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Drug Metabolism & Disposition

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Index by author

April 01, 2017; Volume 45,Issue 4
  • A
  • B
  • C
  • D
  • E
  • F
  • G
  • H
  • I
  • J
  • K
  • L
  • M
  • N
  • O
  • P
  • Q
  • R
  • S
  • T
  • U
  • V
  • W
  • X
  • Y
  • Z

A

  1. Abbas, Richat

    1. You have access
      Application of Physiologically Based Pharmacokinetic Modeling to the Understanding of Bosutinib Pharmacokinetics: Prediction of Drug–Drug and Drug–Disease Interactions
      Chiho Ono, Poe-Hirr Hsyu, Richat Abbas, Cho-Ming Loi and Shinji Yamazaki
      Drug Metabolism and Disposition April 2017, 45 (4) 390-398; DOI: https://doi.org/10.1124/dmd.116.074450
  2. Andersson, Tommy B.

    1. Open Access
      Transcriptional, Functional, and Mechanistic Comparisons of Stem Cell–Derived Hepatocytes, HepaRG Cells, and Three-Dimensional Human Hepatocyte Spheroids as Predictive In Vitro Systems for Drug-Induced Liver Injury
      Catherine C. Bell, Volker M. Lauschke, Sabine U. Vorrink, Henrik Palmgren, Rodger Duffin, Tommy B. Andersson and Magnus Ingelman-Sundberg
      Drug Metabolism and Disposition April 2017, 45 (4) 419-429; DOI: https://doi.org/10.1124/dmd.116.074369
  3. Annalora, Andrew J.

    1. You have access
      Alternative Splicing in the Cytochrome P450 Superfamily Expands Protein Diversity to Augment Gene Function and Redirect Human Drug Metabolism
      Andrew J. Annalora, Craig B. Marcus and Patrick L. Iversen
      Drug Metabolism and Disposition April 2017, 45 (4) 375-389; DOI: https://doi.org/10.1124/dmd.116.073254

B

  1. Bell, Catherine C.

    1. Open Access
      Transcriptional, Functional, and Mechanistic Comparisons of Stem Cell–Derived Hepatocytes, HepaRG Cells, and Three-Dimensional Human Hepatocyte Spheroids as Predictive In Vitro Systems for Drug-Induced Liver Injury
      Catherine C. Bell, Volker M. Lauschke, Sabine U. Vorrink, Henrik Palmgren, Rodger Duffin, Tommy B. Andersson and Magnus Ingelman-Sundberg
      Drug Metabolism and Disposition April 2017, 45 (4) 419-429; DOI: https://doi.org/10.1124/dmd.116.074369
  2. Bergström, Fredrik

    1. You have access
      Intrinsic Clearance Assay Incubational Binding: A Method Comparison
      Sofia Chen, Luna Prieto Garcia, Fredrik Bergström, Pär Nordell and Ken Grime
      Drug Metabolism and Disposition April 2017, 45 (4) 342-345; DOI: https://doi.org/10.1124/dmd.116.074138

C

  1. Chen, Sofia

    1. You have access
      Intrinsic Clearance Assay Incubational Binding: A Method Comparison
      Sofia Chen, Luna Prieto Garcia, Fredrik Bergström, Pär Nordell and Ken Grime
      Drug Metabolism and Disposition April 2017, 45 (4) 342-345; DOI: https://doi.org/10.1124/dmd.116.074138
  2. Czeskis, Boris A.

    1. You have access
      Comparison between Radioanalysis and 19F Nuclear Magnetic Resonance Spectroscopy in the Determination of Mass Balance, Metabolism, and Distribution of Pefloxacin
      Haitao Hu, Kishore Kumar Katyayan, Boris A. Czeskis, Everett J. Perkins and Palaniappan Kulanthaivel
      Drug Metabolism and Disposition April 2017, 45 (4) 399-408; DOI: https://doi.org/10.1124/dmd.116.073809

