Species-Specific Involvement of Aldehyde Oxidase and Xanthine Oxidase in the Metabolism of the Pyrimidine-Containing mGlu5-Negative Allosteric Modulator VU0424238 (Auglurant)

Rachel D. Crouch; Anna L. Blobaum; Andrew S. Felts; P. Jeffrey Conn; Craig W. Lindsley

doi:10.1124/dmd.117.077552

Research ArticleArticle

Species-Specific Involvement of Aldehyde Oxidase and Xanthine Oxidase in the Metabolism of the Pyrimidine-Containing mGlu₅-Negative Allosteric Modulator VU0424238 (Auglurant)

Rachel D. Crouch, Anna L. Blobaum, Andrew S. Felts, P. Jeffrey Conn and Craig W. Lindsley

Drug Metabolism and Disposition December 2017, 45 (12) 1245-1259; DOI: https://doi.org/10.1124/dmd.117.077552

Rachel D. Crouch

Vanderbilt Center for Neuroscience Drug Discovery (R.D.C., A.L.B., A.S.F., P.J.C., C.W.L.), Departments of Pharmacology (R.D.C., A.L.B., A.S.F., P.J.C., C.W.L.), and Chemistry (C.W.L.), Vanderbilt University School of Medicine, Nashville, Tennessee

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Anna L. Blobaum

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Andrew S. Felts

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P. Jeffrey Conn

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Craig W. Lindsley

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Drug Metabolism and Disposition

Vol. 45, Issue 12

1 Dec 2017

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