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Drug Metabolism & Disposition

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Table of Contents

July 01, 2017; Volume 45,Issue 7

Articles

  • You have access
    In Vitro Metabolism of Oprozomib, an Oral Proteasome Inhibitor: Role of Epoxide Hydrolases and Cytochrome P450s
    Zhican Wang, Ying Fang, Juli Teague, Hansen Wong, Christophe Morisseau, Bruce D. Hammock, Dan A. Rock and Zhengping Wang
    Drug Metabolism and Disposition July 2017, 45 (7) 712-720; DOI: https://doi.org/10.1124/dmd.117.075226
  • You have access
    Leveraging of Rifampicin-Dosed Cynomolgus Monkeys to Identify Bile Acid 3-O-Sulfate Conjugates as Potential Novel Biomarkers for Organic Anion-Transporting Polypeptides
    Rhishikesh Thakare, Hongying Gao, Rachel E. Kosa, Yi-An Bi, Manthena V. S. Varma, Matthew A. Cerny, Raman Sharma, Max Kuhn, Bingshou Huang, Yiping Liu, Aijia Yu, Gregory S. Walker, Mark Niosi, Larry Tremaine, Yazen Alnouti and A. David Rodrigues
    Drug Metabolism and Disposition July 2017, 45 (7) 721-733; DOI: https://doi.org/10.1124/dmd.117.075275
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    Transporter-Mediated Disposition, Clinical Pharmacokinetics and Cholestatic Potential of Glyburide and Its Primary Active Metabolites
    Rui Li, Yi-an Bi, Anna Vildhede, Renato J. Scialis, Sumathy Mathialagan, Xin Yang, Lisa D. Marroquin, Jian Lin and Manthena V.S. Varma
    Drug Metabolism and Disposition July 2017, 45 (7) 737-747; DOI: https://doi.org/10.1124/dmd.116.074815
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    Crypt Organoid Culture as an In Vitro Model in Drug Metabolism and Cytotoxicity Studies
    Wenqi Lu, Eva Rettenmeier, Miles Paszek, Mei-Fei Yueh, Robert H. Tukey, Jocelyn Trottier, Olivier Barbier and Shujuan Chen
    Drug Metabolism and Disposition July 2017, 45 (7) 748-754; DOI: https://doi.org/10.1124/dmd.117.075945
  • Open Access
    Mechanisms and Predictions of Drug-Drug Interactions of the Hepatitis C Virus Three Direct-Acting Antiviral Regimen: Paritaprevir/Ritonavir, Ombitasvir, and Dasabuvir
    Mohamad Shebley, Jinrong Liu, Olga Kavetskaia, Jens Sydor, Sonia M. de Morais, Volker Fischer, Marjoleen J.M.A. Nijsen and Daniel A.J. Bow
    Drug Metabolism and Disposition July 2017, 45 (7) 755-764; DOI: https://doi.org/10.1124/dmd.116.074518
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    Interaction and Transport of Methamphetamine and its Primary Metabolites by Organic Cation and Multidrug and Toxin Extrusion Transporters
    David J. Wagner, Jennifer E. Sager, Haichuan Duan, Nina Isoherranen and Joanne Wang
    Drug Metabolism and Disposition July 2017, 45 (7) 770-778; DOI: https://doi.org/10.1124/dmd.116.074708
  • Open Access
    Comparison of Methods for Estimating Unbound Intracellular-to-Medium Concentration Ratios in Rat and Human Hepatocytes Using Statins
    Takashi Yoshikado, Kota Toshimoto, Tomohisa Nakada, Kazuaki Ikejiri, Hiroyuki Kusuhara, Kazuya Maeda and Yuichi Sugiyama
    Drug Metabolism and Disposition July 2017, 45 (7) 779-789; DOI: https://doi.org/10.1124/dmd.116.074823
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    Interrelationships between Infliximab and Recombinant Tumor Necrosis Factor-α in Plasma Using Minimal Physiologically Based Pharmacokinetic Models
    Xi Chen, Debra C. DuBois, Richard R. Almon and William J. Jusko
    Drug Metabolism and Disposition July 2017, 45 (7) 790-797; DOI: https://doi.org/10.1124/dmd.116.074807
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    Characterization and Interspecies Scaling of rhTNF-α Pharmacokinetics with Minimal Physiologically Based Pharmacokinetic Models
    Xi Chen, Debra C. DuBois, Richard R. Almon and William J. Jusko
    Drug Metabolism and Disposition July 2017, 45 (7) 798-806; DOI: https://doi.org/10.1124/dmd.116.074799
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    Characterization of the Tissue Distribution of the Mouse Cyp2c Subfamily by Quantitative PCR Analysis
    Joan P. Graves, Artiom Gruzdev, J. Alyce Bradbury, Laura M. DeGraff, Matthew L. Edin and Darryl C. Zeldin
    Drug Metabolism and Disposition July 2017, 45 (7) 807-816; DOI: https://doi.org/10.1124/dmd.117.075697
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    Absorption, Distribution, Metabolism, and Excretion of the Oral Prostaglandin D2 Receptor 2 Antagonist Fevipiprant (QAW039) in Healthy Volunteers and In Vitro
    David Pearson, H. Markus Weiss, Yi Jin, Jan Jaap van Lier, Veit J. Erpenbeck, Ulrike Glaenzel, Peter End, Ralph Woessner, Fabian Eggimann and Gian Camenisch
    Drug Metabolism and Disposition July 2017, 45 (7) 817-825; DOI: https://doi.org/10.1124/dmd.117.075358
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    Penetration Route of the Selective Glucocorticoid Receptor Agonist SA22465 and Betamethasone into Rabbit Meibomian Gland Based on Pharmacokinetics and Autoradiography
    Nagayoshi Asano, Kenji Ueda and Kouichi Kawazu
    Drug Metabolism and Disposition July 2017, 45 (7) 826-833; DOI: https://doi.org/10.1124/dmd.117.075473
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    Modeling Combined Immunosuppressive and Anti-inflammatory Effects of Dexamethasone and Naproxen in Rats Predicts the Steroid-Sparing Potential of Naproxen
    Xiaonan Li, Debra C. DuBois, Dawei Song, Richard R. Almon, William J. Jusko and Xijing Chen
    Drug Metabolism and Disposition July 2017, 45 (7) 834-845; DOI: https://doi.org/10.1124/dmd.117.075614
  • Inhibition of the <em>all-trans</em> Retinoic Acid (<em>at</em>RA) Hydroxylases CYP26A1 and CYP26B1 Results in Dynamic, Tissue-Specific Changes in Endogenous <em>at</em>RA Signaling
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    Inhibition of the all-trans Retinoic Acid (atRA) Hydroxylases CYP26A1 and CYP26B1 Results in Dynamic, Tissue-Specific Changes in Endogenous atRA Signaling
    Faith Stevison, Cathryn Hogarth, Sasmita Tripathy, Travis Kent and Nina Isoherranen
    Drug Metabolism and Disposition July 2017, 45 (7) 846-854; DOI: https://doi.org/10.1124/dmd.117.075341
  • Open Access
    Integrated Assessment of Diclofenac Biotransformation, Pharmacokinetics, and Omics-Based Toxicity in a Three-Dimensional Human Liver-Immunocompetent Coculture System
    Ujjal Sarkar, Kodihalli C. Ravindra, Emma Large, Carissa L. Young, Dinelia Rivera-Burgos, Jiajie Yu, Murat Cirit, David J. Hughes, John S. Wishnok, Douglas A. Lauffenburger, Linda G. Griffith and Steven R. Tannenbaum
    Drug Metabolism and Disposition July 2017, 45 (7) 855-866; DOI: https://doi.org/10.1124/dmd.116.074005
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    RNA Sequencing Reveals Age and Species Differences of Constitutive Androstane Receptor–Targeted Drug-Processing Genes in the Liver
    Sunny Lihua Cheng, Theo K. Bammler and Julia Yue Cui
    Drug Metabolism and Disposition July 2017, 45 (7) 867-882; DOI: https://doi.org/10.1124/dmd.117.075135