D

  1. Duffin, Rodger

    1. Open Access
      Transcriptional, Functional, and Mechanistic Comparisons of Stem Cell–Derived Hepatocytes, HepaRG Cells, and Three-Dimensional Human Hepatocyte Spheroids as Predictive In Vitro Systems for Drug-Induced Liver Injury
      Catherine C. Bell, Volker M. Lauschke, Sabine U. Vorrink, Henrik Palmgren, Rodger Duffin, Tommy B. Andersson and Magnus Ingelman-Sundberg
      Drug Metabolism and Disposition April 2017, 45 (4) 419-429; DOI: https://doi.org/10.1124/dmd.116.074369

E

  1. Einolf, Heidi J.

    1. You have access
      A Physiologically-Based Pharmacokinetic Modeling Approach To Predict Drug–Drug Interactions of Sonidegib (LDE225) with Perpetrators of CYP3A in Cancer Patients
      Heidi J. Einolf, Jocelyn Zhou, Christina Won, Lai Wang and Sam Rebello
      Drug Metabolism and Disposition April 2017, 45 (4) 361-374; DOI: https://doi.org/10.1124/dmd.116.073585

F

  1. Feng, Bo

    1. You have access
      Quantitative Prediction of Human Renal Clearance and Drug-Drug Interactions of Organic Anion Transporter Substrates Using In Vitro Transport Data: A Relative Activity Factor Approach
      Sumathy Mathialagan, Mary A. Piotrowski, David A. Tess, Bo Feng, John Litchfield and Manthena V. Varma
      Drug Metabolism and Disposition April 2017, 45 (4) 409-417; DOI: https://doi.org/10.1124/dmd.116.074294

G

  1. Grime, Ken

    1. You have access
      Intrinsic Clearance Assay Incubational Binding: A Method Comparison
      Sofia Chen, Luna Prieto Garcia, Fredrik Bergström, Pär Nordell and Ken Grime
      Drug Metabolism and Disposition April 2017, 45 (4) 342-345; DOI: https://doi.org/10.1124/dmd.116.074138

H

  1. Hsyu, Poe-Hirr

    1. You have access
      Application of Physiologically Based Pharmacokinetic Modeling to the Understanding of Bosutinib Pharmacokinetics: Prediction of Drug–Drug and Drug–Disease Interactions
      Chiho Ono, Poe-Hirr Hsyu, Richat Abbas, Cho-Ming Loi and Shinji Yamazaki
      Drug Metabolism and Disposition April 2017, 45 (4) 390-398; DOI: https://doi.org/10.1124/dmd.116.074450
  2. Hu, Haitao

    1. You have access
      Comparison between Radioanalysis and 19F Nuclear Magnetic Resonance Spectroscopy in the Determination of Mass Balance, Metabolism, and Distribution of Pefloxacin
      Haitao Hu, Kishore Kumar Katyayan, Boris A. Czeskis, Everett J. Perkins and Palaniappan Kulanthaivel
      Drug Metabolism and Disposition April 2017, 45 (4) 399-408; DOI: https://doi.org/10.1124/dmd.116.073809

I

  1. Ingelman-Sundberg, Magnus

    1. Open Access
      Transcriptional, Functional, and Mechanistic Comparisons of Stem Cell–Derived Hepatocytes, HepaRG Cells, and Three-Dimensional Human Hepatocyte Spheroids as Predictive In Vitro Systems for Drug-Induced Liver Injury
      Catherine C. Bell, Volker M. Lauschke, Sabine U. Vorrink, Henrik Palmgren, Rodger Duffin, Tommy B. Andersson and Magnus Ingelman-Sundberg
      Drug Metabolism and Disposition April 2017, 45 (4) 419-429; DOI: https://doi.org/10.1124/dmd.116.074369
  2. Iversen, Patrick L.

