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Drug Metabolism & Disposition

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Table of Contents

February 01, 2017; Volume 45,Issue 2

Minireview

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    Organic Anion Transporter 2: An Enigmatic Human Solute Carrier
    Hong Shen, Yurong Lai and A. David Rodrigues
    Drug Metabolism and Disposition February 2017, 45 (2) 228-236; DOI: https://doi.org/10.1124/dmd.116.072264

Articles

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    Role of Glucocorticoid Receptor and Pregnane X Receptor in Dexamethasone Induction of Rat Hepatic Aryl Hydrocarbon Receptor Nuclear Translocator and NADPH-Cytochrome P450 Oxidoreductase
    Sarah R. Hunter, Alex Vonk, Anne K. Mullen Grey and David S. Riddick
    Drug Metabolism and Disposition February 2017, 45 (2) 118-129; DOI: https://doi.org/10.1124/dmd.116.073833
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    Species Differences in Human and Rodent PEPT2-Mediated Transport of Glycylsarcosine and Cefadroxil in Pichia Pastoris Transformants
    Feifeng Song, Yongjun Hu, Huidi Jiang and David E. Smith
    Drug Metabolism and Disposition February 2017, 45 (2) 130-136; DOI: https://doi.org/10.1124/dmd.116.073320
  • Open Access
    In Vitro and Clinical Evaluations of the Drug-Drug Interaction Potential of a Metabotropic Glutamate 2/3 Receptor Agonist Prodrug with Intestinal Peptide Transporter 1
    Y. Anne Pak, Amanda J. Long, William F. Annes, Jennifer W. Witcher, Mary Pat Knadler, Mosun A. Ayan-Oshodi, Malcolm I. Mitchell, Phillip Leese and Kathleen M. Hillgren
    Drug Metabolism and Disposition February 2017, 45 (2) 137-144; DOI: https://doi.org/10.1124/dmd.116.071118
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    Microvilli Morphology Can Affect Efflux Active P-Glycoprotein in Confluent MDCKII -hMDR1-NKI and Caco-2 Cell Monolayers
    Zhou Meng, Sylvain Le Marchand, Deep Agnani, Matthew Szapacs, Harma Ellens and Joe Bentz
    Drug Metabolism and Disposition February 2017, 45 (2) 145-151; DOI: https://doi.org/10.1124/dmd.116.072157
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    Target-Site Investigation for the Plasma Prolactin Response: Mechanism-Based Pharmacokinetic-Pharmacodynamic Analysis of Risperidone and Paliperidone in the Rat
    Shinji Shimizu, Sandra M. den Hoedt, Victor Mangas-Sanjuan, Sinziana Cristea, Jana K. Geuer, Dirk-Jan van den Berg, Robin Hartman, Francisco Bellanti and Elizabeth C. M. de Lange
    Drug Metabolism and Disposition February 2017, 45 (2) 152-159; DOI: https://doi.org/10.1124/dmd.116.072306
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    Management of Rodent Populations by Anticoagulant Rodenticides: Toward Third-Generation Anticoagulant Rodenticides
    Marlène Damin-Pernik, Bernadette Espana, Sebastien Lefebvre, Isabelle Fourel, Hervé Caruel, Etienne Benoit and Virginie Lattard
    Drug Metabolism and Disposition February 2017, 45 (2) 160-165; DOI: https://doi.org/10.1124/dmd.116.073791
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    Impact of Organic Cation Transporters (OCT-SLC22A) on Differential Diagnosis of Intrahepatic Lesions
    Michele Visentin, Belle V. van Rosmalen, Christian Hiller, Matthanja Bieze, Lia Hofstetter, Joanne Verheij, Gerd A. Kullak-Ublick, Hermann Koepsell, Saffire S.K.S. Phoa, Ikumi Tamai, Roelof J. Bennink, Thomas M. van Gulik and Bruno Stieger
