Drug Metabolism and Disposition: 46 (11)

November 01, 2018; Volume 46,Issue 11

Special Section – New Models in Drug Metabolism and Transport

You have access
Emerging Models of Drug Metabolism, Transporters, and Toxicity
Aarti Sawant-Basak and R. Scott Obach

Drug Metabolism and Disposition November 2018, 46 (11) 1556-1561; DOI: https://doi.org/10.1124/dmd.118.084293
You have access
Cryopreserved Human Intestinal Mucosal Epithelium: A Novel In Vitro Experimental System for the Evaluation of Enteric Drug Metabolism, Cytochrome P450 Induction, and Enterotoxicity
Albert P. Li, Novera Alam, Kirsten Amaral, Ming-Chih David Ho, Carol Loretz, Walter Mitchell and Qian Yang

Drug Metabolism and Disposition November 2018, 46 (11) 1562-1571; DOI: https://doi.org/10.1124/dmd.118.082875
You have access
Generation of Intestinal Organoids Suitable for Pharmacokinetic Studies from Human Induced Pluripotent Stem Cells
Daichi Onozato, Misaki Yamashita, Anna Nakanishi, Takumi Akagawa, Yuriko Kida, Isamu Ogawa, Tadahiro Hashita, Takahiro Iwao and Tamihide Matsunaga

Drug Metabolism and Disposition November 2018, 46 (11) 1572-1580; DOI: https://doi.org/10.1124/dmd.118.080374
You have access
Physiologically Relevant, Humanized Intestinal Systems to Study Metabolism and Transport of Small Molecule Therapeutics
Aarti Sawant-Basak, A. David Rodrigues, Matthew Lech, Regis Doyonnas, Marion Kasaian, Bhagwat Prasad and Nikolaos Tsamandouras

Drug Metabolism and Disposition November 2018, 46 (11) 1581-1587; DOI: https://doi.org/10.1124/dmd.118.082784
You have access
How to Determine the Role of the Microbiome in Drug Disposition
Jordan E. Bisanz, Peter Spanogiannopoulos, Lindsey M. Pieper, Annamarie E. Bustion and Peter J. Turnbaugh

Drug Metabolism and Disposition November 2018, 46 (11) 1588-1595; DOI: https://doi.org/10.1124/dmd.118.083402
You have access
An Ex Vivo Fermentation Screening Platform to Study Drug Metabolism by Human Gut Microbiota
E. van de Steeg, F. H. J. Schuren, R. Scott Obach, C. van Woudenbergh, Gregory S. Walker, M. Heerikhuisen, I. H. G. Nooijen and W. H. J. Vaes

Drug Metabolism and Disposition November 2018, 46 (11) 1596-1607; DOI: https://doi.org/10.1124/dmd.118.081026
You have access
A Novel In Vitro Experimental System for the Evaluation of Drug Metabolism: Cofactor-Supplemented Permeabilized Cryopreserved Human Hepatocytes (MetMax Cryopreserved Human Hepatocytes)
Albert P. Li, Ming-Chih David Ho, Kirsten Amaral and Carol Loretz

Drug Metabolism and Disposition November 2018, 46 (11) 1608-1616; DOI: https://doi.org/10.1124/dmd.117.079657
You have access
Assessment of the Biotransformation of Low-Turnover Drugs in the HµREL Human Hepatocyte Coculture Model
Richard D. Burton, Todd Hieronymus, Taysir Chamem, David Heim, Shelby Anderson, Xiaochun Zhu and J. Matthew Hutzler

Drug Metabolism and Disposition November 2018, 46 (11) 1617-1625; DOI: https://doi.org/10.1124/dmd.118.082867
You have access
Advances in Engineered Human Liver Platforms for Drug Metabolism Studies
Gregory H. Underhill and Salman R. Khetani

Drug Metabolism and Disposition November 2018, 46 (11) 1626-1637; DOI: https://doi.org/10.1124/dmd.118.083295
You have access
Microfluidic Cell Culture Platforms to Capture Hepatic Physiology and Complex Cellular Interactions
Shyam Sundhar Bale and Jeffrey T. Borenstein

Drug Metabolism and Disposition November 2018, 46 (11) 1638-1646; DOI: https://doi.org/10.1124/dmd.118.083055
You have access
Perspective on the Application of Microphysiological Systems to Drug Transporter Studies
Pedro Caetano-Pinto and Simone H. Stahl

