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CRISPR/Cas9 Genetic Modification of CYP3A5 *3 in HuH-7 Human Hepatocyte Cell Line Leads to Cell Lines with Increased Midazolam and Tacrolimus Metabolism

Casey R. Dorr, Rory P. Remmel, Amutha Muthusamy, James Fisher, Branden S. Moriarity, Kazuto Yasuda, Baolin Wu, Weihua Guan, Erin G. Schuetz, William S. Oetting, Pamala A. Jacobson and Ajay K. Israni
Drug Metabolism and Disposition August 2017, 45 (8) 957-965; DOI: https://doi.org/10.1124/dmd.117.076307
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Research ArticleArticles

CRISPR Modification of CYP3A5 in HuH-7 Alters Drug Metabolism

Casey R. Dorr, Rory P. Remmel, Amutha Muthusamy, James Fisher, Branden S. Moriarity, Kazuto Yasuda, Baolin Wu, Weihua Guan, Erin G. Schuetz, William S. Oetting, Pamala A. Jacobson and Ajay K. Israni
Drug Metabolism and Disposition August 1, 2017, 45 (8) 957-965; DOI: https://doi.org/10.1124/dmd.117.076307
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