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Research ArticleArticle

Wuzhi Tablet (Schisandra sphenanthera Extract) Is a Promising Tacrolimus-Sparing Agent for Renal Transplant Recipients Who Are CYP3A5 Expressers: a Two-Phase Prospective Study

Jiali Li, Siyang Chen, Xiaoling Qin, Qian Fu, Huichang Bi, Yu Zhang, Xueding Wang, Longshan Liu, Changxi Wang and Min Huang
Drug Metabolism and Disposition November 2017, 45 (11) 1114-1119; DOI: https://doi.org/10.1124/dmd.117.076737
Jiali Li
Institute of Clinical Pharmacology, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China (J.L., X.Q., H.B., Y.Z., X.W., M.H.); Kidney Transplant Department, Transplant Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China (S.C., Q.F., L.L., C.W.); Guangdong Food and Drug Vocational College, Guangzhou, China (X.Q.); and School of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou, China (Y.Z.)
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Siyang Chen
Institute of Clinical Pharmacology, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China (J.L., X.Q., H.B., Y.Z., X.W., M.H.); Kidney Transplant Department, Transplant Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China (S.C., Q.F., L.L., C.W.); Guangdong Food and Drug Vocational College, Guangzhou, China (X.Q.); and School of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou, China (Y.Z.)
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Xiaoling Qin
Institute of Clinical Pharmacology, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China (J.L., X.Q., H.B., Y.Z., X.W., M.H.); Kidney Transplant Department, Transplant Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China (S.C., Q.F., L.L., C.W.); Guangdong Food and Drug Vocational College, Guangzhou, China (X.Q.); and School of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou, China (Y.Z.)
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Qian Fu
Institute of Clinical Pharmacology, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China (J.L., X.Q., H.B., Y.Z., X.W., M.H.); Kidney Transplant Department, Transplant Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China (S.C., Q.F., L.L., C.W.); Guangdong Food and Drug Vocational College, Guangzhou, China (X.Q.); and School of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou, China (Y.Z.)
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Huichang Bi
Institute of Clinical Pharmacology, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China (J.L., X.Q., H.B., Y.Z., X.W., M.H.); Kidney Transplant Department, Transplant Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China (S.C., Q.F., L.L., C.W.); Guangdong Food and Drug Vocational College, Guangzhou, China (X.Q.); and School of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou, China (Y.Z.)
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Yu Zhang
Institute of Clinical Pharmacology, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China (J.L., X.Q., H.B., Y.Z., X.W., M.H.); Kidney Transplant Department, Transplant Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China (S.C., Q.F., L.L., C.W.); Guangdong Food and Drug Vocational College, Guangzhou, China (X.Q.); and School of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou, China (Y.Z.)
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Xueding Wang
Institute of Clinical Pharmacology, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China (J.L., X.Q., H.B., Y.Z., X.W., M.H.); Kidney Transplant Department, Transplant Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China (S.C., Q.F., L.L., C.W.); Guangdong Food and Drug Vocational College, Guangzhou, China (X.Q.); and School of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou, China (Y.Z.)
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Longshan Liu
Institute of Clinical Pharmacology, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China (J.L., X.Q., H.B., Y.Z., X.W., M.H.); Kidney Transplant Department, Transplant Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China (S.C., Q.F., L.L., C.W.); Guangdong Food and Drug Vocational College, Guangzhou, China (X.Q.); and School of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou, China (Y.Z.)
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Changxi Wang
Institute of Clinical Pharmacology, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China (J.L., X.Q., H.B., Y.Z., X.W., M.H.); Kidney Transplant Department, Transplant Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China (S.C., Q.F., L.L., C.W.); Guangdong Food and Drug Vocational College, Guangzhou, China (X.Q.); and School of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou, China (Y.Z.)
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Min Huang
Institute of Clinical Pharmacology, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China (J.L., X.Q., H.B., Y.Z., X.W., M.H.); Kidney Transplant Department, Transplant Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China (S.C., Q.F., L.L., C.W.); Guangdong Food and Drug Vocational College, Guangzhou, China (X.Q.); and School of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou, China (Y.Z.)
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Abstract

Tacrolimus is a potent but expensive first-line immunosuppressant, thus solutions to reduce tacrolimus consumption while maintain therapeutic level are in urgent need. A two-phase prospective study was conducted to assess the efficacy of an ethanolic extraction preparation of Schisandra sphenanthera (Wuzhi tablet) as a tacrolimus-sparing agent in renal transplant recipients who were high-dose tacrolimus consumers (CYP3A5*1 allele carriers, CYP3A5 expressers). A total of 12 patients were included in the Part I study. After co-administration of Wuzhi tablet, the average individual increment (%) in dose-adjusted C0, Cmax and AUC0–12 hour of tacrolimus were 198.8% (95% CI 149.2, 248.3), 111.0% (95% CI 63.4, 158.6) and 126.1% (95% CI 89.4, 162.8), respectively (P < 0.01), while the average individual reduction (%) in tacrolimus daily dose was 40.9% (95% CI 25.2, 56.6) (P < 0.01). Subsequently, 32 patients were enrolled in a prospective, randomized, controlled study and randomly assigned to receive tacrolimus by CYP3A5 genotype plus Wuzhi tablet co-administration guided dosing (study group) or standard dosing (control group). Besides less tacrolimus dose requirement (P < 0.01), a more accurate tacrolimus initial dose characterized by lower incidence of out-of-range C0 after initial dose (P < 0.01) and fewer dose changes (P < 0.01) was found in the study group. Moreover, no significant differences in acute rejection rate and serum creatinine levels were observed between two groups. Our results show that CYP3A5 genotype plus Wuzhi tablet co-administration guided tacrolimus dosing is a promising therapy for CYP3A5 expressers in the early post-transplant stage, while further study with a larger sample size is required to prove these findings.

Footnotes

    • Received May 15, 2017.
    • Accepted August 17, 2017.
  • The authors appreciate the financial supports provided by the National Major Projects for science and technology development from Science and Technology Ministry of China [Grant 2012ZX09506001-004]; National Natural Science Foundations of China [Grants 81102515, 81320108027]; Natural Science Foundations of Guangdong Province, China [Grant 2016A030313219]; National Key Research and Development Program [Grant 2016YFC0905000]; the 111 Project [Grant B16047]; Key Laboratory Foundation of Guangdong Province [Grant 2011A060901014] and Major Scientific and Technological Project of Guangdong Province [Grants 2011A080300001, 2012A080202013).

  • https://doi.org/10.1124/dmd.117.076737.

  • Copyright © 2017 by The American Society for Pharmacology and Experimental Therapeutics
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Drug Metabolism and Disposition: 45 (11)
Drug Metabolism and Disposition
Vol. 45, Issue 11
1 Nov 2017
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Research ArticleArticle

Tacrolimus-Wuzhi tablet interaction in CYP3A5 expressers

Jiali Li, Siyang Chen, Xiaoling Qin, Qian Fu, Huichang Bi, Yu Zhang, Xueding Wang, Longshan Liu, Changxi Wang and Min Huang
Drug Metabolism and Disposition November 1, 2017, 45 (11) 1114-1119; DOI: https://doi.org/10.1124/dmd.117.076737

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Research ArticleArticle

Tacrolimus-Wuzhi tablet interaction in CYP3A5 expressers

Jiali Li, Siyang Chen, Xiaoling Qin, Qian Fu, Huichang Bi, Yu Zhang, Xueding Wang, Longshan Liu, Changxi Wang and Min Huang
Drug Metabolism and Disposition November 1, 2017, 45 (11) 1114-1119; DOI: https://doi.org/10.1124/dmd.117.076737
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