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Research ArticleArticle

Establishment of In Silico Prediction Models for CYP3A4 and CYP2B6 Induction in Human Hepatocytes by Multiple Regression Analysis Using Azole Compounds

Mika Nagai, Yoshihiro Konno, Masahiro Satsukawa, Shinji Yamashita and Kouichi Yoshinari
Drug Metabolism and Disposition August 2016, 44 (8) 1390-1398; DOI: https://doi.org/10.1124/dmd.115.068619
Mika Nagai
Pharmacokinetics and Safety Department, Drug Research Center, Kaken Pharmaceutical, Kyoto, Japan (M.N., Y.K., M.S.); Department of Molecular Toxicology, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan (M.N., K.Y.); and Faculty of Pharmaceutical Sciences, Setsunan University, Osaka, Japan (S.Y.)
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Yoshihiro Konno
Pharmacokinetics and Safety Department, Drug Research Center, Kaken Pharmaceutical, Kyoto, Japan (M.N., Y.K., M.S.); Department of Molecular Toxicology, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan (M.N., K.Y.); and Faculty of Pharmaceutical Sciences, Setsunan University, Osaka, Japan (S.Y.)
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Masahiro Satsukawa
Pharmacokinetics and Safety Department, Drug Research Center, Kaken Pharmaceutical, Kyoto, Japan (M.N., Y.K., M.S.); Department of Molecular Toxicology, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan (M.N., K.Y.); and Faculty of Pharmaceutical Sciences, Setsunan University, Osaka, Japan (S.Y.)
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Shinji Yamashita
Pharmacokinetics and Safety Department, Drug Research Center, Kaken Pharmaceutical, Kyoto, Japan (M.N., Y.K., M.S.); Department of Molecular Toxicology, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan (M.N., K.Y.); and Faculty of Pharmaceutical Sciences, Setsunan University, Osaka, Japan (S.Y.)
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Kouichi Yoshinari
Pharmacokinetics and Safety Department, Drug Research Center, Kaken Pharmaceutical, Kyoto, Japan (M.N., Y.K., M.S.); Department of Molecular Toxicology, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan (M.N., K.Y.); and Faculty of Pharmaceutical Sciences, Setsunan University, Osaka, Japan (S.Y.)
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Article Information

vol. 44 no. 8 1390-1398
DOI 
https://doi.org/10.1124/dmd.115.068619
PubMed 
27208383

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received December 19, 2015
  • Accepted May 18, 2016
  • Published online July 12, 2016.

Article Versions

  • Earlier version (May 20, 2016 - 09:06).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2016 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Mika Nagai,
  2. Yoshihiro Konno,
  3. Masahiro Satsukawa,
  4. Shinji Yamashita, and
  5. Kouichi Yoshinari
  1. Pharmacokinetics and Safety Department, Drug Research Center, Kaken Pharmaceutical, Kyoto, Japan (M.N., Y.K., M.S.); Department of Molecular Toxicology, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan (M.N., K.Y.); and Faculty of Pharmaceutical Sciences, Setsunan University, Osaka, Japan (S.Y.)
  1. Address correspondence to:
    Dr. Mika Nagai, Pharmacokinetics and Safety Department, Drug Research Center, Kaken Pharmaceutical, 14, Shinomiya Minamigawara-cho, Yamashina-ku, Kyoto, 607-8042, Japan. E-mail: nagai_mika{at}kaken.co.jp
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Drug Metabolism and Disposition: 44 (8)
Drug Metabolism and Disposition
Vol. 44, Issue 8
1 Aug 2016
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Research ArticleArticle

In Silico Prediction Models for CYP3A4 and CYP2B6 Induction

Mika Nagai, Yoshihiro Konno, Masahiro Satsukawa, Shinji Yamashita and Kouichi Yoshinari
Drug Metabolism and Disposition August 1, 2016, 44 (8) 1390-1398; DOI: https://doi.org/10.1124/dmd.115.068619

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Research ArticleArticle

In Silico Prediction Models for CYP3A4 and CYP2B6 Induction

Mika Nagai, Yoshihiro Konno, Masahiro Satsukawa, Shinji Yamashita and Kouichi Yoshinari
Drug Metabolism and Disposition August 1, 2016, 44 (8) 1390-1398; DOI: https://doi.org/10.1124/dmd.115.068619
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