https://doi.org/10.1124/dmd.115.069062
Humphreys, W. Griffith
- You have accessApplication of Static Models to Predict Midazolam Clinical Interactions in the Presence of Single or Multiple Hepatitis C Virus DrugsYaofeng Cheng, Li Ma, Shu-Ying Chang, W. Griffith Humphreys and Wenying LiDrug Metabolism and Disposition August 2016, 44 (8) 1372-1380; DOI: https://doi.org/10.1124/dmd.116.070409
I
Ichikawa, Takuya
- You have accessRecommendation to Exclude Bile-Duct-Cannulated Rats with Hyperbilirubinemia for Proper Conduct of Biliary Drug Excretion StudiesKoji Kato, Yoshitaka Hasegawa, Katsuya Iwata, Takuya Ichikawa, Tohru Yahara, Satoshi Tsuji, Masayuki Sugiura and Jun-ichi YamaguchiDrug Metabolism and Disposition August 2016, 44 (8) 1180-1183; DOI: https://doi.org/10.1124/dmd.116.070532
Inaba, Miki
- You have accessDifferences in Gene Regulation by Dual Ligands of Nuclear Receptors Constitutive Androstane Receptor (CAR) and Pregnane X Receptor (PXR) in HepG2 Cells Stably Expressing CAR/PXRYuichiro Kanno, Nobuaki Tanuma, Saki Yazawa, Shuai Zhao, Miki Inaba, Satoshi Nakamura, Kiyomitsu Nemoto and Yoshio InouyeDrug Metabolism and Disposition August 2016, 44 (8) 1158-1163; DOI: https://doi.org/10.1124/dmd.116.070888
Inouye, Yoshio
- You have accessDifferences in Gene Regulation by Dual Ligands of Nuclear Receptors Constitutive Androstane Receptor (CAR) and Pregnane X Receptor (PXR) in HepG2 Cells Stably Expressing CAR/PXRYuichiro Kanno, Nobuaki Tanuma, Saki Yazawa, Shuai Zhao, Miki Inaba, Satoshi Nakamura, Kiyomitsu Nemoto and Yoshio InouyeDrug Metabolism and Disposition August 2016, 44 (8) 1158-1163; DOI: https://doi.org/10.1124/dmd.116.070888
Ishiguro, Naoki
- You have accessImpact of Experimental Conditions on the Evaluation of Interactions between Multidrug and Toxin Extrusion Proteins and Candidate DrugsChristian Lechner, Naoki Ishiguro, Ayano Fukuhara, Hidetada Shimizu, Naoko Ohtsu, Masahito Takatani, Kotaro Nishiyama, Ikumi Washio, Norio Yamamura and Hiroyuki KusuharaDrug Metabolism and Disposition August 2016, 44 (8) 1381-1389; DOI: https://doi.org/10.1124/dmd.115.068163
Itkonen, Matti K.
- You have accessClopidogrel Markedly Increases Plasma Concentrations of CYP2C8 Substrate PioglitazoneMatti K. Itkonen, Aleksi Tornio, Mikko Neuvonen, Pertti J. Neuvonen, Mikko Niemi and Janne T. BackmanDrug Metabolism and Disposition August 2016, 44 (8) 1364-1371; DOI: https://doi.org/10.1124/dmd.116.070375
Iwata, Katsuya
- You have accessRecommendation to Exclude Bile-Duct-Cannulated Rats with Hyperbilirubinemia for Proper Conduct of Biliary Drug Excretion StudiesKoji Kato, Yoshitaka Hasegawa, Katsuya Iwata, Takuya Ichikawa, Tohru Yahara, Satoshi Tsuji, Masayuki Sugiura and Jun-ichi YamaguchiDrug Metabolism and Disposition August 2016, 44 (8) 1180-1183; DOI: https://doi.org/10.1124/dmd.116.070532
J
Jay, Michael
- You have accessBiotransformation Capacity of Carboxylesterase in Skin and Keratinocytes for the Penta-Ethyl Ester Prodrug of DTPAJing Fu, Matthew Sadgrove, Lesley Marson and Michael JayDrug Metabolism and Disposition August 2016, 44 (8) 1313-1318; DOI: https://doi.org/10.1124/dmd.116.069377
Jia, Lin-Jing
- Open AccessCorrelation of Cytochrome P450 Oxidoreductase Expression with the Expression of 10 Isoforms of Cytochrome P450 in Human LiverHai-Feng Zhang, Zhi-Hui Li, Jia-Yu Liu, Ting-Ting Liu, Ping Wang, Yan Fang, Jun Zhou, Ming-Zhu Cui, Na Gao, Xin Tian, Jie Gao, Qiang Wen, Lin-Jing Jia and Hai-Ling QiaoDrug Metabolism and Disposition August 2016, 44 (8) 1193-1200; DOI: https://doi.org/10.1124/dmd.116.069849
Johnson, Benjamin M.
- You have accessPhosphocholine Conjugation: An Unexpected In Vivo Conjugation Pathway Associated with Hepatitis C NS5B Inhibitors Featuring A Bicyclo[1.1.1]PentaneXiaoliang Zhuo, Joseph L. Cantone, Yingzi Wang, John E. Leet, Dieter M. Drexler, Kap-Sun Yeung, Xiaohua Stella Huang, Kyle J. Eastman, Kyle E. Parcella, Kathleen W. Mosure, Matthew G. Soars, John F. Kadow and Benjamin M. JohnsonDrug Metabolism and Disposition August 2016, 44 (8) 1332-1340; DOI: https://doi.org/10.1124/dmd.115.069062
K
Kadow, John F.
- You have accessPhosphocholine Conjugation: An Unexpected In Vivo Conjugation Pathway Associated with Hepatitis C NS5B Inhibitors Featuring A Bicyclo[1.1.1]PentaneXiaoliang Zhuo, Joseph L. Cantone, Yingzi Wang, John E. Leet, Dieter M. Drexler, Kap-Sun Yeung, Xiaohua Stella Huang, Kyle J. Eastman, Kyle E. Parcella, Kathleen W. Mosure, Matthew G. Soars, John F. Kadow and Benjamin M. JohnsonDrug Metabolism and Disposition August 2016, 44 (8) 1332-1340; DOI: https://doi.org/10.1124/dmd.115.069062
Kalgutkar, Amit S.
- You have accessSpecies Differences in the Oxidative Desulfurization of a Thiouracil-Based Irreversible Myeloperoxidase Inactivator by Flavin-Containing Monooxygenase EnzymesHeather Eng, Raman Sharma, Angela Wolford, Li Di, Roger B. Ruggeri, Leonard Buckbinder, Edward L. Conn, Deepak K. Dalvie and Amit S. KalgutkarDrug Metabolism and Disposition August 2016, 44 (8) 1262-1269; DOI: https://doi.org/10.1124/dmd.116.070185
Kanno, Yuichiro
- You have accessDifferences in Gene Regulation by Dual Ligands of Nuclear Receptors Constitutive Androstane Receptor (CAR) and Pregnane X Receptor (PXR) in HepG2 Cells Stably Expressing CAR/PXRYuichiro Kanno, Nobuaki Tanuma, Saki Yazawa, Shuai Zhao, Miki Inaba, Satoshi Nakamura, Kiyomitsu Nemoto and Yoshio InouyeDrug Metabolism and Disposition August 2016, 44 (8) 1158-1163; DOI: https://doi.org/10.1124/dmd.116.070888
Kato, Koji
- You have accessRecommendation to Exclude Bile-Duct-Cannulated Rats with Hyperbilirubinemia for Proper Conduct of Biliary Drug Excretion StudiesKoji Kato, Yoshitaka Hasegawa, Katsuya Iwata, Takuya Ichikawa, Tohru Yahara, Satoshi Tsuji, Masayuki Sugiura and Jun-ichi YamaguchiDrug Metabolism and Disposition August 2016, 44 (8) 1180-1183; DOI: https://doi.org/10.1124/dmd.116.070532
Kavetskaia, Olga
- You have accessMetabolism and Disposition of Pan-Genotypic Inhibitor of Hepatitis C Virus NS5A Ombitasvir in HumansJianwei Shen, Michael Serby, Bruce Surber, Anthony J. Lee, Junli Ma, Prajakta Badri, Rajeev Menon, Olga Kavetskaia, Sonia M. de Morais, Jens Sydor and Volker FischerDrug Metabolism and Disposition August 2016, 44 (8) 1148-1157; DOI: https://doi.org/10.1124/dmd.115.067496
- You have accessMetabolism and Disposition of the Hepatitis C Protease Inhibitor Paritaprevir in HumansJianwei Shen, Michael Serby, Aimee Reed, Anthony J. Lee, Xiaomei Zhang, Kennan Marsh, Amit Khatri, Rajeev Menon, Olga Kavetskaia and Volker FischerDrug Metabolism and Disposition August 2016, 44 (8) 1164-1173; DOI: https://doi.org/10.1124/dmd.115.067488
- You have accessMetabolism and Disposition of Hepatitis C Polymerase Inhibitor Dasabuvir in HumansJianwei Shen, Michael Serby, Aimee Reed, Anthony J. Lee, Rajeev Menon, Xiaomei Zhang, Kennan Marsh, Xia Wan, Olga Kavetskaia and Volker FischerDrug Metabolism and Disposition August 2016, 44 (8) 1139-1147; DOI: https://doi.org/10.1124/dmd.115.067512
Keirns, Jim
- You have accessEvaluation of a New Molecular Entity as a Victim of Metabolic Drug-Drug Interactions—an Industry PerspectiveTonika Bohnert, Aarti Patel, Ian Templeton, Yuan Chen, Chuang Lu, George Lai, Louis Leung, Susanna Tse, Heidi J Einolf, Ying-Hong Wang, Michael Sinz, Ralph Stearns, Robert Walsky, Wanping Geng, Sirimas Sudsakorn, David Moore, Ling He, Jan Wahlstrom, Jim Keirns, Rangaraj Narayanan, Dieter Lang, Xiaoqing Yang and International Consortium for Innovation and Quality in Pharmaceutical Development (IQ) Victim Drug-Drug Interactions Working GroupDrug Metabolism and Disposition August 2016, 44 (8) 1399-1423; DOI: https://doi.org/10.1124/dmd.115.069096
Kerr, Savannah J.