    1. You have access
      Alternative Splicing in the Cytochrome P450 Superfamily Expands Protein Diversity to Augment Gene Function and Redirect Human Drug Metabolism
      Andrew J. Annalora, Craig B. Marcus and Patrick L. Iversen
      Drug Metabolism and Disposition April 2017, 45 (4) 375-389; DOI: https://doi.org/10.1124/dmd.116.073254

J

  1. Jeong, Hyunyoung

    1. You have access
      Cholic Acid Feeding Leads to Increased CYP2D6 Expression in CYP2D6-Humanized Mice
      Xian Pan, Rebecca Kent, Kyoung-Jae Won and Hyunyoung Jeong
      Drug Metabolism and Disposition April 2017, 45 (4) 346-352; DOI: https://doi.org/10.1124/dmd.116.074013

K

  1. Katyayan, Kishore Kumar

    1. You have access
      Comparison between Radioanalysis and 19F Nuclear Magnetic Resonance Spectroscopy in the Determination of Mass Balance, Metabolism, and Distribution of Pefloxacin
      Haitao Hu, Kishore Kumar Katyayan, Boris A. Czeskis, Everett J. Perkins and Palaniappan Kulanthaivel
      Drug Metabolism and Disposition April 2017, 45 (4) 399-408; DOI: https://doi.org/10.1124/dmd.116.073809
  2. Kent, Rebecca

    1. You have access
      Cholic Acid Feeding Leads to Increased CYP2D6 Expression in CYP2D6-Humanized Mice
      Xian Pan, Rebecca Kent, Kyoung-Jae Won and Hyunyoung Jeong
      Drug Metabolism and Disposition April 2017, 45 (4) 346-352; DOI: https://doi.org/10.1124/dmd.116.074013
  3. Krul, Cyrille A.M.

    1. You have access
      Regional Expression Levels of Drug Transporters and Metabolizing Enzymes along the Pig and Human Intestinal Tract and Comparison with Caco-2 Cells
      Stefan F.C. Vaessen, Marola M.H. van Lipzig, Raymond H.H. Pieters, Cyrille A.M. Krul, Heleen M. Wortelboer and Evita van de Steeg
      Drug Metabolism and Disposition April 2017, 45 (4) 353-360; DOI: https://doi.org/10.1124/dmd.116.072231
  4. Kulanthaivel, Palaniappan

    1. You have access
      Comparison between Radioanalysis and 19F Nuclear Magnetic Resonance Spectroscopy in the Determination of Mass Balance, Metabolism, and Distribution of Pefloxacin
      Haitao Hu, Kishore Kumar Katyayan, Boris A. Czeskis, Everett J. Perkins and Palaniappan Kulanthaivel
      Drug Metabolism and Disposition April 2017, 45 (4) 399-408; DOI: https://doi.org/10.1124/dmd.116.073809

L

  1. Lauschke, Volker M.

    1. Open Access
      Transcriptional, Functional, and Mechanistic Comparisons of Stem Cell–Derived Hepatocytes, HepaRG Cells, and Three-Dimensional Human Hepatocyte Spheroids as Predictive In Vitro Systems for Drug-Induced Liver Injury
      Catherine C. Bell, Volker M. Lauschke, Sabine U. Vorrink, Henrik Palmgren, Rodger Duffin, Tommy B. Andersson and Magnus Ingelman-Sundberg
      Drug Metabolism and Disposition April 2017, 45 (4) 419-429; DOI: https://doi.org/10.1124/dmd.116.074369
  2. Litchfield, John

    1. You have access
      Quantitative Prediction of Human Renal Clearance and Drug-Drug Interactions of Organic Anion Transporter Substrates Using In Vitro Transport Data: A Relative Activity Factor Approach
      Sumathy Mathialagan, Mary A. Piotrowski, David A. Tess, Bo Feng, John Litchfield and Manthena V. Varma
      Drug Metabolism and Disposition April 2017, 45 (4) 409-417; DOI: https://doi.org/10.1124/dmd.116.074294
  3. Loi, Cho-Ming

    1. You have access
      Application of Physiologically Based Pharmacokinetic Modeling to the Understanding of Bosutinib Pharmacokinetics: Prediction of Drug–Drug and Drug–Disease Interactions
      Chiho Ono, Poe-Hirr Hsyu, Richat Abbas, Cho-Ming Loi and Shinji Yamazaki
      Drug Metabolism and Disposition April 2017, 45 (4) 390-398; DOI: https://doi.org/10.1124/dmd.116.074450

