Research ArticleArticle
Leveraging of Rifampicin-Dosed Cynomolgus Monkeys to Identify Bile Acid 3-O-Sulfate Conjugates as Potential Novel Biomarkers for Organic Anion-Transporting Polypeptides
Rhishikesh Thakare, Hongying Gao, Rachel E. Kosa, Yi-An Bi, Manthena V. S. Varma, Matthew A. Cerny, Raman Sharma, Max Kuhn, Bingshou Huang, Yiping Liu, Aijia Yu, Gregory S. Walker, Mark Niosi, Larry Tremaine, Yazen Alnouti and A. David Rodrigues
Drug Metabolism and Disposition July 2017, 45 (7) 721-733; DOI: https://doi.org/10.1124/dmd.117.075275
Rhishikesh Thakare
Pharmacokinetics, Dynamics & Metabolism, Medicine Design (H.G., R.E.K., Y.B., M.V.S.V., M.A.C., R.S., G.S.W., M.N., L.T., A.D.R.), and Nonclinical Statistics, Pfizer Inc., Groton, Connecticut (M.K.); Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, Omaha, Nebraska (R. T., Y. A.); and WuXi AppTec, Waigaoqiao Free Trade Zone, Shanghai, China (B. H., Y. L., A.Y.)
Hongying Gao
Pharmacokinetics, Dynamics & Metabolism, Medicine Design (H.G., R.E.K., Y.B., M.V.S.V., M.A.C., R.S., G.S.W., M.N., L.T., A.D.R.), and Nonclinical Statistics, Pfizer Inc., Groton, Connecticut (M.K.); Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, Omaha, Nebraska (R. T., Y. A.); and WuXi AppTec, Waigaoqiao Free Trade Zone, Shanghai, China (B. H., Y. L., A.Y.)
Rachel E. Kosa
Pharmacokinetics, Dynamics & Metabolism, Medicine Design (H.G., R.E.K., Y.B., M.V.S.V., M.A.C., R.S., G.S.W., M.N., L.T., A.D.R.), and Nonclinical Statistics, Pfizer Inc., Groton, Connecticut (M.K.); Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, Omaha, Nebraska (R. T., Y. A.); and WuXi AppTec, Waigaoqiao Free Trade Zone, Shanghai, China (B. H., Y. L., A.Y.)
Yi-An Bi
Pharmacokinetics, Dynamics & Metabolism, Medicine Design (H.G., R.E.K., Y.B., M.V.S.V., M.A.C., R.S., G.S.W., M.N., L.T., A.D.R.), and Nonclinical Statistics, Pfizer Inc., Groton, Connecticut (M.K.); Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, Omaha, Nebraska (R. T., Y. A.); and WuXi AppTec, Waigaoqiao Free Trade Zone, Shanghai, China (B. H., Y. L., A.Y.)
Manthena V. S. Varma
Pharmacokinetics, Dynamics & Metabolism, Medicine Design (H.G., R.E.K., Y.B., M.V.S.V., M.A.C., R.S., G.S.W., M.N., L.T., A.D.R.), and Nonclinical Statistics, Pfizer Inc., Groton, Connecticut (M.K.); Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, Omaha, Nebraska (R. T., Y. A.); and WuXi AppTec, Waigaoqiao Free Trade Zone, Shanghai, China (B. H., Y. L., A.Y.)
Matthew A. Cerny
Pharmacokinetics, Dynamics & Metabolism, Medicine Design (H.G., R.E.K., Y.B., M.V.S.V., M.A.C., R.S., G.S.W., M.N., L.T., A.D.R.), and Nonclinical Statistics, Pfizer Inc., Groton, Connecticut (M.K.); Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, Omaha, Nebraska (R. T., Y. A.); and WuXi AppTec, Waigaoqiao Free Trade Zone, Shanghai, China (B. H., Y. L., A.Y.)
Raman Sharma
Pharmacokinetics, Dynamics & Metabolism, Medicine Design (H.G., R.E.K., Y.B., M.V.S.V., M.A.C., R.S., G.S.W., M.N., L.T., A.D.R.), and Nonclinical Statistics, Pfizer Inc., Groton, Connecticut (M.K.); Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, Omaha, Nebraska (R. T., Y. A.); and WuXi AppTec, Waigaoqiao Free Trade Zone, Shanghai, China (B. H., Y. L., A.Y.)
Max Kuhn
Pharmacokinetics, Dynamics & Metabolism, Medicine Design (H.G., R.E.K., Y.B., M.V.S.V., M.A.C., R.S., G.S.W., M.N., L.T., A.D.R.), and Nonclinical Statistics, Pfizer Inc., Groton, Connecticut (M.K.); Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, Omaha, Nebraska (R. T., Y. A.); and WuXi AppTec, Waigaoqiao Free Trade Zone, Shanghai, China (B. H., Y. L., A.Y.)
