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Drug Metabolism & Disposition

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Table of Contents

January 01, 2017; Volume 45,Issue 1

Perspective

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    Managing the Risk of CYP3A Induction in Drug Development: A Strategic Approach
    Barry C. Jones, Helen Rollison, Susanne Johansson, Kajsa P. Kanebratt, Craig Lambert, Karthick Vishwanathan and Tommy B. Andersson
    Drug Metabolism and Disposition January 2017, 45 (1) 35-41; DOI: https://doi.org/10.1124/dmd.116.072025

Minireviews

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    Transcriptional Regulation of CYP2D6 Expression
    Xian Pan, Miaoran Ning and Hyunyoung Jeong
    Drug Metabolism and Disposition January 2017, 45 (1) 42-48; DOI: https://doi.org/10.1124/dmd.116.072249
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    What Can Be Learned from Recent New Drug Applications? A Systematic Review of Drug Interaction Data for Drugs Approved by the US FDA in 2015
    Jingjing Yu, Zhu Zhou, Katie H. Owens, Tasha K. Ritchie and Isabelle Ragueneau-Majlessi
    Drug Metabolism and Disposition January 2017, 45 (1) 86-108; DOI: https://doi.org/10.1124/dmd.116.073411

Articles

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    Clearance Prediction of Targeted Covalent Inhibitors by In Vitro-In Vivo Extrapolation of Hepatic and Extrahepatic Clearance Mechanisms
    Louis Leung, Xin Yang, Timothy J. Strelevitz, Justin Montgomery, Matthew F. Brown, Michael A. Zientek, Christopher Banfield, Adam M. Gilbert, Atli Thorarensen and Martin E. Dowty
    Drug Metabolism and Disposition January 2017, 45 (1) 1-7; DOI: https://doi.org/10.1124/dmd.116.072983
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    Intracellular CD3+ T Lymphocyte Teriflunomide Concentration Is Poorly Correlated with and Has Greater Variability Than Unbound Plasma Teriflunomide Concentration
    Ashley M. Hopkins, Mahin Moghaddami, David J. R. Foster, Susanna M. Proudman, Richard N. Upton and Michael D. Wiese
    Drug Metabolism and Disposition January 2017, 45 (1) 8-16; DOI: https://doi.org/10.1124/dmd.116.071985
  • Open Access
    Application of Mice Humanized for CYP2D6 to the Study of Tamoxifen Metabolism and Drug–Drug Interaction with Antidepressants
    A. Kenneth MacLeod, Lesley A. McLaughlin, Colin J. Henderson and C. Roland Wolf
    Drug Metabolism and Disposition January 2017, 45 (1) 17-22; DOI: https://doi.org/10.1124/dmd.116.073437
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    Inhibition of Intestinal OATP2B1 by the Calcium Receptor Antagonist Ronacaleret Results in a Significant Drug-Drug Interaction by Causing a 2-Fold Decrease in Exposure of Rosuvastatin
    Marta Johnson, Dipal Patel, Christopher Matheny, May Ho, Liangfu Chen and Harma Ellens
    Drug Metabolism and Disposition January 2017, 45 (1) 27-34; DOI: https://doi.org/10.1124/dmd.116.072397
  • Curcumin, Piperine, and Capsaicin: A Comparative Study of Spice-Mediated Inhibition of Human Cytochrome P450 Isozyme Activities
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    Curcumin, Piperine, and Capsaicin: A Comparative Study of Spice-Mediated Inhibition of Human Cytochrome P450 Isozyme Activities
    Suhaili Shamsi, Huong Tran, Renee Seok Jin Tan, Zee Jian Tan and Lee Yong Lim
    Drug Metabolism and Disposition January 2017, 45 (1) 49-55; DOI: https://doi.org/10.1124/dmd.116.073213
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    Stable Overexpression of the Constitutive Androstane Receptor Reduces the Requirement for Culture with Dimethyl Sulfoxide for High Drug Metabolism in HepaRG Cells
    Vincent A. van der Mark, D. Rudi de Waart, Valery Shevchenko, Ronald P.J. Oude Elferink, Robert A. F. M. Chamuleau and Ruurdtje Hoekstra
    Drug Metabolism and Disposition January 2017, 45 (1) 56-67; DOI: https://doi.org/10.1124/dmd.116.072603
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    Lack of Exposure in a First-in-Man Study Due to Aldehyde Oxidase Metabolism: Investigated by Use of 14C-microdose, Humanized Mice, Monkey Pharmacokinetics, and In Vitro Methods
    Klaus Gjervig Jensen, Anne-Marie Jacobsen, Christoffer Bundgaard, Dorrit Østergaard Nilausen, Zia Thale, Gamini Chandrasena and Martin Jørgensen
    Drug Metabolism and Disposition January 2017, 45 (1) 68-75; DOI: https://doi.org/10.1124/dmd.116.072793
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    Interaction of 2,4-Diaminopyrimidine–Containing Drugs Including Fedratinib and Trimethoprim with Thiamine Transporters
    Marilyn M. Giacomini, Jia Hao, Xiaomin Liang, Jayaraman Chandrasekhar, Jolyn Twelves, J. Andrew Whitney, Eve-Irene Lepist and Adrian S. Ray
    Drug Metabolism and Disposition January 2017, 45 (1) 76-85; DOI: https://doi.org/10.1124/dmd.116.073338
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    Histone H3 Lysine 4 Trimethylation, Lysine 27 Trimethylation, and Lysine 27 Acetylation Contribute to the Transcriptional Repression of Solute Carrier Family 47 Member 2 in Renal Cell Carcinoma
    Qinqin Yu, Yanqing Liu, Xiaoli Zheng, Qianying Zhu, Zhuowei Shen, Hua Wang, Huadong He, Nengming Lin, Huidi Jiang, Lushan Yu and Su Zeng
    Drug Metabolism and Disposition January 2017, 45 (1) 109-117; DOI: https://doi.org/10.1124/dmd.116.073734

Short Communication

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    Developmental Changes in Hepatic Organic Cation Transporter OCT1 Protein Expression from Neonates to Children
    David Hahn, Chie Emoto, Alexander A. Vinks and Tsuyoshi Fukuda
    Drug Metabolism and Disposition January 2017, 45 (1) 23-26; DOI: https://doi.org/10.1124/dmd.116.072256
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Drug Metabolism and Disposition: 45 (1)
Drug Metabolism and Disposition
Vol. 45, Issue 1
1 Jan 2017
  • Table of Contents
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
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