Research ArticleArticle
Metabolism and Disposition of a Novel B-Cell Lymphoma-2 Inhibitor Venetoclax in Humans and Characterization of Its Unusual Metabolites
Hong Liu, Melissa J. Michmerhuizen, Yanbin Lao, Katty Wan, Ahmed Hamed Salem, James Sawicki, Michael Serby, Srirajan Vaidyanathan, Shekman L. Wong, Suresh Agarwal, Martin Dunbar, Jens Sydor, Sonia M. de Morais and Anthony J. Lee
Drug Metabolism and Disposition March 2017, 45 (3) 294-305; DOI: https://doi.org/10.1124/dmd.116.071613
Hong Liu
Bioanalysis and Biotransformation, (H.L., M.J.M., K.W., J.S., M.S., J.S., S.M.M., A.J.L.), Process Chemistry (S.V.), and Clinical Pharmacology and Pharmacometrics (A.H.S., S.L.W., S.A., M.D.), Research & Development, AbbVie, North Chicago, Illinois; Clinical Pharmacy, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt (A.H.S.); Eli Lilly and Company, Indianapolis, Indiana (Y.L.)
Melissa J. Michmerhuizen
Bioanalysis and Biotransformation, (H.L., M.J.M., K.W., J.S., M.S., J.S., S.M.M., A.J.L.), Process Chemistry (S.V.), and Clinical Pharmacology and Pharmacometrics (A.H.S., S.L.W., S.A., M.D.), Research & Development, AbbVie, North Chicago, Illinois; Clinical Pharmacy, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt (A.H.S.); Eli Lilly and Company, Indianapolis, Indiana (Y.L.)
Yanbin Lao
Bioanalysis and Biotransformation, (H.L., M.J.M., K.W., J.S., M.S., J.S., S.M.M., A.J.L.), Process Chemistry (S.V.), and Clinical Pharmacology and Pharmacometrics (A.H.S., S.L.W., S.A., M.D.), Research & Development, AbbVie, North Chicago, Illinois; Clinical Pharmacy, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt (A.H.S.); Eli Lilly and Company, Indianapolis, Indiana (Y.L.)
Katty Wan
Bioanalysis and Biotransformation, (H.L., M.J.M., K.W., J.S., M.S., J.S., S.M.M., A.J.L.), Process Chemistry (S.V.), and Clinical Pharmacology and Pharmacometrics (A.H.S., S.L.W., S.A., M.D.), Research & Development, AbbVie, North Chicago, Illinois; Clinical Pharmacy, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt (A.H.S.); Eli Lilly and Company, Indianapolis, Indiana (Y.L.)
Ahmed Hamed Salem
Bioanalysis and Biotransformation, (H.L., M.J.M., K.W., J.S., M.S., J.S., S.M.M., A.J.L.), Process Chemistry (S.V.), and Clinical Pharmacology and Pharmacometrics (A.H.S., S.L.W., S.A., M.D.), Research & Development, AbbVie, North Chicago, Illinois; Clinical Pharmacy, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt (A.H.S.); Eli Lilly and Company, Indianapolis, Indiana (Y.L.)
James Sawicki
Bioanalysis and Biotransformation, (H.L., M.J.M., K.W., J.S., M.S., J.S., S.M.M., A.J.L.), Process Chemistry (S.V.), and Clinical Pharmacology and Pharmacometrics (A.H.S., S.L.W., S.A., M.D.), Research & Development, AbbVie, North Chicago, Illinois; Clinical Pharmacy, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt (A.H.S.); Eli Lilly and Company, Indianapolis, Indiana (Y.L.)
Michael Serby
Bioanalysis and Biotransformation, (H.L., M.J.M., K.W., J.S., M.S., J.S., S.M.M., A.J.L.), Process Chemistry (S.V.), and Clinical Pharmacology and Pharmacometrics (A.H.S., S.L.W., S.A., M.D.), Research & Development, AbbVie, North Chicago, Illinois; Clinical Pharmacy, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt (A.H.S.); Eli Lilly and Company, Indianapolis, Indiana (Y.L.)