- You have accessNonclinical Pharmacokinetics, Disposition, and Drug-Drug Interaction Potential of a Novel d-Amino Acid Peptide Agonist of the Calcium-Sensing Receptor AMG 416 (Etelcalcetide)Raju Subramanian, Xiaochun Zhu, Savannah J. Kerr, Joel D. Esmay, Steven W. Louie, Katheryne Z. Edson, Sarah Walter, Michael Fitzsimmons, Mylo Wagner, Marcus Soto, Roger Pham, Sarah F. Wilson and Gary L. SkilesDrug Metabolism and Disposition August 2016, 44 (8) 1319-1331; DOI: https://doi.org/10.1124/dmd.115.068007
Khatri, Amit
- You have accessMetabolism and Disposition of the Hepatitis C Protease Inhibitor Paritaprevir in HumansJianwei Shen, Michael Serby, Aimee Reed, Anthony J. Lee, Xiaomei Zhang, Kennan Marsh, Amit Khatri, Rajeev Menon, Olga Kavetskaia and Volker FischerDrug Metabolism and Disposition August 2016, 44 (8) 1164-1173; DOI: https://doi.org/10.1124/dmd.115.067488
Khojasteh, S. Cyrus
- You have accessGoing Beyond Common Drug Metabolizing Enzymes: Case Studies of Biotransformation Involving Aldehyde Oxidase, γ-Glutamyl Transpeptidase, Cathepsin B, Flavin-Containing Monooxygenase, and ADP-RibosyltransferasePeter W. Fan, Donglu Zhang, Jason S. Halladay, James P. Driscoll and S. Cyrus KhojastehDrug Metabolism and Disposition August 2016, 44 (8) 1253-1261; DOI: https://doi.org/10.1124/dmd.116.070169
King, Ivan
- You have accessBiotransformation and Rearrangement of LaromustineAlaa-Eldin F. Nassar, Adam V. Wisnewski and Ivan KingDrug Metabolism and Disposition August 2016, 44 (8) 1349-1363; DOI: https://doi.org/10.1124/dmd.116.069823
Kocarek, Thomas A.
- You have accessTranscriptional Regulation of Cytosolic Sulfotransferase 1C2 by Vitamin D Receptor in LS180 Human Colorectal Adenocarcinoma CellsKathleen G. Barrett, Hailin Fang, Thomas A. Kocarek and Melissa Runge-MorrisDrug Metabolism and Disposition August 2016, 44 (8) 1431-1434; DOI: https://doi.org/10.1124/dmd.116.070300
Konno, Yoshihiro
- You have accessEstablishment of In Silico Prediction Models for CYP3A4 and CYP2B6 Induction in Human Hepatocytes by Multiple Regression Analysis Using Azole CompoundsMika Nagai, Yoshihiro Konno, Masahiro Satsukawa, Shinji Yamashita and Kouichi YoshinariDrug Metabolism and Disposition August 2016, 44 (8) 1390-1398; DOI: https://doi.org/10.1124/dmd.115.068619
Krzek, Marzena
- You have accessMicrobial Flavoprotein Monooxygenases as Mimics of Mammalian Flavin-Containing Monooxygenases for the Enantioselective Preparation of Drug MetabolitesTuran Gul, Marzena Krzek, Hjalmar P. Permentier, Marco W. Fraaije and Rainer BischoffDrug Metabolism and Disposition August 2016, 44 (8) 1270-1276; DOI: https://doi.org/10.1124/dmd.115.069104
Kusuhara, Hiroyuki
- You have accessImpact of Experimental Conditions on the Evaluation of Interactions between Multidrug and Toxin Extrusion Proteins and Candidate DrugsChristian Lechner, Naoki Ishiguro, Ayano Fukuhara, Hidetada Shimizu, Naoko Ohtsu, Masahito Takatani, Kotaro Nishiyama, Ikumi Washio, Norio Yamamura and Hiroyuki KusuharaDrug Metabolism and Disposition August 2016, 44 (8) 1381-1389; DOI: https://doi.org/10.1124/dmd.115.068163
L
Lai, George
- You have accessEvaluation of a New Molecular Entity as a Victim of Metabolic Drug-Drug Interactions—an Industry PerspectiveTonika Bohnert, Aarti Patel, Ian Templeton, Yuan Chen, Chuang Lu, George Lai, Louis Leung, Susanna Tse, Heidi J Einolf, Ying-Hong Wang, Michael Sinz, Ralph Stearns, Robert Walsky, Wanping Geng, Sirimas Sudsakorn, David Moore, Ling He, Jan Wahlstrom, Jim Keirns, Rangaraj Narayanan, Dieter Lang, Xiaoqing Yang and International Consortium for Innovation and Quality in Pharmaceutical Development (IQ) Victim Drug-Drug Interactions Working GroupDrug Metabolism and Disposition August 2016, 44 (8) 1399-1423; DOI: https://doi.org/10.1124/dmd.115.069096
Laitinen, Leena
- You have accessVX-509 (Decernotinib)-Mediated CYP3A Time-Dependent Inhibition: An Aldehyde Oxidase Metabolite as a Perpetrator of Drug-Drug InteractionsCraig Zetterberg, Francois Maltais, Leena Laitinen, Shengkai Liao, Hong Tsao, Ananthsrinivas Chakilam and Niresh HariparsadDrug Metabolism and Disposition August 2016, 44 (8) 1286-1295; DOI: https://doi.org/10.1124/dmd.116.071100
Lamarche, Caroline
- You have accessEffects of Chronic Renal Failure on Brain Cytochrome P450 in RatsJudith Naud, Jessica Harding, Caroline Lamarche, Stephanie Beauchemin, Francois A. Leblond and Vincent PichetteDrug Metabolism and Disposition August 2016, 44 (8) 1174-1179; DOI: https://doi.org/10.1124/dmd.116.070052
Lang, Dieter
- You have accessEvaluation of a New Molecular Entity as a Victim of Metabolic Drug-Drug Interactions—an Industry PerspectiveTonika Bohnert, Aarti Patel, Ian Templeton, Yuan Chen, Chuang Lu, George Lai, Louis Leung, Susanna Tse, Heidi J Einolf, Ying-Hong Wang, Michael Sinz, Ralph Stearns, Robert Walsky, Wanping Geng, Sirimas Sudsakorn, David Moore, Ling He, Jan Wahlstrom, Jim Keirns, Rangaraj Narayanan, Dieter Lang, Xiaoqing Yang and International Consortium for Innovation and Quality in Pharmaceutical Development (IQ) Victim Drug-Drug Interactions Working GroupDrug Metabolism and Disposition August 2016, 44 (8) 1399-1423; DOI: https://doi.org/10.1124/dmd.115.069096
Leblond, Francois A.
- You have accessEffects of Chronic Renal Failure on Brain Cytochrome P450 in RatsJudith Naud, Jessica Harding, Caroline Lamarche, Stephanie Beauchemin, Francois A. Leblond and Vincent PichetteDrug Metabolism and Disposition August 2016, 44 (8) 1174-1179; DOI: https://doi.org/10.1124/dmd.116.070052
Lechner, Christian
- You have accessImpact of Experimental Conditions on the Evaluation of Interactions between Multidrug and Toxin Extrusion Proteins and Candidate DrugsChristian Lechner, Naoki Ishiguro, Ayano Fukuhara, Hidetada Shimizu, Naoko Ohtsu, Masahito Takatani, Kotaro Nishiyama, Ikumi Washio, Norio Yamamura and Hiroyuki KusuharaDrug Metabolism and Disposition August 2016, 44 (8) 1381-1389; DOI: https://doi.org/10.1124/dmd.115.068163
Lee, Anthony J.
- You have accessMetabolism and Disposition of Pan-Genotypic Inhibitor of Hepatitis C Virus NS5A Ombitasvir in HumansJianwei Shen, Michael Serby, Bruce Surber, Anthony J. Lee, Junli Ma, Prajakta Badri, Rajeev Menon, Olga Kavetskaia, Sonia M. de Morais, Jens Sydor and Volker FischerDrug Metabolism and Disposition August 2016, 44 (8) 1148-1157; DOI: https://doi.org/10.1124/dmd.115.067496
- You have accessMetabolism and Disposition of the Hepatitis C Protease Inhibitor Paritaprevir in HumansJianwei Shen, Michael Serby, Aimee Reed, Anthony J. Lee, Xiaomei Zhang, Kennan Marsh, Amit Khatri, Rajeev Menon, Olga Kavetskaia and Volker FischerDrug Metabolism and Disposition August 2016, 44 (8) 1164-1173; DOI: https://doi.org/10.1124/dmd.115.067488
- You have accessMetabolism and Disposition of Hepatitis C Polymerase Inhibitor Dasabuvir in HumansJianwei Shen, Michael Serby, Aimee Reed, Anthony J. Lee, Rajeev Menon, Xiaomei Zhang, Kennan Marsh, Xia Wan, Olga Kavetskaia and Volker FischerDrug Metabolism and Disposition August 2016, 44 (8) 1139-1147; DOI: https://doi.org/10.1124/dmd.115.067512
Leet, John E.