    Drug Metabolism and Disposition February 2017, 45 (2) 166-173; DOI: https://doi.org/10.1124/dmd.116.072371
  • Metabolism of the MEK1/2 Inhibitor Pimasertib Involves a Novel Conjugation with Phosphoethanolamine in Patients with Solid Tumors
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    Metabolism of the MEK1/2 Inhibitor Pimasertib Involves a Novel Conjugation with Phosphoethanolamine in Patients with Solid Tumors
    Holger Scheible, Friedrich Kraetzer, Andreas Marx, Andreas Johne and Elmar Wimmer
    Drug Metabolism and Disposition February 2017, 45 (2) 174-182; DOI: https://doi.org/10.1124/dmd.116.072934
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    Impact of Probe Substrate Selection on Cytochrome P450 Reaction Phenotyping Using the Relative Activity Factor
    Y. Amy Siu and W. George Lai
    Drug Metabolism and Disposition February 2017, 45 (2) 183-189; DOI: https://doi.org/10.1124/dmd.116.073510
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    Extrapolation of Elementary Rate Constants of P-glycoprotein–Mediated Transport from MDCKII-hMDR1-NKI to Caco-2 Cells
    Zhou Meng, Harma Ellens and Joe Bentz
    Drug Metabolism and Disposition February 2017, 45 (2) 190-197; DOI: https://doi.org/10.1124/dmd.116.072140
  • Open Access
    Evaluation of a Novel Renewable Hepatic Cell Model for Prediction of Clinical CYP3A4 Induction Using a Correlation-Based Relative Induction Score Approach
    Rongjun Zuo, Feng Li, Sweta Parikh, Li Cao, Kirsten L. Cooper, Yulong Hong, Jin Liu, Ronald A. Faris, Daochuan Li and Hongbing Wang
    Drug Metabolism and Disposition February 2017, 45 (2) 198-207; DOI: https://doi.org/10.1124/dmd.116.072124
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    In Vivo Hepatic Enhancer Elements in the Human ABCG2 Locus
    Rachel J. Eclov, Mee J. Kim, Robin P. Smith, Xiaomin Liang, Nadav Ahituv and Deanna L. Kroetz
    Drug Metabolism and Disposition February 2017, 45 (2) 208-215; DOI: https://doi.org/10.1124/dmd.116.072033
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    Age-Dependent Absolute Abundance of Hepatic Carboxylesterases (CES1 and CES2) by LC-MS/MS Proteomics: Application to PBPK Modeling of Oseltamivir In Vivo Pharmacokinetics in Infants
    Mikael Boberg, Marc Vrana, Aanchal Mehrotra, Robin E. Pearce, Andrea Gaedigk, Deepak Kumar Bhatt, J. Steven Leeder and Bhagwat Prasad
    Drug Metabolism and Disposition February 2017, 45 (2) 216-223; DOI: https://doi.org/10.1124/dmd.116.072652
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    Hepatic Dipeptidyl Peptidase-4 Controls Pharmacokinetics of Vildagliptin In Vivo
    Mitsutoshi Asakura, Tatsuki Fukami, Miki Nakajima, Hideaki Fujii, Koichiro Atsuda, Tomoo Itoh and Ryoichi Fujiwara
    Drug Metabolism and Disposition February 2017, 45 (2) 237-245; DOI: https://doi.org/10.1124/dmd.116.073866

Short Communication

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    Comparative Evaluation of Dehydroepiandrosterone Sulfate Potential to Predict Hepatic Organic Anion Transporting Polypeptide Transporter-Based Drug-Drug Interactions
    Kei Nishizawa, Takeo Nakanishi and Ikumi Tamai
    Drug Metabolism and Disposition February 2017, 45 (2) 224-227; DOI: https://doi.org/10.1124/dmd.116.072355
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Drug Metabolism and Disposition: 45 (2)
Drug Metabolism and Disposition
Vol. 45, Issue 2
1 Feb 2017
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
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