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Index by author

January 01, 2017; Volume 45,Issue 1

A

  1. Andersson, Tommy B.

    1. Managing the Risk of CYP3A Induction in Drug Development: A Strategic Approach
      Barry C. Jones, Helen Rollison, Susanne Johansson, Kajsa P. Kanebratt, Craig Lambert, Karthick Vishwanathan and Tommy B. Andersson
      Drug Metabolism and Disposition January 2017, 45 (1) 35-41; DOI: https://doi.org/10.1124/dmd.116.072025

B

  1. Banfield, Christopher

    1. Clearance Prediction of Targeted Covalent Inhibitors by In Vitro-In Vivo Extrapolation of Hepatic and Extrahepatic Clearance Mechanisms
      Louis Leung, Xin Yang, Timothy J. Strelevitz, Justin Montgomery, Matthew F. Brown, Michael A. Zientek, Christopher Banfield, Adam M. Gilbert, Atli Thorarensen and Martin E. Dowty
      Drug Metabolism and Disposition January 2017, 45 (1) 1-7; DOI: https://doi.org/10.1124/dmd.116.072983

  2. Brown, Matthew F.

    1. Clearance Prediction of Targeted Covalent Inhibitors by In Vitro-In Vivo Extrapolation of Hepatic and Extrahepatic Clearance Mechanisms
      Louis Leung, Xin Yang, Timothy J. Strelevitz, Justin Montgomery, Matthew F. Brown, Michael A. Zientek, Christopher Banfield, Adam M. Gilbert, Atli Thorarensen and Martin E. Dowty
      Drug Metabolism and Disposition January 2017, 45 (1) 1-7; DOI: https://doi.org/10.1124/dmd.116.072983

  3. Bundgaard, Christoffer

    1. Lack of Exposure in a First-in-Man Study Due to Aldehyde Oxidase Metabolism: Investigated by Use of 14C-microdose, Humanized Mice, Monkey Pharmacokinetics, and In Vitro Methods
      Klaus Gjervig Jensen, Anne-Marie Jacobsen, Christoffer Bundgaard, Dorrit Østergaard Nilausen, Zia Thale, Gamini Chandrasena and Martin Jørgensen
      Drug Metabolism and Disposition January 2017, 45 (1) 68-75; DOI: https://doi.org/10.1124/dmd.116.072793

C

  1. Chamuleau, Robert A. F. M.

    1. Stable Overexpression of the Constitutive Androstane Receptor Reduces the Requirement for Culture with Dimethyl Sulfoxide for High Drug Metabolism in HepaRG Cells
      Vincent A. van der Mark, D. Rudi de Waart, Valery Shevchenko, Ronald P.J. Oude Elferink, Robert A. F. M. Chamuleau and Ruurdtje Hoekstra
      Drug Metabolism and Disposition January 2017, 45 (1) 56-67; DOI: https://doi.org/10.1124/dmd.116.072603

  2. Chandrasekhar, Jayaraman

    1. Interaction of 2,4-Diaminopyrimidine–Containing Drugs Including Fedratinib and Trimethoprim with Thiamine Transporters
      Marilyn M. Giacomini, Jia Hao, Xiaomin Liang, Jayaraman Chandrasekhar, Jolyn Twelves, J. Andrew Whitney, Eve-Irene Lepist and Adrian S. Ray
      Drug Metabolism and Disposition January 2017, 45 (1) 76-85; DOI: https://doi.org/10.1124/dmd.116.073338

  3. Chandrasena, Gamini

    1. Lack of Exposure in a First-in-Man Study Due to Aldehyde Oxidase Metabolism: Investigated by Use of 14C-microdose, Humanized Mice, Monkey Pharmacokinetics, and In Vitro Methods
      Klaus Gjervig Jensen, Anne-Marie Jacobsen, Christoffer Bundgaard, Dorrit Østergaard Nilausen, Zia Thale, Gamini Chandrasena and Martin Jørgensen
      Drug Metabolism and Disposition January 2017, 45 (1) 68-75; DOI: https://doi.org/10.1124/dmd.116.072793

  4. Chen, Liangfu

    1. Inhibition of Intestinal OATP2B1 by the Calcium Receptor Antagonist Ronacaleret Results in a Significant Drug-Drug Interaction by Causing a 2-Fold Decrease in Exposure of Rosuvastatin
      Marta Johnson, Dipal Patel, Christopher Matheny, May Ho, Liangfu Chen and Harma Ellens
      Drug Metabolism and Disposition January 2017, 45 (1) 27-34; DOI: https://doi.org/10.1124/dmd.116.072397

D

  1. Dowty, Martin E.

    1. Clearance Prediction of Targeted Covalent Inhibitors by In Vitro-In Vivo Extrapolation of Hepatic and Extrahepatic Clearance Mechanisms
      Louis Leung, Xin Yang, Timothy J. Strelevitz, Justin Montgomery, Matthew F. Brown, Michael A. Zientek, Christopher Banfield, Adam M. Gilbert, Atli Thorarensen and Martin E. Dowty
      Drug Metabolism and Disposition January 2017, 45 (1) 1-7; DOI: https://doi.org/10.1124/dmd.116.072983

E

  1. Elferink, Ronald P.J. Oude

    1. Stable Overexpression of the Constitutive Androstane Receptor Reduces the Requirement for Culture with Dimethyl Sulfoxide for High Drug Metabolism in HepaRG Cells
      Vincent A. van der Mark, D. Rudi de Waart, Valery Shevchenko, Ronald P.J. Oude Elferink, Robert A. F. M. Chamuleau and Ruurdtje Hoekstra
      Drug Metabolism and Disposition January 2017, 45 (1) 56-67; DOI: https://doi.org/10.1124/dmd.116.072603

