Comparative Evaluation of Plasma Bile Acids, Dehydroepiandrosterone Sulfate, Hexadecanedioate, and Tetradecanedioate with Coproporphyrins I and III as Markers of OATP Inhibition in Healthy Subjects

Hong Shen; Weiqi Chen; Dieter M. Drexler; Sandhya Mandlekar; Vinay K. Holenarsipur; Eric E. Shields; Robert Langish; Kurex Sidik; Jinping Gan; W. Griffith Humphreys; Punit Marathe; Yurong Lai

doi:10.1124/dmd.117.075531

Research ArticleArticle

Comparative Evaluation of Plasma Bile Acids, Dehydroepiandrosterone Sulfate, Hexadecanedioate, and Tetradecanedioate with Coproporphyrins I and III as Markers of OATP Inhibition in Healthy Subjects

Hong Shen, Weiqi Chen, Dieter M. Drexler, Sandhya Mandlekar, Vinay K. Holenarsipur, Eric E. Shields, Robert Langish, Kurex Sidik, Jinping Gan, W. Griffith Humphreys, Punit Marathe and Yurong Lai

Drug Metabolism and Disposition August 2017, 45 (8) 908-919; DOI: https://doi.org/10.1124/dmd.117.075531

Hong Shen

Pharmaceutical Candidate Optimization (H.S., W.C., R.L., J.G., W.G.H., P.M., Y.L.) and Global Biometrics Sciences (K.S.), Bristol-Myers Squibb Company, Princeton, New Jersey; Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Company, Wallingford, Connecticut (D.M.D., E.E.S.); Bristol-Myers Squibb India Pvt. Ltd. (S.M.) and Syngene International Ltd. (V.K.H.), Biocon BMS R&D Center, Bangalore, India

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Weiqi Chen

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Dieter M. Drexler

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Sandhya Mandlekar

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Vinay K. Holenarsipur

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Eric E. Shields

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Robert Langish

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Kurex Sidik

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Jinping Gan

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W. Griffith Humphreys

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Punit Marathe

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Yurong Lai

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Drug Metabolism and Disposition

Vol. 45, Issue 8

1 Aug 2017

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Research ArticleArticle

Endogenous Biomarkers of OATP Inhibition

Hong Shen, Weiqi Chen, Dieter M. Drexler, Sandhya Mandlekar, Vinay K. Holenarsipur, Eric E. Shields, Robert Langish, Kurex Sidik, Jinping Gan, W. Griffith Humphreys, Punit Marathe and Yurong Lai

Drug Metabolism and Disposition August 1, 2017, 45 (8) 908-919; DOI: https://doi.org/10.1124/dmd.117.075531

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Research ArticleArticle

Endogenous Biomarkers of OATP Inhibition

Hong Shen, Weiqi Chen, Dieter M. Drexler, Sandhya Mandlekar, Vinay K. Holenarsipur, Eric E. Shields, Robert Langish, Kurex Sidik, Jinping Gan, W. Griffith Humphreys, Punit Marathe and Yurong Lai

Drug Metabolism and Disposition August 1, 2017, 45 (8) 908-919; DOI: https://doi.org/10.1124/dmd.117.075531

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Comparative Evaluation of Plasma Bile Acids, Dehydroepiandrosterone Sulfate, Hexadecanedioate, and Tetradecanedioate with Coproporphyrins I and III as Markers of OATP Inhibition in Healthy Subjects

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