Drug Metabolism and Disposition: 45 (10)

October 01, 2017; Volume 45,Issue 10

Announcement

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Announcement
Mary Vore

Drug Metabolism and Disposition October 2017, 45 (10) 1101; DOI: https://doi.org/10.1124/dmd.117.078352

Perspective

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Considerations from the IQ Induction Working Group in Response to Drug-Drug Interaction Guidance from Regulatory Agencies: Focus on Downregulation, CYP2C Induction, and CYP2B6 Positive Control
Niresh Hariparsad, Diane Ramsden, Jairam Palamanda, Joshua G. Dekeyser, Odette A. Fahmi, Jane R. Kenny, Heidi Einolf, Michael Mohutsky, Magalie Pardon, Y. Amy Siu, Liangfu Chen, Michael Sinz, Barry Jones, Robert Walsky, Shannon Dallas, Suresh K. Balani, George Zhang, David Buckley and Donald Tweedie

Drug Metabolism and Disposition October 2017, 45 (10) 1049-1059; DOI: https://doi.org/10.1124/dmd.116.074567

Articles

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An Investigation into the Prediction of In Vivo Clearance for a Range of Flavin-containing Monooxygenase Substrates
Barry C. Jones, Abhishek Srivastava, Nicola Colclough, Joanne Wilson, Venkatesh Pilla Reddy, Sara Amberntsson and Danxi Li

Drug Metabolism and Disposition October 2017, 45 (10) 1060-1067; DOI: https://doi.org/10.1124/dmd.117.077396
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Creation and Preliminary Characterization of Pregnane X Receptor and Constitutive Androstane Receptor Knockout Rats
Kevin P. Forbes, Evguenia Kouranova, Daniel Tinker, Karen Janowski, Doug Cortner, Aaron McCoy and Xiaoxia Cui

Drug Metabolism and Disposition October 2017, 45 (10) 1068-1076; DOI: https://doi.org/10.1124/dmd.117.075788
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Involvement of Nuclear Factor κB, not Pregnane X Receptor, in Inflammation-Mediated Regulation of Hepatic Transporters
Walaa A. Abualsunun and Micheline Piquette-Miller

Drug Metabolism and Disposition October 2017, 45 (10) 1077-1083; DOI: https://doi.org/10.1124/dmd.117.076927
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CYP1A1-Mediated Intramolecular Rearrangement of Aminoazepane in GDC-0339
Ryan H. Takahashi, Xiaojing Wang, Nathaniel L. Segraves, Jing Wang, Jae H. Chang, S. Cyrus Khojasteh and Shuguang Ma

Drug Metabolism and Disposition October 2017, 45 (10) 1084-1092; DOI: https://doi.org/10.1124/dmd.117.076786
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Hepatocyte-Specific Deletion of EGFR in Mice Reduces Hepatic Abcg2 Transport Activity Measured by [¹¹C]erlotinib and Positron Emission Tomography
Alexander Traxl, Karin Komposch, Elisabeth Glitzner, Thomas Wanek, Severin Mairinger, Oliver Langer and Maria Sibilia

Drug Metabolism and Disposition October 2017, 45 (10) 1093-1100; DOI: https://doi.org/10.1124/dmd.117.077081
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Quantitative Characterization of Major Hepatic UDP-Glucuronosyltransferase Enzymes in Human Liver Microsomes: Comparison of Two Proteomic Methods and Correlation with Catalytic Activity
Brahim Achour, Alyssa Dantonio, Mark Niosi, Jonathan J. Novak, John K. Fallon, Jill Barber, Philip C. Smith, Amin Rostami-Hodjegan and Theunis C. Goosen

Drug Metabolism and Disposition October 2017, 45 (10) 1102-1112; DOI: https://doi.org/10.1124/dmd.117.076703

Erratum

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Correction to “Identification of genetic polymorphisms of CYP2W1 in the three main Chinese ethnicities: Han, Tibetan, and Uighur”
Drug Metabolism and Disposition October 2017, 45 (10) 1113; DOI: https://doi.org/10.1124/dmd.117.069153err

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