  2. Ellens, Harma

    1. Inhibition of Intestinal OATP2B1 by the Calcium Receptor Antagonist Ronacaleret Results in a Significant Drug-Drug Interaction by Causing a 2-Fold Decrease in Exposure of Rosuvastatin
      Marta Johnson, Dipal Patel, Christopher Matheny, May Ho, Liangfu Chen and Harma Ellens
      Drug Metabolism and Disposition January 2017, 45 (1) 27-34; DOI: https://doi.org/10.1124/dmd.116.072397

  3. Emoto, Chie

    1. Developmental Changes in Hepatic Organic Cation Transporter OCT1 Protein Expression from Neonates to Children
      David Hahn, Chie Emoto, Alexander A. Vinks and Tsuyoshi Fukuda
      Drug Metabolism and Disposition January 2017, 45 (1) 23-26; DOI: https://doi.org/10.1124/dmd.116.072256

F

  1. Foster, David J. R.

    1. Intracellular CD3+ T Lymphocyte Teriflunomide Concentration Is Poorly Correlated with and Has Greater Variability Than Unbound Plasma Teriflunomide Concentration
      Ashley M. Hopkins, Mahin Moghaddami, David J. R. Foster, Susanna M. Proudman, Richard N. Upton and Michael D. Wiese
      Drug Metabolism and Disposition January 2017, 45 (1) 8-16; DOI: https://doi.org/10.1124/dmd.116.071985

  2. Fukuda, Tsuyoshi

    1. Developmental Changes in Hepatic Organic Cation Transporter OCT1 Protein Expression from Neonates to Children
      David Hahn, Chie Emoto, Alexander A. Vinks and Tsuyoshi Fukuda
      Drug Metabolism and Disposition January 2017, 45 (1) 23-26; DOI: https://doi.org/10.1124/dmd.116.072256

G

  1. Giacomini, Marilyn M.

    1. Interaction of 2,4-Diaminopyrimidine–Containing Drugs Including Fedratinib and Trimethoprim with Thiamine Transporters
      Marilyn M. Giacomini, Jia Hao, Xiaomin Liang, Jayaraman Chandrasekhar, Jolyn Twelves, J. Andrew Whitney, Eve-Irene Lepist and Adrian S. Ray
      Drug Metabolism and Disposition January 2017, 45 (1) 76-85; DOI: https://doi.org/10.1124/dmd.116.073338

  2. Gilbert, Adam M.

    1. Clearance Prediction of Targeted Covalent Inhibitors by In Vitro-In Vivo Extrapolation of Hepatic and Extrahepatic Clearance Mechanisms
      Louis Leung, Xin Yang, Timothy J. Strelevitz, Justin Montgomery, Matthew F. Brown, Michael A. Zientek, Christopher Banfield, Adam M. Gilbert, Atli Thorarensen and Martin E. Dowty
      Drug Metabolism and Disposition January 2017, 45 (1) 1-7; DOI: https://doi.org/10.1124/dmd.116.072983

H

  1. Hahn, David

    1. Developmental Changes in Hepatic Organic Cation Transporter OCT1 Protein Expression from Neonates to Children
      David Hahn, Chie Emoto, Alexander A. Vinks and Tsuyoshi Fukuda
      Drug Metabolism and Disposition January 2017, 45 (1) 23-26; DOI: https://doi.org/10.1124/dmd.116.072256

  2. Hao, Jia

    1. Interaction of 2,4-Diaminopyrimidine–Containing Drugs Including Fedratinib and Trimethoprim with Thiamine Transporters
      Marilyn M. Giacomini, Jia Hao, Xiaomin Liang, Jayaraman Chandrasekhar, Jolyn Twelves, J. Andrew Whitney, Eve-Irene Lepist and Adrian S. Ray
      Drug Metabolism and Disposition January 2017, 45 (1) 76-85; DOI: https://doi.org/10.1124/dmd.116.073338

  3. He, Huadong

    1. Histone H3 Lysine 4 Trimethylation, Lysine 27 Trimethylation, and Lysine 27 Acetylation Contribute to the Transcriptional Repression of Solute Carrier Family 47 Member 2 in Renal Cell Carcinoma
      Qinqin Yu, Yanqing Liu, Xiaoli Zheng, Qianying Zhu, Zhuowei Shen, Hua Wang, Huadong He, Nengming Lin, Huidi Jiang, Lushan Yu and Su Zeng
      Drug Metabolism and Disposition January 2017, 45 (1) 109-117; DOI: https://doi.org/10.1124/dmd.116.073734

  4. Henderson, Colin J.

    1. Open Access
      Application of Mice Humanized for CYP2D6 to the Study of Tamoxifen Metabolism and Drug–Drug Interaction with Antidepressants
      A. Kenneth MacLeod, Lesley A. McLaughlin, Colin J. Henderson and C. Roland Wolf
      Drug Metabolism and Disposition January 2017, 45 (1) 17-22; DOI: https://doi.org/10.1124/dmd.116.073437

  5. Ho, May

    1. Inhibition of Intestinal OATP2B1 by the Calcium Receptor Antagonist Ronacaleret Results in a Significant Drug-Drug Interaction by Causing a 2-Fold Decrease in Exposure of Rosuvastatin
      Marta Johnson, Dipal Patel, Christopher Matheny, May Ho, Liangfu Chen and Harma Ellens
      Drug Metabolism and Disposition January 2017, 45 (1) 27-34; DOI: https://doi.org/10.1124/dmd.116.072397

