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Research ArticleArticle

Successful Prediction of In Vivo Hepatobiliary Clearances and Hepatic Concentrations of Rosuvastatin Using Sandwich-Cultured Rat Hepatocytes, Transporter-Expressing Cell Lines, and Quantitative Proteomics

Kazuya Ishida, Mohammed Ullah, Beáta Tóth, Viktoria Juhasz and Jashvant D. Unadkat
Drug Metabolism and Disposition January 2018, 46 (1) 66-74; DOI: https://doi.org/10.1124/dmd.117.076539

Article Information

vol. 46 no. 1 66-74
DOI 
https://doi.org/10.1124/dmd.117.076539
PubMed 
29084782
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received April 27, 2017
  • Accepted October 25, 2017
  • Published online December 18, 2017.

Article Versions

Copyright & Usage 
Copyright © 2017 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Kazuya Ishida,
  2. Mohammed Ullah,
  3. Beáta Tóth,
  4. Viktoria Juhasz, and
  5. Jashvant D. Unadkat
  1. Department of Pharmaceutics, University of Washington, Seattle, Washington (K.I., J.D.U.); Cellular Transport Group, Pharmaceutical Sciences, Roche Innovation Centre Basel, F. Hoffmann-La Roche Ltd, Basel, Switzerland (M.U.); and SOLVO Biotechnology, Budaörs, Hungary (B.T., V.J.)
  1. Address correspondence to:
    Jashvant D. Unadkat, Department of Pharmaceutics, Box 357610, University of Washington, Seattle, WA 98195. E-mail: jash{at}uw.edu
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Successful IVIVE of Rat Hepatic Rosuvastatin Disposition

Kazuya Ishida, Mohammed Ullah, Beáta Tóth, Viktoria Juhasz and Jashvant D. Unadkat
Drug Metabolism and Disposition January 1, 2018, 46 (1) 66-74; DOI: https://doi.org/10.1124/dmd.117.076539
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