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Research ArticleArticle

Pediatric Cytochrome P450 Activity Alterations in Nonalcoholic Steatohepatitis

Hui Li, Mark J. Canet, John D. Clarke, Dean Billheimer, Stavra A. Xanthakos, Joel E. Lavine, Robert P. Erickson and Nathan J. Cherrington
Drug Metabolism and Disposition December 2017, 45 (12) 1317-1325; DOI: https://doi.org/10.1124/dmd.117.077644
Hui Li
Department of Pharmacology and Toxicology (H.L., M.J.C., J.D.C., N.J.C.), Department of Epidemiology and Biostatistics (D.B.), and Department of Pediatrics (R.P.E.), University of Arizona, Tucson, Arizona; Cincinnati Children’s Hospital, University of Cincinnati, Cincinnati, Ohio (S.A.X.); Columbia University, New York, New York (J.E.L.)
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Mark J. Canet
Department of Pharmacology and Toxicology (H.L., M.J.C., J.D.C., N.J.C.), Department of Epidemiology and Biostatistics (D.B.), and Department of Pediatrics (R.P.E.), University of Arizona, Tucson, Arizona; Cincinnati Children’s Hospital, University of Cincinnati, Cincinnati, Ohio (S.A.X.); Columbia University, New York, New York (J.E.L.)
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John D. Clarke
Department of Pharmacology and Toxicology (H.L., M.J.C., J.D.C., N.J.C.), Department of Epidemiology and Biostatistics (D.B.), and Department of Pediatrics (R.P.E.), University of Arizona, Tucson, Arizona; Cincinnati Children’s Hospital, University of Cincinnati, Cincinnati, Ohio (S.A.X.); Columbia University, New York, New York (J.E.L.)
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Dean Billheimer
Department of Pharmacology and Toxicology (H.L., M.J.C., J.D.C., N.J.C.), Department of Epidemiology and Biostatistics (D.B.), and Department of Pediatrics (R.P.E.), University of Arizona, Tucson, Arizona; Cincinnati Children’s Hospital, University of Cincinnati, Cincinnati, Ohio (S.A.X.); Columbia University, New York, New York (J.E.L.)
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Stavra A. Xanthakos
Department of Pharmacology and Toxicology (H.L., M.J.C., J.D.C., N.J.C.), Department of Epidemiology and Biostatistics (D.B.), and Department of Pediatrics (R.P.E.), University of Arizona, Tucson, Arizona; Cincinnati Children’s Hospital, University of Cincinnati, Cincinnati, Ohio (S.A.X.); Columbia University, New York, New York (J.E.L.)
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Joel E. Lavine
Department of Pharmacology and Toxicology (H.L., M.J.C., J.D.C., N.J.C.), Department of Epidemiology and Biostatistics (D.B.), and Department of Pediatrics (R.P.E.), University of Arizona, Tucson, Arizona; Cincinnati Children’s Hospital, University of Cincinnati, Cincinnati, Ohio (S.A.X.); Columbia University, New York, New York (J.E.L.)
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Robert P. Erickson
Department of Pharmacology and Toxicology (H.L., M.J.C., J.D.C., N.J.C.), Department of Epidemiology and Biostatistics (D.B.), and Department of Pediatrics (R.P.E.), University of Arizona, Tucson, Arizona; Cincinnati Children’s Hospital, University of Cincinnati, Cincinnati, Ohio (S.A.X.); Columbia University, New York, New York (J.E.L.)
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Nathan J. Cherrington
Department of Pharmacology and Toxicology (H.L., M.J.C., J.D.C., N.J.C.), Department of Epidemiology and Biostatistics (D.B.), and Department of Pediatrics (R.P.E.), University of Arizona, Tucson, Arizona; Cincinnati Children’s Hospital, University of Cincinnati, Cincinnati, Ohio (S.A.X.); Columbia University, New York, New York (J.E.L.)
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Article Information

vol. 45 no. 12 1317-1325
DOI 
https://doi.org/10.1124/dmd.117.077644
PubMed 
28986475

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received July 18, 2017
  • Accepted September 28, 2017
  • Published online November 8, 2017.

Article Versions

  • Earlier version (October 6, 2017 - 08:24).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2017 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Hui Li,
  2. Mark J. Canet,
  3. John D. Clarke,
  4. Dean Billheimer,
  5. Stavra A. Xanthakos,
  6. Joel E. Lavine,
  7. Robert P. Erickson, and
  8. Nathan J. Cherrington
  1. Department of Pharmacology and Toxicology (H.L., M.J.C., J.D.C., N.J.C.), Department of Epidemiology and Biostatistics (D.B.), and Department of Pediatrics (R.P.E.), University of Arizona, Tucson, Arizona; Cincinnati Children’s Hospital, University of Cincinnati, Cincinnati, Ohio (S.A.X.); Columbia University, New York, New York (J.E.L.)
  1. Address correspondence to:
    Dr. Nathan J. Cherrington, University of Arizona, 1703 E. Mabel Street, Tucson, AZ 85721. E-mail: cherrington{at}pharmacy.arizona.edu
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Drug Metabolism and Disposition: 45 (12)
Drug Metabolism and Disposition
Vol. 45, Issue 12
1 Dec 2017
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Research ArticleArticle

Pediatric CYP Activity Alterations in NASH

Hui Li, Mark J. Canet, John D. Clarke, Dean Billheimer, Stavra A. Xanthakos, Joel E. Lavine, Robert P. Erickson and Nathan J. Cherrington
Drug Metabolism and Disposition December 1, 2017, 45 (12) 1317-1325; DOI: https://doi.org/10.1124/dmd.117.077644

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Research ArticleArticle

Pediatric CYP Activity Alterations in NASH

Hui Li, Mark J. Canet, John D. Clarke, Dean Billheimer, Stavra A. Xanthakos, Joel E. Lavine, Robert P. Erickson and Nathan J. Cherrington
Drug Metabolism and Disposition December 1, 2017, 45 (12) 1317-1325; DOI: https://doi.org/10.1124/dmd.117.077644
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