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Research ArticleMinireview

Alternative Splicing in the Cytochrome P450 Superfamily Expands Protein Diversity to Augment Gene Function and Redirect Human Drug Metabolism

Andrew J. Annalora, Craig B. Marcus and Patrick L. Iversen
Drug Metabolism and Disposition April 2017, 45 (4) 375-389; DOI: https://doi.org/10.1124/dmd.116.073254
Andrew J. Annalora
Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, Oregon
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Craig B. Marcus
Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, Oregon
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Patrick L. Iversen
Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, Oregon
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Article Information

vol. 45 no. 4 375-389
DOI 
https://doi.org/10.1124/dmd.116.073254
PubMed 
28188297

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received September 2, 2016
  • Accepted February 6, 2017
  • Published online March 2, 2017.

Article Versions

  • Earlier version (February 10, 2017 - 09:42).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2017 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Andrew J. Annalora,
  2. Craig B. Marcus, and
  3. Patrick L. Iversen
  1. Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, Oregon
  1. Address correspondence to:
    Dr. Andrew J. Annalora, Department of Environmental and Molecular Toxicology, Oregon State University, 1007 Agriculture and Life Sciences Building, Corvallis, OR 97331. E-mail: Andrew.Annalora{at}oregonstate.edu
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Drug Metabolism and Disposition: 45 (4)
Drug Metabolism and Disposition
Vol. 45, Issue 4
1 Apr 2017
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Research ArticleMinireview

Alternative P450 Splicing Redirects Human Drug Metabolism

Andrew J. Annalora, Craig B. Marcus and Patrick L. Iversen
Drug Metabolism and Disposition April 1, 2017, 45 (4) 375-389; DOI: https://doi.org/10.1124/dmd.116.073254

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Research ArticleMinireview

Alternative P450 Splicing Redirects Human Drug Metabolism

Andrew J. Annalora, Craig B. Marcus and Patrick L. Iversen
Drug Metabolism and Disposition April 1, 2017, 45 (4) 375-389; DOI: https://doi.org/10.1124/dmd.116.073254
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  • Article
    • Abstract
    • Introduction
    • Meta-Analysis of Alternative Gene Splicing in the Cytochrome P450 Superfamily
    • Tissue-Specific Alternative Splicing of Cytochrome P450 Genes: Historical Perspective
    • Transformation-Sensitive Alternative Splicing in the Cytochrome P450 Superfamily
    • Trans-Splicing of Cytochrome P450 Gene Chimeras
    • SNP-Sensitive Alternative Splicing in the Cytochrome P450 Superfamily
    • Addressing Nontraditional P450 Function and Trafficking Events
    • Shaping an Improved Roadmap toward Precision Medicine
    • Acknowledgments
    • Authorship Contributions
    • Footnotes
    • Abbreviations
    • References
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