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Applying Stable Isotope Labeled Amino Acids in Micropatterned Hepatocyte Coculture to Directly Determine the Degradation Rate Constant for CYP3A4

Ryan H. Takahashi, Sheerin K. Shahidi-Latham, Susan Wong and Jae H. Chang
Drug Metabolism and Disposition June 2017, 45 (6) 581-585; DOI: https://doi.org/10.1124/dmd.116.074393

Article Information

vol. 45 no. 6 581-585
DOI 
https://doi.org/10.1124/dmd.116.074393
PubMed 
28289057
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received November 21, 2016
  • Accepted March 10, 2017
  • Published online April 27, 2017.

Article Versions

Copyright & Usage 
Copyright © 2017 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Ryan H. Takahashi,
  2. Sheerin K. Shahidi-Latham,
  3. Susan Wong, and
  4. Jae H. Chang
  1. Department of Drug Metabolism and Pharmacokinetics, Genentech Inc., South San Francisco, California
  1. Address correspondence to:
    Dr. Jae H. Chang, Drug Metabolism and Pharmacokinetics, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080. E-mail: jaechang{at}gmail.com
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Utility of SILAC in HepatoPac to Determine CYP3A4 kdeg

Ryan H. Takahashi, Sheerin K. Shahidi-Latham, Susan Wong and Jae H. Chang
Drug Metabolism and Disposition June 1, 2017, 45 (6) 581-585; DOI: https://doi.org/10.1124/dmd.116.074393
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