Table of Contents

Articles

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  PKC/Nedd4-2 Signaling Pathway Regulates the Cell Surface Expression of Drug Transporter hOAT1

  Da Xu, Jinghui Zhang, Qiang Zhang, Yunzhou Fan, Chenchang Liu and Guofeng You

  Drug Metabolism and Disposition August 2017, 45 (8) 887-895; DOI: https://doi.org/10.1124/dmd.117.075861
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  Comparison of ¹⁹F NMR and ¹⁴C Measurements for the Assessment of ADME of BYL719 (Alpelisib) in Humans

  Alexander David James, Cyrille Marvalin, Alexandre Luneau, Axel Meissner and Gian Camenisch

  Drug Metabolism and Disposition August 2017, 45 (8) 900-907; DOI: https://doi.org/10.1124/dmd.117.075424
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  Comparative Evaluation of Plasma Bile Acids, Dehydroepiandrosterone Sulfate, Hexadecanedioate, and Tetradecanedioate with Coproporphyrins I and III as Markers of OATP Inhibition in Healthy Subjects

  Hong Shen, Weiqi Chen, Dieter M. Drexler, Sandhya Mandlekar, Vinay K. Holenarsipur, Eric E. Shields, Robert Langish, Kurex Sidik, Jinping Gan, W. Griffith Humphreys, Punit Marathe and Yurong Lai

  Drug Metabolism and Disposition August 2017, 45 (8) 908-919; DOI: https://doi.org/10.1124/dmd.117.075531
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  Development of a Novel Maternal-Fetal Physiologically Based Pharmacokinetic Model I: Insights into Factors that Determine Fetal Drug Exposure through Simulations and Sensitivity Analyses

  Zufei Zhang, Marjorie Z. Imperial, Gabriela I. Patilea-Vrana, Janak Wedagedera, Lu Gaohua and Jashvant D. Unadkat

  Drug Metabolism and Disposition August 2017, 45 (8) 920-938; DOI: https://doi.org/10.1124/dmd.117.075192
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  Development of a Novel Maternal-Fetal Physiologically Based Pharmacokinetic Model II: Verification of the Model for Passive Placental Permeability Drugs

  Zufei Zhang and Jashvant D. Unadkat

  Drug Metabolism and Disposition August 2017, 45 (8) 939-946; DOI: https://doi.org/10.1124/dmd.116.073957
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  Direct Comparison of the Enzymatic Characteristics and Superoxide Production of the Four Aldehyde Oxidase Enzymes Present in Mouse

  Gökhan Kücükgöze, Mineko Terao, Enrico Garattini and Silke Leimkühler

  Drug Metabolism and Disposition August 2017, 45 (8) 947-955; DOI: https://doi.org/10.1124/dmd.117.075937
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  CRISPR/Cas9 Genetic Modification of CYP3A5 *3 in HuH-7 Human Hepatocyte Cell Line Leads to Cell Lines with Increased Midazolam and Tacrolimus Metabolism

  Casey R. Dorr, Rory P. Remmel, Amutha Muthusamy, James Fisher, Branden S. Moriarity, Kazuto Yasuda, Baolin Wu, Weihua Guan, Erin G. Schuetz, William S. Oetting, Pamala A. Jacobson and Ajay K. Israni

  Drug Metabolism and Disposition August 2017, 45 (8) 957-965; DOI: https://doi.org/10.1124/dmd.117.076307
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  Oxetane Substrates of Human Microsomal Epoxide Hydrolase

  Francesca Toselli, Marlene Fredenwall, Peder Svensson, Xue-Qing Li, Anders Johansson, Lars Weidolf and Martin A. Hayes

  Drug Metabolism and Disposition August 2017, 45 (8) 966-973; DOI: https://doi.org/10.1124/dmd.117.076489