Drug Metabolism and Disposition November 2018, 46 (11) 1647-1657; DOI: https://doi.org/10.1124/dmd.118.082750
Open Access
Do In Vitro Assays Predict Drug Candidate Idiosyncratic Drug-Induced Liver Injury Risk?
J. Gerry Kenna and Jack Uetrecht

Drug Metabolism and Disposition November 2018, 46 (11) 1658-1669; DOI: https://doi.org/10.1124/dmd.118.082719
You have access
Models and Approaches Describing the Metabolism, Transport, and Toxicity of Drugs Administered by the Ocular Route
Jennifer L. Dumouchel, Nagendra Chemuturi, Mark N. Milton, Gian Camenisch, James Chastain, Markus Walles, Vito Sasseville, Mithat Gunduz, Ganesh R. Iyer and Upendra A. Argikar

Drug Metabolism and Disposition November 2018, 46 (11) 1670-1683; DOI: https://doi.org/10.1124/dmd.118.082974
Open Access
Fabrication of a Corneal Model Composed of Corneal Epithelial and Endothelial Cells via a Collagen Vitrigel Membrane Functioned as an Acellular Stroma and Its Application to the Corneal Permeability Test of Chemicals
Hiroyuki Yamaguchi and Toshiaki Takezawa

Drug Metabolism and Disposition November 2018, 46 (11) 1684-1691; DOI: https://doi.org/10.1124/dmd.118.080820
You have access
Emerging Kidney Models to Investigate Metabolism, Transport, and Toxicity of Drugs and Xenobiotics
Piyush Bajaj, Swapan K. Chowdhury, Robert Yucha, Edward J. Kelly and Guangqing Xiao

Drug Metabolism and Disposition November 2018, 46 (11) 1692-1702; DOI: https://doi.org/10.1124/dmd.118.082958
You have access
Human Pluripotent Stem Cell–Derived Kidney Model for Nephrotoxicity Studies
Piyush Bajaj, A. David Rodrigues, Claire M. Steppan, Sandra J. Engle, Sumathy Mathialagan and Thomas Schroeter

Drug Metabolism and Disposition November 2018, 46 (11) 1703-1711; DOI: https://doi.org/10.1124/dmd.118.082727
You have access
Porcine Prediction of Pharmacokinetic Parameters in People: A Pig in a Poke?
Huadong Tang and Michael Mayersohn

Drug Metabolism and Disposition November 2018, 46 (11) 1712-1724; DOI: https://doi.org/10.1124/dmd.118.083311
You have access
Pheophorbide A: Fluorescent Bcrp Substrate to Measure Oral Drug-Drug Interactions in Real-Time In Vivo
Kazuto Yasuda, Samit Ganguly and Erin G. Schuetz

Drug Metabolism and Disposition November 2018, 46 (11) 1725-1733; DOI: https://doi.org/10.1124/dmd.118.083584
You have access
P450-Humanized and Human Liver Chimeric Mouse Models for Studying Xenobiotic Metabolism and Toxicity
Karl-Dimiter Bissig, Weiguo Han, Mercedes Barzi, Nataliia Kovalchuk, Liang Ding, Xiaoyu Fan, Francis P. Pankowicz, Qing-Yu Zhang and Xinxin Ding

Drug Metabolism and Disposition November 2018, 46 (11) 1734-1744; DOI: https://doi.org/10.1124/dmd.118.083303
You have access
Humanized UGT1 Mice, Regulation of UGT1A1, and the Role of the Intestinal Tract in Neonatal Hyperbilirubinemia and Breast Milk-Induced Jaundice
Shujuan Chen and Robert H. Tukey

Drug Metabolism and Disposition November 2018, 46 (11) 1745-1755; DOI: https://doi.org/10.1124/dmd.118.083212
You have access
Characterization of P-Glycoprotein Humanized Mice Generated by Chromosome Engineering Technology: Its Utility for Prediction of Drug Distribution to the Brain in Humans
Yuki Yamasaki, Kaoru Kobayashi, Fuka Okuya, Naoyo Kajitani, Kanako Kazuki, Satoshi Abe, Shoko Takehara, Shingo Ito, Seiryo Ogata, Tatsuki Uemura, Sumio Ohtsuki, Genki Minegishi, Hidetaka Akita, Kan Chiba, Mitsuo Oshimura and Yasuhiro Kazuki

