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Research ArticleMinireviews

What Can Be Learned from Recent New Drug Applications? A Systematic Review of Drug Interaction Data for Drugs Approved by the US FDA in 2015

Jingjing Yu, Zhu Zhou, Katie H. Owens, Tasha K. Ritchie and Isabelle Ragueneau-Majlessi
Drug Metabolism and Disposition January 2017, 45 (1) 86-108; DOI: https://doi.org/10.1124/dmd.116.073411
Jingjing Yu
Department of Pharmaceutics, School of Pharmacy, University of Washington, Seattle, Washington
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Zhu Zhou
Department of Pharmaceutics, School of Pharmacy, University of Washington, Seattle, Washington
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Katie H. Owens
Department of Pharmaceutics, School of Pharmacy, University of Washington, Seattle, Washington
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Tasha K. Ritchie
Department of Pharmaceutics, School of Pharmacy, University of Washington, Seattle, Washington
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Isabelle Ragueneau-Majlessi
Department of Pharmaceutics, School of Pharmacy, University of Washington, Seattle, Washington
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In this issue

Drug Metabolism and Disposition: 45 (1)
Drug Metabolism and Disposition
Vol. 45, Issue 1
1 Jan 2017
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Research ArticleMinireviews

A review of drug disposition and DDIs in 2015 NDAs

Jingjing Yu, Zhu Zhou, Katie H. Owens, Tasha K. Ritchie and Isabelle Ragueneau-Majlessi
Drug Metabolism and Disposition January 1, 2017, 45 (1) 86-108; DOI: https://doi.org/10.1124/dmd.116.073411

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Research ArticleMinireviews

A review of drug disposition and DDIs in 2015 NDAs

Jingjing Yu, Zhu Zhou, Katie H. Owens, Tasha K. Ritchie and Isabelle Ragueneau-Majlessi
Drug Metabolism and Disposition January 1, 2017, 45 (1) 86-108; DOI: https://doi.org/10.1124/dmd.116.073411
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  • Article
    • Abstract
    • Introduction
    • Metabolism and Enzyme-Mediated DDIs
    • Transport and Transporter-Mediated DDIs
    • PGx Studies
    • PBPK Modeling and Simulations
    • Clinically Significant DDIs
    • Hepatic Impairment (HI) and Renal Impairment (RI) Studies
    • Conclusions
    • Acknowledgments
    • Authorship Contributions
    • Footnotes
    • Abbreviations
    • References
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  • A Decade in the MIST
  • A Review of PK-Based DDIs in 2013–2016 NDAs
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