The Complexities of Interpreting Reversible Elevated Serum Creatinine Levels in Drug Development: Does a Correlation with Inhibition of Renal Transporters Exist?

Xiaoyan Chu; Kelly Bleasby; Grace Hoyee Chan; Irene Nunes; Raymond Evers

doi:10.1124/dmd.115.067694

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The Complexities of Interpreting Reversible Elevated Serum Creatinine Levels in Drug Development: Does a Correlation with Inhibition of Renal Transporters Exist?

Xiaoyan Chu, Kelly Bleasby, Grace Hoyee Chan, Irene Nunes and Raymond Evers

Drug Metabolism and Disposition September 2016, 44 (9) 1498-1509; DOI: https://doi.org/10.1124/dmd.115.067694

Xiaoyan Chu

Department of Pharmacokinetics, Pharmacodynamics and Drug Metabolism (X.C., K.B., G.H.C., R.E.), and Global Regulatory Affairs, Oncology, Immunology, Biologics & Devices (I.N.), Merck Sharp & Dohme Corporation, Kenilworth, New Jersey

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Kelly Bleasby

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Grace Hoyee Chan

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Irene Nunes

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Raymond Evers

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Drug Metabolism and Disposition

Vol. 44, Issue 9

1 Sep 2016

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Research ArticleMinireview

Serum Creatinine and Inhibition of Renal Transporters

Xiaoyan Chu, Kelly Bleasby, Grace Hoyee Chan, Irene Nunes and Raymond Evers

Drug Metabolism and Disposition September 1, 2016, 44 (9) 1498-1509; DOI: https://doi.org/10.1124/dmd.115.067694

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Research ArticleMinireview

Serum Creatinine and Inhibition of Renal Transporters

Xiaoyan Chu, Kelly Bleasby, Grace Hoyee Chan, Irene Nunes and Raymond Evers

Drug Metabolism and Disposition September 1, 2016, 44 (9) 1498-1509; DOI: https://doi.org/10.1124/dmd.115.067694

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