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Research ArticleMinireview

The Complexities of Interpreting Reversible Elevated Serum Creatinine Levels in Drug Development: Does a Correlation with Inhibition of Renal Transporters Exist?

Xiaoyan Chu, Kelly Bleasby, Grace Hoyee Chan, Irene Nunes and Raymond Evers
Drug Metabolism and Disposition September 2016, 44 (9) 1498-1509; DOI: https://doi.org/10.1124/dmd.115.067694
Xiaoyan Chu
Department of Pharmacokinetics, Pharmacodynamics and Drug Metabolism (X.C., K.B., G.H.C., R.E.), and Global Regulatory Affairs, Oncology, Immunology, Biologics & Devices (I.N.), Merck Sharp & Dohme Corporation, Kenilworth, New Jersey
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Kelly Bleasby
Department of Pharmacokinetics, Pharmacodynamics and Drug Metabolism (X.C., K.B., G.H.C., R.E.), and Global Regulatory Affairs, Oncology, Immunology, Biologics & Devices (I.N.), Merck Sharp & Dohme Corporation, Kenilworth, New Jersey
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Grace Hoyee Chan
Department of Pharmacokinetics, Pharmacodynamics and Drug Metabolism (X.C., K.B., G.H.C., R.E.), and Global Regulatory Affairs, Oncology, Immunology, Biologics & Devices (I.N.), Merck Sharp & Dohme Corporation, Kenilworth, New Jersey
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Irene Nunes
Department of Pharmacokinetics, Pharmacodynamics and Drug Metabolism (X.C., K.B., G.H.C., R.E.), and Global Regulatory Affairs, Oncology, Immunology, Biologics & Devices (I.N.), Merck Sharp & Dohme Corporation, Kenilworth, New Jersey
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Raymond Evers
Department of Pharmacokinetics, Pharmacodynamics and Drug Metabolism (X.C., K.B., G.H.C., R.E.), and Global Regulatory Affairs, Oncology, Immunology, Biologics & Devices (I.N.), Merck Sharp & Dohme Corporation, Kenilworth, New Jersey
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Article Information

vol. 44 no. 9 1498-1509
DOI 
https://doi.org/10.1124/dmd.115.067694
PubMed 
26825641

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received October 6, 2015
  • Accepted January 28, 2016
  • Published online August 10, 2016.

Article Versions

  • Earlier version (January 29, 2016 - 07:57).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2016 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Xiaoyan Chu,
  2. Kelly Bleasby,
  3. Grace Hoyee Chan,
  4. Irene Nunes, and
  5. Raymond Evers
  1. Department of Pharmacokinetics, Pharmacodynamics and Drug Metabolism (X.C., K.B., G.H.C., R.E.), and Global Regulatory Affairs, Oncology, Immunology, Biologics & Devices (I.N.), Merck Sharp & Dohme Corporation, Kenilworth, New Jersey
  1. Address correspondence to:
    Dr. Xiaoyan Chu, Merck & Co., RY800-D211, 126 East Lincoln Avenue, Rahway, NJ 07065. E-mail: xiaoyan_chu{at}merck.com
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Drug Metabolism and Disposition: 44 (9)
Drug Metabolism and Disposition
Vol. 44, Issue 9
1 Sep 2016
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Research ArticleMinireview

Serum Creatinine and Inhibition of Renal Transporters

Xiaoyan Chu, Kelly Bleasby, Grace Hoyee Chan, Irene Nunes and Raymond Evers
Drug Metabolism and Disposition September 1, 2016, 44 (9) 1498-1509; DOI: https://doi.org/10.1124/dmd.115.067694

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Research ArticleMinireview

Serum Creatinine and Inhibition of Renal Transporters

Xiaoyan Chu, Kelly Bleasby, Grace Hoyee Chan, Irene Nunes and Raymond Evers
Drug Metabolism and Disposition September 1, 2016, 44 (9) 1498-1509; DOI: https://doi.org/10.1124/dmd.115.067694
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  • Article
    • Abstract
    • Introduction
    • Markers of Renal Function
    • Biosynthesis and Disposition of Creatinine
    • Mathematical Concepts of Renal Clearance of Creatinine
    • Transporters Involved in Active Renal Secretion of Creatinine
    • Inhibition of Renal Transporters and Elevation of SCr: An In Vitro–In Vivo Correlation Analysis
    • Conclusions
    • Acknowledgments
    • Authorship Contributions
    • Footnotes
    • Abbreviations
    • References
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF

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