Article Figures & Data
Figures
Tables
Data Supplement
- Supplemental Data -
Supplemental Text - Theoretical derivation of the equations for Kp,uu considering the
plasma membrane potential of cells and the fraction of drugs ionizedSupplemental Table 1 - Intracellular volumes of rat and human hepatocytes
Supplemental Figure 1 - The pH-dependent membrane permeation clearance of pitavastatin (A),
rosuvastatin (B), and pravastatin (C) across Caco-2 cell monolayers was measured in an apical-tobasal
direction with an apical pH of 5.5, 6.0, 6.5, and 7.4, and a basal pH of 7.4 in the presence of
rifamycin SV (100 mu-M), cyclosporin A (10 mu-M), and Ko143 (10 mu-M)Supplemental Figure 2 - Concentration-dependent uptake of pitavastatin (A), rosuvastatin (B), and
pravastatin (C) by rat hepatocytesSupplemental Figure 3 - Concentration-dependent uptake of pitavastatin (A, D), rosuvastatin (B, E),
and pravastatin (C) by human hepatocytes
- Supplemental Data -