  6. Hoekstra, Ruurdtje

    1. Stable Overexpression of the Constitutive Androstane Receptor Reduces the Requirement for Culture with Dimethyl Sulfoxide for High Drug Metabolism in HepaRG Cells
      Vincent A. van der Mark, D. Rudi de Waart, Valery Shevchenko, Ronald P.J. Oude Elferink, Robert A. F. M. Chamuleau and Ruurdtje Hoekstra
      Drug Metabolism and Disposition January 2017, 45 (1) 56-67; DOI: https://doi.org/10.1124/dmd.116.072603

  7. Hopkins, Ashley M.

    1. Intracellular CD3+ T Lymphocyte Teriflunomide Concentration Is Poorly Correlated with and Has Greater Variability Than Unbound Plasma Teriflunomide Concentration
      Ashley M. Hopkins, Mahin Moghaddami, David J. R. Foster, Susanna M. Proudman, Richard N. Upton and Michael D. Wiese
      Drug Metabolism and Disposition January 2017, 45 (1) 8-16; DOI: https://doi.org/10.1124/dmd.116.071985

J

  1. Jacobsen, Anne-Marie

    1. Lack of Exposure in a First-in-Man Study Due to Aldehyde Oxidase Metabolism: Investigated by Use of 14C-microdose, Humanized Mice, Monkey Pharmacokinetics, and In Vitro Methods
      Klaus Gjervig Jensen, Anne-Marie Jacobsen, Christoffer Bundgaard, Dorrit Østergaard Nilausen, Zia Thale, Gamini Chandrasena and Martin Jørgensen
      Drug Metabolism and Disposition January 2017, 45 (1) 68-75; DOI: https://doi.org/10.1124/dmd.116.072793

  2. Jensen, Klaus Gjervig

    1. Lack of Exposure in a First-in-Man Study Due to Aldehyde Oxidase Metabolism: Investigated by Use of 14C-microdose, Humanized Mice, Monkey Pharmacokinetics, and In Vitro Methods
      Klaus Gjervig Jensen, Anne-Marie Jacobsen, Christoffer Bundgaard, Dorrit Østergaard Nilausen, Zia Thale, Gamini Chandrasena and Martin Jørgensen
      Drug Metabolism and Disposition January 2017, 45 (1) 68-75; DOI: https://doi.org/10.1124/dmd.116.072793

  3. Jeong, Hyunyoung

    1. Transcriptional Regulation of CYP2D6 Expression
      Xian Pan, Miaoran Ning and Hyunyoung Jeong
      Drug Metabolism and Disposition January 2017, 45 (1) 42-48; DOI: https://doi.org/10.1124/dmd.116.072249

  4. Jiang, Huidi

    1. Histone H3 Lysine 4 Trimethylation, Lysine 27 Trimethylation, and Lysine 27 Acetylation Contribute to the Transcriptional Repression of Solute Carrier Family 47 Member 2 in Renal Cell Carcinoma
      Qinqin Yu, Yanqing Liu, Xiaoli Zheng, Qianying Zhu, Zhuowei Shen, Hua Wang, Huadong He, Nengming Lin, Huidi Jiang, Lushan Yu and Su Zeng
      Drug Metabolism and Disposition January 2017, 45 (1) 109-117; DOI: https://doi.org/10.1124/dmd.116.073734

  5. Johansson, Susanne

    1. Managing the Risk of CYP3A Induction in Drug Development: A Strategic Approach
      Barry C. Jones, Helen Rollison, Susanne Johansson, Kajsa P. Kanebratt, Craig Lambert, Karthick Vishwanathan and Tommy B. Andersson
      Drug Metabolism and Disposition January 2017, 45 (1) 35-41; DOI: https://doi.org/10.1124/dmd.116.072025

  6. Johnson, Marta

    1. Inhibition of Intestinal OATP2B1 by the Calcium Receptor Antagonist Ronacaleret Results in a Significant Drug-Drug Interaction by Causing a 2-Fold Decrease in Exposure of Rosuvastatin
      Marta Johnson, Dipal Patel, Christopher Matheny, May Ho, Liangfu Chen and Harma Ellens
      Drug Metabolism and Disposition January 2017, 45 (1) 27-34; DOI: https://doi.org/10.1124/dmd.116.072397

  7. Jones, Barry C.

    1. Managing the Risk of CYP3A Induction in Drug Development: A Strategic Approach
      Barry C. Jones, Helen Rollison, Susanne Johansson, Kajsa P. Kanebratt, Craig Lambert, Karthick Vishwanathan and Tommy B. Andersson
      Drug Metabolism and Disposition January 2017, 45 (1) 35-41; DOI: https://doi.org/10.1124/dmd.116.072025

  8. Jørgensen, Martin

    1. Lack of Exposure in a First-in-Man Study Due to Aldehyde Oxidase Metabolism: Investigated by Use of 14C-microdose, Humanized Mice, Monkey Pharmacokinetics, and In Vitro Methods
      Klaus Gjervig Jensen, Anne-Marie Jacobsen, Christoffer Bundgaard, Dorrit Østergaard Nilausen, Zia Thale, Gamini Chandrasena and Martin Jørgensen
      Drug Metabolism and Disposition January 2017, 45 (1) 68-75; DOI: https://doi.org/10.1124/dmd.116.072793