M

  1. Marcus, Craig B.

    1. You have access
      Alternative Splicing in the Cytochrome P450 Superfamily Expands Protein Diversity to Augment Gene Function and Redirect Human Drug Metabolism
      Andrew J. Annalora, Craig B. Marcus and Patrick L. Iversen
      Drug Metabolism and Disposition April 2017, 45 (4) 375-389; DOI: https://doi.org/10.1124/dmd.116.073254
  2. Mathialagan, Sumathy

    1. You have access
      Quantitative Prediction of Human Renal Clearance and Drug-Drug Interactions of Organic Anion Transporter Substrates Using In Vitro Transport Data: A Relative Activity Factor Approach
      Sumathy Mathialagan, Mary A. Piotrowski, David A. Tess, Bo Feng, John Litchfield and Manthena V. Varma
      Drug Metabolism and Disposition April 2017, 45 (4) 409-417; DOI: https://doi.org/10.1124/dmd.116.074294

N

  1. Nordell, Pär

    1. You have access
      Intrinsic Clearance Assay Incubational Binding: A Method Comparison
      Sofia Chen, Luna Prieto Garcia, Fredrik Bergström, Pär Nordell and Ken Grime
      Drug Metabolism and Disposition April 2017, 45 (4) 342-345; DOI: https://doi.org/10.1124/dmd.116.074138

O

  1. Ono, Chiho

    1. You have access
      Application of Physiologically Based Pharmacokinetic Modeling to the Understanding of Bosutinib Pharmacokinetics: Prediction of Drug–Drug and Drug–Disease Interactions
      Chiho Ono, Poe-Hirr Hsyu, Richat Abbas, Cho-Ming Loi and Shinji Yamazaki
      Drug Metabolism and Disposition April 2017, 45 (4) 390-398; DOI: https://doi.org/10.1124/dmd.116.074450

P

  1. Palmgren, Henrik

    1. Open Access
      Transcriptional, Functional, and Mechanistic Comparisons of Stem Cell–Derived Hepatocytes, HepaRG Cells, and Three-Dimensional Human Hepatocyte Spheroids as Predictive In Vitro Systems for Drug-Induced Liver Injury
      Catherine C. Bell, Volker M. Lauschke, Sabine U. Vorrink, Henrik Palmgren, Rodger Duffin, Tommy B. Andersson and Magnus Ingelman-Sundberg
      Drug Metabolism and Disposition April 2017, 45 (4) 419-429; DOI: https://doi.org/10.1124/dmd.116.074369
  2. Pan, Xian

    1. You have access
      Cholic Acid Feeding Leads to Increased CYP2D6 Expression in CYP2D6-Humanized Mice
      Xian Pan, Rebecca Kent, Kyoung-Jae Won and Hyunyoung Jeong
      Drug Metabolism and Disposition April 2017, 45 (4) 346-352; DOI: https://doi.org/10.1124/dmd.116.074013
  3. Perkins, Everett J.

    1. You have access
      Comparison between Radioanalysis and 19F Nuclear Magnetic Resonance Spectroscopy in the Determination of Mass Balance, Metabolism, and Distribution of Pefloxacin
      Haitao Hu, Kishore Kumar Katyayan, Boris A. Czeskis, Everett J. Perkins and Palaniappan Kulanthaivel
      Drug Metabolism and Disposition April 2017, 45 (4) 399-408; DOI: https://doi.org/10.1124/dmd.116.073809
  4. Pieters, Raymond H.H.

    1. You have access
      Regional Expression Levels of Drug Transporters and Metabolizing Enzymes along the Pig and Human Intestinal Tract and Comparison with Caco-2 Cells
      Stefan F.C. Vaessen, Marola M.H. van Lipzig, Raymond H.H. Pieters, Cyrille A.M. Krul, Heleen M. Wortelboer and Evita van de Steeg
      Drug Metabolism and Disposition April 2017, 45 (4) 353-360; DOI: https://doi.org/10.1124/dmd.116.072231
  5. Piotrowski, Mary A.

