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Novel Method to Predict In Vivo Liver-to-Plasma Kpuu for OATP Substrates Using Suspension Hepatocytes
Keith Riccardi, Jian Lin, Zhenhong Li, Mark Niosi, Sangwoo Ryu, Wenyi Hua, Karen Atkinson, Rachel E. Kosa, John Litchfield and Li Di
Drug Metabolism and Disposition May 2017, 45 (5) 576-580; DOI: https://doi.org/10.1124/dmd.116.074575
Keith Riccardi
Pharmacokinetics, Dynamics and Metabolism, Pfizer Inc., Groton, Connecticut (K.R., Ji.L., M.N., S.R., W.H., K.A., R.E.K., L.D.); Cambridge, Massachusetts (Z.L., Jo.L.)
Jian Lin
Pharmacokinetics, Dynamics and Metabolism, Pfizer Inc., Groton, Connecticut (K.R., Ji.L., M.N., S.R., W.H., K.A., R.E.K., L.D.); Cambridge, Massachusetts (Z.L., Jo.L.)
Zhenhong Li
Pharmacokinetics, Dynamics and Metabolism, Pfizer Inc., Groton, Connecticut (K.R., Ji.L., M.N., S.R., W.H., K.A., R.E.K., L.D.); Cambridge, Massachusetts (Z.L., Jo.L.)
Mark Niosi
Pharmacokinetics, Dynamics and Metabolism, Pfizer Inc., Groton, Connecticut (K.R., Ji.L., M.N., S.R., W.H., K.A., R.E.K., L.D.); Cambridge, Massachusetts (Z.L., Jo.L.)
Sangwoo Ryu
Pharmacokinetics, Dynamics and Metabolism, Pfizer Inc., Groton, Connecticut (K.R., Ji.L., M.N., S.R., W.H., K.A., R.E.K., L.D.); Cambridge, Massachusetts (Z.L., Jo.L.)
Wenyi Hua
Pharmacokinetics, Dynamics and Metabolism, Pfizer Inc., Groton, Connecticut (K.R., Ji.L., M.N., S.R., W.H., K.A., R.E.K., L.D.); Cambridge, Massachusetts (Z.L., Jo.L.)
Karen Atkinson
Pharmacokinetics, Dynamics and Metabolism, Pfizer Inc., Groton, Connecticut (K.R., Ji.L., M.N., S.R., W.H., K.A., R.E.K., L.D.); Cambridge, Massachusetts (Z.L., Jo.L.)
Rachel E. Kosa
Pharmacokinetics, Dynamics and Metabolism, Pfizer Inc., Groton, Connecticut (K.R., Ji.L., M.N., S.R., W.H., K.A., R.E.K., L.D.); Cambridge, Massachusetts (Z.L., Jo.L.)
John Litchfield
Pharmacokinetics, Dynamics and Metabolism, Pfizer Inc., Groton, Connecticut (K.R., Ji.L., M.N., S.R., W.H., K.A., R.E.K., L.D.); Cambridge, Massachusetts (Z.L., Jo.L.)
Li Di
Pharmacokinetics, Dynamics and Metabolism, Pfizer Inc., Groton, Connecticut (K.R., Ji.L., M.N., S.R., W.H., K.A., R.E.K., L.D.); Cambridge, Massachusetts (Z.L., Jo.L.)
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Research ArticleArticle
Prediction of In Vivo Liver-to-Plasma Kpuu
Keith Riccardi, Jian Lin, Zhenhong Li, Mark Niosi, Sangwoo Ryu, Wenyi Hua, Karen Atkinson, Rachel E. Kosa, John Litchfield and Li Di
Drug Metabolism and Disposition May 1, 2017, 45 (5) 576-580; DOI: https://doi.org/10.1124/dmd.116.074575
Research ArticleArticle
Prediction of In Vivo Liver-to-Plasma Kpuu
Keith Riccardi, Jian Lin, Zhenhong Li, Mark Niosi, Sangwoo Ryu, Wenyi Hua, Karen Atkinson, Rachel E. Kosa, John Litchfield and Li Di
Drug Metabolism and Disposition May 1, 2017, 45 (5) 576-580; DOI: https://doi.org/10.1124/dmd.116.074575
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