Functional Characterization of 34 CYP2A6 Allelic Variants by Assessment of Nicotine C-Oxidation and Coumarin 7-Hydroxylation Activities

Hiroki Hosono; Masaki Kumondai; Masamitsu Maekawa; Hiroaki Yamaguchi; Nariyasu Mano; Akifumi Oda; Noriyasu Hirasawa; Masahiro Hiratsuka

doi:10.1124/dmd.116.073494

Research ArticleArticle

Functional Characterization of 34 CYP2A6 Allelic Variants by Assessment of Nicotine C-Oxidation and Coumarin 7-Hydroxylation Activities

Hiroki Hosono, Masaki Kumondai, Masamitsu Maekawa, Hiroaki Yamaguchi, Nariyasu Mano, Akifumi Oda, Noriyasu Hirasawa and Masahiro Hiratsuka

Drug Metabolism and Disposition March 2017, 45 (3) 279-285; DOI: https://doi.org/10.1124/dmd.116.073494

Hiroki Hosono

Laboratory of Pharmacotherapy of Life-Style Related Diseases, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan (H.H., M.K., N.H., M.H.), Department of Pharmaceutical Sciences, Tohoku University Hospital, Sendai, Japan (M.M., H.Y., N.M.), Department of Biophysical Chemistry, Faculty of Pharmacy, Meijo University, Nagoya, Japan (A.O.)

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Masaki Kumondai

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Masamitsu Maekawa

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Hiroaki Yamaguchi

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Nariyasu Mano

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Akifumi Oda

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Noriyasu Hirasawa

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Masahiro Hiratsuka

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Drug Metabolism and Disposition

Vol. 45, Issue 3

1 Mar 2017

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