Skip to main content
Advertisement

Main menu

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Special Sections
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Submit
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET

User menu

  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
Drug Metabolism & Disposition
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET
  • My alerts
  • Log in
  • My Cart
Drug Metabolism & Disposition

Advanced Search

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Special Sections
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Submit
  • Visit dmd on Facebook
  • Follow dmd on Twitter
  • Follow ASPET on LinkedIn

Table of Contents

November 01, 2018; Volume 46,Issue 11

Special Section – New Models in Drug Metabolism and Transport

  • You have access
    Emerging Models of Drug Metabolism, Transporters, and Toxicity
    Aarti Sawant-Basak and R. Scott Obach
    Drug Metabolism and Disposition November 2018, 46 (11) 1556-1561; DOI: https://doi.org/10.1124/dmd.118.084293
  • You have access
    Cryopreserved Human Intestinal Mucosal Epithelium: A Novel In Vitro Experimental System for the Evaluation of Enteric Drug Metabolism, Cytochrome P450 Induction, and Enterotoxicity
    Albert P. Li, Novera Alam, Kirsten Amaral, Ming-Chih David Ho, Carol Loretz, Walter Mitchell and Qian Yang
    Drug Metabolism and Disposition November 2018, 46 (11) 1562-1571; DOI: https://doi.org/10.1124/dmd.118.082875
  • You have access
    Generation of Intestinal Organoids Suitable for Pharmacokinetic Studies from Human Induced Pluripotent Stem Cells
    Daichi Onozato, Misaki Yamashita, Anna Nakanishi, Takumi Akagawa, Yuriko Kida, Isamu Ogawa, Tadahiro Hashita, Takahiro Iwao and Tamihide Matsunaga
    Drug Metabolism and Disposition November 2018, 46 (11) 1572-1580; DOI: https://doi.org/10.1124/dmd.118.080374
  • You have access
    Physiologically Relevant, Humanized Intestinal Systems to Study Metabolism and Transport of Small Molecule Therapeutics
    Aarti Sawant-Basak, A. David Rodrigues, Matthew Lech, Regis Doyonnas, Marion Kasaian, Bhagwat Prasad and Nikolaos Tsamandouras
    Drug Metabolism and Disposition November 2018, 46 (11) 1581-1587; DOI: https://doi.org/10.1124/dmd.118.082784
  • You have access
    How to Determine the Role of the Microbiome in Drug Disposition
    Jordan E. Bisanz, Peter Spanogiannopoulos, Lindsey M. Pieper, Annamarie E. Bustion and Peter J. Turnbaugh
    Drug Metabolism and Disposition November 2018, 46 (11) 1588-1595; DOI: https://doi.org/10.1124/dmd.118.083402
  • You have access
    An Ex Vivo Fermentation Screening Platform to Study Drug Metabolism by Human Gut Microbiota
    E. van de Steeg, F. H. J. Schuren, R. Scott Obach, C. van Woudenbergh, Gregory S. Walker, M. Heerikhuisen, I. H. G. Nooijen and W. H. J. Vaes
    Drug Metabolism and Disposition November 2018, 46 (11) 1596-1607; DOI: https://doi.org/10.1124/dmd.118.081026
  • You have access
