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Drug Metabolism & Disposition

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Table of Contents

January 01, 2018; Volume 46,Issue 1

Articles

  • Bioengineered NRF2-siRNA Is Effective to Interfere with NRF2 Pathways and Improve Chemosensitivity of Human Cancer Cells
    You have access
    Bioengineered NRF2-siRNA Is Effective to Interfere with NRF2 Pathways and Improve Chemosensitivity of Human Cancer Cells
    Peng-Cheng Li, Mei-Juan Tu, Pui Yan Ho, Joseph L. Jilek, Zhijian Duan, Qian-Yu Zhang, Ai-Xi Yu and Ai-Ming Yu
    Drug Metabolism and Disposition January 2018, 46 (1) 2-10; DOI: https://doi.org/10.1124/dmd.117.078741
  • You have access
    Organic Anion–Transporting Polypeptide (OATP)–Mediated Drug-Drug Interaction Study between Rosuvastatin and Cyclosporine A in Chimeric Mice with Humanized Liver
    Masashi Uchida, Yoriko Tajima, Masakazu Kakuni, Yutaka Kageyama, Taro Okada, Eri Sakurada, Chise Tateno and Ryoji Hayashi
    Drug Metabolism and Disposition January 2018, 46 (1) 11-19; DOI: https://doi.org/10.1124/dmd.117.075994
  • Open Access
    Effect of Flavin-Containing Monooxygenase Genotype, Mouse Strain, and Gender on Trimethylamine N-oxide Production, Plasma Cholesterol Concentration, and an Index of Atherosclerosis
    Sunil Veeravalli, Kersti Karu, Flora Scott, Diede Fennema, Ian R. Phillips and Elizabeth A. Shephard
    Drug Metabolism and Disposition January 2018, 46 (1) 20-25; DOI: https://doi.org/10.1124/dmd.117.077636
  • You have access
    Evaluation of Clinical Drug Interaction Potential of Clofazimine Using Static and Dynamic Modeling Approaches
    Ramachandra Sangana, Helen Gu, Dung Yu Chun and Heidi J. Einolf
    Drug Metabolism and Disposition January 2018, 46 (1) 26-32; DOI: https://doi.org/10.1124/dmd.117.077834
  • You have access
    Organic Cation Transporter 1 Is Responsible for Hepatocellular Uptake of the Tyrosine Kinase Inhibitor Pazopanib
    Waleed Elsayed Ahmed Ellawatty, Yusuke Masuo, Ken-ichi Fujita, Erina Yamazaki, Hiroo Ishida, Hiroshi Arakawa, Noritaka Nakamichi, Ramadan Abdelwahed, Yasutsuna Sasaki and Yukio Kato
    Drug Metabolism and Disposition January 2018, 46 (1) 33-40; DOI: https://doi.org/10.1124/dmd.117.076554
  • You have access
    Tripartite Motif Containing 24 Acts as a Novel Coactivator of the Constitutive Active/Androstane Receptor
    Yuichiro Kanno, Yuki Kure, Saori Kobayashi, Mariko Mizuno, Yumi Tsuchiya, Naoya Yamashita, Kiyomitsu Nemoto and Yoshio Inouye
    Drug Metabolism and Disposition January 2018, 46 (1) 46-52; DOI: https://doi.org/10.1124/dmd.117.077693
  • Low Cerebral Exposure Cannot Hinder the Neuroprotective Effects of Panax Notoginsenosides
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    Low Cerebral Exposure Cannot Hinder the Neuroprotective Effects of Panax Notoginsenosides
    Haofeng Li, Jingcheng Xiao, Xinuo Li, Huimin Chen, Dian Kang, Yuhao Shao, Boyu Shen, Zhangpei Zhu, Xiaoxi Yin, Lin Xie, Guangji Wang and Yan Liang
    Drug Metabolism and Disposition January 2018, 46 (1) 53-65; DOI: https://doi.org/10.1124/dmd.117.078436
  • You have access
    Successful Prediction of In Vivo Hepatobiliary Clearances and Hepatic Concentrations of Rosuvastatin Using Sandwich-Cultured Rat Hepatocytes, Transporter-Expressing Cell Lines, and Quantitative Proteomics
    Kazuya Ishida, Mohammed Ullah, Beáta Tóth, Viktoria Juhasz and Jashvant D. Unadkat
    Drug Metabolism and Disposition January 2018, 46 (1) 66-74; DOI: https://doi.org/10.1124/dmd.117.076539
  • You have access
    Highlighting Vitamin D Receptor–Targeted Activities of 1α,25-Dihydroxyvitamin D3 in Mice via Physiologically Based Pharmacokinetic-Pharmacodynamic Modeling
    Qi Joy Yang, Paola Bukuroshi, Holly P. Quach, Edwin C. Y. Chow and K. Sandy Pang
    Drug Metabolism and Disposition January 2018, 46 (1) 75-87; DOI: https://doi.org/10.1124/dmd.117.077271

Short Communication

  • You have access
    Generation and Characterization of SULT4A1 Mutant Mouse Models
    Patrick L. Garcia, Mohammed I. Hossain, Shaida A. Andrabi and Charles N. Falany
    Drug Metabolism and Disposition January 2018, 46 (1) 41-45; DOI: https://doi.org/10.1124/dmd.117.077560

Erratum

  • You have access
    Correction to “Metabolic Disposition of Luteolin Is Mediated by the Interplay of UDP-Glucuronosyltransferases and Catechol-O-Methyltransferases in Rats”
    Drug Metabolism and Disposition January 2018, 46 (1) 1; DOI: https://doi.org/10.1124/dmd.116.073619err
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In this issue

Drug Metabolism and Disposition: 46 (1)
Drug Metabolism and Disposition
Vol. 46, Issue 1
1 Jan 2018
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
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