Drug Metabolism and Disposition: 45 (6)

June 01, 2017; Volume 45,Issue 6

Articles

You have access
Applying Stable Isotope Labeled Amino Acids in Micropatterned Hepatocyte Coculture to Directly Determine the Degradation Rate Constant for CYP3A4
Ryan H. Takahashi, Sheerin K. Shahidi-Latham, Susan Wong and Jae H. Chang

Drug Metabolism and Disposition June 2017, 45 (6) 581-585; DOI: https://doi.org/10.1124/dmd.116.074393
You have access
Prolactin Upregulates Female-Predominant P450 Gene Expressions and Downregulates Male-Predominant Gene Expressions in Mouse Liver
Yuya Sato, Yoshikatsu Kaneko, Takamasa Cho, Kei Goto, Tadashi Otsuka, Suguru Yamamoto, Shin Goto, Hiroki Maruyama and Ichiei Narita

Drug Metabolism and Disposition June 2017, 45 (6) 586-592; DOI: https://doi.org/10.1124/dmd.116.074658
You have access
Increased Plasma Exposures of Conjugated Metabolites of Morinidazole in Renal Failure Patients: A Critical Role of Uremic Toxins
Fandi Kong, Xiaoyan Pang, Kan Zhong, Zitao Guo, Xiuli Li, Dafang Zhong and Xiaoyan Chen

Drug Metabolism and Disposition June 2017, 45 (6) 593-603; DOI: https://doi.org/10.1124/dmd.116.074492
You have access
Coproporphyrin-I: A Fluorescent, Endogenous Optimal Probe Substrate for ABCC2 (MRP2) Suitable for Vesicle-Based MRP2 Inhibition Assay
Ravindranath Reddy Gilibili, Sagnik Chatterjee, Pravin Bagul, Kathleen W. Mosure, Bokka Venkata Murali, T. Thanga Mariappan, Sandhya Mandlekar and Yurong Lai

Drug Metabolism and Disposition June 2017, 45 (6) 604-611; DOI: https://doi.org/10.1124/dmd.116.074740
You have access
In Vitro Interactions of Epacadostat and its Major Metabolites with Human Efflux and Uptake Transporters: Implications for Pharmacokinetics and Drug Interactions
Qiang Zhang, Yan Zhang, Jason Boer, Jack G. Shi, Peidi Hu, Sharon Diamond and Swamy Yeleswaram

Drug Metabolism and Disposition June 2017, 45 (6) 612-623; DOI: https://doi.org/10.1124/dmd.116.074609
You have access
High-Throughput and Reliable Isotope Label-free Approach for Profiling 24 Metabolic Enzymes in FVB Mice and Sex Differences
Jiamei Chen, Lijun Zhu, Xiaoyan Li, Haihui Zheng, Tongmeng Yan, Cong Xie, Sijing Zeng, Jia Yu, Huangyu Jiang, Linlin Lu, Xiaoxiao Qi, Ying Wang, Ming Hu and Zhongqiu Liu

Drug Metabolism and Disposition June 2017, 45 (6) 624-634; DOI: https://doi.org/10.1124/dmd.116.074682
You have access
Structural and Functional Evaluation of Clinically Relevant Inhibitors of Steroidogenic Cytochrome P450 17A1
Elyse M. Petrunak, Steven A. Rogers, Jeffrey Aubé and Emily E. Scott

Drug Metabolism and Disposition June 2017, 45 (6) 635-645; DOI: https://doi.org/10.1124/dmd.117.075317
You have access
Prediction of the Transporter-Mediated Drug-Drug Interaction Potential of Dabrafenib and Its Major Circulating Metabolites
Harma Ellens, Marta Johnson, Sarah K. Lawrence, Cory Watson, Liangfu Chen and Lauren E. Richards-Peterson

Drug Metabolism and Disposition June 2017, 45 (6) 646-656; DOI: https://doi.org/10.1124/dmd.116.073932
You have access
Phase II Conjugates of Urolithins Isolated from Human Urine and Potential Role of β-Glucuronidases in Their Disposition
Jakub P. Piwowarski, Iwona Stanisławska, Sebastian Granica, Joanna Stefańska and Anna K. Kiss

Drug Metabolism and Disposition June 2017, 45 (6) 657-665; DOI: https://doi.org/10.1124/dmd.117.075200
You have access
Global Proteomic Analysis of Human Liver Microsomes: Rapid Characterization and Quantification of Hepatic Drug-Metabolizing Enzymes
Brahim Achour, Hajar Al Feteisi, Francesco Lanucara, Amin Rostami-Hodjegan and Jill Barber

Drug Metabolism and Disposition June 2017, 45 (6) 666-675; DOI: https://doi.org/10.1124/dmd.116.074732
You have access
Metabolite Identification, Reaction Phenotyping, and Retrospective Drug-Drug Interaction Predictions of 17-Deacetylnorgestimate, the Active Component of the Oral Contraceptive Norgestimate
Deepak Ahire, Sarmistha Sinha, Barry Brock, Ramaswamy Iyer, Sandhya Mandlekar and Murali Subramanian

Drug Metabolism and Disposition June 2017, 45 (6) 676-685; DOI: https://doi.org/10.1124/dmd.116.073940
You have access
Quantitative Prediction of CYP3A4 Induction: Impact of Measured, Free, and Intracellular Perpetrator Concentrations from Human Hepatocyte Induction Studies on Drug-Drug Interaction Predictions
Yongkai Sun, Paresh P. Chothe, Jennifer E. Sager, Hong Tsao, Amanda Moore, Leena Laitinen and Niresh Hariparsad

Drug Metabolism and Disposition June 2017, 45 (6) 692-705; DOI: https://doi.org/10.1124/dmd.117.075481