Research ArticleArticle
Comparative Evaluation of Plasma Bile Acids, Dehydroepiandrosterone Sulfate, Hexadecanedioate, and Tetradecanedioate with Coproporphyrins I and III as Markers of OATP Inhibition in Healthy Subjects
Hong Shen, Weiqi Chen, Dieter M. Drexler, Sandhya Mandlekar, Vinay K. Holenarsipur, Eric E. Shields, Robert Langish, Kurex Sidik, Jinping Gan, W. Griffith Humphreys, Punit Marathe and Yurong Lai
Drug Metabolism and Disposition August 2017, 45 (8) 908-919; DOI: https://doi.org/10.1124/dmd.117.075531
Hong Shen
Pharmaceutical Candidate Optimization (H.S., W.C., R.L., J.G., W.G.H., P.M., Y.L.) and Global Biometrics Sciences (K.S.), Bristol-Myers Squibb Company, Princeton, New Jersey; Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Company, Wallingford, Connecticut (D.M.D., E.E.S.); Bristol-Myers Squibb India Pvt. Ltd. (S.M.) and Syngene International Ltd. (V.K.H.), Biocon BMS R&D Center, Bangalore, India
Weiqi Chen
Pharmaceutical Candidate Optimization (H.S., W.C., R.L., J.G., W.G.H., P.M., Y.L.) and Global Biometrics Sciences (K.S.), Bristol-Myers Squibb Company, Princeton, New Jersey; Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Company, Wallingford, Connecticut (D.M.D., E.E.S.); Bristol-Myers Squibb India Pvt. Ltd. (S.M.) and Syngene International Ltd. (V.K.H.), Biocon BMS R&D Center, Bangalore, India
Dieter M. Drexler
Pharmaceutical Candidate Optimization (H.S., W.C., R.L., J.G., W.G.H., P.M., Y.L.) and Global Biometrics Sciences (K.S.), Bristol-Myers Squibb Company, Princeton, New Jersey; Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Company, Wallingford, Connecticut (D.M.D., E.E.S.); Bristol-Myers Squibb India Pvt. Ltd. (S.M.) and Syngene International Ltd. (V.K.H.), Biocon BMS R&D Center, Bangalore, India
Sandhya Mandlekar
Pharmaceutical Candidate Optimization (H.S., W.C., R.L., J.G., W.G.H., P.M., Y.L.) and Global Biometrics Sciences (K.S.), Bristol-Myers Squibb Company, Princeton, New Jersey; Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Company, Wallingford, Connecticut (D.M.D., E.E.S.); Bristol-Myers Squibb India Pvt. Ltd. (S.M.) and Syngene International Ltd. (V.K.H.), Biocon BMS R&D Center, Bangalore, India
Vinay K. Holenarsipur
Pharmaceutical Candidate Optimization (H.S., W.C., R.L., J.G., W.G.H., P.M., Y.L.) and Global Biometrics Sciences (K.S.), Bristol-Myers Squibb Company, Princeton, New Jersey; Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Company, Wallingford, Connecticut (D.M.D., E.E.S.); Bristol-Myers Squibb India Pvt. Ltd. (S.M.) and Syngene International Ltd. (V.K.H.), Biocon BMS R&D Center, Bangalore, India
Eric E. Shields
Pharmaceutical Candidate Optimization (H.S., W.C., R.L., J.G., W.G.H., P.M., Y.L.) and Global Biometrics Sciences (K.S.), Bristol-Myers Squibb Company, Princeton, New Jersey; Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Company, Wallingford, Connecticut (D.M.D., E.E.S.); Bristol-Myers Squibb India Pvt. Ltd. (S.M.) and Syngene International Ltd. (V.K.H.), Biocon BMS R&D Center, Bangalore, India
Robert Langish