K

  1. Kanebratt, Kajsa P.

    1. Managing the Risk of CYP3A Induction in Drug Development: A Strategic Approach
      Barry C. Jones, Helen Rollison, Susanne Johansson, Kajsa P. Kanebratt, Craig Lambert, Karthick Vishwanathan and Tommy B. Andersson
      Drug Metabolism and Disposition January 2017, 45 (1) 35-41; DOI: https://doi.org/10.1124/dmd.116.072025

L

  1. Lambert, Craig

    1. Managing the Risk of CYP3A Induction in Drug Development: A Strategic Approach
      Barry C. Jones, Helen Rollison, Susanne Johansson, Kajsa P. Kanebratt, Craig Lambert, Karthick Vishwanathan and Tommy B. Andersson
      Drug Metabolism and Disposition January 2017, 45 (1) 35-41; DOI: https://doi.org/10.1124/dmd.116.072025

  2. Lepist, Eve-Irene

    1. Interaction of 2,4-Diaminopyrimidine–Containing Drugs Including Fedratinib and Trimethoprim with Thiamine Transporters
      Marilyn M. Giacomini, Jia Hao, Xiaomin Liang, Jayaraman Chandrasekhar, Jolyn Twelves, J. Andrew Whitney, Eve-Irene Lepist and Adrian S. Ray
      Drug Metabolism and Disposition January 2017, 45 (1) 76-85; DOI: https://doi.org/10.1124/dmd.116.073338

  3. Leung, Louis

    1. Clearance Prediction of Targeted Covalent Inhibitors by In Vitro-In Vivo Extrapolation of Hepatic and Extrahepatic Clearance Mechanisms
      Louis Leung, Xin Yang, Timothy J. Strelevitz, Justin Montgomery, Matthew F. Brown, Michael A. Zientek, Christopher Banfield, Adam M. Gilbert, Atli Thorarensen and Martin E. Dowty
      Drug Metabolism and Disposition January 2017, 45 (1) 1-7; DOI: https://doi.org/10.1124/dmd.116.072983

  4. Liang, Xiaomin

    1. Interaction of 2,4-Diaminopyrimidine–Containing Drugs Including Fedratinib and Trimethoprim with Thiamine Transporters
      Marilyn M. Giacomini, Jia Hao, Xiaomin Liang, Jayaraman Chandrasekhar, Jolyn Twelves, J. Andrew Whitney, Eve-Irene Lepist and Adrian S. Ray
      Drug Metabolism and Disposition January 2017, 45 (1) 76-85; DOI: https://doi.org/10.1124/dmd.116.073338

  5. Lim, Lee Yong

    1. Curcumin, Piperine, and Capsaicin: A Comparative Study of Spice-Mediated Inhibition of Human Cytochrome P450 Isozyme Activities
      Curcumin, Piperine, and Capsaicin: A Comparative Study of Spice-Mediated Inhibition of Human Cytochrome P450 Isozyme Activities
      Suhaili Shamsi, Huong Tran, Renee Seok Jin Tan, Zee Jian Tan and Lee Yong Lim
      Drug Metabolism and Disposition January 2017, 45 (1) 49-55; DOI: https://doi.org/10.1124/dmd.116.073213

  6. Lin, Nengming

    1. Histone H3 Lysine 4 Trimethylation, Lysine 27 Trimethylation, and Lysine 27 Acetylation Contribute to the Transcriptional Repression of Solute Carrier Family 47 Member 2 in Renal Cell Carcinoma
      Qinqin Yu, Yanqing Liu, Xiaoli Zheng, Qianying Zhu, Zhuowei Shen, Hua Wang, Huadong He, Nengming Lin, Huidi Jiang, Lushan Yu and Su Zeng
      Drug Metabolism and Disposition January 2017, 45 (1) 109-117; DOI: https://doi.org/10.1124/dmd.116.073734

  7. Liu, Yanqing

    1. Histone H3 Lysine 4 Trimethylation, Lysine 27 Trimethylation, and Lysine 27 Acetylation Contribute to the Transcriptional Repression of Solute Carrier Family 47 Member 2 in Renal Cell Carcinoma
      Qinqin Yu, Yanqing Liu, Xiaoli Zheng, Qianying Zhu, Zhuowei Shen, Hua Wang, Huadong He, Nengming Lin, Huidi Jiang, Lushan Yu and Su Zeng
      Drug Metabolism and Disposition January 2017, 45 (1) 109-117; DOI: https://doi.org/10.1124/dmd.116.073734

M

  1. MacLeod, A. Kenneth

    1. Open Access
      Application of Mice Humanized for CYP2D6 to the Study of Tamoxifen Metabolism and Drug–Drug Interaction with Antidepressants
      A. Kenneth MacLeod, Lesley A. McLaughlin, Colin J. Henderson and C. Roland Wolf
      Drug Metabolism and Disposition January 2017, 45 (1) 17-22; DOI: https://doi.org/10.1124/dmd.116.073437

  2. Matheny, Christopher

    1. Inhibition of Intestinal OATP2B1 by the Calcium Receptor Antagonist Ronacaleret Results in a Significant Drug-Drug Interaction by Causing a 2-Fold Decrease in Exposure of Rosuvastatin
      Marta Johnson, Dipal Patel, Christopher Matheny, May Ho, Liangfu Chen and Harma Ellens
      Drug Metabolism and Disposition January 2017, 45 (1) 27-34; DOI: https://doi.org/10.1124/dmd.116.072397

