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History
- Received October 6, 2015
- Accepted January 28, 2016
- Published online August 10, 2016.
Article Versions
- Earlier version (January 29, 2016 - 07:57).
- You are viewing the most recent version of this article.
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Copyright © 2016 by The American Society for Pharmacology and Experimental Therapeutics
Author Information
- Xiaoyan Chu,
- Kelly Bleasby,
- Grace Hoyee Chan,
- Irene Nunes, and
- Raymond Evers
- Department of Pharmacokinetics, Pharmacodynamics and Drug Metabolism (X.C., K.B., G.H.C., R.E.), and Global Regulatory Affairs, Oncology, Immunology, Biologics & Devices (I.N.), Merck Sharp & Dohme Corporation, Kenilworth, New Jersey
- Address correspondence to:
Dr. Xiaoyan Chu, Merck & Co., RY800-D211, 126 East Lincoln Avenue, Rahway, NJ 07065. E-mail: xiaoyan_chu{at}merck.com
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- Abstract
- Introduction
- Markers of Renal Function
- Biosynthesis and Disposition of Creatinine
- Mathematical Concepts of Renal Clearance of Creatinine
- Transporters Involved in Active Renal Secretion of Creatinine
- Inhibition of Renal Transporters and Elevation of SCr: An In Vitro–In Vivo Correlation Analysis
- Conclusions
- Acknowledgments
- Authorship Contributions
- Footnotes
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