- You have accessPhosphocholine Conjugation: An Unexpected In Vivo Conjugation Pathway Associated with Hepatitis C NS5B Inhibitors Featuring A Bicyclo[1.1.1]PentaneXiaoliang Zhuo, Joseph L. Cantone, Yingzi Wang, John E. Leet, Dieter M. Drexler, Kap-Sun Yeung, Xiaohua Stella Huang, Kyle J. Eastman, Kyle E. Parcella, Kathleen W. Mosure, Matthew G. Soars, John F. Kadow and Benjamin M. JohnsonDrug Metabolism and Disposition August 2016, 44 (8) 1332-1340; DOI: https://doi.org/10.1124/dmd.115.069062
Leimkühler, Silke
- You have accessOptimization of the Expression of Human Aldehyde Oxidase for Investigations of Single-Nucleotide PolymorphismsAlessandro Foti, Tobias Hartmann, Catarina Coelho, Teresa Santos-Silva, Maria João Romão and Silke LeimkühlerDrug Metabolism and Disposition August 2016, 44 (8) 1277-1285; DOI: https://doi.org/10.1124/dmd.115.068395
Leung, Louis
- You have accessEvaluation of a New Molecular Entity as a Victim of Metabolic Drug-Drug Interactions—an Industry PerspectiveTonika Bohnert, Aarti Patel, Ian Templeton, Yuan Chen, Chuang Lu, George Lai, Louis Leung, Susanna Tse, Heidi J Einolf, Ying-Hong Wang, Michael Sinz, Ralph Stearns, Robert Walsky, Wanping Geng, Sirimas Sudsakorn, David Moore, Ling He, Jan Wahlstrom, Jim Keirns, Rangaraj Narayanan, Dieter Lang, Xiaoqing Yang and International Consortium for Innovation and Quality in Pharmaceutical Development (IQ) Victim Drug-Drug Interactions Working GroupDrug Metabolism and Disposition August 2016, 44 (8) 1399-1423; DOI: https://doi.org/10.1124/dmd.115.069096
Li, Wenying
- You have accessApplication of Static Models to Predict Midazolam Clinical Interactions in the Presence of Single or Multiple Hepatitis C Virus DrugsYaofeng Cheng, Li Ma, Shu-Ying Chang, W. Griffith Humphreys and Wenying LiDrug Metabolism and Disposition August 2016, 44 (8) 1372-1380; DOI: https://doi.org/10.1124/dmd.116.070409
Li, Xue-Qing
- You have accessDiscovery of a Novel Microsomal Epoxide Hydrolase–Catalyzed Hydration of a Spiro OxetaneXue-Qing Li, Martin A. Hayes, Gunnar Grönberg, Kristina Berggren, Neal Castagnoli and Lars WeidolfDrug Metabolism and Disposition August 2016, 44 (8) 1341-1348; DOI: https://doi.org/10.1124/dmd.116.071142
Li, Zhi-Hui
- Open AccessCorrelation of Cytochrome P450 Oxidoreductase Expression with the Expression of 10 Isoforms of Cytochrome P450 in Human LiverHai-Feng Zhang, Zhi-Hui Li, Jia-Yu Liu, Ting-Ting Liu, Ping Wang, Yan Fang, Jun Zhou, Ming-Zhu Cui, Na Gao, Xin Tian, Jie Gao, Qiang Wen, Lin-Jing Jia and Hai-Ling QiaoDrug Metabolism and Disposition August 2016, 44 (8) 1193-1200; DOI: https://doi.org/10.1124/dmd.116.069849
Liao, Shengkai
- You have accessVX-509 (Decernotinib)-Mediated CYP3A Time-Dependent Inhibition: An Aldehyde Oxidase Metabolite as a Perpetrator of Drug-Drug InteractionsCraig Zetterberg, Francois Maltais, Leena Laitinen, Shengkai Liao, Hong Tsao, Ananthsrinivas Chakilam and Niresh HariparsadDrug Metabolism and Disposition August 2016, 44 (8) 1286-1295; DOI: https://doi.org/10.1124/dmd.116.071100
Lindsley, Craig W.
- You have accessEvaluating the Disposition of a Mixed Aldehyde Oxidase/Cytochrome P450 Substrate in Rats with Attenuated P450 ActivityRachel D. Crouch, Ryan D. Morrison, Frank W. Byers, Craig W. Lindsley, Kyle A. Emmitte and J. Scott DanielsDrug Metabolism and Disposition August 2016, 44 (8) 1296-1303; DOI: https://doi.org/10.1124/dmd.115.068338
Liu, Jia-Yu
- Open AccessCorrelation of Cytochrome P450 Oxidoreductase Expression with the Expression of 10 Isoforms of Cytochrome P450 in Human LiverHai-Feng Zhang, Zhi-Hui Li, Jia-Yu Liu, Ting-Ting Liu, Ping Wang, Yan Fang, Jun Zhou, Ming-Zhu Cui, Na Gao, Xin Tian, Jie Gao, Qiang Wen, Lin-Jing Jia and Hai-Ling QiaoDrug Metabolism and Disposition August 2016, 44 (8) 1193-1200; DOI: https://doi.org/10.1124/dmd.116.069849
Liu, Ting-Ting
- Open AccessCorrelation of Cytochrome P450 Oxidoreductase Expression with the Expression of 10 Isoforms of Cytochrome P450 in Human LiverHai-Feng Zhang, Zhi-Hui Li, Jia-Yu Liu, Ting-Ting Liu, Ping Wang, Yan Fang, Jun Zhou, Ming-Zhu Cui, Na Gao, Xin Tian, Jie Gao, Qiang Wen, Lin-Jing Jia and Hai-Ling QiaoDrug Metabolism and Disposition August 2016, 44 (8) 1193-1200; DOI: https://doi.org/10.1124/dmd.116.069849
Louie, Steven W.
- You have accessNonclinical Pharmacokinetics, Disposition, and Drug-Drug Interaction Potential of a Novel d-Amino Acid Peptide Agonist of the Calcium-Sensing Receptor AMG 416 (Etelcalcetide)Raju Subramanian, Xiaochun Zhu, Savannah J. Kerr, Joel D. Esmay, Steven W. Louie, Katheryne Z. Edson, Sarah Walter, Michael Fitzsimmons, Mylo Wagner, Marcus Soto, Roger Pham, Sarah F. Wilson and Gary L. SkilesDrug Metabolism and Disposition August 2016, 44 (8) 1319-1331; DOI: https://doi.org/10.1124/dmd.115.068007
Lu, Chuang
- You have accessEvaluation of a New Molecular Entity as a Victim of Metabolic Drug-Drug Interactions—an Industry PerspectiveTonika Bohnert, Aarti Patel, Ian Templeton, Yuan Chen, Chuang Lu, George Lai, Louis Leung, Susanna Tse, Heidi J Einolf, Ying-Hong Wang, Michael Sinz, Ralph Stearns, Robert Walsky, Wanping Geng, Sirimas Sudsakorn, David Moore, Ling He, Jan Wahlstrom, Jim Keirns, Rangaraj Narayanan, Dieter Lang, Xiaoqing Yang and International Consortium for Innovation and Quality in Pharmaceutical Development (IQ) Victim Drug-Drug Interactions Working GroupDrug Metabolism and Disposition August 2016, 44 (8) 1399-1423; DOI: https://doi.org/10.1124/dmd.115.069096
M
Ma, Junli
- You have accessMetabolism and Disposition of Pan-Genotypic Inhibitor of Hepatitis C Virus NS5A Ombitasvir in HumansJianwei Shen, Michael Serby, Bruce Surber, Anthony J. Lee, Junli Ma, Prajakta Badri, Rajeev Menon, Olga Kavetskaia, Sonia M. de Morais, Jens Sydor and Volker FischerDrug Metabolism and Disposition August 2016, 44 (8) 1148-1157; DOI: https://doi.org/10.1124/dmd.115.067496
Ma, Li
- You have accessApplication of Static Models to Predict Midazolam Clinical Interactions in the Presence of Single or Multiple Hepatitis C Virus DrugsYaofeng Cheng, Li Ma, Shu-Ying Chang, W. Griffith Humphreys and Wenying LiDrug Metabolism and Disposition August 2016, 44 (8) 1372-1380; DOI: https://doi.org/10.1124/dmd.116.070409
Maltais, Francois
- You have accessVX-509 (Decernotinib)-Mediated CYP3A Time-Dependent Inhibition: An Aldehyde Oxidase Metabolite as a Perpetrator of Drug-Drug InteractionsCraig Zetterberg, Francois Maltais, Leena Laitinen, Shengkai Liao, Hong Tsao, Ananthsrinivas Chakilam and Niresh HariparsadDrug Metabolism and Disposition August 2016, 44 (8) 1286-1295; DOI: https://doi.org/10.1124/dmd.116.071100
Marsh, Kennan
- You have accessMetabolism and Disposition of the Hepatitis C Protease Inhibitor Paritaprevir in HumansJianwei Shen, Michael Serby, Aimee Reed, Anthony J. Lee, Xiaomei Zhang, Kennan Marsh, Amit Khatri, Rajeev Menon, Olga Kavetskaia and Volker FischerDrug Metabolism and Disposition August 2016, 44 (8) 1164-1173; DOI: https://doi.org/10.1124/dmd.115.067488
- You have accessMetabolism and Disposition of Hepatitis C Polymerase Inhibitor Dasabuvir in HumansJianwei Shen, Michael Serby, Aimee Reed, Anthony J. Lee, Rajeev Menon, Xiaomei Zhang, Kennan Marsh, Xia Wan, Olga Kavetskaia and Volker FischerDrug Metabolism and Disposition August 2016, 44 (8) 1139-1147; DOI: https://doi.org/10.1124/dmd.115.067512
Marson, Lesley
- You have accessBiotransformation Capacity of Carboxylesterase in Skin and Keratinocytes for the Penta-Ethyl Ester Prodrug of DTPAJing Fu, Matthew Sadgrove, Lesley Marson and Michael JayDrug Metabolism and Disposition August 2016, 44 (8) 1313-1318; DOI: https://doi.org/10.1124/dmd.116.069377
Martin, Iain J.
- You have accessA Pharmacokinetic Modeling Approach to Predict the Contribution of Active Metabolites to Human Efficacious DoseIain J. Martin, Susan E. Hill, James A. Baker, Sujal V. Deshmukh and Erin F. MulrooneyDrug Metabolism and Disposition August 2016, 44 (8) 1435-1440; DOI: https://doi.org/10.1124/dmd.116.070391
Martin, Scott
- You have accessMetabolic Disposition of Osimertinib in Rats, Dogs, and Humans: Insights into a Drug Designed to Bind Covalently to a Cysteine Residue of Epidermal Growth Factor ReceptorPaul A. Dickinson, Mireille V. Cantarini, Jo Collier, Paul Frewer, Scott Martin, Kathryn Pickup and Peter BallardDrug Metabolism and Disposition August 2016, 44 (8) 1201-1212; DOI: https://doi.org/10.1124/dmd.115.069203
Mason, Andrew K.