Drug Metabolism and Disposition November 2018, 46 (11) 1756-1766; DOI: https://doi.org/10.1124/dmd.118.081216
You have access
Evaluation of Organic Anion Transporter 1A2-knock-in Mice as a Model of Human Blood-brain Barrier
Yamato Sano, Tadahaya Mizuno, Tatsuki Mochizuki, Yasuo Uchida, Mina Umetsu, Tetsuya Terasaki and Hiroyuki Kusuhara

Drug Metabolism and Disposition November 2018, 46 (11) 1767-1775; DOI: https://doi.org/10.1124/dmd.118.081877
Open Access
CRISPR-Cas9: A New Addition to the Drug Metabolism and Disposition Tool Box
M. Karlgren, I. Simoff, M. Keiser, S. Oswald and P. Artursson

Drug Metabolism and Disposition November 2018, 46 (11) 1776-1786; DOI: https://doi.org/10.1124/dmd.118.082842
You have access
Mouse Population-Based Approaches to Investigate Adverse Drug Reactions
Merrie Mosedale

Drug Metabolism and Disposition November 2018, 46 (11) 1787-1795; DOI: https://doi.org/10.1124/dmd.118.082834

Commentary

You have access
Finding T_max and C_max in Multicompartmental Models
Yi Rang Han, Ping I. Lee and K. Sandy Pang

Drug Metabolism and Disposition November 2018, 46 (11) 1796-1804; DOI: https://doi.org/10.1124/dmd.118.082636

Articles

You have access
Trend Analysis of a Database of Intravenous Pharmacokinetic Parameters in Humans for 1352 Drug Compounds
Franco Lombardo, Giuliano Berellini and R. Scott Obach

Drug Metabolism and Disposition November 2018, 46 (11) 1466-1477; DOI: https://doi.org/10.1124/dmd.118.082966
You have access
Gene-by-Environment Interaction of Bcrp^−/− and Methionine- and Choline-Deficient Diet–Induced Nonalcoholic Steatohepatitis Alters SN-38 Disposition
Erica L. Toth, Hui Li, Anika L. Dzierlenga, John D. Clarke, Anna Vildhede, Michael Goedken and Nathan J. Cherrington

Drug Metabolism and Disposition November 2018, 46 (11) 1478-1486; DOI: https://doi.org/10.1124/dmd.118.082081
You have access
When Does the Rate-Determining Step in the Hepatic Clearance of a Drug Switch from Sinusoidal Uptake to All Hepatobiliary Clearances? Implications for Predicting Drug-Drug Interactions
Gabriela I. Patilea-Vrana and Jashvant D. Unadkat

Drug Metabolism and Disposition November 2018, 46 (11) 1487-1496; DOI: https://doi.org/10.1124/dmd.118.081307
You have access
Application of Intestinal Epithelial Cells Differentiated from Human Induced Pluripotent Stem Cells for Studies of Prodrug Hydrolysis and Drug Absorption in the Small Intestine
Takanori Akazawa, Shinpei Yoshida, Shuichi Ohnishi, Takushi Kanazu, Makoto Kawai and Koji Takahashi

Drug Metabolism and Disposition November 2018, 46 (11) 1497-1506; DOI: https://doi.org/10.1124/dmd.118.083246
You have access
Relationship between In Vivo CYP3A4 Activity, CYP3A5 Genotype, and Systemic Tacrolimus Metabolite/Parent Drug Ratio in Renal Transplant Recipients and Healthy Volunteers
Thomas Vanhove, Hylke de Jonge, Henriëtte de Loor, Marlies Oorts, Jan de Hoon, Anton Pohanka, Pieter Annaert and Dirk R. J. Kuypers

Drug Metabolism and Disposition November 2018, 46 (11) 1507-1513; DOI: https://doi.org/10.1124/dmd.118.081935
You have access
Effect of Celecoxib on Differentiation of Human Induced Pluripotent Stem Cells into Hepatocytes Involves STAT5 Activation
Hiroki Okumura, Anna Nakanishi, Tadahiro Hashita, Takahiro Iwao and Tamihide Matsunaga

