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Research ArticleArticle

Development of a Novel Maternal-Fetal Physiologically Based Pharmacokinetic Model I: Insights into Factors that Determine Fetal Drug Exposure through Simulations and Sensitivity Analyses

Zufei Zhang, Marjorie Z. Imperial, Gabriela I. Patilea-Vrana, Janak Wedagedera, Lu Gaohua and Jashvant D. Unadkat
Drug Metabolism and Disposition August 2017, 45 (8) 920-938; DOI: https://doi.org/10.1124/dmd.117.075192

Article Information

vol. 45 no. 8 920-938
DOI 
https://doi.org/10.1124/dmd.117.075192
PubMed 
28588050
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received January 25, 2017
  • Accepted May 25, 2017
  • Published online July 10, 2017.

Article Versions

Copyright & Usage 
Copyright © 2017 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Zufei Zhang1,
  2. Marjorie Z. Imperial2,
  3. Gabriela I. Patilea-Vrana,
  4. Janak Wedagedera,
  5. Lu Gaohua, and
  6. Jashvant D. Unadkat
  1. Department of Pharmaceutics, University of Washington, Seattle, Washington (Z.Z., M.Z.I., G.I.P.-V, J.D.U.); and Simcyp Limited (a Certara company), Sheffield, United Kingdom (J.W., L.G.)
  1. Address correspondence to:
    Jashvant D. Unadkat, Department of Pharmaceutics, University of Washington, Box 357610, Seattle, WA 98195. E-mail: jash{at}u.washington.edu
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A PBPK Model of Factors Determining Fetal Drug Exposure

Zufei Zhang, Marjorie Z. Imperial, Gabriela I. Patilea-Vrana, Janak Wedagedera, Lu Gaohua and Jashvant D. Unadkat
Drug Metabolism and Disposition August 1, 2017, 45 (8) 920-938; DOI: https://doi.org/10.1124/dmd.117.075192
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