Drug Metabolism and Disposition: 45 (7)

July 01, 2017; Volume 45,Issue 7

Articles

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In Vitro Metabolism of Oprozomib, an Oral Proteasome Inhibitor: Role of Epoxide Hydrolases and Cytochrome P450s
Zhican Wang, Ying Fang, Juli Teague, Hansen Wong, Christophe Morisseau, Bruce D. Hammock, Dan A. Rock and Zhengping Wang

Drug Metabolism and Disposition July 2017, 45 (7) 712-720; DOI: https://doi.org/10.1124/dmd.117.075226
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Leveraging of Rifampicin-Dosed Cynomolgus Monkeys to Identify Bile Acid 3-O-Sulfate Conjugates as Potential Novel Biomarkers for Organic Anion-Transporting Polypeptides
Rhishikesh Thakare, Hongying Gao, Rachel E. Kosa, Yi-An Bi, Manthena V. S. Varma, Matthew A. Cerny, Raman Sharma, Max Kuhn, Bingshou Huang, Yiping Liu, Aijia Yu, Gregory S. Walker, Mark Niosi, Larry Tremaine, Yazen Alnouti and A. David Rodrigues

Drug Metabolism and Disposition July 2017, 45 (7) 721-733; DOI: https://doi.org/10.1124/dmd.117.075275
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Transporter-Mediated Disposition, Clinical Pharmacokinetics and Cholestatic Potential of Glyburide and Its Primary Active Metabolites
Rui Li, Yi-an Bi, Anna Vildhede, Renato J. Scialis, Sumathy Mathialagan, Xin Yang, Lisa D. Marroquin, Jian Lin and Manthena V.S. Varma

Drug Metabolism and Disposition July 2017, 45 (7) 737-747; DOI: https://doi.org/10.1124/dmd.116.074815
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Crypt Organoid Culture as an In Vitro Model in Drug Metabolism and Cytotoxicity Studies
Wenqi Lu, Eva Rettenmeier, Miles Paszek, Mei-Fei Yueh, Robert H. Tukey, Jocelyn Trottier, Olivier Barbier and Shujuan Chen

Drug Metabolism and Disposition July 2017, 45 (7) 748-754; DOI: https://doi.org/10.1124/dmd.117.075945
Open Access
Mechanisms and Predictions of Drug-Drug Interactions of the Hepatitis C Virus Three Direct-Acting Antiviral Regimen: Paritaprevir/Ritonavir, Ombitasvir, and Dasabuvir
Mohamad Shebley, Jinrong Liu, Olga Kavetskaia, Jens Sydor, Sonia M. de Morais, Volker Fischer, Marjoleen J.M.A. Nijsen and Daniel A.J. Bow

Drug Metabolism and Disposition July 2017, 45 (7) 755-764; DOI: https://doi.org/10.1124/dmd.116.074518
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Interaction and Transport of Methamphetamine and its Primary Metabolites by Organic Cation and Multidrug and Toxin Extrusion Transporters
David J. Wagner, Jennifer E. Sager, Haichuan Duan, Nina Isoherranen and Joanne Wang

Drug Metabolism and Disposition July 2017, 45 (7) 770-778; DOI: https://doi.org/10.1124/dmd.116.074708
Open Access
Comparison of Methods for Estimating Unbound Intracellular-to-Medium Concentration Ratios in Rat and Human Hepatocytes Using Statins
Takashi Yoshikado, Kota Toshimoto, Tomohisa Nakada, Kazuaki Ikejiri, Hiroyuki Kusuhara, Kazuya Maeda and Yuichi Sugiyama

Drug Metabolism and Disposition July 2017, 45 (7) 779-789; DOI: https://doi.org/10.1124/dmd.116.074823
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Interrelationships between Infliximab and Recombinant Tumor Necrosis Factor-α in Plasma Using Minimal Physiologically Based Pharmacokinetic Models
Xi Chen, Debra C. DuBois, Richard R. Almon and William J. Jusko

Drug Metabolism and Disposition July 2017, 45 (7) 790-797; DOI: https://doi.org/10.1124/dmd.116.074807
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Characterization and Interspecies Scaling of rhTNF-α Pharmacokinetics with Minimal Physiologically Based Pharmacokinetic Models
Xi Chen, Debra C. DuBois, Richard R. Almon and William J. Jusko

Drug Metabolism and Disposition July 2017, 45 (7) 798-806; DOI: https://doi.org/10.1124/dmd.116.074799
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Characterization of the Tissue Distribution of the Mouse Cyp2c Subfamily by Quantitative PCR Analysis
Joan P. Graves, Artiom Gruzdev, J. Alyce Bradbury, Laura M. DeGraff, Matthew L. Edin and Darryl C. Zeldin