  3. McLaughlin, Lesley A.

    1. Open Access
      Application of Mice Humanized for CYP2D6 to the Study of Tamoxifen Metabolism and Drug–Drug Interaction with Antidepressants
      A. Kenneth MacLeod, Lesley A. McLaughlin, Colin J. Henderson and C. Roland Wolf
      Drug Metabolism and Disposition January 2017, 45 (1) 17-22; DOI: https://doi.org/10.1124/dmd.116.073437

  4. Moghaddami, Mahin

    1. Intracellular CD3+ T Lymphocyte Teriflunomide Concentration Is Poorly Correlated with and Has Greater Variability Than Unbound Plasma Teriflunomide Concentration
      Ashley M. Hopkins, Mahin Moghaddami, David J. R. Foster, Susanna M. Proudman, Richard N. Upton and Michael D. Wiese
      Drug Metabolism and Disposition January 2017, 45 (1) 8-16; DOI: https://doi.org/10.1124/dmd.116.071985

  5. Montgomery, Justin

    1. Clearance Prediction of Targeted Covalent Inhibitors by In Vitro-In Vivo Extrapolation of Hepatic and Extrahepatic Clearance Mechanisms
      Louis Leung, Xin Yang, Timothy J. Strelevitz, Justin Montgomery, Matthew F. Brown, Michael A. Zientek, Christopher Banfield, Adam M. Gilbert, Atli Thorarensen and Martin E. Dowty
      Drug Metabolism and Disposition January 2017, 45 (1) 1-7; DOI: https://doi.org/10.1124/dmd.116.072983

N

  1. Nilausen, Dorrit Østergaard

    1. Lack of Exposure in a First-in-Man Study Due to Aldehyde Oxidase Metabolism: Investigated by Use of 14C-microdose, Humanized Mice, Monkey Pharmacokinetics, and In Vitro Methods
      Klaus Gjervig Jensen, Anne-Marie Jacobsen, Christoffer Bundgaard, Dorrit Østergaard Nilausen, Zia Thale, Gamini Chandrasena and Martin Jørgensen
      Drug Metabolism and Disposition January 2017, 45 (1) 68-75; DOI: https://doi.org/10.1124/dmd.116.072793

  2. Ning, Miaoran

    1. Transcriptional Regulation of CYP2D6 Expression
      Xian Pan, Miaoran Ning and Hyunyoung Jeong
      Drug Metabolism and Disposition January 2017, 45 (1) 42-48; DOI: https://doi.org/10.1124/dmd.116.072249

O

  1. Owens, Katie H.

    1. What Can Be Learned from Recent New Drug Applications? A Systematic Review of Drug Interaction Data for Drugs Approved by the US FDA in 2015
      Jingjing Yu, Zhu Zhou, Katie H. Owens, Tasha K. Ritchie and Isabelle Ragueneau-Majlessi
      Drug Metabolism and Disposition January 2017, 45 (1) 86-108; DOI: https://doi.org/10.1124/dmd.116.073411

P

  1. Pan, Xian

    1. Transcriptional Regulation of CYP2D6 Expression
      Xian Pan, Miaoran Ning and Hyunyoung Jeong
      Drug Metabolism and Disposition January 2017, 45 (1) 42-48; DOI: https://doi.org/10.1124/dmd.116.072249

  2. Patel, Dipal

    1. Inhibition of Intestinal OATP2B1 by the Calcium Receptor Antagonist Ronacaleret Results in a Significant Drug-Drug Interaction by Causing a 2-Fold Decrease in Exposure of Rosuvastatin
      Marta Johnson, Dipal Patel, Christopher Matheny, May Ho, Liangfu Chen and Harma Ellens
      Drug Metabolism and Disposition January 2017, 45 (1) 27-34; DOI: https://doi.org/10.1124/dmd.116.072397

  3. Proudman, Susanna M.

    1. Intracellular CD3+ T Lymphocyte Teriflunomide Concentration Is Poorly Correlated with and Has Greater Variability Than Unbound Plasma Teriflunomide Concentration
      Ashley M. Hopkins, Mahin Moghaddami, David J. R. Foster, Susanna M. Proudman, Richard N. Upton and Michael D. Wiese
      Drug Metabolism and Disposition January 2017, 45 (1) 8-16; DOI: https://doi.org/10.1124/dmd.116.071985

R

  1. Ragueneau-Majlessi, Isabelle

    1. What Can Be Learned from Recent New Drug Applications? A Systematic Review of Drug Interaction Data for Drugs Approved by the US FDA in 2015
      Jingjing Yu, Zhu Zhou, Katie H. Owens, Tasha K. Ritchie and Isabelle Ragueneau-Majlessi
      Drug Metabolism and Disposition January 2017, 45 (1) 86-108; DOI: https://doi.org/10.1124/dmd.116.073411

  2. Ray, Adrian S.

    1. Interaction of 2,4-Diaminopyrimidine–Containing Drugs Including Fedratinib and Trimethoprim with Thiamine Transporters
      Marilyn M. Giacomini, Jia Hao, Xiaomin Liang, Jayaraman Chandrasekhar, Jolyn Twelves, J. Andrew Whitney, Eve-Irene Lepist and Adrian S. Ray
      Drug Metabolism and Disposition January 2017, 45 (1) 76-85; DOI: https://doi.org/10.1124/dmd.116.073338

  3. Ritchie, Tasha K.

    1. What Can Be Learned from Recent New Drug Applications? A Systematic Review of Drug Interaction Data for Drugs Approved by the US FDA in 2015
      Jingjing Yu, Zhu Zhou, Katie H. Owens, Tasha K. Ritchie and Isabelle Ragueneau-Majlessi
      Drug Metabolism and Disposition January 2017, 45 (1) 86-108; DOI: https://doi.org/10.1124/dmd.116.073411