Bingshou Huang
Pharmacokinetics, Dynamics & Metabolism, Medicine Design (H.G., R.E.K., Y.B., M.V.S.V., M.A.C., R.S., G.S.W., M.N., L.T., A.D.R.), and Nonclinical Statistics, Pfizer Inc., Groton, Connecticut (M.K.); Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, Omaha, Nebraska (R. T., Y. A.); and WuXi AppTec, Waigaoqiao Free Trade Zone, Shanghai, China (B. H., Y. L., A.Y.)
Yiping Liu
Pharmacokinetics, Dynamics & Metabolism, Medicine Design (H.G., R.E.K., Y.B., M.V.S.V., M.A.C., R.S., G.S.W., M.N., L.T., A.D.R.), and Nonclinical Statistics, Pfizer Inc., Groton, Connecticut (M.K.); Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, Omaha, Nebraska (R. T., Y. A.); and WuXi AppTec, Waigaoqiao Free Trade Zone, Shanghai, China (B. H., Y. L., A.Y.)
Aijia Yu
Pharmacokinetics, Dynamics & Metabolism, Medicine Design (H.G., R.E.K., Y.B., M.V.S.V., M.A.C., R.S., G.S.W., M.N., L.T., A.D.R.), and Nonclinical Statistics, Pfizer Inc., Groton, Connecticut (M.K.); Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, Omaha, Nebraska (R. T., Y. A.); and WuXi AppTec, Waigaoqiao Free Trade Zone, Shanghai, China (B. H., Y. L., A.Y.)
Gregory S. Walker
Pharmacokinetics, Dynamics & Metabolism, Medicine Design (H.G., R.E.K., Y.B., M.V.S.V., M.A.C., R.S., G.S.W., M.N., L.T., A.D.R.), and Nonclinical Statistics, Pfizer Inc., Groton, Connecticut (M.K.); Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, Omaha, Nebraska (R. T., Y. A.); and WuXi AppTec, Waigaoqiao Free Trade Zone, Shanghai, China (B. H., Y. L., A.Y.)
Mark Niosi
Pharmacokinetics, Dynamics & Metabolism, Medicine Design (H.G., R.E.K., Y.B., M.V.S.V., M.A.C., R.S., G.S.W., M.N., L.T., A.D.R.), and Nonclinical Statistics, Pfizer Inc., Groton, Connecticut (M.K.); Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, Omaha, Nebraska (R. T., Y. A.); and WuXi AppTec, Waigaoqiao Free Trade Zone, Shanghai, China (B. H., Y. L., A.Y.)
Larry Tremaine
Pharmacokinetics, Dynamics & Metabolism, Medicine Design (H.G., R.E.K., Y.B., M.V.S.V., M.A.C., R.S., G.S.W., M.N., L.T., A.D.R.), and Nonclinical Statistics, Pfizer Inc., Groton, Connecticut (M.K.); Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, Omaha, Nebraska (R. T., Y. A.); and WuXi AppTec, Waigaoqiao Free Trade Zone, Shanghai, China (B. H., Y. L., A.Y.)
Yazen Alnouti
Pharmacokinetics, Dynamics & Metabolism, Medicine Design (H.G., R.E.K., Y.B., M.V.S.V., M.A.C., R.S., G.S.W., M.N., L.T., A.D.R.), and Nonclinical Statistics, Pfizer Inc., Groton, Connecticut (M.K.); Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, Omaha, Nebraska (R. T., Y. A.); and WuXi AppTec, Waigaoqiao Free Trade Zone, Shanghai, China (B. H., Y. L., A.Y.)
A. David Rodrigues
Pharmacokinetics, Dynamics & Metabolism, Medicine Design (H.G., R.E.K., Y.B., M.V.S.V., M.A.C., R.S., G.S.W., M.N., L.T., A.D.R.), and Nonclinical Statistics, Pfizer Inc., Groton, Connecticut (M.K.); Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, Omaha, Nebraska (R. T., Y. A.); and WuXi AppTec, Waigaoqiao Free Trade Zone, Shanghai, China (B. H., Y. L., A.Y.)

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Bile Acid Sulfates as Potential Novel OATP Biomarkers
Rhishikesh Thakare, Hongying Gao, Rachel E. Kosa, Yi-An Bi, Manthena V. S. Varma, Matthew A. Cerny, Raman Sharma, Max Kuhn, Bingshou Huang, Yiping Liu, Aijia Yu, Gregory S. Walker, Mark Niosi, Larry Tremaine, Yazen Alnouti and A. David Rodrigues
Drug Metabolism and Disposition July 1, 2017, 45 (7) 721-733; DOI: https://doi.org/10.1124/dmd.117.075275
Research ArticleArticle
Bile Acid Sulfates as Potential Novel OATP Biomarkers
Rhishikesh Thakare, Hongying Gao, Rachel E. Kosa, Yi-An Bi, Manthena V. S. Varma, Matthew A. Cerny, Raman Sharma, Max Kuhn, Bingshou Huang, Yiping Liu, Aijia Yu, Gregory S. Walker, Mark Niosi, Larry Tremaine, Yazen Alnouti and A. David Rodrigues
Drug Metabolism and Disposition July 1, 2017, 45 (7) 721-733; DOI: https://doi.org/10.1124/dmd.117.075275
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