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Research ArticleArticle

Elucidation of the Impact of P-glycoprotein and Breast Cancer Resistance Protein on the Brain Distribution of Catechol-O-Methyltransferase Inhibitors

Joana Bicker, Ana Fortuna, Gilberto Alves, Patrício Soares-da-Silva and Amílcar Falcão
Drug Metabolism and Disposition December 2017, 45 (12) 1282-1291; DOI: https://doi.org/10.1124/dmd.117.077883
Joana Bicker
Laboratory of Pharmacology, Faculty of Pharmacy (J.B., A.Fo., A.Fa.), and Center for Neuroscience and Cell Biology (J.B., A.Fo., G.A., A.Fa.), University of Coimbra, Coimbra, Portugal; Health Sciences Research Centre, University of Beira Interior, Covilhã, Portugal (G.A.); Department of Research and Development, BIAL, Sao Mamede do Coronado, Portugal (P.S.-d.S.); and Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Porto, Porto, Portugal (P.S.-d.S.)
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Ana Fortuna
Laboratory of Pharmacology, Faculty of Pharmacy (J.B., A.Fo., A.Fa.), and Center for Neuroscience and Cell Biology (J.B., A.Fo., G.A., A.Fa.), University of Coimbra, Coimbra, Portugal; Health Sciences Research Centre, University of Beira Interior, Covilhã, Portugal (G.A.); Department of Research and Development, BIAL, Sao Mamede do Coronado, Portugal (P.S.-d.S.); and Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Porto, Porto, Portugal (P.S.-d.S.)
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Gilberto Alves
Laboratory of Pharmacology, Faculty of Pharmacy (J.B., A.Fo., A.Fa.), and Center for Neuroscience and Cell Biology (J.B., A.Fo., G.A., A.Fa.), University of Coimbra, Coimbra, Portugal; Health Sciences Research Centre, University of Beira Interior, Covilhã, Portugal (G.A.); Department of Research and Development, BIAL, Sao Mamede do Coronado, Portugal (P.S.-d.S.); and Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Porto, Porto, Portugal (P.S.-d.S.)
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Patrício Soares-da-Silva
Laboratory of Pharmacology, Faculty of Pharmacy (J.B., A.Fo., A.Fa.), and Center for Neuroscience and Cell Biology (J.B., A.Fo., G.A., A.Fa.), University of Coimbra, Coimbra, Portugal; Health Sciences Research Centre, University of Beira Interior, Covilhã, Portugal (G.A.); Department of Research and Development, BIAL, Sao Mamede do Coronado, Portugal (P.S.-d.S.); and Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Porto, Porto, Portugal (P.S.-d.S.)
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Amílcar Falcão
Laboratory of Pharmacology, Faculty of Pharmacy (J.B., A.Fo., A.Fa.), and Center for Neuroscience and Cell Biology (J.B., A.Fo., G.A., A.Fa.), University of Coimbra, Coimbra, Portugal; Health Sciences Research Centre, University of Beira Interior, Covilhã, Portugal (G.A.); Department of Research and Development, BIAL, Sao Mamede do Coronado, Portugal (P.S.-d.S.); and Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Porto, Porto, Portugal (P.S.-d.S.)
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Article Information

vol. 45 no. 12 1282-1291
DOI 
https://doi.org/10.1124/dmd.117.077883
PubMed 
28916530

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received August 7, 2017
  • Accepted September 13, 2017
  • Published online November 3, 2017.

Article Versions

  • Earlier version (September 15, 2017 - 08:42).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2017 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Joana Bicker,
  2. Ana Fortuna,
  3. Gilberto Alves,
  4. Patrício Soares-da-Silva, and
  5. Amílcar Falcão
  1. Laboratory of Pharmacology, Faculty of Pharmacy (J.B., A.Fo., A.Fa.), and Center for Neuroscience and Cell Biology (J.B., A.Fo., G.A., A.Fa.), University of Coimbra, Coimbra, Portugal; Health Sciences Research Centre, University of Beira Interior, Covilhã, Portugal (G.A.); Department of Research and Development, BIAL, Sao Mamede do Coronado, Portugal (P.S.-d.S.); and Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Porto, Porto, Portugal (P.S.-d.S.)
  1. Address correspondence to:
    Dr. Gilberto Alves, Faculty of Health Sciences, CICS-UBI–Health Sciences Research Centre, University of Beira Interior, Avenue Infante D. Henrique, 6200-506 Covilhã, Portugal. E-mail: gilberto{at}fcsaude.ubi.pt
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Drug Metabolism and Disposition: 45 (12)
Drug Metabolism and Disposition
Vol. 45, Issue 12
1 Dec 2017
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P-gp and BCRP Impact on the Brain Access of COMT Inhibitors

Joana Bicker, Ana Fortuna, Gilberto Alves, Patrício Soares-da-Silva and Amílcar Falcão
Drug Metabolism and Disposition December 1, 2017, 45 (12) 1282-1291; DOI: https://doi.org/10.1124/dmd.117.077883

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Research ArticleArticle

P-gp and BCRP Impact on the Brain Access of COMT Inhibitors

Joana Bicker, Ana Fortuna, Gilberto Alves, Patrício Soares-da-Silva and Amílcar Falcão
Drug Metabolism and Disposition December 1, 2017, 45 (12) 1282-1291; DOI: https://doi.org/10.1124/dmd.117.077883
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