Drug Metabolism and Disposition November 2018, 46 (11) 1519-1527; DOI: https://doi.org/10.1124/dmd.118.082982
You have access
Retinal Cholesterol Content Is Reduced in Simvastatin-Treated Mice Due to Inhibited Local Biosynthesis Albeit Increased Uptake of Serum Cholesterol
Natalia Mast, Ilya R. Bederman and Irina A. Pikuleva

Drug Metabolism and Disposition November 2018, 46 (11) 1528-1537; DOI: https://doi.org/10.1124/dmd.118.083345
You have access
Circadian Regulation of Hepatic Cytochrome P450 2a5 by Peroxisome Proliferator-Activated Receptor γ
Jiangming Deng, Lianxia Guo and Baojian Wu

Drug Metabolism and Disposition November 2018, 46 (11) 1538-1545; DOI: https://doi.org/10.1124/dmd.118.083071
Open Access
Biotransformation of Finerenone, a Novel Nonsteroidal Mineralocorticoid Receptor Antagonist, in Dogs, Rats, and Humans, In Vivo and In Vitro
Michael Gerisch, Roland Heinig, Anna Engelen, Dieter Lang, Peter Kolkhof, Martin Radtke, Johannes Platzek, Kai Lovis, Gabriele Rohde and Thomas Schwarz

Drug Metabolism and Disposition November 2018, 46 (11) 1546-1555; DOI: https://doi.org/10.1124/dmd.118.083337
You have access
Accurate Estimation of In Vivo Inhibition Constants of Inhibitors and Fraction Metabolized of Substrates with Physiologically Based Pharmacokinetic Drug–Drug Interaction Models Incorporating Parent Drugs and Metabolites of Substrates with Cluster Newton Method
Kenta Yoshida, Kazuya Maeda, Akihiko Konagaya and Hiroyuki Kusuhara

Drug Metabolism and Disposition November 2018, 46 (11) 1805-1816; DOI: https://doi.org/10.1124/dmd.118.081828
You have access
Equilibrative Nucleoside Transporter 1 (ENT1, SLC29A1) Facilitates Transfer of the Antiretroviral Drug Abacavir across the Placenta
Lukas Cerveny, Zuzana Ptackova, Martina Ceckova, Rona Karahoda, Sara Karbanova, Lucie Jiraskova, Susan L. Greenwood, Jocelyn D. Glazier and Frantisek Staud

Drug Metabolism and Disposition November 2018, 46 (11) 1817-1826; DOI: https://doi.org/10.1124/dmd.118.083329
You have access
Health-Relevant Phenotypes in the Offspring of Mice Given CAR Activators Prior to Pregnancy
Karin Dietrich, Jan Baumgart, Leonid Eshkind, Lea Reuter, Ute Gödtel-Armbrust, Elke Butt, Michael Musheev, Federico Marini, Piyush More, Tanja Grosser, Christof Niehrs, Leszek Wojnowski and Marianne Mathäs

Drug Metabolism and Disposition November 2018, 46 (11) 1827-1835; DOI: https://doi.org/10.1124/dmd.118.082925

Short Communication

You have access
Mouse Hepatomas with Ha-ras and B-raf Mutations Differ in Mitogen-Activated Protein Kinase Signaling and Response to Constitutive Androstane Receptor Activation
Albert Braeuning, Ferdinand Kollotzek, Eva Zeller, Thomas Knorpp, Markus F. Templin and Michael Schwarz

Drug Metabolism and Disposition November 2018, 46 (11) 1462-1465; DOI: https://doi.org/10.1124/dmd.118.083014
You have access
Brain Uptake of [¹³C] and [¹⁴C]Sucrose Quantified by Microdialysis and Whole Tissue Analysis in Mice
Faleh Alqahtani, Ekram Ahmed Chowdhury, Raktima Bhattacharya, Behnam Noorani, Reza Mehvar and Ulrich Bickel

Drug Metabolism and Disposition November 2018, 46 (11) 1514-1518; DOI: https://doi.org/10.1124/dmd.118.082909

Main menu

User menu

Search

Table of Contents

Special Section – New Models in Drug Metabolism and Transport

Commentary

Articles

Short Communication

In this issue

Jump to

Navigate

More Information

ASPET's Other Journals