- You have accessSelective Time- and NADPH-Dependent Inhibition of Human CYP2E1 by ClomethiazoleDavid M. Stresser, Elke S. Perloff, Andrew K. Mason, Andrew P. Blanchard, Shangara S. Dehal, Timothy P. Creegan, Ritu Singh and Eric T. GanglDrug Metabolism and Disposition August 2016, 44 (8) 1424-1430; DOI: https://doi.org/10.1124/dmd.116.070193
Menon, Rajeev
- You have accessMetabolism and Disposition of Pan-Genotypic Inhibitor of Hepatitis C Virus NS5A Ombitasvir in HumansJianwei Shen, Michael Serby, Bruce Surber, Anthony J. Lee, Junli Ma, Prajakta Badri, Rajeev Menon, Olga Kavetskaia, Sonia M. de Morais, Jens Sydor and Volker FischerDrug Metabolism and Disposition August 2016, 44 (8) 1148-1157; DOI: https://doi.org/10.1124/dmd.115.067496
- You have accessMetabolism and Disposition of the Hepatitis C Protease Inhibitor Paritaprevir in HumansJianwei Shen, Michael Serby, Aimee Reed, Anthony J. Lee, Xiaomei Zhang, Kennan Marsh, Amit Khatri, Rajeev Menon, Olga Kavetskaia and Volker FischerDrug Metabolism and Disposition August 2016, 44 (8) 1164-1173; DOI: https://doi.org/10.1124/dmd.115.067488
- You have accessMetabolism and Disposition of Hepatitis C Polymerase Inhibitor Dasabuvir in HumansJianwei Shen, Michael Serby, Aimee Reed, Anthony J. Lee, Rajeev Menon, Xiaomei Zhang, Kennan Marsh, Xia Wan, Olga Kavetskaia and Volker FischerDrug Metabolism and Disposition August 2016, 44 (8) 1139-1147; DOI: https://doi.org/10.1124/dmd.115.067512
Mohutsky, Michael A.
- You have accessDifference in the Pharmacokinetics and Hepatic Metabolism of Antidiabetic Drugs in Zucker Diabetic Fatty and Sprague-Dawley RatsXin Zhou, Luc R. A. Rougée, David W. Bedwell, Jeff W. Cramer, Michael A. Mohutsky, Nathan A. Calvert, Richard D. Moulton, Kenneth C. Cassidy, Nathan P. Yumibe, Lisa A. Adams and Kenneth J. RuterboriesDrug Metabolism and Disposition August 2016, 44 (8) 1184-1192; DOI: https://doi.org/10.1124/dmd.116.070623
Moore, David
- You have accessEvaluation of a New Molecular Entity as a Victim of Metabolic Drug-Drug Interactions—an Industry PerspectiveTonika Bohnert, Aarti Patel, Ian Templeton, Yuan Chen, Chuang Lu, George Lai, Louis Leung, Susanna Tse, Heidi J Einolf, Ying-Hong Wang, Michael Sinz, Ralph Stearns, Robert Walsky, Wanping Geng, Sirimas Sudsakorn, David Moore, Ling He, Jan Wahlstrom, Jim Keirns, Rangaraj Narayanan, Dieter Lang, Xiaoqing Yang and International Consortium for Innovation and Quality in Pharmaceutical Development (IQ) Victim Drug-Drug Interactions Working GroupDrug Metabolism and Disposition August 2016, 44 (8) 1399-1423; DOI: https://doi.org/10.1124/dmd.115.069096
Morrison, Ryan D.
- You have accessEvaluating the Disposition of a Mixed Aldehyde Oxidase/Cytochrome P450 Substrate in Rats with Attenuated P450 ActivityRachel D. Crouch, Ryan D. Morrison, Frank W. Byers, Craig W. Lindsley, Kyle A. Emmitte and J. Scott DanielsDrug Metabolism and Disposition August 2016, 44 (8) 1296-1303; DOI: https://doi.org/10.1124/dmd.115.068338
Mosure, Kathleen W.
- You have accessPhosphocholine Conjugation: An Unexpected In Vivo Conjugation Pathway Associated with Hepatitis C NS5B Inhibitors Featuring A Bicyclo[1.1.1]PentaneXiaoliang Zhuo, Joseph L. Cantone, Yingzi Wang, John E. Leet, Dieter M. Drexler, Kap-Sun Yeung, Xiaohua Stella Huang, Kyle J. Eastman, Kyle E. Parcella, Kathleen W. Mosure, Matthew G. Soars, John F. Kadow and Benjamin M. JohnsonDrug Metabolism and Disposition August 2016, 44 (8) 1332-1340; DOI: https://doi.org/10.1124/dmd.115.069062
Moulton, Richard D.
- You have accessDifference in the Pharmacokinetics and Hepatic Metabolism of Antidiabetic Drugs in Zucker Diabetic Fatty and Sprague-Dawley RatsXin Zhou, Luc R. A. Rougée, David W. Bedwell, Jeff W. Cramer, Michael A. Mohutsky, Nathan A. Calvert, Richard D. Moulton, Kenneth C. Cassidy, Nathan P. Yumibe, Lisa A. Adams and Kenneth J. RuterboriesDrug Metabolism and Disposition August 2016, 44 (8) 1184-1192; DOI: https://doi.org/10.1124/dmd.116.070623
Mulrooney, Erin F.
- You have accessA Pharmacokinetic Modeling Approach to Predict the Contribution of Active Metabolites to Human Efficacious DoseIain J. Martin, Susan E. Hill, James A. Baker, Sujal V. Deshmukh and Erin F. MulrooneyDrug Metabolism and Disposition August 2016, 44 (8) 1435-1440; DOI: https://doi.org/10.1124/dmd.116.070391
N
Nagai, Mika
- You have accessEstablishment of In Silico Prediction Models for CYP3A4 and CYP2B6 Induction in Human Hepatocytes by Multiple Regression Analysis Using Azole CompoundsMika Nagai, Yoshihiro Konno, Masahiro Satsukawa, Shinji Yamashita and Kouichi YoshinariDrug Metabolism and Disposition August 2016, 44 (8) 1390-1398; DOI: https://doi.org/10.1124/dmd.115.068619
Nakamura, Satoshi
- You have accessDifferences in Gene Regulation by Dual Ligands of Nuclear Receptors Constitutive Androstane Receptor (CAR) and Pregnane X Receptor (PXR) in HepG2 Cells Stably Expressing CAR/PXRYuichiro Kanno, Nobuaki Tanuma, Saki Yazawa, Shuai Zhao, Miki Inaba, Satoshi Nakamura, Kiyomitsu Nemoto and Yoshio InouyeDrug Metabolism and Disposition August 2016, 44 (8) 1158-1163; DOI: https://doi.org/10.1124/dmd.116.070888
Narayanan, Rangaraj
- You have accessEvaluation of a New Molecular Entity as a Victim of Metabolic Drug-Drug Interactions—an Industry PerspectiveTonika Bohnert, Aarti Patel, Ian Templeton, Yuan Chen, Chuang Lu, George Lai, Louis Leung, Susanna Tse, Heidi J Einolf, Ying-Hong Wang, Michael Sinz, Ralph Stearns, Robert Walsky, Wanping Geng, Sirimas Sudsakorn, David Moore, Ling He, Jan Wahlstrom, Jim Keirns, Rangaraj Narayanan, Dieter Lang, Xiaoqing Yang and International Consortium for Innovation and Quality in Pharmaceutical Development (IQ) Victim Drug-Drug Interactions Working GroupDrug Metabolism and Disposition August 2016, 44 (8) 1399-1423; DOI: https://doi.org/10.1124/dmd.115.069096
Nassar, Alaa-Eldin F.
- You have accessBiotransformation and Rearrangement of LaromustineAlaa-Eldin F. Nassar, Adam V. Wisnewski and Ivan KingDrug Metabolism and Disposition August 2016, 44 (8) 1349-1363; DOI: https://doi.org/10.1124/dmd.116.069823
Naud, Judith
- You have accessEffects of Chronic Renal Failure on Brain Cytochrome P450 in RatsJudith Naud, Jessica Harding, Caroline Lamarche, Stephanie Beauchemin, Francois A. Leblond and Vincent PichetteDrug Metabolism and Disposition August 2016, 44 (8) 1174-1179; DOI: https://doi.org/10.1124/dmd.116.070052
Nemoto, Kiyomitsu
- You have accessDifferences in Gene Regulation by Dual Ligands of Nuclear Receptors Constitutive Androstane Receptor (CAR) and Pregnane X Receptor (PXR) in HepG2 Cells Stably Expressing CAR/PXRYuichiro Kanno, Nobuaki Tanuma, Saki Yazawa, Shuai Zhao, Miki Inaba, Satoshi Nakamura, Kiyomitsu Nemoto and Yoshio InouyeDrug Metabolism and Disposition August 2016, 44 (8) 1158-1163; DOI: https://doi.org/10.1124/dmd.116.070888
Neuvonen, Mikko
- You have accessClopidogrel Markedly Increases Plasma Concentrations of CYP2C8 Substrate PioglitazoneMatti K. Itkonen, Aleksi Tornio, Mikko Neuvonen, Pertti J. Neuvonen, Mikko Niemi and Janne T. BackmanDrug Metabolism and Disposition August 2016, 44 (8) 1364-1371; DOI: https://doi.org/10.1124/dmd.116.070375
Neuvonen, Pertti J.
- You have accessClopidogrel Markedly Increases Plasma Concentrations of CYP2C8 Substrate PioglitazoneMatti K. Itkonen, Aleksi Tornio, Mikko Neuvonen, Pertti J. Neuvonen, Mikko Niemi and Janne T. BackmanDrug Metabolism and Disposition August 2016, 44 (8) 1364-1371; DOI: https://doi.org/10.1124/dmd.116.070375
Niemi, Mikko
- You have accessClopidogrel Markedly Increases Plasma Concentrations of CYP2C8 Substrate PioglitazoneMatti K. Itkonen, Aleksi Tornio, Mikko Neuvonen, Pertti J. Neuvonen, Mikko Niemi and Janne T. BackmanDrug Metabolism and Disposition August 2016, 44 (8) 1364-1371; DOI: https://doi.org/10.1124/dmd.116.070375
Nishiyama, Kotaro
- You have accessImpact of Experimental Conditions on the Evaluation of Interactions between Multidrug and Toxin Extrusion Proteins and Candidate DrugsChristian Lechner, Naoki Ishiguro, Ayano Fukuhara, Hidetada Shimizu, Naoko Ohtsu, Masahito Takatani, Kotaro Nishiyama, Ikumi Washio, Norio Yamamura and Hiroyuki KusuharaDrug Metabolism and Disposition August 2016, 44 (8) 1381-1389; DOI: https://doi.org/10.1124/dmd.115.068163
O
Obach, R. Scott
- You have accessUse of Human Plasma Samples to Identify Circulating Drug Metabolites that Inhibit Cytochrome P450 EnzymesHeather Eng and R. Scott ObachDrug Metabolism and Disposition August 2016, 44 (8) 1217-1228; DOI: https://doi.org/10.1124/dmd.116.071084
Ohtsu, Naoko
- You have accessImpact of Experimental Conditions on the Evaluation of Interactions between Multidrug and Toxin Extrusion Proteins and Candidate DrugsChristian Lechner, Naoki Ishiguro, Ayano Fukuhara, Hidetada Shimizu, Naoko Ohtsu, Masahito Takatani, Kotaro Nishiyama, Ikumi Washio, Norio Yamamura and Hiroyuki KusuharaDrug Metabolism and Disposition August 2016, 44 (8) 1381-1389; DOI: https://doi.org/10.1124/dmd.115.068163
P
Parcella, Kyle E.
