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Rapid CommunicationShort Communication

Rosuvastatin and Atorvastatin Are Ligands of the Human Constitutive Androstane Receptor/Retinoid X Receptor α Complex

Tadeja Režen, Mateja Hafner, Sandhya Kortagere, Sean Ekins, Vesna Hodnik and Damjana Rozman
Drug Metabolism and Disposition August 2017, 45 (8) 974-976; DOI: https://doi.org/10.1124/dmd.117.075523
Tadeja Režen
Centre for Functional Genomics and Bio-Chips, Institute of Biochemistry, Faculty of Medicine (T.R., M.H., D.R.), and Department of Biology, Biotechnical Faculty (V.H.), University of Ljubljana, Ljubljana, Slovenia; Department of Microbiology and Immunology, College of Medicine, Drexel University, Philadelphia, Pennsylvania (S.K.); Collaborations Pharmaceuticals, Inc., Fuquay Varina, North Carolina (S.E.)
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Mateja Hafner
Centre for Functional Genomics and Bio-Chips, Institute of Biochemistry, Faculty of Medicine (T.R., M.H., D.R.), and Department of Biology, Biotechnical Faculty (V.H.), University of Ljubljana, Ljubljana, Slovenia; Department of Microbiology and Immunology, College of Medicine, Drexel University, Philadelphia, Pennsylvania (S.K.); Collaborations Pharmaceuticals, Inc., Fuquay Varina, North Carolina (S.E.)
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Sandhya Kortagere
Centre for Functional Genomics and Bio-Chips, Institute of Biochemistry, Faculty of Medicine (T.R., M.H., D.R.), and Department of Biology, Biotechnical Faculty (V.H.), University of Ljubljana, Ljubljana, Slovenia; Department of Microbiology and Immunology, College of Medicine, Drexel University, Philadelphia, Pennsylvania (S.K.); Collaborations Pharmaceuticals, Inc., Fuquay Varina, North Carolina (S.E.)
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Sean Ekins
Centre for Functional Genomics and Bio-Chips, Institute of Biochemistry, Faculty of Medicine (T.R., M.H., D.R.), and Department of Biology, Biotechnical Faculty (V.H.), University of Ljubljana, Ljubljana, Slovenia; Department of Microbiology and Immunology, College of Medicine, Drexel University, Philadelphia, Pennsylvania (S.K.); Collaborations Pharmaceuticals, Inc., Fuquay Varina, North Carolina (S.E.)
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Vesna Hodnik
Centre for Functional Genomics and Bio-Chips, Institute of Biochemistry, Faculty of Medicine (T.R., M.H., D.R.), and Department of Biology, Biotechnical Faculty (V.H.), University of Ljubljana, Ljubljana, Slovenia; Department of Microbiology and Immunology, College of Medicine, Drexel University, Philadelphia, Pennsylvania (S.K.); Collaborations Pharmaceuticals, Inc., Fuquay Varina, North Carolina (S.E.)
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Damjana Rozman
Centre for Functional Genomics and Bio-Chips, Institute of Biochemistry, Faculty of Medicine (T.R., M.H., D.R.), and Department of Biology, Biotechnical Faculty (V.H.), University of Ljubljana, Ljubljana, Slovenia; Department of Microbiology and Immunology, College of Medicine, Drexel University, Philadelphia, Pennsylvania (S.K.); Collaborations Pharmaceuticals, Inc., Fuquay Varina, North Carolina (S.E.)
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Article Information

vol. 45 no. 8 974-976
DOI 
https://doi.org/10.1124/dmd.117.075523
PubMed 
28536098

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received February 21, 2017
  • Accepted May 17, 2017
  • Published online July 17, 2017.

Article Versions

  • Earlier version (May 23, 2017 - 08:40).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2017 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Tadeja Režen,
  2. Mateja Hafner,
  3. Sandhya Kortagere,
  4. Sean Ekins,
  5. Vesna Hodnik, and
  6. Damjana Rozman
  1. Centre for Functional Genomics and Bio-Chips, Institute of Biochemistry, Faculty of Medicine (T.R., M.H., D.R.), and Department of Biology, Biotechnical Faculty (V.H.), University of Ljubljana, Ljubljana, Slovenia; Department of Microbiology and Immunology, College of Medicine, Drexel University, Philadelphia, Pennsylvania (S.K.); Collaborations Pharmaceuticals, Inc., Fuquay Varina, North Carolina (S.E.)
  1. Address correspondence to:
    Dr. Damjana Rozman, Centre for Functional Genomics and Bio-Chips, Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Vrazov trg 2, SI-1000 Ljubljana, Slovenia. E-mail: damjana.rozman{at}mf.uni-lj.si
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Drug Metabolism and Disposition: 45 (8)
Drug Metabolism and Disposition
Vol. 45, Issue 8
1 Aug 2017
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Rapid CommunicationShort Communication

Statins Are Ligands of Human CAR/RXRα Complex

Tadeja Režen, Mateja Hafner, Sandhya Kortagere, Sean Ekins, Vesna Hodnik and Damjana Rozman
Drug Metabolism and Disposition August 1, 2017, 45 (8) 974-976; DOI: https://doi.org/10.1124/dmd.117.075523

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Statins Are Ligands of Human CAR/RXRα Complex

Tadeja Režen, Mateja Hafner, Sandhya Kortagere, Sean Ekins, Vesna Hodnik and Damjana Rozman
Drug Metabolism and Disposition August 1, 2017, 45 (8) 974-976; DOI: https://doi.org/10.1124/dmd.117.075523
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