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Research ArticleArticle

When Does the Rate-Determining Step in the Hepatic Clearance of a Drug Switch from Sinusoidal Uptake to All Hepatobiliary Clearances? Implications for Predicting Drug-Drug Interactions

Gabriela I. Patilea-Vrana and Jashvant D. Unadkat
Drug Metabolism and Disposition November 2018, 46 (11) 1487-1496; DOI: https://doi.org/10.1124/dmd.118.081307

Article Information

vol. 46 no. 11 1487-1496
DOI 
https://doi.org/10.1124/dmd.118.081307
PubMed 
30115647
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received March 7, 2018
  • Accepted August 10, 2018
  • Published online October 12, 2018.

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Copyright & Usage 
Copyright © 2018 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Gabriela I. Patilea-Vrana and
  2. Jashvant D. Unadkat
  1. Department of Pharmaceutics, University of Washington, Seattle, Washington
  1. Address correspondence to:
    Dr. Jashvant D. Unadkat, Department of Pharmaceutics, University of Washington, Box 357610, Seattle, WA 98195. E-mail: jash{at}uw.edu
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RDS Switch from Uptake to All Hepatobiliary Clearances

Gabriela I. Patilea-Vrana and Jashvant D. Unadkat
Drug Metabolism and Disposition November 1, 2018, 46 (11) 1487-1496; DOI: https://doi.org/10.1124/dmd.118.081307
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