    1. You have access
      Quantitative Prediction of Human Renal Clearance and Drug-Drug Interactions of Organic Anion Transporter Substrates Using In Vitro Transport Data: A Relative Activity Factor Approach
      Sumathy Mathialagan, Mary A. Piotrowski, David A. Tess, Bo Feng, John Litchfield and Manthena V. Varma
      Drug Metabolism and Disposition April 2017, 45 (4) 409-417; DOI: https://doi.org/10.1124/dmd.116.074294
  6. Prieto Garcia, Luna

    1. You have access
      Intrinsic Clearance Assay Incubational Binding: A Method Comparison
      Sofia Chen, Luna Prieto Garcia, Fredrik Bergström, Pär Nordell and Ken Grime
      Drug Metabolism and Disposition April 2017, 45 (4) 342-345; DOI: https://doi.org/10.1124/dmd.116.074138

R

  1. Rebello, Sam

    1. You have access
      A Physiologically-Based Pharmacokinetic Modeling Approach To Predict Drug–Drug Interactions of Sonidegib (LDE225) with Perpetrators of CYP3A in Cancer Patients
      Heidi J. Einolf, Jocelyn Zhou, Christina Won, Lai Wang and Sam Rebello
      Drug Metabolism and Disposition April 2017, 45 (4) 361-374; DOI: https://doi.org/10.1124/dmd.116.073585

T

  1. Tess, David A.

    1. You have access
      Quantitative Prediction of Human Renal Clearance and Drug-Drug Interactions of Organic Anion Transporter Substrates Using In Vitro Transport Data: A Relative Activity Factor Approach
      Sumathy Mathialagan, Mary A. Piotrowski, David A. Tess, Bo Feng, John Litchfield and Manthena V. Varma
      Drug Metabolism and Disposition April 2017, 45 (4) 409-417; DOI: https://doi.org/10.1124/dmd.116.074294

V

  1. Vaessen, Stefan F.C.

    1. You have access
      Regional Expression Levels of Drug Transporters and Metabolizing Enzymes along the Pig and Human Intestinal Tract and Comparison with Caco-2 Cells
      Stefan F.C. Vaessen, Marola M.H. van Lipzig, Raymond H.H. Pieters, Cyrille A.M. Krul, Heleen M. Wortelboer and Evita van de Steeg
      Drug Metabolism and Disposition April 2017, 45 (4) 353-360; DOI: https://doi.org/10.1124/dmd.116.072231
  2. van de Steeg, Evita

    1. You have access
      Regional Expression Levels of Drug Transporters and Metabolizing Enzymes along the Pig and Human Intestinal Tract and Comparison with Caco-2 Cells
      Stefan F.C. Vaessen, Marola M.H. van Lipzig, Raymond H.H. Pieters, Cyrille A.M. Krul, Heleen M. Wortelboer and Evita van de Steeg
      Drug Metabolism and Disposition April 2017, 45 (4) 353-360; DOI: https://doi.org/10.1124/dmd.116.072231
  3. van Lipzig, Marola M.H.

    1. You have access
      Regional Expression Levels of Drug Transporters and Metabolizing Enzymes along the Pig and Human Intestinal Tract and Comparison with Caco-2 Cells
      Stefan F.C. Vaessen, Marola M.H. van Lipzig, Raymond H.H. Pieters, Cyrille A.M. Krul, Heleen M. Wortelboer and Evita van de Steeg
      Drug Metabolism and Disposition April 2017, 45 (4) 353-360; DOI: https://doi.org/10.1124/dmd.116.072231
  4. Varma, Manthena V.

    1. You have access
      Quantitative Prediction of Human Renal Clearance and Drug-Drug Interactions of Organic Anion Transporter Substrates Using In Vitro Transport Data: A Relative Activity Factor Approach
      Sumathy Mathialagan, Mary A. Piotrowski, David A. Tess, Bo Feng, John Litchfield and Manthena V. Varma
      Drug Metabolism and Disposition April 2017, 45 (4) 409-417; DOI: https://doi.org/10.1124/dmd.116.074294
  5. Vorrink, Sabine U.

