Research ArticleArticle
In Vitro Metabolism of Oprozomib, an Oral Proteasome Inhibitor: Role of Epoxide Hydrolases and Cytochrome P450s
Zhican Wang, Ying Fang, Juli Teague, Hansen Wong, Christophe Morisseau, Bruce D. Hammock, Dan A. Rock and Zhengping Wang
Drug Metabolism and Disposition July 2017, 45 (7) 712-720; DOI: https://doi.org/10.1124/dmd.117.075226
Zhican Wang
Department of Pharmacokinetics and Drug Metabolism (Zhi.W., Y.F., D.A.R., Zhe.W.), and Clinical Pharmacology Modeling and Simulation (H.W.), Amgen Inc., South San Francisco, California; Drug Metabolism and Pharmacokinetics, Onyx Pharmaceuticals, an Amgen Subsidiary, South San Francisco, California (J.T.); and Department of Entomology and Nematology, and UC Davis Comprehensive Cancer Center, University of California, Davis, Davis, California (C.M., B.D.H.)
Ying Fang
Department of Pharmacokinetics and Drug Metabolism (Zhi.W., Y.F., D.A.R., Zhe.W.), and Clinical Pharmacology Modeling and Simulation (H.W.), Amgen Inc., South San Francisco, California; Drug Metabolism and Pharmacokinetics, Onyx Pharmaceuticals, an Amgen Subsidiary, South San Francisco, California (J.T.); and Department of Entomology and Nematology, and UC Davis Comprehensive Cancer Center, University of California, Davis, Davis, California (C.M., B.D.H.)
Juli Teague
Department of Pharmacokinetics and Drug Metabolism (Zhi.W., Y.F., D.A.R., Zhe.W.), and Clinical Pharmacology Modeling and Simulation (H.W.), Amgen Inc., South San Francisco, California; Drug Metabolism and Pharmacokinetics, Onyx Pharmaceuticals, an Amgen Subsidiary, South San Francisco, California (J.T.); and Department of Entomology and Nematology, and UC Davis Comprehensive Cancer Center, University of California, Davis, Davis, California (C.M., B.D.H.)
Hansen Wong
Department of Pharmacokinetics and Drug Metabolism (Zhi.W., Y.F., D.A.R., Zhe.W.), and Clinical Pharmacology Modeling and Simulation (H.W.), Amgen Inc., South San Francisco, California; Drug Metabolism and Pharmacokinetics, Onyx Pharmaceuticals, an Amgen Subsidiary, South San Francisco, California (J.T.); and Department of Entomology and Nematology, and UC Davis Comprehensive Cancer Center, University of California, Davis, Davis, California (C.M., B.D.H.)
Christophe Morisseau
Department of Pharmacokinetics and Drug Metabolism (Zhi.W., Y.F., D.A.R., Zhe.W.), and Clinical Pharmacology Modeling and Simulation (H.W.), Amgen Inc., South San Francisco, California; Drug Metabolism and Pharmacokinetics, Onyx Pharmaceuticals, an Amgen Subsidiary, South San Francisco, California (J.T.); and Department of Entomology and Nematology, and UC Davis Comprehensive Cancer Center, University of California, Davis, Davis, California (C.M., B.D.H.)
Bruce D. Hammock
Department of Pharmacokinetics and Drug Metabolism (Zhi.W., Y.F., D.A.R., Zhe.W.), and Clinical Pharmacology Modeling and Simulation (H.W.), Amgen Inc., South San Francisco, California; Drug Metabolism and Pharmacokinetics, Onyx Pharmaceuticals, an Amgen Subsidiary, South San Francisco, California (J.T.); and Department of Entomology and Nematology, and UC Davis Comprehensive Cancer Center, University of California, Davis, Davis, California (C.M., B.D.H.)
Dan A. Rock
Department of Pharmacokinetics and Drug Metabolism (Zhi.W., Y.F., D.A.R., Zhe.W.), and Clinical Pharmacology Modeling and Simulation (H.W.), Amgen Inc., South San Francisco, California; Drug Metabolism and Pharmacokinetics, Onyx Pharmaceuticals, an Amgen Subsidiary, South San Francisco, California (J.T.); and Department of Entomology and Nematology, and UC Davis Comprehensive Cancer Center, University of California, Davis, Davis, California (C.M., B.D.H.)
Zhengping Wang
Department of Pharmacokinetics and Drug Metabolism (Zhi.W., Y.F., D.A.R., Zhe.W.), and Clinical Pharmacology Modeling and Simulation (H.W.), Amgen Inc., South San Francisco, California; Drug Metabolism and Pharmacokinetics, Onyx Pharmaceuticals, an Amgen Subsidiary, South San Francisco, California (J.T.); and Department of Entomology and Nematology, and UC Davis Comprehensive Cancer Center, University of California, Davis, Davis, California (C.M., B.D.H.)
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Research ArticleArticle
Metabolism of Oprozomib by Microsomal Epoxide Hydrolase
Zhican Wang, Ying Fang, Juli Teague, Hansen Wong, Christophe Morisseau, Bruce D. Hammock, Dan A. Rock and Zhengping Wang
Drug Metabolism and Disposition July 1, 2017, 45 (7) 712-720; DOI: https://doi.org/10.1124/dmd.117.075226
Research ArticleArticle
Metabolism of Oprozomib by Microsomal Epoxide Hydrolase
Zhican Wang, Ying Fang, Juli Teague, Hansen Wong, Christophe Morisseau, Bruce D. Hammock, Dan A. Rock and Zhengping Wang
Drug Metabolism and Disposition July 1, 2017, 45 (7) 712-720; DOI: https://doi.org/10.1124/dmd.117.075226
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