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Drug Metabolism & Disposition

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Table of Contents

August 01, 2017; Volume 45,Issue 8

Articles

  • You have access
    PKC/Nedd4-2 Signaling Pathway Regulates the Cell Surface Expression of Drug Transporter hOAT1
    Da Xu, Jinghui Zhang, Qiang Zhang, Yunzhou Fan, Chenchang Liu and Guofeng You
    Drug Metabolism and Disposition August 2017, 45 (8) 887-895; DOI: https://doi.org/10.1124/dmd.117.075861
  • Open Access
    Comparison of 19F NMR and 14C Measurements for the Assessment of ADME of BYL719 (Alpelisib) in Humans
    Alexander David James, Cyrille Marvalin, Alexandre Luneau, Axel Meissner and Gian Camenisch
    Drug Metabolism and Disposition August 2017, 45 (8) 900-907; DOI: https://doi.org/10.1124/dmd.117.075424
  • You have access
    Comparative Evaluation of Plasma Bile Acids, Dehydroepiandrosterone Sulfate, Hexadecanedioate, and Tetradecanedioate with Coproporphyrins I and III as Markers of OATP Inhibition in Healthy Subjects
    Hong Shen, Weiqi Chen, Dieter M. Drexler, Sandhya Mandlekar, Vinay K. Holenarsipur, Eric E. Shields, Robert Langish, Kurex Sidik, Jinping Gan, W. Griffith Humphreys, Punit Marathe and Yurong Lai
    Drug Metabolism and Disposition August 2017, 45 (8) 908-919; DOI: https://doi.org/10.1124/dmd.117.075531
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    Development of a Novel Maternal-Fetal Physiologically Based Pharmacokinetic Model I: Insights into Factors that Determine Fetal Drug Exposure through Simulations and Sensitivity Analyses
    Zufei Zhang, Marjorie Z. Imperial, Gabriela I. Patilea-Vrana, Janak Wedagedera, Lu Gaohua and Jashvant D. Unadkat
    Drug Metabolism and Disposition August 2017, 45 (8) 920-938; DOI: https://doi.org/10.1124/dmd.117.075192
  • You have access
    Development of a Novel Maternal-Fetal Physiologically Based Pharmacokinetic Model II: Verification of the Model for Passive Placental Permeability Drugs
    Zufei Zhang and Jashvant D. Unadkat
    Drug Metabolism and Disposition August 2017, 45 (8) 939-946; DOI: https://doi.org/10.1124/dmd.116.073957
  • You have access
    Direct Comparison of the Enzymatic Characteristics and Superoxide Production of the Four Aldehyde Oxidase Enzymes Present in Mouse
    Gökhan Kücükgöze, Mineko Terao, Enrico Garattini and Silke Leimkühler
    Drug Metabolism and Disposition August 2017, 45 (8) 947-955; DOI: https://doi.org/10.1124/dmd.117.075937
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    CRISPR/Cas9 Genetic Modification of CYP3A5 *3 in HuH-7 Human Hepatocyte Cell Line Leads to Cell Lines with Increased Midazolam and Tacrolimus Metabolism
    Casey R. Dorr, Rory P. Remmel, Amutha Muthusamy, James Fisher, Branden S. Moriarity, Kazuto Yasuda, Baolin Wu, Weihua Guan, Erin G. Schuetz, William S. Oetting, Pamala A. Jacobson and Ajay K. Israni
    Drug Metabolism and Disposition August 2017, 45 (8) 957-965; DOI: https://doi.org/10.1124/dmd.117.076307
  • Oxetane Substrates of Human Microsomal Epoxide Hydrolase
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    Oxetane Substrates of Human Microsomal Epoxide Hydrolase
    Francesca Toselli, Marlene Fredenwall, Peder Svensson, Xue-Qing Li, Anders Johansson, Lars Weidolf and Martin A. Hayes
    Drug Metabolism and Disposition August 2017, 45 (8) 966-973; DOI: https://doi.org/10.1124/dmd.117.076489

Short Communications

  • Molecular Cloning and Characterization of Marmoset Aldehyde Oxidase
    You have access
    Molecular Cloning and Characterization of Marmoset Aldehyde Oxidase
    Shotaro Uehara, Yasuhiro Uno, Eriko Okamoto, Takashi Inoue, Erika Sasaki and Hiroshi Yamazaki
    Drug Metabolism and Disposition August 2017, 45 (8) 883-886; DOI: https://doi.org/10.1124/dmd.117.076042
  • Regio- and Stereo-Selective Oxidation of a Cardiovascular Drug, Metoprolol, Mediated by Cytochrome P450 2D and 3A Enzymes in Marmoset Livers
    You have access
    Regio- and Stereo-Selective Oxidation of a Cardiovascular Drug, Metoprolol, Mediated by Cytochrome P450 2D and 3A Enzymes in Marmoset Livers
    Shotaro Uehara, Sakura Ishii, Yasuhiro Uno, Takashi Inoue, Erika Sasaki and Hiroshi Yamazaki
    Drug Metabolism and Disposition August 2017, 45 (8) 896-899; DOI: https://doi.org/10.1124/dmd.117.075630
  • You have access
    Rosuvastatin and Atorvastatin Are Ligands of the Human Constitutive Androstane Receptor/Retinoid X Receptor α Complex
    Tadeja Režen, Mateja Hafner, Sandhya Kortagere, Sean Ekins, Vesna Hodnik and Damjana Rozman
    Drug Metabolism and Disposition August 2017, 45 (8) 974-976; DOI: https://doi.org/10.1124/dmd.117.075523
  • You have access
    Role of CYP2B in Phenobarbital-Induced Hepatocyte Proliferation in Mice
    Lei Li, Xiaochen Bao, Qing-Yu Zhang, Masahiko Negishi and Xinxin Ding
    Drug Metabolism and Disposition August 2017, 45 (8) 977-981; DOI: https://doi.org/10.1124/dmd.117.076406

Erratum

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    Correction to “Molecular Cloning, Tissue Distribution, and Functional Characterization of Marmoset Cytochrome P450 1A1, 1A2, and 1B1”
    Drug Metabolism and Disposition August 2017, 45 (8) 956; DOI: https://doi.org/10.1124/dmd.115.067561err
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Drug Metabolism and Disposition: 45 (8)
Drug Metabolism and Disposition
Vol. 45, Issue 8
1 Aug 2017
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
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