    A Novel In Vitro Experimental System for the Evaluation of Drug Metabolism: Cofactor-Supplemented Permeabilized Cryopreserved Human Hepatocytes (MetMax Cryopreserved Human Hepatocytes)
    Albert P. Li, Ming-Chih David Ho, Kirsten Amaral and Carol Loretz
    Drug Metabolism and Disposition November 2018, 46 (11) 1608-1616; DOI: https://doi.org/10.1124/dmd.117.079657
  • You have access
    Assessment of the Biotransformation of Low-Turnover Drugs in the HµREL Human Hepatocyte Coculture Model
    Richard D. Burton, Todd Hieronymus, Taysir Chamem, David Heim, Shelby Anderson, Xiaochun Zhu and J. Matthew Hutzler
    Drug Metabolism and Disposition November 2018, 46 (11) 1617-1625; DOI: https://doi.org/10.1124/dmd.118.082867
  • You have access
    Advances in Engineered Human Liver Platforms for Drug Metabolism Studies
    Gregory H. Underhill and Salman R. Khetani
    Drug Metabolism and Disposition November 2018, 46 (11) 1626-1637; DOI: https://doi.org/10.1124/dmd.118.083295
  • You have access
    Microfluidic Cell Culture Platforms to Capture Hepatic Physiology and Complex Cellular Interactions
    Shyam Sundhar Bale and Jeffrey T. Borenstein
    Drug Metabolism and Disposition November 2018, 46 (11) 1638-1646; DOI: https://doi.org/10.1124/dmd.118.083055
  • You have access
    Perspective on the Application of Microphysiological Systems to Drug Transporter Studies
    Pedro Caetano-Pinto and Simone H. Stahl
    Drug Metabolism and Disposition November 2018, 46 (11) 1647-1657; DOI: https://doi.org/10.1124/dmd.118.082750
  • Do In Vitro Assays Predict Drug Candidate Idiosyncratic Drug-Induced Liver Injury Risk?
    Open Access
    Do In Vitro Assays Predict Drug Candidate Idiosyncratic Drug-Induced Liver Injury Risk?
    J. Gerry Kenna and Jack Uetrecht
    Drug Metabolism and Disposition November 2018, 46 (11) 1658-1669; DOI: https://doi.org/10.1124/dmd.118.082719
  • You have access
    Models and Approaches Describing the Metabolism, Transport, and Toxicity of Drugs Administered by the Ocular Route
    Jennifer L. Dumouchel, Nagendra Chemuturi, Mark N. Milton, Gian Camenisch, James Chastain, Markus Walles, Vito Sasseville, Mithat Gunduz, Ganesh R. Iyer and Upendra A. Argikar
    Drug Metabolism and Disposition November 2018, 46 (11) 1670-1683; DOI: https://doi.org/10.1124/dmd.118.082974
  • Open Access
    Fabrication of a Corneal Model Composed of Corneal Epithelial and Endothelial Cells via a Collagen Vitrigel Membrane Functioned as an Acellular Stroma and Its Application to the Corneal Permeability Test of Chemicals
    Hiroyuki Yamaguchi and Toshiaki Takezawa
    Drug Metabolism and Disposition November 2018, 46 (11) 1684-1691; DOI: https://doi.org/10.1124/dmd.118.080820
  • You have access
    Emerging Kidney Models to Investigate Metabolism, Transport, and Toxicity of Drugs and Xenobiotics
    Piyush Bajaj, Swapan K. Chowdhury, Robert Yucha, Edward J. Kelly and Guangqing Xiao
    Drug Metabolism and Disposition November 2018, 46 (11) 1692-1702; DOI: https://doi.org/10.1124/dmd.118.082958
  • You have access