- You have accessPhosphocholine Conjugation: An Unexpected In Vivo Conjugation Pathway Associated with Hepatitis C NS5B Inhibitors Featuring A Bicyclo[1.1.1]PentaneXiaoliang Zhuo, Joseph L. Cantone, Yingzi Wang, John E. Leet, Dieter M. Drexler, Kap-Sun Yeung, Xiaohua Stella Huang, Kyle J. Eastman, Kyle E. Parcella, Kathleen W. Mosure, Matthew G. Soars, John F. Kadow and Benjamin M. JohnsonDrug Metabolism and Disposition August 2016, 44 (8) 1332-1340; DOI: https://doi.org/10.1124/dmd.115.069062
Patel, Aarti
- You have accessEvaluation of a New Molecular Entity as a Victim of Metabolic Drug-Drug Interactions—an Industry PerspectiveTonika Bohnert, Aarti Patel, Ian Templeton, Yuan Chen, Chuang Lu, George Lai, Louis Leung, Susanna Tse, Heidi J Einolf, Ying-Hong Wang, Michael Sinz, Ralph Stearns, Robert Walsky, Wanping Geng, Sirimas Sudsakorn, David Moore, Ling He, Jan Wahlstrom, Jim Keirns, Rangaraj Narayanan, Dieter Lang, Xiaoqing Yang and International Consortium for Innovation and Quality in Pharmaceutical Development (IQ) Victim Drug-Drug Interactions Working GroupDrug Metabolism and Disposition August 2016, 44 (8) 1399-1423; DOI: https://doi.org/10.1124/dmd.115.069096
Perloff, Elke S.
- You have accessSelective Time- and NADPH-Dependent Inhibition of Human CYP2E1 by ClomethiazoleDavid M. Stresser, Elke S. Perloff, Andrew K. Mason, Andrew P. Blanchard, Shangara S. Dehal, Timothy P. Creegan, Ritu Singh and Eric T. GanglDrug Metabolism and Disposition August 2016, 44 (8) 1424-1430; DOI: https://doi.org/10.1124/dmd.116.070193
Permentier, Hjalmar P.
- You have accessMicrobial Flavoprotein Monooxygenases as Mimics of Mammalian Flavin-Containing Monooxygenases for the Enantioselective Preparation of Drug MetabolitesTuran Gul, Marzena Krzek, Hjalmar P. Permentier, Marco W. Fraaije and Rainer BischoffDrug Metabolism and Disposition August 2016, 44 (8) 1270-1276; DOI: https://doi.org/10.1124/dmd.115.069104
Pham, Roger
- You have accessNonclinical Pharmacokinetics, Disposition, and Drug-Drug Interaction Potential of a Novel d-Amino Acid Peptide Agonist of the Calcium-Sensing Receptor AMG 416 (Etelcalcetide)Raju Subramanian, Xiaochun Zhu, Savannah J. Kerr, Joel D. Esmay, Steven W. Louie, Katheryne Z. Edson, Sarah Walter, Michael Fitzsimmons, Mylo Wagner, Marcus Soto, Roger Pham, Sarah F. Wilson and Gary L. SkilesDrug Metabolism and Disposition August 2016, 44 (8) 1319-1331; DOI: https://doi.org/10.1124/dmd.115.068007
Pichette, Vincent
- You have accessEffects of Chronic Renal Failure on Brain Cytochrome P450 in RatsJudith Naud, Jessica Harding, Caroline Lamarche, Stephanie Beauchemin, Francois A. Leblond and Vincent PichetteDrug Metabolism and Disposition August 2016, 44 (8) 1174-1179; DOI: https://doi.org/10.1124/dmd.116.070052
Pickup, Kathryn
- You have accessMetabolic Disposition of Osimertinib in Rats, Dogs, and Humans: Insights into a Drug Designed to Bind Covalently to a Cysteine Residue of Epidermal Growth Factor ReceptorPaul A. Dickinson, Mireille V. Cantarini, Jo Collier, Paul Frewer, Scott Martin, Kathryn Pickup and Peter BallardDrug Metabolism and Disposition August 2016, 44 (8) 1201-1212; DOI: https://doi.org/10.1124/dmd.115.069203
Q
Qiao, Hai-Ling
- Open AccessCorrelation of Cytochrome P450 Oxidoreductase Expression with the Expression of 10 Isoforms of Cytochrome P450 in Human LiverHai-Feng Zhang, Zhi-Hui Li, Jia-Yu Liu, Ting-Ting Liu, Ping Wang, Yan Fang, Jun Zhou, Ming-Zhu Cui, Na Gao, Xin Tian, Jie Gao, Qiang Wen, Lin-Jing Jia and Hai-Ling QiaoDrug Metabolism and Disposition August 2016, 44 (8) 1193-1200; DOI: https://doi.org/10.1124/dmd.116.069849
R
Reed, Aimee
- You have accessMetabolism and Disposition of the Hepatitis C Protease Inhibitor Paritaprevir in HumansJianwei Shen, Michael Serby, Aimee Reed, Anthony J. Lee, Xiaomei Zhang, Kennan Marsh, Amit Khatri, Rajeev Menon, Olga Kavetskaia and Volker FischerDrug Metabolism and Disposition August 2016, 44 (8) 1164-1173; DOI: https://doi.org/10.1124/dmd.115.067488
- You have accessMetabolism and Disposition of Hepatitis C Polymerase Inhibitor Dasabuvir in HumansJianwei Shen, Michael Serby, Aimee Reed, Anthony J. Lee, Rajeev Menon, Xiaomei Zhang, Kennan Marsh, Xia Wan, Olga Kavetskaia and Volker FischerDrug Metabolism and Disposition August 2016, 44 (8) 1139-1147; DOI: https://doi.org/10.1124/dmd.115.067512
Romão, Maria João
- You have accessOptimization of the Expression of Human Aldehyde Oxidase for Investigations of Single-Nucleotide PolymorphismsAlessandro Foti, Tobias Hartmann, Catarina Coelho, Teresa Santos-Silva, Maria João Romão and Silke LeimkühlerDrug Metabolism and Disposition August 2016, 44 (8) 1277-1285; DOI: https://doi.org/10.1124/dmd.115.068395
Ronseaux, Sebastien
- You have accessApplication of Osmotic Pumps for Sustained Release of 1-Aminobenzotriazole and Inhibition of Cytochrome P450 Enzymes in Mice: Model Comparison with the Hepatic P450 Reductase Null MouseRowan A. Stringer, Suzie Ferreira, Jonathan Rose and Sebastien RonseauxDrug Metabolism and Disposition August 2016, 44 (8) 1213-1216; DOI: https://doi.org/10.1124/dmd.116.070151
Rose, Jonathan
- You have accessApplication of Osmotic Pumps for Sustained Release of 1-Aminobenzotriazole and Inhibition of Cytochrome P450 Enzymes in Mice: Model Comparison with the Hepatic P450 Reductase Null MouseRowan A. Stringer, Suzie Ferreira, Jonathan Rose and Sebastien RonseauxDrug Metabolism and Disposition August 2016, 44 (8) 1213-1216; DOI: https://doi.org/10.1124/dmd.116.070151
Rougée, Luc R. A.
- You have accessDifference in the Pharmacokinetics and Hepatic Metabolism of Antidiabetic Drugs in Zucker Diabetic Fatty and Sprague-Dawley RatsXin Zhou, Luc R. A. Rougée, David W. Bedwell, Jeff W. Cramer, Michael A. Mohutsky, Nathan A. Calvert, Richard D. Moulton, Kenneth C. Cassidy, Nathan P. Yumibe, Lisa A. Adams and Kenneth J. RuterboriesDrug Metabolism and Disposition August 2016, 44 (8) 1184-1192; DOI: https://doi.org/10.1124/dmd.116.070623
Ruggeri, Roger B.
- You have accessSpecies Differences in the Oxidative Desulfurization of a Thiouracil-Based Irreversible Myeloperoxidase Inactivator by Flavin-Containing Monooxygenase EnzymesHeather Eng, Raman Sharma, Angela Wolford, Li Di, Roger B. Ruggeri, Leonard Buckbinder, Edward L. Conn, Deepak K. Dalvie and Amit S. KalgutkarDrug Metabolism and Disposition August 2016, 44 (8) 1262-1269; DOI: https://doi.org/10.1124/dmd.116.070185
Runge-Morris, Melissa
- You have accessTranscriptional Regulation of Cytosolic Sulfotransferase 1C2 by Vitamin D Receptor in LS180 Human Colorectal Adenocarcinoma CellsKathleen G. Barrett, Hailin Fang, Thomas A. Kocarek and Melissa Runge-MorrisDrug Metabolism and Disposition August 2016, 44 (8) 1431-1434; DOI: https://doi.org/10.1124/dmd.116.070300
Ruterbories, Kenneth J.
