Table of Contents

Articles

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  Role of Glucocorticoid Receptor and Pregnane X Receptor in Dexamethasone Induction of Rat Hepatic Aryl Hydrocarbon Receptor Nuclear Translocator and NADPH-Cytochrome P450 Oxidoreductase

  Sarah R. Hunter, Alex Vonk, Anne K. Mullen Grey and David S. Riddick

  Drug Metabolism and Disposition February 2017, 45 (2) 118-129; DOI: https://doi.org/10.1124/dmd.116.073833
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  Species Differences in Human and Rodent PEPT2-Mediated Transport of Glycylsarcosine and Cefadroxil in Pichia Pastoris Transformants

  Feifeng Song, Yongjun Hu, Huidi Jiang and David E. Smith

  Drug Metabolism and Disposition February 2017, 45 (2) 130-136; DOI: https://doi.org/10.1124/dmd.116.073320
• Open Access

  In Vitro and Clinical Evaluations of the Drug-Drug Interaction Potential of a Metabotropic Glutamate 2/3 Receptor Agonist Prodrug with Intestinal Peptide Transporter 1

  Y. Anne Pak, Amanda J. Long, William F. Annes, Jennifer W. Witcher, Mary Pat Knadler, Mosun A. Ayan-Oshodi, Malcolm I. Mitchell, Phillip Leese and Kathleen M. Hillgren

  Drug Metabolism and Disposition February 2017, 45 (2) 137-144; DOI: https://doi.org/10.1124/dmd.116.071118
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  Microvilli Morphology Can Affect Efflux Active P-Glycoprotein in Confluent MDCKII -hMDR1-NKI and Caco-2 Cell Monolayers

  Zhou Meng, Sylvain Le Marchand, Deep Agnani, Matthew Szapacs, Harma Ellens and Joe Bentz

  Drug Metabolism and Disposition February 2017, 45 (2) 145-151; DOI: https://doi.org/10.1124/dmd.116.072157
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  Target-Site Investigation for the Plasma Prolactin Response: Mechanism-Based Pharmacokinetic-Pharmacodynamic Analysis of Risperidone and Paliperidone in the Rat

  Shinji Shimizu, Sandra M. den Hoedt, Victor Mangas-Sanjuan, Sinziana Cristea, Jana K. Geuer, Dirk-Jan van den Berg, Robin Hartman, Francisco Bellanti and Elizabeth C. M. de Lange

  Drug Metabolism and Disposition February 2017, 45 (2) 152-159; DOI: https://doi.org/10.1124/dmd.116.072306
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  Management of Rodent Populations by Anticoagulant Rodenticides: Toward Third-Generation Anticoagulant Rodenticides

  Marlène Damin-Pernik, Bernadette Espana, Sebastien Lefebvre, Isabelle Fourel, Hervé Caruel, Etienne Benoit and Virginie Lattard

  Drug Metabolism and Disposition February 2017, 45 (2) 160-165; DOI: https://doi.org/10.1124/dmd.116.073791
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  Impact of Organic Cation Transporters (OCT-SLC22A) on Differential Diagnosis of Intrahepatic Lesions

  Michele Visentin, Belle V. van Rosmalen, Christian Hiller, Matthanja Bieze, Lia Hofstetter, Joanne Verheij, Gerd A. Kullak-Ublick, Hermann Koepsell, Saffire S.K.S. Phoa, Ikumi Tamai, Roelof J. Bennink, Thomas M. van Gulik and Bruno Stieger

  Drug Metabolism and Disposition February 2017, 45 (2) 166-173; DOI: https://doi.org/10.1124/dmd.116.072371
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  Metabolism of the MEK1/2 Inhibitor Pimasertib Involves a Novel Conjugation with Phosphoethanolamine in Patients with Solid Tumors

  Holger Scheible, Friedrich Kraetzer, Andreas Marx, Andreas Johne and Elmar Wimmer

  Drug Metabolism and Disposition February 2017, 45 (2) 174-182; DOI: https://doi.org/10.1124/dmd.116.072934
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  Impact of Probe Substrate Selection on Cytochrome P450 Reaction Phenotyping Using the Relative Activity Factor

  Y. Amy Siu and W. George Lai

  Drug Metabolism and Disposition February 2017, 45 (2) 183-189; DOI: https://doi.org/10.1124/dmd.116.073510
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  Extrapolation of Elementary Rate Constants of P-glycoprotein–Mediated Transport from MDCKII-hMDR1-NKI to Caco-2 Cells

  Zhou Meng, Harma Ellens and Joe Bentz

  Drug Metabolism and Disposition February 2017, 45 (2) 190-197; DOI: https://doi.org/10.1124/dmd.116.072140
• Open Access

  Evaluation of a Novel Renewable Hepatic Cell Model for Prediction of Clinical CYP3A4 Induction Using a Correlation-Based Relative Induction Score Approach

  Rongjun Zuo, Feng Li, Sweta Parikh, Li Cao, Kirsten L. Cooper, Yulong Hong, Jin Liu, Ronald A. Faris, Daochuan Li and Hongbing Wang

  Drug Metabolism and Disposition February 2017, 45 (2) 198-207; DOI: https://doi.org/10.1124/dmd.116.072124
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  In Vivo Hepatic Enhancer Elements in the Human ABCG2 Locus

  Rachel J. Eclov, Mee J. Kim, Robin P. Smith, Xiaomin Liang, Nadav Ahituv and Deanna L. Kroetz

  Drug Metabolism and Disposition February 2017, 45 (2) 208-215; DOI: https://doi.org/10.1124/dmd.116.072033
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  Age-Dependent Absolute Abundance of Hepatic Carboxylesterases (CES1 and CES2) by LC-MS/MS Proteomics: Application to PBPK Modeling of Oseltamivir In Vivo Pharmacokinetics in Infants

  Mikael Boberg, Marc Vrana, Aanchal Mehrotra, Robin E. Pearce, Andrea Gaedigk, Deepak Kumar Bhatt, J. Steven Leeder and Bhagwat Prasad

  Drug Metabolism and Disposition February 2017, 45 (2) 216-223; DOI: https://doi.org/10.1124/dmd.116.072652
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  Hepatic Dipeptidyl Peptidase-4 Controls Pharmacokinetics of Vildagliptin In Vivo

  Mitsutoshi Asakura, Tatsuki Fukami, Miki Nakajima, Hideaki Fujii, Koichiro Atsuda, Tomoo Itoh and Ryoichi Fujiwara

  Drug Metabolism and Disposition February 2017, 45 (2) 237-245; DOI: https://doi.org/10.1124/dmd.116.073866