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Research ArticleArticle

Absorption, Distribution, Metabolism, and Excretion of the Oral Prostaglandin D2 Receptor 2 Antagonist Fevipiprant (QAW039) in Healthy Volunteers and In Vitro

David Pearson, H. Markus Weiss, Yi Jin, Jan Jaap van Lier, Veit J. Erpenbeck, Ulrike Glaenzel, Peter End, Ralph Woessner, Fabian Eggimann and Gian Camenisch
Drug Metabolism and Disposition July 2017, 45 (7) 817-825; DOI: https://doi.org/10.1124/dmd.117.075358
David Pearson
Novartis Institutes for Biomedical Research, Novartis Pharma AG, Basel, Switzerland (D.P., H.M.W., Y.J., V.J.E., U.G., P.E., R.W., F.E., G.C.); PRA International, Early Development Services, Zuidlaren, the Netherlands (J.J.v.L.)
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H. Markus Weiss
Novartis Institutes for Biomedical Research, Novartis Pharma AG, Basel, Switzerland (D.P., H.M.W., Y.J., V.J.E., U.G., P.E., R.W., F.E., G.C.); PRA International, Early Development Services, Zuidlaren, the Netherlands (J.J.v.L.)
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Yi Jin
Novartis Institutes for Biomedical Research, Novartis Pharma AG, Basel, Switzerland (D.P., H.M.W., Y.J., V.J.E., U.G., P.E., R.W., F.E., G.C.); PRA International, Early Development Services, Zuidlaren, the Netherlands (J.J.v.L.)
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Jan Jaap van Lier
Novartis Institutes for Biomedical Research, Novartis Pharma AG, Basel, Switzerland (D.P., H.M.W., Y.J., V.J.E., U.G., P.E., R.W., F.E., G.C.); PRA International, Early Development Services, Zuidlaren, the Netherlands (J.J.v.L.)
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Veit J. Erpenbeck
Novartis Institutes for Biomedical Research, Novartis Pharma AG, Basel, Switzerland (D.P., H.M.W., Y.J., V.J.E., U.G., P.E., R.W., F.E., G.C.); PRA International, Early Development Services, Zuidlaren, the Netherlands (J.J.v.L.)
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Ulrike Glaenzel
Novartis Institutes for Biomedical Research, Novartis Pharma AG, Basel, Switzerland (D.P., H.M.W., Y.J., V.J.E., U.G., P.E., R.W., F.E., G.C.); PRA International, Early Development Services, Zuidlaren, the Netherlands (J.J.v.L.)
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Peter End
Novartis Institutes for Biomedical Research, Novartis Pharma AG, Basel, Switzerland (D.P., H.M.W., Y.J., V.J.E., U.G., P.E., R.W., F.E., G.C.); PRA International, Early Development Services, Zuidlaren, the Netherlands (J.J.v.L.)
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Ralph Woessner
Novartis Institutes for Biomedical Research, Novartis Pharma AG, Basel, Switzerland (D.P., H.M.W., Y.J., V.J.E., U.G., P.E., R.W., F.E., G.C.); PRA International, Early Development Services, Zuidlaren, the Netherlands (J.J.v.L.)
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Fabian Eggimann
Novartis Institutes for Biomedical Research, Novartis Pharma AG, Basel, Switzerland (D.P., H.M.W., Y.J., V.J.E., U.G., P.E., R.W., F.E., G.C.); PRA International, Early Development Services, Zuidlaren, the Netherlands (J.J.v.L.)
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Gian Camenisch
Novartis Institutes for Biomedical Research, Novartis Pharma AG, Basel, Switzerland (D.P., H.M.W., Y.J., V.J.E., U.G., P.E., R.W., F.E., G.C.); PRA International, Early Development Services, Zuidlaren, the Netherlands (J.J.v.L.)
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Article Information

vol. 45 no. 7 817-825
DOI 
https://doi.org/10.1124/dmd.117.075358
PubMed 
28442499

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received February 2, 2017
  • Accepted April 20, 2017
  • Published online June 9, 2017.

Article Versions

  • Earlier version (April 25, 2017 - 07:17).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2017 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. David Pearson,
  2. H. Markus Weiss,
  3. Yi Jin,
  4. Jan Jaap van Lier,
  5. Veit J. Erpenbeck,
  6. Ulrike Glaenzel,
  7. Peter End,
  8. Ralph Woessner,
  9. Fabian Eggimann, and
  10. Gian Camenisch
  1. Novartis Institutes for Biomedical Research, Novartis Pharma AG, Basel, Switzerland (D.P., H.M.W., Y.J., V.J.E., U.G., P.E., R.W., F.E., G.C.); PRA International, Early Development Services, Zuidlaren, the Netherlands (J.J.v.L.)
  1. Address correspondence to:
    Dr. David Pearson, Pharmacokinetics Sciences, Novartis Institutes for Biomedical Research, Postfach, CH-4002 Basel, Switzerland. E-mail: david.pearson{at}novartis.com
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Drug Metabolism and Disposition: 45 (7)
Drug Metabolism and Disposition
Vol. 45, Issue 7
1 Jul 2017
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Research ArticleArticle

Fevipiprant ADME in Healthy Volunteers and In Vitro

David Pearson, H. Markus Weiss, Yi Jin, Jan Jaap van Lier, Veit J. Erpenbeck, Ulrike Glaenzel, Peter End, Ralph Woessner, Fabian Eggimann and Gian Camenisch
Drug Metabolism and Disposition July 1, 2017, 45 (7) 817-825; DOI: https://doi.org/10.1124/dmd.117.075358

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Research ArticleArticle

Fevipiprant ADME in Healthy Volunteers and In Vitro

David Pearson, H. Markus Weiss, Yi Jin, Jan Jaap van Lier, Veit J. Erpenbeck, Ulrike Glaenzel, Peter End, Ralph Woessner, Fabian Eggimann and Gian Camenisch
Drug Metabolism and Disposition July 1, 2017, 45 (7) 817-825; DOI: https://doi.org/10.1124/dmd.117.075358
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