    Human Pluripotent Stem Cell–Derived Kidney Model for Nephrotoxicity Studies
    Piyush Bajaj, A. David Rodrigues, Claire M. Steppan, Sandra J. Engle, Sumathy Mathialagan and Thomas Schroeter
    Drug Metabolism and Disposition November 2018, 46 (11) 1703-1711; DOI: https://doi.org/10.1124/dmd.118.082727
  • You have access
    Porcine Prediction of Pharmacokinetic Parameters in People: A Pig in a Poke?
    Huadong Tang and Michael Mayersohn
    Drug Metabolism and Disposition November 2018, 46 (11) 1712-1724; DOI: https://doi.org/10.1124/dmd.118.083311
  • Pheophorbide A: Fluorescent Bcrp Substrate to Measure Oral Drug-Drug Interactions in Real-Time In Vivo
    You have access
    Pheophorbide A: Fluorescent Bcrp Substrate to Measure Oral Drug-Drug Interactions in Real-Time In Vivo
    Kazuto Yasuda, Samit Ganguly and Erin G. Schuetz
    Drug Metabolism and Disposition November 2018, 46 (11) 1725-1733; DOI: https://doi.org/10.1124/dmd.118.083584
  • You have access
    P450-Humanized and Human Liver Chimeric Mouse Models for Studying Xenobiotic Metabolism and Toxicity
    Karl-Dimiter Bissig, Weiguo Han, Mercedes Barzi, Nataliia Kovalchuk, Liang Ding, Xiaoyu Fan, Francis P. Pankowicz, Qing-Yu Zhang and Xinxin Ding
    Drug Metabolism and Disposition November 2018, 46 (11) 1734-1744; DOI: https://doi.org/10.1124/dmd.118.083303
  • You have access
    Humanized UGT1 Mice, Regulation of UGT1A1, and the Role of the Intestinal Tract in Neonatal Hyperbilirubinemia and Breast Milk-Induced Jaundice
    Shujuan Chen and Robert H. Tukey
    Drug Metabolism and Disposition November 2018, 46 (11) 1745-1755; DOI: https://doi.org/10.1124/dmd.118.083212
  • You have access
    Characterization of P-Glycoprotein Humanized Mice Generated by Chromosome Engineering Technology: Its Utility for Prediction of Drug Distribution to the Brain in Humans
    Yuki Yamasaki, Kaoru Kobayashi, Fuka Okuya, Naoyo Kajitani, Kanako Kazuki, Satoshi Abe, Shoko Takehara, Shingo Ito, Seiryo Ogata, Tatsuki Uemura, Sumio Ohtsuki, Genki Minegishi, Hidetaka Akita, Kan Chiba, Mitsuo Oshimura and Yasuhiro Kazuki
    Drug Metabolism and Disposition November 2018, 46 (11) 1756-1766; DOI: https://doi.org/10.1124/dmd.118.081216
  • You have access
    Evaluation of Organic Anion Transporter 1A2-knock-in Mice as a Model of Human Blood-brain Barrier
    Yamato Sano, Tadahaya Mizuno, Tatsuki Mochizuki, Yasuo Uchida, Mina Umetsu, Tetsuya Terasaki and Hiroyuki Kusuhara
    Drug Metabolism and Disposition November 2018, 46 (11) 1767-1775; DOI: https://doi.org/10.1124/dmd.118.081877
  • Open Access
    CRISPR-Cas9: A New Addition to the Drug Metabolism and Disposition Tool Box
    M. Karlgren, I. Simoff, M. Keiser, S. Oswald and P. Artursson
    Drug Metabolism and Disposition November 2018, 46 (11) 1776-1786; DOI: https://doi.org/10.1124/dmd.118.082842
  • You have access
    Mouse Population-Based Approaches to Investigate Adverse Drug Reactions
    Merrie Mosedale
    Drug Metabolism and Disposition November 2018, 46 (11) 1787-1795; DOI: https://doi.org/10.1124/dmd.118.082834