- You have accessDifference in the Pharmacokinetics and Hepatic Metabolism of Antidiabetic Drugs in Zucker Diabetic Fatty and Sprague-Dawley RatsXin Zhou, Luc R. A. Rougée, David W. Bedwell, Jeff W. Cramer, Michael A. Mohutsky, Nathan A. Calvert, Richard D. Moulton, Kenneth C. Cassidy, Nathan P. Yumibe, Lisa A. Adams and Kenneth J. RuterboriesDrug Metabolism and Disposition August 2016, 44 (8) 1184-1192; DOI: https://doi.org/10.1124/dmd.116.070623
S
Sadgrove, Matthew
- You have accessBiotransformation Capacity of Carboxylesterase in Skin and Keratinocytes for the Penta-Ethyl Ester Prodrug of DTPAJing Fu, Matthew Sadgrove, Lesley Marson and Michael JayDrug Metabolism and Disposition August 2016, 44 (8) 1313-1318; DOI: https://doi.org/10.1124/dmd.116.069377
Santos-Silva, Teresa
- You have accessOptimization of the Expression of Human Aldehyde Oxidase for Investigations of Single-Nucleotide PolymorphismsAlessandro Foti, Tobias Hartmann, Catarina Coelho, Teresa Santos-Silva, Maria João Romão and Silke LeimkühlerDrug Metabolism and Disposition August 2016, 44 (8) 1277-1285; DOI: https://doi.org/10.1124/dmd.115.068395
Saran, Chitra
- You have accessOcular Metabolism of Levobunolol: Historic and Emerging Metabolic PathwaysUpendra A. Argikar, Jennifer L. Dumouchel, Christine E. Dunne, Chitra Saran, Amanda L. Cirello and Mithat GunduzDrug Metabolism and Disposition August 2016, 44 (8) 1304-1312; DOI: https://doi.org/10.1124/dmd.116.070458
Satsukawa, Masahiro
- You have accessEstablishment of In Silico Prediction Models for CYP3A4 and CYP2B6 Induction in Human Hepatocytes by Multiple Regression Analysis Using Azole CompoundsMika Nagai, Yoshihiro Konno, Masahiro Satsukawa, Shinji Yamashita and Kouichi YoshinariDrug Metabolism and Disposition August 2016, 44 (8) 1390-1398; DOI: https://doi.org/10.1124/dmd.115.068619
Serby, Michael
- You have accessMetabolism and Disposition of Pan-Genotypic Inhibitor of Hepatitis C Virus NS5A Ombitasvir in HumansJianwei Shen, Michael Serby, Bruce Surber, Anthony J. Lee, Junli Ma, Prajakta Badri, Rajeev Menon, Olga Kavetskaia, Sonia M. de Morais, Jens Sydor and Volker FischerDrug Metabolism and Disposition August 2016, 44 (8) 1148-1157; DOI: https://doi.org/10.1124/dmd.115.067496
- You have accessMetabolism and Disposition of the Hepatitis C Protease Inhibitor Paritaprevir in HumansJianwei Shen, Michael Serby, Aimee Reed, Anthony J. Lee, Xiaomei Zhang, Kennan Marsh, Amit Khatri, Rajeev Menon, Olga Kavetskaia and Volker FischerDrug Metabolism and Disposition August 2016, 44 (8) 1164-1173; DOI: https://doi.org/10.1124/dmd.115.067488
- You have accessMetabolism and Disposition of Hepatitis C Polymerase Inhibitor Dasabuvir in HumansJianwei Shen, Michael Serby, Aimee Reed, Anthony J. Lee, Rajeev Menon, Xiaomei Zhang, Kennan Marsh, Xia Wan, Olga Kavetskaia and Volker FischerDrug Metabolism and Disposition August 2016, 44 (8) 1139-1147; DOI: https://doi.org/10.1124/dmd.115.067512
Sharma, Raman
- You have accessSpecies Differences in the Oxidative Desulfurization of a Thiouracil-Based Irreversible Myeloperoxidase Inactivator by Flavin-Containing Monooxygenase EnzymesHeather Eng, Raman Sharma, Angela Wolford, Li Di, Roger B. Ruggeri, Leonard Buckbinder, Edward L. Conn, Deepak K. Dalvie and Amit S. KalgutkarDrug Metabolism and Disposition August 2016, 44 (8) 1262-1269; DOI: https://doi.org/10.1124/dmd.116.070185
Shen, Jianwei
- You have accessMetabolism and Disposition of Pan-Genotypic Inhibitor of Hepatitis C Virus NS5A Ombitasvir in HumansJianwei Shen, Michael Serby, Bruce Surber, Anthony J. Lee, Junli Ma, Prajakta Badri, Rajeev Menon, Olga Kavetskaia, Sonia M. de Morais, Jens Sydor and Volker FischerDrug Metabolism and Disposition August 2016, 44 (8) 1148-1157; DOI: https://doi.org/10.1124/dmd.115.067496
- You have accessMetabolism and Disposition of the Hepatitis C Protease Inhibitor Paritaprevir in HumansJianwei Shen, Michael Serby, Aimee Reed, Anthony J. Lee, Xiaomei Zhang, Kennan Marsh, Amit Khatri, Rajeev Menon, Olga Kavetskaia and Volker FischerDrug Metabolism and Disposition August 2016, 44 (8) 1164-1173; DOI: https://doi.org/10.1124/dmd.115.067488
- You have accessMetabolism and Disposition of Hepatitis C Polymerase Inhibitor Dasabuvir in HumansJianwei Shen, Michael Serby, Aimee Reed, Anthony J. Lee, Rajeev Menon, Xiaomei Zhang, Kennan Marsh, Xia Wan, Olga Kavetskaia and Volker FischerDrug Metabolism and Disposition August 2016, 44 (8) 1139-1147; DOI: https://doi.org/10.1124/dmd.115.067512
Shimizu, Hidetada
- You have accessImpact of Experimental Conditions on the Evaluation of Interactions between Multidrug and Toxin Extrusion Proteins and Candidate DrugsChristian Lechner, Naoki Ishiguro, Ayano Fukuhara, Hidetada Shimizu, Naoko Ohtsu, Masahito Takatani, Kotaro Nishiyama, Ikumi Washio, Norio Yamamura and Hiroyuki KusuharaDrug Metabolism and Disposition August 2016, 44 (8) 1381-1389; DOI: https://doi.org/10.1124/dmd.115.068163
Singh, Ritu
- You have accessSelective Time- and NADPH-Dependent Inhibition of Human CYP2E1 by ClomethiazoleDavid M. Stresser, Elke S. Perloff, Andrew K. Mason, Andrew P. Blanchard, Shangara S. Dehal, Timothy P. Creegan, Ritu Singh and Eric T. GanglDrug Metabolism and Disposition August 2016, 44 (8) 1424-1430; DOI: https://doi.org/10.1124/dmd.116.070193
Sinz, Michael
- You have accessEvaluation of a New Molecular Entity as a Victim of Metabolic Drug-Drug Interactions—an Industry PerspectiveTonika Bohnert, Aarti Patel, Ian Templeton, Yuan Chen, Chuang Lu, George Lai, Louis Leung, Susanna Tse, Heidi J Einolf, Ying-Hong Wang, Michael Sinz, Ralph Stearns, Robert Walsky, Wanping Geng, Sirimas Sudsakorn, David Moore, Ling He, Jan Wahlstrom, Jim Keirns, Rangaraj Narayanan, Dieter Lang, Xiaoqing Yang and International Consortium for Innovation and Quality in Pharmaceutical Development (IQ) Victim Drug-Drug Interactions Working GroupDrug Metabolism and Disposition August 2016, 44 (8) 1399-1423; DOI: https://doi.org/10.1124/dmd.115.069096
Skiles, Gary L.
- You have accessNonclinical Pharmacokinetics, Disposition, and Drug-Drug Interaction Potential of a Novel d-Amino Acid Peptide Agonist of the Calcium-Sensing Receptor AMG 416 (Etelcalcetide)Raju Subramanian, Xiaochun Zhu, Savannah J. Kerr, Joel D. Esmay, Steven W. Louie, Katheryne Z. Edson, Sarah Walter, Michael Fitzsimmons, Mylo Wagner, Marcus Soto, Roger Pham, Sarah F. Wilson and Gary L. SkilesDrug Metabolism and Disposition August 2016, 44 (8) 1319-1331; DOI: https://doi.org/10.1124/dmd.115.068007
Soars, Matthew G.
- You have accessPhosphocholine Conjugation: An Unexpected In Vivo Conjugation Pathway Associated with Hepatitis C NS5B Inhibitors Featuring A Bicyclo[1.1.1]PentaneXiaoliang Zhuo, Joseph L. Cantone, Yingzi Wang, John E. Leet, Dieter M. Drexler, Kap-Sun Yeung, Xiaohua Stella Huang, Kyle J. Eastman, Kyle E. Parcella, Kathleen W. Mosure, Matthew G. Soars, John F. Kadow and Benjamin M. JohnsonDrug Metabolism and Disposition August 2016, 44 (8) 1332-1340; DOI: https://doi.org/10.1124/dmd.115.069062
Soto, Marcus
- You have accessNonclinical Pharmacokinetics, Disposition, and Drug-Drug Interaction Potential of a Novel d-Amino Acid Peptide Agonist of the Calcium-Sensing Receptor AMG 416 (Etelcalcetide)Raju Subramanian, Xiaochun Zhu, Savannah J. Kerr, Joel D. Esmay, Steven W. Louie, Katheryne Z. Edson, Sarah Walter, Michael Fitzsimmons, Mylo Wagner, Marcus Soto, Roger Pham, Sarah F. Wilson and Gary L. SkilesDrug Metabolism and Disposition August 2016, 44 (8) 1319-1331; DOI: https://doi.org/10.1124/dmd.115.068007
Stearns, Ralph
- You have accessEvaluation of a New Molecular Entity as a Victim of Metabolic Drug-Drug Interactions—an Industry PerspectiveTonika Bohnert, Aarti Patel, Ian Templeton, Yuan Chen, Chuang Lu, George Lai, Louis Leung, Susanna Tse, Heidi J Einolf, Ying-Hong Wang, Michael Sinz, Ralph Stearns, Robert Walsky, Wanping Geng, Sirimas Sudsakorn, David Moore, Ling He, Jan Wahlstrom, Jim Keirns, Rangaraj Narayanan, Dieter Lang, Xiaoqing Yang and International Consortium for Innovation and Quality in Pharmaceutical Development (IQ) Victim Drug-Drug Interactions Working GroupDrug Metabolism and Disposition August 2016, 44 (8) 1399-1423; DOI: https://doi.org/10.1124/dmd.115.069096
Stresser, David M.
- You have accessSelective Time- and NADPH-Dependent Inhibition of Human CYP2E1 by ClomethiazoleDavid M. Stresser, Elke S. Perloff, Andrew K. Mason, Andrew P. Blanchard, Shangara S. Dehal, Timothy P. Creegan, Ritu Singh and Eric T. GanglDrug Metabolism and Disposition August 2016, 44 (8) 1424-1430; DOI: https://doi.org/10.1124/dmd.116.070193
Stringer, Rowan A.