Drug Metabolism and Disposition July 2017, 45 (7) 807-816; DOI: https://doi.org/10.1124/dmd.117.075697
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Absorption, Distribution, Metabolism, and Excretion of the Oral Prostaglandin D2 Receptor 2 Antagonist Fevipiprant (QAW039) in Healthy Volunteers and In Vitro
David Pearson, H. Markus Weiss, Yi Jin, Jan Jaap van Lier, Veit J. Erpenbeck, Ulrike Glaenzel, Peter End, Ralph Woessner, Fabian Eggimann and Gian Camenisch

Drug Metabolism and Disposition July 2017, 45 (7) 817-825; DOI: https://doi.org/10.1124/dmd.117.075358
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Penetration Route of the Selective Glucocorticoid Receptor Agonist SA22465 and Betamethasone into Rabbit Meibomian Gland Based on Pharmacokinetics and Autoradiography
Nagayoshi Asano, Kenji Ueda and Kouichi Kawazu

Drug Metabolism and Disposition July 2017, 45 (7) 826-833; DOI: https://doi.org/10.1124/dmd.117.075473
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Modeling Combined Immunosuppressive and Anti-inflammatory Effects of Dexamethasone and Naproxen in Rats Predicts the Steroid-Sparing Potential of Naproxen
Xiaonan Li, Debra C. DuBois, Dawei Song, Richard R. Almon, William J. Jusko and Xijing Chen

Drug Metabolism and Disposition July 2017, 45 (7) 834-845; DOI: https://doi.org/10.1124/dmd.117.075614
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Inhibition of the all-trans Retinoic Acid (atRA) Hydroxylases CYP26A1 and CYP26B1 Results in Dynamic, Tissue-Specific Changes in Endogenous atRA Signaling
Faith Stevison, Cathryn Hogarth, Sasmita Tripathy, Travis Kent and Nina Isoherranen

Drug Metabolism and Disposition July 2017, 45 (7) 846-854; DOI: https://doi.org/10.1124/dmd.117.075341
Open Access
Integrated Assessment of Diclofenac Biotransformation, Pharmacokinetics, and Omics-Based Toxicity in a Three-Dimensional Human Liver-Immunocompetent Coculture System
Ujjal Sarkar, Kodihalli C. Ravindra, Emma Large, Carissa L. Young, Dinelia Rivera-Burgos, Jiajie Yu, Murat Cirit, David J. Hughes, John S. Wishnok, Douglas A. Lauffenburger, Linda G. Griffith and Steven R. Tannenbaum

Drug Metabolism and Disposition July 2017, 45 (7) 855-866; DOI: https://doi.org/10.1124/dmd.116.074005
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RNA Sequencing Reveals Age and Species Differences of Constitutive Androstane Receptor–Targeted Drug-Processing Genes in the Liver
Sunny Lihua Cheng, Theo K. Bammler and Julia Yue Cui

Drug Metabolism and Disposition July 2017, 45 (7) 867-882; DOI: https://doi.org/10.1124/dmd.117.075135

Short Communications

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High-Fat Diet Feeding Alters Expression of Hepatic Drug-Metabolizing Enzymes in Mice
Miaoran Ning and Hyunyoung Jeong

Drug Metabolism and Disposition July 2017, 45 (7) 707-711; DOI: https://doi.org/10.1124/dmd.117.075655
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Long-Term Stability of Cryopreserved Human Hepatocytes: Evaluation of Phase I and II Drug-Metabolizing Enzyme Activities and CYP3A4/5 Induction for More than a Decade
Miyako Sudo, Mitsuhiro Nishihara, Junzo Takahashi and Satoru Asahi

Drug Metabolism and Disposition July 2017, 45 (7) 734-736; DOI: https://doi.org/10.1124/dmd.117.075234
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LKY-047: First Selective Inhibitor of Cytochrome P450 2J2
Nguyen Minh Phuc, Zhexue Wu, Yuseok O, Jee-Hyun Lee, Sangtaek Oh, Gyu-Yong Song and Kwang-Hyeon Liu

Drug Metabolism and Disposition July 2017, 45 (7) 765-769; DOI: https://doi.org/10.1124/dmd.117.075036

Erratum

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Correction to “Tramadol Metabolism to O-Desmethyl Tramadol (M1) and N-Desmethyl Tramadol (M2) by Dog Liver Microsomes: Species Comparison and Identification of Responsible Canine Cytochrome P450s”
Drug Metabolism and Disposition July 2017, 45 (7) 706; DOI: https://doi.org/10.1124/dmd.115.071902err

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