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Research ArticleArticle

Metabolism and Disposition of Hepatitis C Polymerase Inhibitor Dasabuvir in Humans

Jianwei Shen, Michael Serby, Aimee Reed, Anthony J. Lee, Rajeev Menon, Xiaomei Zhang, Kennan Marsh, Xia Wan, Olga Kavetskaia and Volker Fischer
Drug Metabolism and Disposition August 2016, 44 (8) 1139-1147; DOI: https://doi.org/10.1124/dmd.115.067512
Jianwei Shen
Drug Metabolism and Pharmacokinetics, Research & Development (J.S., M.S., A.J.L., X.Z., V.F.), Process Chemistry (A.R.), Clinical Pharmacology and Pharmacometrics–Clinical Pharmacokinetics/Pharmacodynamics (R.M.), Exploratory Science (K.M.), and Drug Analysis (X.W., O.K.), AbbVie, North Chicago, Illinois
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Michael Serby
Drug Metabolism and Pharmacokinetics, Research & Development (J.S., M.S., A.J.L., X.Z., V.F.), Process Chemistry (A.R.), Clinical Pharmacology and Pharmacometrics–Clinical Pharmacokinetics/Pharmacodynamics (R.M.), Exploratory Science (K.M.), and Drug Analysis (X.W., O.K.), AbbVie, North Chicago, Illinois
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Aimee Reed
Drug Metabolism and Pharmacokinetics, Research & Development (J.S., M.S., A.J.L., X.Z., V.F.), Process Chemistry (A.R.), Clinical Pharmacology and Pharmacometrics–Clinical Pharmacokinetics/Pharmacodynamics (R.M.), Exploratory Science (K.M.), and Drug Analysis (X.W., O.K.), AbbVie, North Chicago, Illinois
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Anthony J. Lee
Drug Metabolism and Pharmacokinetics, Research & Development (J.S., M.S., A.J.L., X.Z., V.F.), Process Chemistry (A.R.), Clinical Pharmacology and Pharmacometrics–Clinical Pharmacokinetics/Pharmacodynamics (R.M.), Exploratory Science (K.M.), and Drug Analysis (X.W., O.K.), AbbVie, North Chicago, Illinois
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Rajeev Menon
Drug Metabolism and Pharmacokinetics, Research & Development (J.S., M.S., A.J.L., X.Z., V.F.), Process Chemistry (A.R.), Clinical Pharmacology and Pharmacometrics–Clinical Pharmacokinetics/Pharmacodynamics (R.M.), Exploratory Science (K.M.), and Drug Analysis (X.W., O.K.), AbbVie, North Chicago, Illinois
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Xiaomei Zhang
Drug Metabolism and Pharmacokinetics, Research & Development (J.S., M.S., A.J.L., X.Z., V.F.), Process Chemistry (A.R.), Clinical Pharmacology and Pharmacometrics–Clinical Pharmacokinetics/Pharmacodynamics (R.M.), Exploratory Science (K.M.), and Drug Analysis (X.W., O.K.), AbbVie, North Chicago, Illinois
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Kennan Marsh
Drug Metabolism and Pharmacokinetics, Research & Development (J.S., M.S., A.J.L., X.Z., V.F.), Process Chemistry (A.R.), Clinical Pharmacology and Pharmacometrics–Clinical Pharmacokinetics/Pharmacodynamics (R.M.), Exploratory Science (K.M.), and Drug Analysis (X.W., O.K.), AbbVie, North Chicago, Illinois
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Xia Wan
Drug Metabolism and Pharmacokinetics, Research & Development (J.S., M.S., A.J.L., X.Z., V.F.), Process Chemistry (A.R.), Clinical Pharmacology and Pharmacometrics–Clinical Pharmacokinetics/Pharmacodynamics (R.M.), Exploratory Science (K.M.), and Drug Analysis (X.W., O.K.), AbbVie, North Chicago, Illinois
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Olga Kavetskaia
Drug Metabolism and Pharmacokinetics, Research & Development (J.S., M.S., A.J.L., X.Z., V.F.), Process Chemistry (A.R.), Clinical Pharmacology and Pharmacometrics–Clinical Pharmacokinetics/Pharmacodynamics (R.M.), Exploratory Science (K.M.), and Drug Analysis (X.W., O.K.), AbbVie, North Chicago, Illinois
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Volker Fischer
Drug Metabolism and Pharmacokinetics, Research & Development (J.S., M.S., A.J.L., X.Z., V.F.), Process Chemistry (A.R.), Clinical Pharmacology and Pharmacometrics–Clinical Pharmacokinetics/Pharmacodynamics (R.M.), Exploratory Science (K.M.), and Drug Analysis (X.W., O.K.), AbbVie, North Chicago, Illinois
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Article Information

vol. 44 no. 8 1139-1147
DOI 
https://doi.org/10.1124/dmd.115.067512
PubMed 
27179126

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received October 1, 2015
  • Accepted May 12, 2016
  • Published online June 28, 2016.

Article Versions

  • Earlier version (May 13, 2016 - 07:59).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2016 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Jianwei Shen,
  2. Michael Serby,
  3. Aimee Reed,
  4. Anthony J. Lee,
  5. Rajeev Menon,
  6. Xiaomei Zhang,
  7. Kennan Marsh,
  8. Xia Wan,
  9. Olga Kavetskaia1, and
  10. Volker Fischer
  1. Drug Metabolism and Pharmacokinetics, Research & Development (J.S., M.S., A.J.L., X.Z., V.F.), Process Chemistry (A.R.), Clinical Pharmacology and Pharmacometrics–Clinical Pharmacokinetics/Pharmacodynamics (R.M.), Exploratory Science (K.M.), and Drug Analysis (X.W., O.K.), AbbVie, North Chicago, Illinois
  1. Address correspondence to:
    Dr. Jianwei Shen, Drug Metabolism and Pharmacokinetics, AbbVie, 1 N. Waukegan Road, North Chicago, IL 60064. E-mail: jianwei.shen{at}abbvie.com
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Drug Metabolism and Disposition: 44 (8)
Drug Metabolism and Disposition
Vol. 44, Issue 8
1 Aug 2016
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Research ArticleArticle

Metabolism and Disposition of [14C]Dasabuvir in Humans

Jianwei Shen, Michael Serby, Aimee Reed, Anthony J. Lee, Rajeev Menon, Xiaomei Zhang, Kennan Marsh, Xia Wan, Olga Kavetskaia and Volker Fischer
Drug Metabolism and Disposition August 1, 2016, 44 (8) 1139-1147; DOI: https://doi.org/10.1124/dmd.115.067512

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Research ArticleArticle

Metabolism and Disposition of [14C]Dasabuvir in Humans

Jianwei Shen, Michael Serby, Aimee Reed, Anthony J. Lee, Rajeev Menon, Xiaomei Zhang, Kennan Marsh, Xia Wan, Olga Kavetskaia and Volker Fischer
Drug Metabolism and Disposition August 1, 2016, 44 (8) 1139-1147; DOI: https://doi.org/10.1124/dmd.115.067512
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