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Comparative Evaluation of Plasma Bile Acids, Dehydroepiandrosterone Sulfate, Hexadecanedioate, and Tetradecanedioate with Coproporphyrins I and III as Markers of OATP Inhibition in Healthy Subjects

Hong Shen, Weiqi Chen, Dieter M. Drexler, Sandhya Mandlekar, Vinay K. Holenarsipur, Eric E. Shields, Robert Langish, Kurex Sidik, Jinping Gan, W. Griffith Humphreys, Punit Marathe and Yurong Lai
Drug Metabolism and Disposition August 2017, 45 (8) 908-919; DOI: https://doi.org/10.1124/dmd.117.075531

Article Information

vol. 45 no. 8 908-919
DOI 
https://doi.org/10.1124/dmd.117.075531
PubMed 
28576766
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received February 17, 2017
  • Accepted May 31, 2017
  • Published online July 10, 2017.

Article Versions

Copyright & Usage 
Copyright © 2017 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Hong Shen,
  2. Weiqi Chen,
  3. Dieter M. Drexler,
  4. Sandhya Mandlekar,
  5. Vinay K. Holenarsipur,
  6. Eric E. Shields,
  7. Robert Langish,
  8. Kurex Sidik,
  9. Jinping Gan,
  10. W. Griffith Humphreys,
  11. Punit Marathe, and
  12. Yurong Lai
  1. Pharmaceutical Candidate Optimization (H.S., W.C., R.L., J.G., W.G.H., P.M., Y.L.) and Global Biometrics Sciences (K.S.), Bristol-Myers Squibb Company, Princeton, New Jersey; Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Company, Wallingford, Connecticut (D.M.D., E.E.S.); Bristol-Myers Squibb India Pvt. Ltd. (S.M.) and Syngene International Ltd. (V.K.H.), Biocon BMS R&D Center, Bangalore, India
  1. Address correspondence to:
    Dr. Hong Shen, Bristol-Myers Squibb Company, Route 206 and Province Line Road, Princeton, NJ 08543-4000. E-mail: hong.shen1{at}bms.com
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Endogenous Biomarkers of OATP Inhibition

Hong Shen, Weiqi Chen, Dieter M. Drexler, Sandhya Mandlekar, Vinay K. Holenarsipur, Eric E. Shields, Robert Langish, Kurex Sidik, Jinping Gan, W. Griffith Humphreys, Punit Marathe and Yurong Lai
Drug Metabolism and Disposition August 1, 2017, 45 (8) 908-919; DOI: https://doi.org/10.1124/dmd.117.075531
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