Table of Contents

Articles

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  Use of Hybrid Capillary Tube Apparatus on 400 MHz NMR for Quantitation of Crucial Low-Quantity Metabolites Using aSICCO Signal

  Ranjeet Tiwari, Deepak Ahire, Hemantha Kumar, Sarmistha Sinha, Siddheshwar Kisan Chauthe, Murali Subramanian, Ramaswamy Iyer, Ramakanth Sarabu and Lakshmikant Bajpai

  Drug Metabolism and Disposition December 2017, 45 (12) 1215-1224; DOI: https://doi.org/10.1124/dmd.117.077073
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  RNA-Seq Profiling of Intestinal Expression of Xenobiotic Processing Genes in Germ-Free Mice

  Zidong Donna Fu, Felcy P. Selwyn, Julia Yue Cui and Curtis D. Klaassen

  Drug Metabolism and Disposition December 2017, 45 (12) 1225-1238; DOI: https://doi.org/10.1124/dmd.117.077313
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  Species-Specific Involvement of Aldehyde Oxidase and Xanthine Oxidase in the Metabolism of the Pyrimidine-Containing mGlu₅-Negative Allosteric Modulator VU0424238 (Auglurant)

  Rachel D. Crouch, Anna L. Blobaum, Andrew S. Felts, P. Jeffrey Conn and Craig W. Lindsley

  Drug Metabolism and Disposition December 2017, 45 (12) 1245-1259; DOI: https://doi.org/10.1124/dmd.117.077552
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  Recovery of CYP3A Phenotype after Kidney Transplantation

  Kristine Hole, Elisabet Størset, Ane Olastuen, Tore Haslemo, Grete Birkeland Kro, Karsten Midtvedt, Anders Åsberg and Espen Molden

  Drug Metabolism and Disposition December 2017, 45 (12) 1260-1265; DOI: https://doi.org/10.1124/dmd.117.078030
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  Digging Deeper into CYP3A Testosterone Metabolism: Kinetic, Regioselectivity, and Stereoselectivity Differences between CYP3A4/5 and CYP3A7

  Sylvie E. Kandel, Lyrialle W. Han, Qingcheng Mao and Jed N. Lampe

  Drug Metabolism and Disposition December 2017, 45 (12) 1266-1275; DOI: https://doi.org/10.1124/dmd.117.078055
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  N-Acetyltransferase 2 Genotype-Dependent N-Acetylation of Hydralazine in Human Hepatocytes

  Cecily E. Allen, Mark A. Doll and David W. Hein

  Drug Metabolism and Disposition December 2017, 45 (12) 1276-1281; DOI: https://doi.org/10.1124/dmd.117.078543
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  Elucidation of the Impact of P-glycoprotein and Breast Cancer Resistance Protein on the Brain Distribution of Catechol-O-Methyltransferase Inhibitors

  Joana Bicker, Ana Fortuna, Gilberto Alves, Patrício Soares-da-Silva and Amílcar Falcão

  Drug Metabolism and Disposition December 2017, 45 (12) 1282-1291; DOI: https://doi.org/10.1124/dmd.117.077883
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  Progressive and Preferential Cellular Accumulation of Hydrophobic Bile Acids Induced by Cholestatic Drugs Is Associated with Inhibition of Their Amidation and Sulfation

  Ahmad Sharanek, Audrey Burban, Lydie Humbert, Christiane Guguen-Guillouzo, Dominique Rainteau and André Guillouzo

  Drug Metabolism and Disposition December 2017, 45 (12) 1292-1303; DOI: https://doi.org/10.1124/dmd.117.077420
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  Physiologically Based Pharmacokinetic Model Predictions of Panobinostat (LBH589) as a Victim and Perpetrator of Drug-Drug Interactions

  Heidi J. Einolf, Wen Lin, Christina S. Won, Lai Wang, Helen Gu, Dung Y. Chun, Handan He and James B. Mangold

  Drug Metabolism and Disposition December 2017, 45 (12) 1304-1316; DOI: https://doi.org/10.1124/dmd.117.076851
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  Pediatric Cytochrome P450 Activity Alterations in Nonalcoholic Steatohepatitis

  Hui Li, Mark J. Canet, John D. Clarke, Dean Billheimer, Stavra A. Xanthakos, Joel E. Lavine, Robert P. Erickson and Nathan J. Cherrington

  Drug Metabolism and Disposition December 2017, 45 (12) 1317-1325; DOI: https://doi.org/10.1124/dmd.117.077644
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  Studies on Para-Methoxymethamphetamine (PMMA) Metabolite Pattern and Influence of CYP2D6 Genetics in Human Liver Microsomes and Authentic Samples from Fatal PMMA Intoxications

  Merete Vevelstad, Elisabeth Leere Øiestad, Elisabeth Nerem, Marianne Arnestad and Inger Lise Bogen

  Drug Metabolism and Disposition December 2017, 45 (12) 1326-1335; DOI: https://doi.org/10.1124/dmd.117.077263
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  The Effect of Chronic Treatment with Lurasidone on Rat Liver Cytochrome P450 Expression and Activity in the Chronic Mild Stress Model of Depression

  Marta Kot, Anna Haduch, Mariusz Papp and Władysława A. Daniel

  Drug Metabolism and Disposition December 2017, 45 (12) 1336-1344; DOI: https://doi.org/10.1124/dmd.117.077826
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  Mouse Red Blood Cell–Mediated Rare Xenobiotic Phosphorylation of a Drug Molecule Not Intended to Be a Kinase Substrate

  Chungang Gu, Shenghua Wen, Peter Doig, Eric Gangl, Xiaolan Zheng, Yanjun Wang and Jeffrey W. Johannes

  Drug Metabolism and Disposition December 2017, 45 (12) 1345-1353; DOI: https://doi.org/10.1124/dmd.117.076869
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  Metabolic Epoxidation Is a Critical Step for the Development of Benzbromarone-Induced Hepatotoxicity

  Hui Wang, Ying Peng, Tingjian Zhang, Qunsheng Lan, Huimin Zhao, Wenbao Wang, Yufei Zhao, Xu Wang, Jianxin Pang, Shaojie Wang and Jiang Zheng

  Drug Metabolism and Disposition December 2017, 45 (12) 1354-1363; DOI: https://doi.org/10.1124/dmd.117.077818
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  Expression and Functional Characterization of Breast Cancer-Associated Cytochrome P450 4Z1 in Saccharomyces cerevisiae

  Matthew G. McDonald, Sutapa Ray, Clara J. Amorosi, Katherine A. Sitko, John P. Kowalski, Lorela Paco, Abhinav Nath, Byron Gallis, Rheem A. Totah, Maitreya J. Dunham, Douglas M. Fowler and Allan E. Rettie

  Drug Metabolism and Disposition December 2017, 45 (12) 1364-1371; DOI: https://doi.org/10.1124/dmd.117.078188
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  Histone Modifications Regulate the Developmental Expression of Human Hepatic UDP-Glucuronosyltransferase 1A1

  Ya-Li Nie, Xiang-Guang Meng, Jing-Yang Liu, Liang Yan, Pei Wang, Hong-Zheng Bi, Quan-Cheng Kan and Li-Rong Zhang

  Drug Metabolism and Disposition December 2017, 45 (12) 1372-1378; DOI: https://doi.org/10.1124/dmd.117.076109