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Drug Metabolism & Disposition

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Table of Contents

June 01, 2017; Volume 45,Issue 6

Articles

  • You have access
    Applying Stable Isotope Labeled Amino Acids in Micropatterned Hepatocyte Coculture to Directly Determine the Degradation Rate Constant for CYP3A4
    Ryan H. Takahashi, Sheerin K. Shahidi-Latham, Susan Wong and Jae H. Chang
    Drug Metabolism and Disposition June 2017, 45 (6) 581-585; DOI: https://doi.org/10.1124/dmd.116.074393
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    Prolactin Upregulates Female-Predominant P450 Gene Expressions and Downregulates Male-Predominant Gene Expressions in Mouse Liver
    Yuya Sato, Yoshikatsu Kaneko, Takamasa Cho, Kei Goto, Tadashi Otsuka, Suguru Yamamoto, Shin Goto, Hiroki Maruyama and Ichiei Narita
    Drug Metabolism and Disposition June 2017, 45 (6) 586-592; DOI: https://doi.org/10.1124/dmd.116.074658
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    Increased Plasma Exposures of Conjugated Metabolites of Morinidazole in Renal Failure Patients: A Critical Role of Uremic Toxins
    Fandi Kong, Xiaoyan Pang, Kan Zhong, Zitao Guo, Xiuli Li, Dafang Zhong and Xiaoyan Chen
    Drug Metabolism and Disposition June 2017, 45 (6) 593-603; DOI: https://doi.org/10.1124/dmd.116.074492
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    Coproporphyrin-I: A Fluorescent, Endogenous Optimal Probe Substrate for ABCC2 (MRP2) Suitable for Vesicle-Based MRP2 Inhibition Assay
    Ravindranath Reddy Gilibili, Sagnik Chatterjee, Pravin Bagul, Kathleen W. Mosure, Bokka Venkata Murali, T. Thanga Mariappan, Sandhya Mandlekar and Yurong Lai
    Drug Metabolism and Disposition June 2017, 45 (6) 604-611; DOI: https://doi.org/10.1124/dmd.116.074740
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    In Vitro Interactions of Epacadostat and its Major Metabolites with Human Efflux and Uptake Transporters: Implications for Pharmacokinetics and Drug Interactions
    Qiang Zhang, Yan Zhang, Jason Boer, Jack G. Shi, Peidi Hu, Sharon Diamond and Swamy Yeleswaram
    Drug Metabolism and Disposition June 2017, 45 (6) 612-623; DOI: https://doi.org/10.1124/dmd.116.074609
  • High-Throughput and Reliable Isotope Label-free Approach for Profiling 24 Metabolic Enzymes in FVB Mice and Sex Differences
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    High-Throughput and Reliable Isotope Label-free Approach for Profiling 24 Metabolic Enzymes in FVB Mice and Sex Differences
    Jiamei Chen, Lijun Zhu, Xiaoyan Li, Haihui Zheng, Tongmeng Yan, Cong Xie, Sijing Zeng, Jia Yu, Huangyu Jiang, Linlin Lu, Xiaoxiao Qi, Ying Wang, Ming Hu and Zhongqiu Liu
    Drug Metabolism and Disposition June 2017, 45 (6) 624-634; DOI: https://doi.org/10.1124/dmd.116.074682
  • Structural and Functional Evaluation of Clinically Relevant Inhibitors of Steroidogenic Cytochrome P450 17A1
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    Structural and Functional Evaluation of Clinically Relevant Inhibitors of Steroidogenic Cytochrome P450 17A1
    Elyse M. Petrunak, Steven A. Rogers, Jeffrey Aubé and Emily E. Scott
    Drug Metabolism and Disposition June 2017, 45 (6) 635-645; DOI: https://doi.org/10.1124/dmd.117.075317
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    Prediction of the Transporter-Mediated Drug-Drug Interaction Potential of Dabrafenib and Its Major Circulating Metabolites
    Harma Ellens, Marta Johnson, Sarah K. Lawrence, Cory Watson, Liangfu Chen and Lauren E. Richards-Peterson
    Drug Metabolism and Disposition June 2017, 45 (6) 646-656; DOI: https://doi.org/10.1124/dmd.116.073932
  • Phase II Conjugates of Urolithins Isolated from Human Urine and Potential Role of <em>β</em>-Glucuronidases in Their Disposition
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    Phase II Conjugates of Urolithins Isolated from Human Urine and Potential Role of β-Glucuronidases in Their Disposition
    Jakub P. Piwowarski, Iwona Stanisławska, Sebastian Granica, Joanna Stefańska and Anna K. Kiss
    Drug Metabolism and Disposition June 2017, 45 (6) 657-665; DOI: https://doi.org/10.1124/dmd.117.075200
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    Global Proteomic Analysis of Human Liver Microsomes: Rapid Characterization and Quantification of Hepatic Drug-Metabolizing Enzymes
    Brahim Achour, Hajar Al Feteisi, Francesco Lanucara, Amin Rostami-Hodjegan and Jill Barber
    Drug Metabolism and Disposition June 2017, 45 (6) 666-675; DOI: https://doi.org/10.1124/dmd.116.074732
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    Metabolite Identification, Reaction Phenotyping, and Retrospective Drug-Drug Interaction Predictions of 17-Deacetylnorgestimate, the Active Component of the Oral Contraceptive Norgestimate
    Deepak Ahire, Sarmistha Sinha, Barry Brock, Ramaswamy Iyer, Sandhya Mandlekar and Murali Subramanian
    Drug Metabolism and Disposition June 2017, 45 (6) 676-685; DOI: https://doi.org/10.1124/dmd.116.073940
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    Quantitative Prediction of CYP3A4 Induction: Impact of Measured, Free, and Intracellular Perpetrator Concentrations from Human Hepatocyte Induction Studies on Drug-Drug Interaction Predictions
    Yongkai Sun, Paresh P. Chothe, Jennifer E. Sager, Hong Tsao, Amanda Moore, Leena Laitinen and Niresh Hariparsad
    Drug Metabolism and Disposition June 2017, 45 (6) 692-705; DOI: https://doi.org/10.1124/dmd.117.075481

Short Communication

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    Human Enterocytes as an In Vitro Model for the Evaluation of Intestinal Drug Metabolism: Characterization of Drug-Metabolizing Enzyme Activities of Cryopreserved Human Enterocytes from Twenty-Four Donors
    Ming-Chih David Ho, Nicholas Ring, Kirsten Amaral, Utkarsh Doshi and Albert P. Li
    Drug Metabolism and Disposition June 2017, 45 (6) 686-691; DOI: https://doi.org/10.1124/dmd.116.074377
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Drug Metabolism and Disposition: 45 (6)
Drug Metabolism and Disposition
Vol. 45, Issue 6
1 Jun 2017
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