  4. Rollison, Helen

    1. Managing the Risk of CYP3A Induction in Drug Development: A Strategic Approach
      Barry C. Jones, Helen Rollison, Susanne Johansson, Kajsa P. Kanebratt, Craig Lambert, Karthick Vishwanathan and Tommy B. Andersson
      Drug Metabolism and Disposition January 2017, 45 (1) 35-41; DOI: https://doi.org/10.1124/dmd.116.072025

  5. Rudi de Waart, D.

    1. Stable Overexpression of the Constitutive Androstane Receptor Reduces the Requirement for Culture with Dimethyl Sulfoxide for High Drug Metabolism in HepaRG Cells
      Vincent A. van der Mark, D. Rudi de Waart, Valery Shevchenko, Ronald P.J. Oude Elferink, Robert A. F. M. Chamuleau and Ruurdtje Hoekstra
      Drug Metabolism and Disposition January 2017, 45 (1) 56-67; DOI: https://doi.org/10.1124/dmd.116.072603

S

  1. Shamsi, Suhaili

    1. Curcumin, Piperine, and Capsaicin: A Comparative Study of Spice-Mediated Inhibition of Human Cytochrome P450 Isozyme Activities
      Curcumin, Piperine, and Capsaicin: A Comparative Study of Spice-Mediated Inhibition of Human Cytochrome P450 Isozyme Activities
      Suhaili Shamsi, Huong Tran, Renee Seok Jin Tan, Zee Jian Tan and Lee Yong Lim
      Drug Metabolism and Disposition January 2017, 45 (1) 49-55; DOI: https://doi.org/10.1124/dmd.116.073213

  2. Shen, Zhuowei

    1. Histone H3 Lysine 4 Trimethylation, Lysine 27 Trimethylation, and Lysine 27 Acetylation Contribute to the Transcriptional Repression of Solute Carrier Family 47 Member 2 in Renal Cell Carcinoma
      Qinqin Yu, Yanqing Liu, Xiaoli Zheng, Qianying Zhu, Zhuowei Shen, Hua Wang, Huadong He, Nengming Lin, Huidi Jiang, Lushan Yu and Su Zeng
      Drug Metabolism and Disposition January 2017, 45 (1) 109-117; DOI: https://doi.org/10.1124/dmd.116.073734

  3. Shevchenko, Valery

    1. Stable Overexpression of the Constitutive Androstane Receptor Reduces the Requirement for Culture with Dimethyl Sulfoxide for High Drug Metabolism in HepaRG Cells
      Vincent A. van der Mark, D. Rudi de Waart, Valery Shevchenko, Ronald P.J. Oude Elferink, Robert A. F. M. Chamuleau and Ruurdtje Hoekstra
      Drug Metabolism and Disposition January 2017, 45 (1) 56-67; DOI: https://doi.org/10.1124/dmd.116.072603

  4. Strelevitz, Timothy J.

    1. Clearance Prediction of Targeted Covalent Inhibitors by In Vitro-In Vivo Extrapolation of Hepatic and Extrahepatic Clearance Mechanisms
      Louis Leung, Xin Yang, Timothy J. Strelevitz, Justin Montgomery, Matthew F. Brown, Michael A. Zientek, Christopher Banfield, Adam M. Gilbert, Atli Thorarensen and Martin E. Dowty
      Drug Metabolism and Disposition January 2017, 45 (1) 1-7; DOI: https://doi.org/10.1124/dmd.116.072983

T

  1. Tan, Renee Seok Jin

    1. Curcumin, Piperine, and Capsaicin: A Comparative Study of Spice-Mediated Inhibition of Human Cytochrome P450 Isozyme Activities
      Curcumin, Piperine, and Capsaicin: A Comparative Study of Spice-Mediated Inhibition of Human Cytochrome P450 Isozyme Activities
      Suhaili Shamsi, Huong Tran, Renee Seok Jin Tan, Zee Jian Tan and Lee Yong Lim
      Drug Metabolism and Disposition January 2017, 45 (1) 49-55; DOI: https://doi.org/10.1124/dmd.116.073213

  2. Tan, Zee Jian

    1. Curcumin, Piperine, and Capsaicin: A Comparative Study of Spice-Mediated Inhibition of Human Cytochrome P450 Isozyme Activities
      Curcumin, Piperine, and Capsaicin: A Comparative Study of Spice-Mediated Inhibition of Human Cytochrome P450 Isozyme Activities
      Suhaili Shamsi, Huong Tran, Renee Seok Jin Tan, Zee Jian Tan and Lee Yong Lim
      Drug Metabolism and Disposition January 2017, 45 (1) 49-55; DOI: https://doi.org/10.1124/dmd.116.073213

  3. Thale, Zia

    1. Lack of Exposure in a First-in-Man Study Due to Aldehyde Oxidase Metabolism: Investigated by Use of 14C-microdose, Humanized Mice, Monkey Pharmacokinetics, and In Vitro Methods
      Klaus Gjervig Jensen, Anne-Marie Jacobsen, Christoffer Bundgaard, Dorrit Østergaard Nilausen, Zia Thale, Gamini Chandrasena and Martin Jørgensen
      Drug Metabolism and Disposition January 2017, 45 (1) 68-75; DOI: https://doi.org/10.1124/dmd.116.072793