- You have accessApplication of Osmotic Pumps for Sustained Release of 1-Aminobenzotriazole and Inhibition of Cytochrome P450 Enzymes in Mice: Model Comparison with the Hepatic P450 Reductase Null MouseRowan A. Stringer, Suzie Ferreira, Jonathan Rose and Sebastien RonseauxDrug Metabolism and Disposition August 2016, 44 (8) 1213-1216; DOI: https://doi.org/10.1124/dmd.116.070151
Subramanian, Raju
- You have accessNonclinical Pharmacokinetics, Disposition, and Drug-Drug Interaction Potential of a Novel d-Amino Acid Peptide Agonist of the Calcium-Sensing Receptor AMG 416 (Etelcalcetide)Raju Subramanian, Xiaochun Zhu, Savannah J. Kerr, Joel D. Esmay, Steven W. Louie, Katheryne Z. Edson, Sarah Walter, Michael Fitzsimmons, Mylo Wagner, Marcus Soto, Roger Pham, Sarah F. Wilson and Gary L. SkilesDrug Metabolism and Disposition August 2016, 44 (8) 1319-1331; DOI: https://doi.org/10.1124/dmd.115.068007
Sudsakorn, Sirimas
- You have accessEvaluation of a New Molecular Entity as a Victim of Metabolic Drug-Drug Interactions—an Industry PerspectiveTonika Bohnert, Aarti Patel, Ian Templeton, Yuan Chen, Chuang Lu, George Lai, Louis Leung, Susanna Tse, Heidi J Einolf, Ying-Hong Wang, Michael Sinz, Ralph Stearns, Robert Walsky, Wanping Geng, Sirimas Sudsakorn, David Moore, Ling He, Jan Wahlstrom, Jim Keirns, Rangaraj Narayanan, Dieter Lang, Xiaoqing Yang and International Consortium for Innovation and Quality in Pharmaceutical Development (IQ) Victim Drug-Drug Interactions Working GroupDrug Metabolism and Disposition August 2016, 44 (8) 1399-1423; DOI: https://doi.org/10.1124/dmd.115.069096
Sugiura, Masayuki
- You have accessRecommendation to Exclude Bile-Duct-Cannulated Rats with Hyperbilirubinemia for Proper Conduct of Biliary Drug Excretion StudiesKoji Kato, Yoshitaka Hasegawa, Katsuya Iwata, Takuya Ichikawa, Tohru Yahara, Satoshi Tsuji, Masayuki Sugiura and Jun-ichi YamaguchiDrug Metabolism and Disposition August 2016, 44 (8) 1180-1183; DOI: https://doi.org/10.1124/dmd.116.070532
Surber, Bruce
- You have accessMetabolism and Disposition of Pan-Genotypic Inhibitor of Hepatitis C Virus NS5A Ombitasvir in HumansJianwei Shen, Michael Serby, Bruce Surber, Anthony J. Lee, Junli Ma, Prajakta Badri, Rajeev Menon, Olga Kavetskaia, Sonia M. de Morais, Jens Sydor and Volker FischerDrug Metabolism and Disposition August 2016, 44 (8) 1148-1157; DOI: https://doi.org/10.1124/dmd.115.067496
Sydor, Jens
- You have accessMetabolism and Disposition of Pan-Genotypic Inhibitor of Hepatitis C Virus NS5A Ombitasvir in HumansJianwei Shen, Michael Serby, Bruce Surber, Anthony J. Lee, Junli Ma, Prajakta Badri, Rajeev Menon, Olga Kavetskaia, Sonia M. de Morais, Jens Sydor and Volker FischerDrug Metabolism and Disposition August 2016, 44 (8) 1148-1157; DOI: https://doi.org/10.1124/dmd.115.067496
T
Takatani, Masahito
- You have accessImpact of Experimental Conditions on the Evaluation of Interactions between Multidrug and Toxin Extrusion Proteins and Candidate DrugsChristian Lechner, Naoki Ishiguro, Ayano Fukuhara, Hidetada Shimizu, Naoko Ohtsu, Masahito Takatani, Kotaro Nishiyama, Ikumi Washio, Norio Yamamura and Hiroyuki KusuharaDrug Metabolism and Disposition August 2016, 44 (8) 1381-1389; DOI: https://doi.org/10.1124/dmd.115.068163
Tanuma, Nobuaki
- You have accessDifferences in Gene Regulation by Dual Ligands of Nuclear Receptors Constitutive Androstane Receptor (CAR) and Pregnane X Receptor (PXR) in HepG2 Cells Stably Expressing CAR/PXRYuichiro Kanno, Nobuaki Tanuma, Saki Yazawa, Shuai Zhao, Miki Inaba, Satoshi Nakamura, Kiyomitsu Nemoto and Yoshio InouyeDrug Metabolism and Disposition August 2016, 44 (8) 1158-1163; DOI: https://doi.org/10.1124/dmd.116.070888
Templeton, Ian
- You have accessEvaluation of a New Molecular Entity as a Victim of Metabolic Drug-Drug Interactions—an Industry PerspectiveTonika Bohnert, Aarti Patel, Ian Templeton, Yuan Chen, Chuang Lu, George Lai, Louis Leung, Susanna Tse, Heidi J Einolf, Ying-Hong Wang, Michael Sinz, Ralph Stearns, Robert Walsky, Wanping Geng, Sirimas Sudsakorn, David Moore, Ling He, Jan Wahlstrom, Jim Keirns, Rangaraj Narayanan, Dieter Lang, Xiaoqing Yang and International Consortium for Innovation and Quality in Pharmaceutical Development (IQ) Victim Drug-Drug Interactions Working GroupDrug Metabolism and Disposition August 2016, 44 (8) 1399-1423; DOI: https://doi.org/10.1124/dmd.115.069096
Tian, Xin
- Open AccessCorrelation of Cytochrome P450 Oxidoreductase Expression with the Expression of 10 Isoforms of Cytochrome P450 in Human LiverHai-Feng Zhang, Zhi-Hui Li, Jia-Yu Liu, Ting-Ting Liu, Ping Wang, Yan Fang, Jun Zhou, Ming-Zhu Cui, Na Gao, Xin Tian, Jie Gao, Qiang Wen, Lin-Jing Jia and Hai-Ling QiaoDrug Metabolism and Disposition August 2016, 44 (8) 1193-1200; DOI: https://doi.org/10.1124/dmd.116.069849
Tornio, Aleksi
- You have accessClopidogrel Markedly Increases Plasma Concentrations of CYP2C8 Substrate PioglitazoneMatti K. Itkonen, Aleksi Tornio, Mikko Neuvonen, Pertti J. Neuvonen, Mikko Niemi and Janne T. BackmanDrug Metabolism and Disposition August 2016, 44 (8) 1364-1371; DOI: https://doi.org/10.1124/dmd.116.070375
Tsao, Hong
- You have accessVX-509 (Decernotinib)-Mediated CYP3A Time-Dependent Inhibition: An Aldehyde Oxidase Metabolite as a Perpetrator of Drug-Drug InteractionsCraig Zetterberg, Francois Maltais, Leena Laitinen, Shengkai Liao, Hong Tsao, Ananthsrinivas Chakilam and Niresh HariparsadDrug Metabolism and Disposition August 2016, 44 (8) 1286-1295; DOI: https://doi.org/10.1124/dmd.116.071100
Tse, Susanna
- You have accessEvaluation of a New Molecular Entity as a Victim of Metabolic Drug-Drug Interactions—an Industry PerspectiveTonika Bohnert, Aarti Patel, Ian Templeton, Yuan Chen, Chuang Lu, George Lai, Louis Leung, Susanna Tse, Heidi J Einolf, Ying-Hong Wang, Michael Sinz, Ralph Stearns, Robert Walsky, Wanping Geng, Sirimas Sudsakorn, David Moore, Ling He, Jan Wahlstrom, Jim Keirns, Rangaraj Narayanan, Dieter Lang, Xiaoqing Yang and International Consortium for Innovation and Quality in Pharmaceutical Development (IQ) Victim Drug-Drug Interactions Working GroupDrug Metabolism and Disposition August 2016, 44 (8) 1399-1423; DOI: https://doi.org/10.1124/dmd.115.069096
Tsuji, Satoshi
- You have accessRecommendation to Exclude Bile-Duct-Cannulated Rats with Hyperbilirubinemia for Proper Conduct of Biliary Drug Excretion StudiesKoji Kato, Yoshitaka Hasegawa, Katsuya Iwata, Takuya Ichikawa, Tohru Yahara, Satoshi Tsuji, Masayuki Sugiura and Jun-ichi YamaguchiDrug Metabolism and Disposition August 2016, 44 (8) 1180-1183; DOI: https://doi.org/10.1124/dmd.116.070532
W
Wagner, Mylo
- You have accessNonclinical Pharmacokinetics, Disposition, and Drug-Drug Interaction Potential of a Novel d-Amino Acid Peptide Agonist of the Calcium-Sensing Receptor AMG 416 (Etelcalcetide)Raju Subramanian, Xiaochun Zhu, Savannah J. Kerr, Joel D. Esmay, Steven W. Louie, Katheryne Z. Edson, Sarah Walter, Michael Fitzsimmons, Mylo Wagner, Marcus Soto, Roger Pham, Sarah F. Wilson and Gary L. SkilesDrug Metabolism and Disposition August 2016, 44 (8) 1319-1331; DOI: https://doi.org/10.1124/dmd.115.068007
Wahlstrom, Jan
- You have accessEvaluation of a New Molecular Entity as a Victim of Metabolic Drug-Drug Interactions—an Industry PerspectiveTonika Bohnert, Aarti Patel, Ian Templeton, Yuan Chen, Chuang Lu, George Lai, Louis Leung, Susanna Tse, Heidi J Einolf, Ying-Hong Wang, Michael Sinz, Ralph Stearns, Robert Walsky, Wanping Geng, Sirimas Sudsakorn, David Moore, Ling He, Jan Wahlstrom, Jim Keirns, Rangaraj Narayanan, Dieter Lang, Xiaoqing Yang and International Consortium for Innovation and Quality in Pharmaceutical Development (IQ) Victim Drug-Drug Interactions Working GroupDrug Metabolism and Disposition August 2016, 44 (8) 1399-1423; DOI: https://doi.org/10.1124/dmd.115.069096
Walsky, Robert