Commentary

  • You have access
    Finding Tmax and Cmax in Multicompartmental Models
    Yi Rang Han, Ping I. Lee and K. Sandy Pang
    Drug Metabolism and Disposition November 2018, 46 (11) 1796-1804; DOI: https://doi.org/10.1124/dmd.118.082636

Articles

  • You have access
    Trend Analysis of a Database of Intravenous Pharmacokinetic Parameters in Humans for 1352 Drug Compounds
    Franco Lombardo, Giuliano Berellini and R. Scott Obach
    Drug Metabolism and Disposition November 2018, 46 (11) 1466-1477; DOI: https://doi.org/10.1124/dmd.118.082966
  • You have access
    Gene-by-Environment Interaction of Bcrp−/− and Methionine- and Choline-Deficient Diet–Induced Nonalcoholic Steatohepatitis Alters SN-38 Disposition
    Erica L. Toth, Hui Li, Anika L. Dzierlenga, John D. Clarke, Anna Vildhede, Michael Goedken and Nathan J. Cherrington
    Drug Metabolism and Disposition November 2018, 46 (11) 1478-1486; DOI: https://doi.org/10.1124/dmd.118.082081
  • You have access
    When Does the Rate-Determining Step in the Hepatic Clearance of a Drug Switch from Sinusoidal Uptake to All Hepatobiliary Clearances? Implications for Predicting Drug-Drug Interactions
    Gabriela I. Patilea-Vrana and Jashvant D. Unadkat
    Drug Metabolism and Disposition November 2018, 46 (11) 1487-1496; DOI: https://doi.org/10.1124/dmd.118.081307
  • You have access
    Application of Intestinal Epithelial Cells Differentiated from Human Induced Pluripotent Stem Cells for Studies of Prodrug Hydrolysis and Drug Absorption in the Small Intestine
    Takanori Akazawa, Shinpei Yoshida, Shuichi Ohnishi, Takushi Kanazu, Makoto Kawai and Koji Takahashi
    Drug Metabolism and Disposition November 2018, 46 (11) 1497-1506; DOI: https://doi.org/10.1124/dmd.118.083246
  • You have access
    Relationship between In Vivo CYP3A4 Activity, CYP3A5 Genotype, and Systemic Tacrolimus Metabolite/Parent Drug Ratio in Renal Transplant Recipients and Healthy Volunteers
    Thomas Vanhove, Hylke de Jonge, Henriëtte de Loor, Marlies Oorts, Jan de Hoon, Anton Pohanka, Pieter Annaert and Dirk R. J. Kuypers
    Drug Metabolism and Disposition November 2018, 46 (11) 1507-1513; DOI: https://doi.org/10.1124/dmd.118.081935
  • You have access
    Effect of Celecoxib on Differentiation of Human Induced Pluripotent Stem Cells into Hepatocytes Involves STAT5 Activation
    Hiroki Okumura, Anna Nakanishi, Tadahiro Hashita, Takahiro Iwao and Tamihide Matsunaga
    Drug Metabolism and Disposition November 2018, 46 (11) 1519-1527; DOI: https://doi.org/10.1124/dmd.118.082982
  • Retinal Cholesterol Content Is Reduced in Simvastatin-Treated Mice Due to Inhibited Local Biosynthesis Albeit Increased Uptake of Serum Cholesterol
    You have access
    Retinal Cholesterol Content Is Reduced in Simvastatin-Treated Mice Due to Inhibited Local Biosynthesis Albeit Increased Uptake of Serum Cholesterol
    Natalia Mast, Ilya R. Bederman and Irina A. Pikuleva
    Drug Metabolism and Disposition November 2018, 46 (11) 1528-1537; DOI: https://doi.org/10.1124/dmd.118.083345
  • You have access
    Circadian Regulation of Hepatic Cytochrome P450 2a5 by Peroxisome Proliferator-Activated Receptor γ
    Jiangming Deng, Lianxia Guo and Baojian Wu
    Drug Metabolism and Disposition November 2018, 46 (11) 1538-1545; DOI: https://doi.org/10.1124/dmd.118.083071
  • Open Access
    Biotransformation of Finerenone, a Novel Nonsteroidal Mineralocorticoid Receptor Antagonist, in Dogs, Rats, and Humans, In Vivo and In Vitro
    Michael Gerisch, Roland Heinig, Anna Engelen, Dieter Lang, Peter Kolkhof, Martin Radtke, Johannes Platzek, Kai Lovis, Gabriele Rohde and Thomas Schwarz
    Drug Metabolism and Disposition November 2018, 46 (11) 1546-1555; DOI: https://doi.org/10.1124/dmd.118.083337
  • You have access
    Accurate Estimation of In Vivo Inhibition Constants of Inhibitors and Fraction Metabolized of Substrates with Physiologically Based Pharmacokinetic Drug–Drug Interaction Models Incorporating Parent Drugs and Metabolites of Substrates with Cluster Newton Method
    Kenta Yoshida, Kazuya Maeda, Akihiko Konagaya and Hiroyuki Kusuhara
    Drug Metabolism and Disposition November 2018, 46 (11) 1805-1816; DOI: https://doi.org/10.1124/dmd.118.081828
  • You have access
    Equilibrative Nucleoside Transporter 1 (ENT1, SLC29A1) Facilitates Transfer of the Antiretroviral Drug Abacavir across the Placenta
    Lukas Cerveny, Zuzana Ptackova, Martina Ceckova, Rona Karahoda, Sara Karbanova, Lucie Jiraskova, Susan L. Greenwood, Jocelyn D. Glazier and Frantisek Staud
    Drug Metabolism and Disposition November 2018, 46 (11) 1817-1826; DOI: https://doi.org/10.1124/dmd.118.083329
  • You have access
    Health-Relevant Phenotypes in the Offspring of Mice Given CAR Activators Prior to Pregnancy
    Karin Dietrich, Jan Baumgart, Leonid Eshkind, Lea Reuter, Ute Gödtel-Armbrust, Elke Butt, Michael Musheev, Federico Marini, Piyush More, Tanja Grosser, Christof Niehrs, Leszek Wojnowski and Marianne Mathäs
    Drug Metabolism and Disposition November 2018, 46 (11) 1827-1835; DOI: https://doi.org/10.1124/dmd.118.082925

