Table of Contents

Articles

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  Clearance Prediction of Targeted Covalent Inhibitors by In Vitro-In Vivo Extrapolation of Hepatic and Extrahepatic Clearance Mechanisms

  Louis Leung, Xin Yang, Timothy J. Strelevitz, Justin Montgomery, Matthew F. Brown, Michael A. Zientek, Christopher Banfield, Adam M. Gilbert, Atli Thorarensen and Martin E. Dowty

  Drug Metabolism and Disposition January 2017, 45 (1) 1-7; DOI: https://doi.org/10.1124/dmd.116.072983
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  Intracellular CD3⁺ T Lymphocyte Teriflunomide Concentration Is Poorly Correlated with and Has Greater Variability Than Unbound Plasma Teriflunomide Concentration

  Ashley M. Hopkins, Mahin Moghaddami, David J. R. Foster, Susanna M. Proudman, Richard N. Upton and Michael D. Wiese

  Drug Metabolism and Disposition January 2017, 45 (1) 8-16; DOI: https://doi.org/10.1124/dmd.116.071985
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  Application of Mice Humanized for CYP2D6 to the Study of Tamoxifen Metabolism and Drug–Drug Interaction with Antidepressants

  A. Kenneth MacLeod, Lesley A. McLaughlin, Colin J. Henderson and C. Roland Wolf

  Drug Metabolism and Disposition January 2017, 45 (1) 17-22; DOI: https://doi.org/10.1124/dmd.116.073437
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  Inhibition of Intestinal OATP2B1 by the Calcium Receptor Antagonist Ronacaleret Results in a Significant Drug-Drug Interaction by Causing a 2-Fold Decrease in Exposure of Rosuvastatin

  Marta Johnson, Dipal Patel, Christopher Matheny, May Ho, Liangfu Chen and Harma Ellens

  Drug Metabolism and Disposition January 2017, 45 (1) 27-34; DOI: https://doi.org/10.1124/dmd.116.072397
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  Curcumin, Piperine, and Capsaicin: A Comparative Study of Spice-Mediated Inhibition of Human Cytochrome P450 Isozyme Activities

  Suhaili Shamsi, Huong Tran, Renee Seok Jin Tan, Zee Jian Tan and Lee Yong Lim

  Drug Metabolism and Disposition January 2017, 45 (1) 49-55; DOI: https://doi.org/10.1124/dmd.116.073213
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  Stable Overexpression of the Constitutive Androstane Receptor Reduces the Requirement for Culture with Dimethyl Sulfoxide for High Drug Metabolism in HepaRG Cells

  Vincent A. van der Mark, D. Rudi de Waart, Valery Shevchenko, Ronald P.J. Oude Elferink, Robert A. F. M. Chamuleau and Ruurdtje Hoekstra

  Drug Metabolism and Disposition January 2017, 45 (1) 56-67; DOI: https://doi.org/10.1124/dmd.116.072603
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  Lack of Exposure in a First-in-Man Study Due to Aldehyde Oxidase Metabolism: Investigated by Use of ¹⁴C-microdose, Humanized Mice, Monkey Pharmacokinetics, and In Vitro Methods

  Klaus Gjervig Jensen, Anne-Marie Jacobsen, Christoffer Bundgaard, Dorrit Østergaard Nilausen, Zia Thale, Gamini Chandrasena and Martin Jørgensen

  Drug Metabolism and Disposition January 2017, 45 (1) 68-75; DOI: https://doi.org/10.1124/dmd.116.072793
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  Interaction of 2,4-Diaminopyrimidine–Containing Drugs Including Fedratinib and Trimethoprim with Thiamine Transporters

  Marilyn M. Giacomini, Jia Hao, Xiaomin Liang, Jayaraman Chandrasekhar, Jolyn Twelves, J. Andrew Whitney, Eve-Irene Lepist and Adrian S. Ray

  Drug Metabolism and Disposition January 2017, 45 (1) 76-85; DOI: https://doi.org/10.1124/dmd.116.073338
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  Histone H3 Lysine 4 Trimethylation, Lysine 27 Trimethylation, and Lysine 27 Acetylation Contribute to the Transcriptional Repression of Solute Carrier Family 47 Member 2 in Renal Cell Carcinoma

  Qinqin Yu, Yanqing Liu, Xiaoli Zheng, Qianying Zhu, Zhuowei Shen, Hua Wang, Huadong He, Nengming Lin, Huidi Jiang, Lushan Yu and Su Zeng

  Drug Metabolism and Disposition January 2017, 45 (1) 109-117; DOI: https://doi.org/10.1124/dmd.116.073734