Species Differences in the Oxidative Desulfurization of a Thiouracil-Based Irreversible Myeloperoxidase Inactivator by Flavin-Containing Monooxygenase Enzymes

Heather Eng; Raman Sharma; Angela Wolford; Li Di; Roger B. Ruggeri; Leonard Buckbinder; Edward L. Conn; Deepak K. Dalvie; Amit S. Kalgutkar

doi:10.1124/dmd.116.070185

Research ArticleSpecial Section on Emerging Novel Enzyme Pathways in Drug Metabolism

Species Differences in the Oxidative Desulfurization of a Thiouracil-Based Irreversible Myeloperoxidase Inactivator by Flavin-Containing Monooxygenase Enzymes

Heather Eng, Raman Sharma, Angela Wolford, Li Di, Roger B. Ruggeri, Leonard Buckbinder, Edward L. Conn, Deepak K. Dalvie and Amit S. Kalgutkar

Drug Metabolism and Disposition August 2016, 44 (8) 1262-1269; DOI: https://doi.org/10.1124/dmd.116.070185

Heather Eng

Pharmacokinetics, Pharmacodynamics, and Metabolism Department, Pfizer Inc., Groton, Connecticut (H.E., R.S., A.W., L.D.); Pharmacokinetics, Pharmacodynamics, and Metabolism Department, Pfizer Inc., La Jolla, California (D.K.D.); Pharmacokinetics, Pharmacodynamics, and Metabolism Department (A.S.K.), Worldwide Medicinal Chemistry (E.L.C., R.B.R.), and Cardiovascular and Metabolic Research Unit (L.B.), Pfizer Inc., Cambridge, Massachusetts

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Raman Sharma

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Angela Wolford

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Li Di

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Roger B. Ruggeri

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Leonard Buckbinder

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Edward L. Conn

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Deepak K. Dalvie

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Amit S. Kalgutkar

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Research ArticleSpecial Section on Emerging Novel Enzyme Pathways in Drug Metabolism

Oxidative Desulfurization by FMOs

Heather Eng, Raman Sharma, Angela Wolford, Li Di, Roger B. Ruggeri, Leonard Buckbinder, Edward L. Conn, Deepak K. Dalvie and Amit S. Kalgutkar

Drug Metabolism and Disposition August 1, 2016, 44 (8) 1262-1269; DOI: https://doi.org/10.1124/dmd.116.070185

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Research ArticleSpecial Section on Emerging Novel Enzyme Pathways in Drug Metabolism

Oxidative Desulfurization by FMOs

Heather Eng, Raman Sharma, Angela Wolford, Li Di, Roger B. Ruggeri, Leonard Buckbinder, Edward L. Conn, Deepak K. Dalvie and Amit S. Kalgutkar

Drug Metabolism and Disposition August 1, 2016, 44 (8) 1262-1269; DOI: https://doi.org/10.1124/dmd.116.070185

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Species Differences in the Oxidative Desulfurization of a Thiouracil-Based Irreversible Myeloperoxidase Inactivator by Flavin-Containing Monooxygenase Enzymes

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