- You have accessEvaluation of a New Molecular Entity as a Victim of Metabolic Drug-Drug Interactions—an Industry PerspectiveTonika Bohnert, Aarti Patel, Ian Templeton, Yuan Chen, Chuang Lu, George Lai, Louis Leung, Susanna Tse, Heidi J Einolf, Ying-Hong Wang, Michael Sinz, Ralph Stearns, Robert Walsky, Wanping Geng, Sirimas Sudsakorn, David Moore, Ling He, Jan Wahlstrom, Jim Keirns, Rangaraj Narayanan, Dieter Lang, Xiaoqing Yang and International Consortium for Innovation and Quality in Pharmaceutical Development (IQ) Victim Drug-Drug Interactions Working GroupDrug Metabolism and Disposition August 2016, 44 (8) 1399-1423; DOI: https://doi.org/10.1124/dmd.115.069096
Walter, Sarah
- You have accessNonclinical Pharmacokinetics, Disposition, and Drug-Drug Interaction Potential of a Novel d-Amino Acid Peptide Agonist of the Calcium-Sensing Receptor AMG 416 (Etelcalcetide)Raju Subramanian, Xiaochun Zhu, Savannah J. Kerr, Joel D. Esmay, Steven W. Louie, Katheryne Z. Edson, Sarah Walter, Michael Fitzsimmons, Mylo Wagner, Marcus Soto, Roger Pham, Sarah F. Wilson and Gary L. SkilesDrug Metabolism and Disposition August 2016, 44 (8) 1319-1331; DOI: https://doi.org/10.1124/dmd.115.068007
Wan, Xia
- You have accessMetabolism and Disposition of Hepatitis C Polymerase Inhibitor Dasabuvir in HumansJianwei Shen, Michael Serby, Aimee Reed, Anthony J. Lee, Rajeev Menon, Xiaomei Zhang, Kennan Marsh, Xia Wan, Olga Kavetskaia and Volker FischerDrug Metabolism and Disposition August 2016, 44 (8) 1139-1147; DOI: https://doi.org/10.1124/dmd.115.067512
Wang, Ping
- Open AccessCorrelation of Cytochrome P450 Oxidoreductase Expression with the Expression of 10 Isoforms of Cytochrome P450 in Human LiverHai-Feng Zhang, Zhi-Hui Li, Jia-Yu Liu, Ting-Ting Liu, Ping Wang, Yan Fang, Jun Zhou, Ming-Zhu Cui, Na Gao, Xin Tian, Jie Gao, Qiang Wen, Lin-Jing Jia and Hai-Ling QiaoDrug Metabolism and Disposition August 2016, 44 (8) 1193-1200; DOI: https://doi.org/10.1124/dmd.116.069849
Wang, Ying-Hong
- You have accessEvaluation of a New Molecular Entity as a Victim of Metabolic Drug-Drug Interactions—an Industry PerspectiveTonika Bohnert, Aarti Patel, Ian Templeton, Yuan Chen, Chuang Lu, George Lai, Louis Leung, Susanna Tse, Heidi J Einolf, Ying-Hong Wang, Michael Sinz, Ralph Stearns, Robert Walsky, Wanping Geng, Sirimas Sudsakorn, David Moore, Ling He, Jan Wahlstrom, Jim Keirns, Rangaraj Narayanan, Dieter Lang, Xiaoqing Yang and International Consortium for Innovation and Quality in Pharmaceutical Development (IQ) Victim Drug-Drug Interactions Working GroupDrug Metabolism and Disposition August 2016, 44 (8) 1399-1423; DOI: https://doi.org/10.1124/dmd.115.069096
Wang, Yingzi
- You have accessPhosphocholine Conjugation: An Unexpected In Vivo Conjugation Pathway Associated with Hepatitis C NS5B Inhibitors Featuring A Bicyclo[1.1.1]PentaneXiaoliang Zhuo, Joseph L. Cantone, Yingzi Wang, John E. Leet, Dieter M. Drexler, Kap-Sun Yeung, Xiaohua Stella Huang, Kyle J. Eastman, Kyle E. Parcella, Kathleen W. Mosure, Matthew G. Soars, John F. Kadow and Benjamin M. JohnsonDrug Metabolism and Disposition August 2016, 44 (8) 1332-1340; DOI: https://doi.org/10.1124/dmd.115.069062
Washio, Ikumi
- You have accessImpact of Experimental Conditions on the Evaluation of Interactions between Multidrug and Toxin Extrusion Proteins and Candidate DrugsChristian Lechner, Naoki Ishiguro, Ayano Fukuhara, Hidetada Shimizu, Naoko Ohtsu, Masahito Takatani, Kotaro Nishiyama, Ikumi Washio, Norio Yamamura and Hiroyuki KusuharaDrug Metabolism and Disposition August 2016, 44 (8) 1381-1389; DOI: https://doi.org/10.1124/dmd.115.068163
Weidolf, Lars
- You have accessDiscovery of a Novel Microsomal Epoxide Hydrolase–Catalyzed Hydration of a Spiro OxetaneXue-Qing Li, Martin A. Hayes, Gunnar Grönberg, Kristina Berggren, Neal Castagnoli and Lars WeidolfDrug Metabolism and Disposition August 2016, 44 (8) 1341-1348; DOI: https://doi.org/10.1124/dmd.116.071142
Wen, Qiang
- Open AccessCorrelation of Cytochrome P450 Oxidoreductase Expression with the Expression of 10 Isoforms of Cytochrome P450 in Human LiverHai-Feng Zhang, Zhi-Hui Li, Jia-Yu Liu, Ting-Ting Liu, Ping Wang, Yan Fang, Jun Zhou, Ming-Zhu Cui, Na Gao, Xin Tian, Jie Gao, Qiang Wen, Lin-Jing Jia and Hai-Ling QiaoDrug Metabolism and Disposition August 2016, 44 (8) 1193-1200; DOI: https://doi.org/10.1124/dmd.116.069849
Wilson, Sarah F.
- You have accessNonclinical Pharmacokinetics, Disposition, and Drug-Drug Interaction Potential of a Novel d-Amino Acid Peptide Agonist of the Calcium-Sensing Receptor AMG 416 (Etelcalcetide)Raju Subramanian, Xiaochun Zhu, Savannah J. Kerr, Joel D. Esmay, Steven W. Louie, Katheryne Z. Edson, Sarah Walter, Michael Fitzsimmons, Mylo Wagner, Marcus Soto, Roger Pham, Sarah F. Wilson and Gary L. SkilesDrug Metabolism and Disposition August 2016, 44 (8) 1319-1331; DOI: https://doi.org/10.1124/dmd.115.068007
Wisnewski, Adam V.
- You have accessBiotransformation and Rearrangement of LaromustineAlaa-Eldin F. Nassar, Adam V. Wisnewski and Ivan KingDrug Metabolism and Disposition August 2016, 44 (8) 1349-1363; DOI: https://doi.org/10.1124/dmd.116.069823
Wolford, Angela
- You have accessSpecies Differences in the Oxidative Desulfurization of a Thiouracil-Based Irreversible Myeloperoxidase Inactivator by Flavin-Containing Monooxygenase EnzymesHeather Eng, Raman Sharma, Angela Wolford, Li Di, Roger B. Ruggeri, Leonard Buckbinder, Edward L. Conn, Deepak K. Dalvie and Amit S. KalgutkarDrug Metabolism and Disposition August 2016, 44 (8) 1262-1269; DOI: https://doi.org/10.1124/dmd.116.070185
Y
Yahara, Tohru
- You have accessRecommendation to Exclude Bile-Duct-Cannulated Rats with Hyperbilirubinemia for Proper Conduct of Biliary Drug Excretion StudiesKoji Kato, Yoshitaka Hasegawa, Katsuya Iwata, Takuya Ichikawa, Tohru Yahara, Satoshi Tsuji, Masayuki Sugiura and Jun-ichi YamaguchiDrug Metabolism and Disposition August 2016, 44 (8) 1180-1183; DOI: https://doi.org/10.1124/dmd.116.070532
Yamaguchi, Jun-ichi
- You have accessRecommendation to Exclude Bile-Duct-Cannulated Rats with Hyperbilirubinemia for Proper Conduct of Biliary Drug Excretion StudiesKoji Kato, Yoshitaka Hasegawa, Katsuya Iwata, Takuya Ichikawa, Tohru Yahara, Satoshi Tsuji, Masayuki Sugiura and Jun-ichi YamaguchiDrug Metabolism and Disposition August 2016, 44 (8) 1180-1183; DOI: https://doi.org/10.1124/dmd.116.070532
Yamamura, Norio
- You have accessImpact of Experimental Conditions on the Evaluation of Interactions between Multidrug and Toxin Extrusion Proteins and Candidate DrugsChristian Lechner, Naoki Ishiguro, Ayano Fukuhara, Hidetada Shimizu, Naoko Ohtsu, Masahito Takatani, Kotaro Nishiyama, Ikumi Washio, Norio Yamamura and Hiroyuki KusuharaDrug Metabolism and Disposition August 2016, 44 (8) 1381-1389; DOI: https://doi.org/10.1124/dmd.115.068163
Yamashita, Shinji
- You have accessEstablishment of In Silico Prediction Models for CYP3A4 and CYP2B6 Induction in Human Hepatocytes by Multiple Regression Analysis Using Azole CompoundsMika Nagai, Yoshihiro Konno, Masahiro Satsukawa, Shinji Yamashita and Kouichi YoshinariDrug Metabolism and Disposition August 2016, 44 (8) 1390-1398; DOI: https://doi.org/10.1124/dmd.115.068619
Yang, Xiaoqing
- You have accessEvaluation of a New Molecular Entity as a Victim of Metabolic Drug-Drug Interactions—an Industry PerspectiveTonika Bohnert, Aarti Patel, Ian Templeton, Yuan Chen, Chuang Lu, George Lai, Louis Leung, Susanna Tse, Heidi J Einolf, Ying-Hong Wang, Michael Sinz, Ralph Stearns, Robert Walsky, Wanping Geng, Sirimas Sudsakorn, David Moore, Ling He, Jan Wahlstrom, Jim Keirns, Rangaraj Narayanan, Dieter Lang, Xiaoqing Yang and International Consortium for Innovation and Quality in Pharmaceutical Development (IQ) Victim Drug-Drug Interactions Working GroupDrug Metabolism and Disposition August 2016, 44 (8) 1399-1423; DOI: https://doi.org/10.1124/dmd.115.069096
Yazawa, Saki
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