Short Communication

  • You have access
    Mouse Hepatomas with Ha-ras and B-raf Mutations Differ in Mitogen-Activated Protein Kinase Signaling and Response to Constitutive Androstane Receptor Activation
    Albert Braeuning, Ferdinand Kollotzek, Eva Zeller, Thomas Knorpp, Markus F. Templin and Michael Schwarz
    Drug Metabolism and Disposition November 2018, 46 (11) 1462-1465; DOI: https://doi.org/10.1124/dmd.118.083014
  • You have access
    Brain Uptake of [13C] and [14C]Sucrose Quantified by Microdialysis and Whole Tissue Analysis in Mice
    Faleh Alqahtani, Ekram Ahmed Chowdhury, Raktima Bhattacharya, Behnam Noorani, Reza Mehvar and Ulrich Bickel
    Drug Metabolism and Disposition November 2018, 46 (11) 1514-1518; DOI: https://doi.org/10.1124/dmd.118.082909
Back to top
PreviousNext

In this issue

Drug Metabolism and Disposition: 46 (11)
Drug Metabolism and Disposition
Vol. 46, Issue 11
1 Nov 2018
  • Table of Contents
  • Table of Contents (PDF)
  • About the Cover
  • Index by author
  • Editorial Board (PDF)
  • Front Matter (PDF)
Sign up for alerts

Jump to

  • Special Section – New Models in Drug Metabolism and Transport
  • Commentary
  • Articles
  • Short Communication
  • Most Cited
  • Most Read
Loading
  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
More...
Advertisement
  • Home
  • Alerts
Facebook   Twitter   LinkedIn   RSS

Navigate

  • Current Issue
  • Fast Forward by date
  • Fast Forward by section
  • Latest Articles
  • Archive
  • Search for Articles
  • Feedback
  • ASPET

More Information

  • About DMD
  • Editorial Board
  • Instructions to Authors
  • Submit a Manuscript
  • Customized Alerts
  • RSS Feeds
  • Subscriptions
  • Permissions
  • Terms & Conditions of Use

ASPET's Other Journals

  • Journal of Pharmacology and Experimental Therapeutics
  • Molecular Pharmacology
  • Pharmacological Reviews
  • Pharmacology Research & Perspectives
ISSN 1521-009X (Online)

Copyright © 2023 by the American Society for Pharmacology and Experimental Therapeutics