Short Communications

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    High-Fat Diet Feeding Alters Expression of Hepatic Drug-Metabolizing Enzymes in Mice
    Miaoran Ning and Hyunyoung Jeong
    Drug Metabolism and Disposition July 2017, 45 (7) 707-711; DOI: https://doi.org/10.1124/dmd.117.075655
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    Long-Term Stability of Cryopreserved Human Hepatocytes: Evaluation of Phase I and II Drug-Metabolizing Enzyme Activities and CYP3A4/5 Induction for More than a Decade
    Miyako Sudo, Mitsuhiro Nishihara, Junzo Takahashi and Satoru Asahi
    Drug Metabolism and Disposition July 2017, 45 (7) 734-736; DOI: https://doi.org/10.1124/dmd.117.075234
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    LKY-047: First Selective Inhibitor of Cytochrome P450 2J2
    Nguyen Minh Phuc, Zhexue Wu, Yuseok O, Jee-Hyun Lee, Sangtaek Oh, Gyu-Yong Song and Kwang-Hyeon Liu
    Drug Metabolism and Disposition July 2017, 45 (7) 765-769; DOI: https://doi.org/10.1124/dmd.117.075036

Erratum

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    Correction to “Tramadol Metabolism to O-Desmethyl Tramadol (M1) and N-Desmethyl Tramadol (M2) by Dog Liver Microsomes: Species Comparison and Identification of Responsible Canine Cytochrome P450s”
    Drug Metabolism and Disposition July 2017, 45 (7) 706; DOI: https://doi.org/10.1124/dmd.115.071902err
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Drug Metabolism and Disposition: 45 (7)
Drug Metabolism and Disposition
Vol. 45, Issue 7
1 Jul 2017
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
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