    1. Open Access
      Transcriptional, Functional, and Mechanistic Comparisons of Stem Cell–Derived Hepatocytes, HepaRG Cells, and Three-Dimensional Human Hepatocyte Spheroids as Predictive In Vitro Systems for Drug-Induced Liver Injury
      Catherine C. Bell, Volker M. Lauschke, Sabine U. Vorrink, Henrik Palmgren, Rodger Duffin, Tommy B. Andersson and Magnus Ingelman-Sundberg
      Drug Metabolism and Disposition April 2017, 45 (4) 419-429; DOI: https://doi.org/10.1124/dmd.116.074369

W

  1. Wang, Lai

    1. You have access
      A Physiologically-Based Pharmacokinetic Modeling Approach To Predict Drug–Drug Interactions of Sonidegib (LDE225) with Perpetrators of CYP3A in Cancer Patients
      Heidi J. Einolf, Jocelyn Zhou, Christina Won, Lai Wang and Sam Rebello
      Drug Metabolism and Disposition April 2017, 45 (4) 361-374; DOI: https://doi.org/10.1124/dmd.116.073585
  2. Won, Christina

    1. You have access
      A Physiologically-Based Pharmacokinetic Modeling Approach To Predict Drug–Drug Interactions of Sonidegib (LDE225) with Perpetrators of CYP3A in Cancer Patients
      Heidi J. Einolf, Jocelyn Zhou, Christina Won, Lai Wang and Sam Rebello
      Drug Metabolism and Disposition April 2017, 45 (4) 361-374; DOI: https://doi.org/10.1124/dmd.116.073585
  3. Won, Kyoung-Jae

    1. You have access
      Cholic Acid Feeding Leads to Increased CYP2D6 Expression in CYP2D6-Humanized Mice
      Xian Pan, Rebecca Kent, Kyoung-Jae Won and Hyunyoung Jeong
      Drug Metabolism and Disposition April 2017, 45 (4) 346-352; DOI: https://doi.org/10.1124/dmd.116.074013
  4. Wortelboer, Heleen M.

    1. You have access
      Regional Expression Levels of Drug Transporters and Metabolizing Enzymes along the Pig and Human Intestinal Tract and Comparison with Caco-2 Cells
      Stefan F.C. Vaessen, Marola M.H. van Lipzig, Raymond H.H. Pieters, Cyrille A.M. Krul, Heleen M. Wortelboer and Evita van de Steeg
      Drug Metabolism and Disposition April 2017, 45 (4) 353-360; DOI: https://doi.org/10.1124/dmd.116.072231

Y

  1. Yamazaki, Shinji

    1. You have access
      Application of Physiologically Based Pharmacokinetic Modeling to the Understanding of Bosutinib Pharmacokinetics: Prediction of Drug–Drug and Drug–Disease Interactions
      Chiho Ono, Poe-Hirr Hsyu, Richat Abbas, Cho-Ming Loi and Shinji Yamazaki
      Drug Metabolism and Disposition April 2017, 45 (4) 390-398; DOI: https://doi.org/10.1124/dmd.116.074450

Z

  1. Zhou, Jocelyn

    1. You have access
      A Physiologically-Based Pharmacokinetic Modeling Approach To Predict Drug–Drug Interactions of Sonidegib (LDE225) with Perpetrators of CYP3A in Cancer Patients
      Heidi J. Einolf, Jocelyn Zhou, Christina Won, Lai Wang and Sam Rebello
      Drug Metabolism and Disposition April 2017, 45 (4) 361-374; DOI: https://doi.org/10.1124/dmd.116.073585
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In this issue

Drug Metabolism and Disposition: 45 (4)
Drug Metabolism and Disposition
Vol. 45, Issue 4
1 Apr 2017
  • Table of Contents
  • Table of Contents (PDF)
  • About the Cover
  • Index by author
  • Editorial Board (PDF)
  • Front Matter (PDF)
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
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