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Drug Metabolism & Disposition

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Table of Contents

November 01, 2017; Volume 45,Issue 11

Commentary

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    Clearance Prediction Methodology Needs Fundamental Improvement: Trends Common to Rat and Human Hepatocytes/Microsomes and Implications for Experimental Methodology
    F. L. Wood, J. B. Houston and D. Hallifax
    Drug Metabolism and Disposition November 2017, 45 (11) 1178-1188; DOI: https://doi.org/10.1124/dmd.117.077040

Articles

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    Wuzhi Tablet (Schisandra sphenanthera Extract) Is a Promising Tacrolimus-Sparing Agent for Renal Transplant Recipients Who Are CYP3A5 Expressers: a Two-Phase Prospective Study
    Jiali Li, Siyang Chen, Xiaoling Qin, Qian Fu, Huichang Bi, Yu Zhang, Xueding Wang, Longshan Liu, Changxi Wang and Min Huang
    Drug Metabolism and Disposition November 2017, 45 (11) 1114-1119; DOI: https://doi.org/10.1124/dmd.117.076737
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    Measurement and Mathematical Characterization of Cell-Level Pharmacokinetics of Antibody-Drug Conjugates: A Case Study with Trastuzumab-vc-MMAE
    Aman P. Singh and Dhaval K. Shah
    Drug Metabolism and Disposition November 2017, 45 (11) 1120-1132; DOI: https://doi.org/10.1124/dmd.117.076414
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    CYP-Mediated Sulfoximine Deimination of AZD6738
    Barry C. Jones, Roshini Markandu, Chungang Gu and Graeme Scarfe
    Drug Metabolism and Disposition November 2017, 45 (11) 1133-1138; DOI: https://doi.org/10.1124/dmd.117.077776
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    Simple Evaluation Method for CYP3A4 Induction from Human Hepatocytes: The Relative Factor Approach with an Induction Detection Limit Concentration Based on the Emax Model
    Shino Kuramoto, Motohiro Kato, Hidetoshi Shindoh, Akihisa Kaneko, Masaki Ishigai and Seiji Miyauchi
    Drug Metabolism and Disposition November 2017, 45 (11) 1139-1145; DOI: https://doi.org/10.1124/dmd.117.076349
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    A Comprehensive Functional Assessment of Carboxylesterase 1 Nonsynonymous Polymorphisms
    Xinwen Wang, Nada Rida, Jian Shi, Audrey H. Wu, Barry E. Bleske and Hao-Jie Zhu
    Drug Metabolism and Disposition November 2017, 45 (11) 1149-1155; DOI: https://doi.org/10.1124/dmd.117.077669
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    Physiologically Based Pharmacokinetic Model of the CYP2D6 Probe Atomoxetine: Extrapolation to Special Populations and Drug-Drug Interactions
    Weize Huang, Mariko Nakano, Jennifer Sager, Isabelle Ragueneau-Majlessi and Nina Isoherranen
    Drug Metabolism and Disposition November 2017, 45 (11) 1156-1165; DOI: https://doi.org/10.1124/dmd.117.076455
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    Synthetic Analogs of Curcumin Modulate the Function of Multidrug Resistance–Linked ATP-Binding Cassette Transporter ABCG2
    Megumi Murakami, Shinobu Ohnuma, Michihiro Fukuda, Eduardo E. Chufan, Katsuyoshi Kudoh, Keigo Kanehara, Norihiko Sugisawa, Masaharu Ishida, Takeshi Naitoh, Hiroyuki Shibata, Yoshiharu Iwabuchi, Suresh V. Ambudkar and Michiaki Unno
    Drug Metabolism and Disposition November 2017, 45 (11) 1166-1177; DOI: https://doi.org/10.1124/dmd.117.076000
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    Hepatic Flavin-Containing Monooxygenase 3 Enzyme Suppressed by Type 1 Allergy-Produced Nitric Oxide
    Tadatoshi Tanino, Toru Bando, Akira Komada, Yukie Nojiri, Yuna Okada, Yukari Ueda and Eiichi Sakurai
    Drug Metabolism and Disposition November 2017, 45 (11) 1189-1196; DOI: https://doi.org/10.1124/dmd.117.076570
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    Novel Interactions between Gut Microbiome and Host Drug-Processing Genes Modify the Hepatic Metabolism of the Environmental Chemicals Polybrominated Diphenyl Ethers
    Cindy Yanfei Li, Soowan Lee, Sara Cade, Li-Jung Kuo, Irvin R. Schultz, Deepak K. Bhatt, Bhagwat Prasad, Theo K. Bammler and Julia Yue Cui
    Drug Metabolism and Disposition November 2017, 45 (11) 1197-1214; DOI: https://doi.org/10.1124/dmd.117.077024

Errata

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    Correction to “Interaction of 2,4-Diaminopyrimidine Containing Drugs Including Fedratinib and Trimethoprim with Thiamine Transporters”
    Drug Metabolism and Disposition November 2017, 45 (11) 1146-1147; DOI: https://doi.org/10.1124/dmd.116.073338err
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    Correction to “Involvement of Nuclear Factor κB, not Pregnane X Receptor, in Inflammation-Mediated Regulation of Hepatic Transporters”
    Drug Metabolism and Disposition November 2017, 45 (11) 1148; DOI: https://doi.org/10.1124/dmd.117.076927err
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In this issue

Drug Metabolism and Disposition: 45 (11)
Drug Metabolism and Disposition
Vol. 45, Issue 11
1 Nov 2017
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
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