Srirajan Vaidyanathan
Bioanalysis and Biotransformation, (H.L., M.J.M., K.W., J.S., M.S., J.S., S.M.M., A.J.L.), Process Chemistry (S.V.), and Clinical Pharmacology and Pharmacometrics (A.H.S., S.L.W., S.A., M.D.), Research & Development, AbbVie, North Chicago, Illinois; Clinical Pharmacy, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt (A.H.S.); Eli Lilly and Company, Indianapolis, Indiana (Y.L.)
Shekman L. Wong
Bioanalysis and Biotransformation, (H.L., M.J.M., K.W., J.S., M.S., J.S., S.M.M., A.J.L.), Process Chemistry (S.V.), and Clinical Pharmacology and Pharmacometrics (A.H.S., S.L.W., S.A., M.D.), Research & Development, AbbVie, North Chicago, Illinois; Clinical Pharmacy, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt (A.H.S.); Eli Lilly and Company, Indianapolis, Indiana (Y.L.)
Suresh Agarwal
Bioanalysis and Biotransformation, (H.L., M.J.M., K.W., J.S., M.S., J.S., S.M.M., A.J.L.), Process Chemistry (S.V.), and Clinical Pharmacology and Pharmacometrics (A.H.S., S.L.W., S.A., M.D.), Research & Development, AbbVie, North Chicago, Illinois; Clinical Pharmacy, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt (A.H.S.); Eli Lilly and Company, Indianapolis, Indiana (Y.L.)
Martin Dunbar
Bioanalysis and Biotransformation, (H.L., M.J.M., K.W., J.S., M.S., J.S., S.M.M., A.J.L.), Process Chemistry (S.V.), and Clinical Pharmacology and Pharmacometrics (A.H.S., S.L.W., S.A., M.D.), Research & Development, AbbVie, North Chicago, Illinois; Clinical Pharmacy, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt (A.H.S.); Eli Lilly and Company, Indianapolis, Indiana (Y.L.)
Jens Sydor
Bioanalysis and Biotransformation, (H.L., M.J.M., K.W., J.S., M.S., J.S., S.M.M., A.J.L.), Process Chemistry (S.V.), and Clinical Pharmacology and Pharmacometrics (A.H.S., S.L.W., S.A., M.D.), Research & Development, AbbVie, North Chicago, Illinois; Clinical Pharmacy, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt (A.H.S.); Eli Lilly and Company, Indianapolis, Indiana (Y.L.)
Sonia M. de Morais
Bioanalysis and Biotransformation, (H.L., M.J.M., K.W., J.S., M.S., J.S., S.M.M., A.J.L.), Process Chemistry (S.V.), and Clinical Pharmacology and Pharmacometrics (A.H.S., S.L.W., S.A., M.D.), Research & Development, AbbVie, North Chicago, Illinois; Clinical Pharmacy, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt (A.H.S.); Eli Lilly and Company, Indianapolis, Indiana (Y.L.)
Anthony J. Lee
Bioanalysis and Biotransformation, (H.L., M.J.M., K.W., J.S., M.S., J.S., S.M.M., A.J.L.), Process Chemistry (S.V.), and Clinical Pharmacology and Pharmacometrics (A.H.S., S.L.W., S.A., M.D.), Research & Development, AbbVie, North Chicago, Illinois; Clinical Pharmacy, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt (A.H.S.); Eli Lilly and Company, Indianapolis, Indiana (Y.L.)
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Research ArticleArticle
Metabolism of Venetoclax in Humans
Hong Liu, Melissa J. Michmerhuizen, Yanbin Lao, Katty Wan, Ahmed Hamed Salem, James Sawicki, Michael Serby, Srirajan Vaidyanathan, Shekman L. Wong, Suresh Agarwal, Martin Dunbar, Jens Sydor, Sonia M. de Morais and Anthony J. Lee
Drug Metabolism and Disposition March 1, 2017, 45 (3) 294-305; DOI: https://doi.org/10.1124/dmd.116.071613
Research ArticleArticle
Metabolism of Venetoclax in Humans
Hong Liu, Melissa J. Michmerhuizen, Yanbin Lao, Katty Wan, Ahmed Hamed Salem, James Sawicki, Michael Serby, Srirajan Vaidyanathan, Shekman L. Wong, Suresh Agarwal, Martin Dunbar, Jens Sydor, Sonia M. de Morais and Anthony J. Lee
Drug Metabolism and Disposition March 1, 2017, 45 (3) 294-305; DOI: https://doi.org/10.1124/dmd.116.071613
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