  4. Thorarensen, Atli

    1. Clearance Prediction of Targeted Covalent Inhibitors by In Vitro-In Vivo Extrapolation of Hepatic and Extrahepatic Clearance Mechanisms
      Louis Leung, Xin Yang, Timothy J. Strelevitz, Justin Montgomery, Matthew F. Brown, Michael A. Zientek, Christopher Banfield, Adam M. Gilbert, Atli Thorarensen and Martin E. Dowty
      Drug Metabolism and Disposition January 2017, 45 (1) 1-7; DOI: https://doi.org/10.1124/dmd.116.072983

  5. Tran, Huong

    1. Curcumin, Piperine, and Capsaicin: A Comparative Study of Spice-Mediated Inhibition of Human Cytochrome P450 Isozyme Activities
      Curcumin, Piperine, and Capsaicin: A Comparative Study of Spice-Mediated Inhibition of Human Cytochrome P450 Isozyme Activities
      Suhaili Shamsi, Huong Tran, Renee Seok Jin Tan, Zee Jian Tan and Lee Yong Lim
      Drug Metabolism and Disposition January 2017, 45 (1) 49-55; DOI: https://doi.org/10.1124/dmd.116.073213

  6. Twelves, Jolyn

    1. Interaction of 2,4-Diaminopyrimidine–Containing Drugs Including Fedratinib and Trimethoprim with Thiamine Transporters
      Marilyn M. Giacomini, Jia Hao, Xiaomin Liang, Jayaraman Chandrasekhar, Jolyn Twelves, J. Andrew Whitney, Eve-Irene Lepist and Adrian S. Ray
      Drug Metabolism and Disposition January 2017, 45 (1) 76-85; DOI: https://doi.org/10.1124/dmd.116.073338

U

  1. Upton, Richard N.

    1. Intracellular CD3+ T Lymphocyte Teriflunomide Concentration Is Poorly Correlated with and Has Greater Variability Than Unbound Plasma Teriflunomide Concentration
      Ashley M. Hopkins, Mahin Moghaddami, David J. R. Foster, Susanna M. Proudman, Richard N. Upton and Michael D. Wiese
      Drug Metabolism and Disposition January 2017, 45 (1) 8-16; DOI: https://doi.org/10.1124/dmd.116.071985

V

  1. van der Mark, Vincent A.

    1. Stable Overexpression of the Constitutive Androstane Receptor Reduces the Requirement for Culture with Dimethyl Sulfoxide for High Drug Metabolism in HepaRG Cells
      Vincent A. van der Mark, D. Rudi de Waart, Valery Shevchenko, Ronald P.J. Oude Elferink, Robert A. F. M. Chamuleau and Ruurdtje Hoekstra
      Drug Metabolism and Disposition January 2017, 45 (1) 56-67; DOI: https://doi.org/10.1124/dmd.116.072603

  2. Vinks, Alexander A.

    1. Developmental Changes in Hepatic Organic Cation Transporter OCT1 Protein Expression from Neonates to Children
      David Hahn, Chie Emoto, Alexander A. Vinks and Tsuyoshi Fukuda
      Drug Metabolism and Disposition January 2017, 45 (1) 23-26; DOI: https://doi.org/10.1124/dmd.116.072256

  3. Vishwanathan, Karthick

    1. Managing the Risk of CYP3A Induction in Drug Development: A Strategic Approach
      Barry C. Jones, Helen Rollison, Susanne Johansson, Kajsa P. Kanebratt, Craig Lambert, Karthick Vishwanathan and Tommy B. Andersson
      Drug Metabolism and Disposition January 2017, 45 (1) 35-41; DOI: https://doi.org/10.1124/dmd.116.072025

W

  1. Wang, Hua

    1. Histone H3 Lysine 4 Trimethylation, Lysine 27 Trimethylation, and Lysine 27 Acetylation Contribute to the Transcriptional Repression of Solute Carrier Family 47 Member 2 in Renal Cell Carcinoma
      Qinqin Yu, Yanqing Liu, Xiaoli Zheng, Qianying Zhu, Zhuowei Shen, Hua Wang, Huadong He, Nengming Lin, Huidi Jiang, Lushan Yu and Su Zeng
      Drug Metabolism and Disposition January 2017, 45 (1) 109-117; DOI: https://doi.org/10.1124/dmd.116.073734

  2. Whitney, J. Andrew

    1. Interaction of 2,4-Diaminopyrimidine–Containing Drugs Including Fedratinib and Trimethoprim with Thiamine Transporters
      Marilyn M. Giacomini, Jia Hao, Xiaomin Liang, Jayaraman Chandrasekhar, Jolyn Twelves, J. Andrew Whitney, Eve-Irene Lepist and Adrian S. Ray
      Drug Metabolism and Disposition January 2017, 45 (1) 76-85; DOI: https://doi.org/10.1124/dmd.116.073338

  3. Wiese, Michael D.

    1. Intracellular CD3+ T Lymphocyte Teriflunomide Concentration Is Poorly Correlated with and Has Greater Variability Than Unbound Plasma Teriflunomide Concentration
      Ashley M. Hopkins, Mahin Moghaddami, David J. R. Foster, Susanna M. Proudman, Richard N. Upton and Michael D. Wiese
      Drug Metabolism and Disposition January 2017, 45 (1) 8-16; DOI: https://doi.org/10.1124/dmd.116.071985

  4. Wolf, C. Roland

    1. Open Access
      Application of Mice Humanized for CYP2D6 to the Study of Tamoxifen Metabolism and Drug–Drug Interaction with Antidepressants
      A. Kenneth MacLeod, Lesley A. McLaughlin, Colin J. Henderson and C. Roland Wolf
      Drug Metabolism and Disposition January 2017, 45 (1) 17-22; DOI: https://doi.org/10.1124/dmd.116.073437