Pharmaceutical Candidate Optimization (H.S., W.C., R.L., J.G., W.G.H., P.M., Y.L.) and Global Biometrics Sciences (K.S.), Bristol-Myers Squibb Company, Princeton, New Jersey; Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Company, Wallingford, Connecticut (D.M.D., E.E.S.); Bristol-Myers Squibb India Pvt. Ltd. (S.M.) and Syngene International Ltd. (V.K.H.), Biocon BMS R&D Center, Bangalore, India
Kurex Sidik
Pharmaceutical Candidate Optimization (H.S., W.C., R.L., J.G., W.G.H., P.M., Y.L.) and Global Biometrics Sciences (K.S.), Bristol-Myers Squibb Company, Princeton, New Jersey; Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Company, Wallingford, Connecticut (D.M.D., E.E.S.); Bristol-Myers Squibb India Pvt. Ltd. (S.M.) and Syngene International Ltd. (V.K.H.), Biocon BMS R&D Center, Bangalore, India
Jinping Gan
Pharmaceutical Candidate Optimization (H.S., W.C., R.L., J.G., W.G.H., P.M., Y.L.) and Global Biometrics Sciences (K.S.), Bristol-Myers Squibb Company, Princeton, New Jersey; Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Company, Wallingford, Connecticut (D.M.D., E.E.S.); Bristol-Myers Squibb India Pvt. Ltd. (S.M.) and Syngene International Ltd. (V.K.H.), Biocon BMS R&D Center, Bangalore, India
W. Griffith Humphreys
Pharmaceutical Candidate Optimization (H.S., W.C., R.L., J.G., W.G.H., P.M., Y.L.) and Global Biometrics Sciences (K.S.), Bristol-Myers Squibb Company, Princeton, New Jersey; Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Company, Wallingford, Connecticut (D.M.D., E.E.S.); Bristol-Myers Squibb India Pvt. Ltd. (S.M.) and Syngene International Ltd. (V.K.H.), Biocon BMS R&D Center, Bangalore, India
Punit Marathe
Pharmaceutical Candidate Optimization (H.S., W.C., R.L., J.G., W.G.H., P.M., Y.L.) and Global Biometrics Sciences (K.S.), Bristol-Myers Squibb Company, Princeton, New Jersey; Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Company, Wallingford, Connecticut (D.M.D., E.E.S.); Bristol-Myers Squibb India Pvt. Ltd. (S.M.) and Syngene International Ltd. (V.K.H.), Biocon BMS R&D Center, Bangalore, India
Yurong Lai
Pharmaceutical Candidate Optimization (H.S., W.C., R.L., J.G., W.G.H., P.M., Y.L.) and Global Biometrics Sciences (K.S.), Bristol-Myers Squibb Company, Princeton, New Jersey; Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Company, Wallingford, Connecticut (D.M.D., E.E.S.); Bristol-Myers Squibb India Pvt. Ltd. (S.M.) and Syngene International Ltd. (V.K.H.), Biocon BMS R&D Center, Bangalore, India
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Research ArticleArticle
Endogenous Biomarkers of OATP Inhibition
Hong Shen, Weiqi Chen, Dieter M. Drexler, Sandhya Mandlekar, Vinay K. Holenarsipur, Eric E. Shields, Robert Langish, Kurex Sidik, Jinping Gan, W. Griffith Humphreys, Punit Marathe and Yurong Lai
Drug Metabolism and Disposition August 1, 2017, 45 (8) 908-919; DOI: https://doi.org/10.1124/dmd.117.075531
Research ArticleArticle
Endogenous Biomarkers of OATP Inhibition
Hong Shen, Weiqi Chen, Dieter M. Drexler, Sandhya Mandlekar, Vinay K. Holenarsipur, Eric E. Shields, Robert Langish, Kurex Sidik, Jinping Gan, W. Griffith Humphreys, Punit Marathe and Yurong Lai
Drug Metabolism and Disposition August 1, 2017, 45 (8) 908-919; DOI: https://doi.org/10.1124/dmd.117.075531
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