Y

  1. Yang, Xin

    1. Clearance Prediction of Targeted Covalent Inhibitors by In Vitro-In Vivo Extrapolation of Hepatic and Extrahepatic Clearance Mechanisms
      Louis Leung, Xin Yang, Timothy J. Strelevitz, Justin Montgomery, Matthew F. Brown, Michael A. Zientek, Christopher Banfield, Adam M. Gilbert, Atli Thorarensen and Martin E. Dowty
      Drug Metabolism and Disposition January 2017, 45 (1) 1-7; DOI: https://doi.org/10.1124/dmd.116.072983

  2. Yu, Jingjing

    1. What Can Be Learned from Recent New Drug Applications? A Systematic Review of Drug Interaction Data for Drugs Approved by the US FDA in 2015
      Jingjing Yu, Zhu Zhou, Katie H. Owens, Tasha K. Ritchie and Isabelle Ragueneau-Majlessi
      Drug Metabolism and Disposition January 2017, 45 (1) 86-108; DOI: https://doi.org/10.1124/dmd.116.073411

  3. Yu, Lushan

    1. Histone H3 Lysine 4 Trimethylation, Lysine 27 Trimethylation, and Lysine 27 Acetylation Contribute to the Transcriptional Repression of Solute Carrier Family 47 Member 2 in Renal Cell Carcinoma
      Qinqin Yu, Yanqing Liu, Xiaoli Zheng, Qianying Zhu, Zhuowei Shen, Hua Wang, Huadong He, Nengming Lin, Huidi Jiang, Lushan Yu and Su Zeng
      Drug Metabolism and Disposition January 2017, 45 (1) 109-117; DOI: https://doi.org/10.1124/dmd.116.073734

  4. Yu, Qinqin

    1. Histone H3 Lysine 4 Trimethylation, Lysine 27 Trimethylation, and Lysine 27 Acetylation Contribute to the Transcriptional Repression of Solute Carrier Family 47 Member 2 in Renal Cell Carcinoma
      Qinqin Yu, Yanqing Liu, Xiaoli Zheng, Qianying Zhu, Zhuowei Shen, Hua Wang, Huadong He, Nengming Lin, Huidi Jiang, Lushan Yu and Su Zeng
      Drug Metabolism and Disposition January 2017, 45 (1) 109-117; DOI: https://doi.org/10.1124/dmd.116.073734

Z

  1. Zeng, Su

    1. Histone H3 Lysine 4 Trimethylation, Lysine 27 Trimethylation, and Lysine 27 Acetylation Contribute to the Transcriptional Repression of Solute Carrier Family 47 Member 2 in Renal Cell Carcinoma
      Qinqin Yu, Yanqing Liu, Xiaoli Zheng, Qianying Zhu, Zhuowei Shen, Hua Wang, Huadong He, Nengming Lin, Huidi Jiang, Lushan Yu and Su Zeng
      Drug Metabolism and Disposition January 2017, 45 (1) 109-117; DOI: https://doi.org/10.1124/dmd.116.073734

  2. Zheng, Xiaoli

    1. Histone H3 Lysine 4 Trimethylation, Lysine 27 Trimethylation, and Lysine 27 Acetylation Contribute to the Transcriptional Repression of Solute Carrier Family 47 Member 2 in Renal Cell Carcinoma
      Qinqin Yu, Yanqing Liu, Xiaoli Zheng, Qianying Zhu, Zhuowei Shen, Hua Wang, Huadong He, Nengming Lin, Huidi Jiang, Lushan Yu and Su Zeng
      Drug Metabolism and Disposition January 2017, 45 (1) 109-117; DOI: https://doi.org/10.1124/dmd.116.073734

  3. Zhou, Zhu

    1. What Can Be Learned from Recent New Drug Applications? A Systematic Review of Drug Interaction Data for Drugs Approved by the US FDA in 2015
      Jingjing Yu, Zhu Zhou, Katie H. Owens, Tasha K. Ritchie and Isabelle Ragueneau-Majlessi
      Drug Metabolism and Disposition January 2017, 45 (1) 86-108; DOI: https://doi.org/10.1124/dmd.116.073411

  4. Zhu, Qianying

    1. Histone H3 Lysine 4 Trimethylation, Lysine 27 Trimethylation, and Lysine 27 Acetylation Contribute to the Transcriptional Repression of Solute Carrier Family 47 Member 2 in Renal Cell Carcinoma
      Qinqin Yu, Yanqing Liu, Xiaoli Zheng, Qianying Zhu, Zhuowei Shen, Hua Wang, Huadong He, Nengming Lin, Huidi Jiang, Lushan Yu and Su Zeng
      Drug Metabolism and Disposition January 2017, 45 (1) 109-117; DOI: https://doi.org/10.1124/dmd.116.073734

  5. Zientek, Michael A.

    1. Clearance Prediction of Targeted Covalent Inhibitors by In Vitro-In Vivo Extrapolation of Hepatic and Extrahepatic Clearance Mechanisms
      Louis Leung, Xin Yang, Timothy J. Strelevitz, Justin Montgomery, Matthew F. Brown, Michael A. Zientek, Christopher Banfield, Adam M. Gilbert, Atli Thorarensen and Martin E. Dowty
      Drug Metabolism and Disposition January 2017, 45 (1) 1-7; DOI: https://doi.org/10.1124/dmd.116.072983
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